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References from Eriodictyol regulates LDHB to trigger mitophagy-mediated NLRP3 inflammasome inactivation as a therapeutic strategy for bone loss. Local targets link to admitted publications; unresolved targets remain external evidence.
Modulation of SIRT6 activity acts as an emerging therapeutic implication for pathological disorders in the skeletal system
10.1016/j.gendis.2021.12.024 · 2023 · External reference
Parathyroid Hormone Derivative with Reduced Osteoclastic Activity Promoted Bone Regeneration via Synergistic Bone Remodeling and Angiogenesis
10.1002/smll.201905876 · 2020 · External reference
Intestinal Inflammation Promotes MDL-1+ Osteoclast Precursor Expansion to Trigger Osteoclastogenesis and Bone Loss
10.1016/j.jcmgh.2022.07.002 · 2022 · External reference
Identification of lactylation-related biomarkers in osteoporosis from transcriptome and single-cell data
10.3389/fendo.2025.1621878 · 2025 · External reference
The pharmacological and biological roles of eriodictyol
10.1007/s12272-020-01243-0 · 2020 · External reference
Eriodictyol alleviates ovarian dysfunction in a mouse model of premature ovarian failure via the PI3K/Akt/NF-κB pathway and suppression of macrophage inflammation
10.3389/fphar.2025.1710805 · 2025 · External reference
Eriodictyol inhibits IL-1β-induced inflammatory response in human osteoarthritis chondrocytes
10.1016/j.biopha.2018.08.103 · 2018 · External reference
The Extraction, Biosynthesis, Health-Promoting and Therapeutic Properties of Natural Flavanone Eriodictyol
10.3390/nu16234237 · 2024 · External reference
Eriodictyol mitigates polystyrene nanoplastic-induced ovarian toxicity via targeted inhibition of the TLR4/NF-κB/NLRP3 inflammatory axis
10.1016/j.envpol.2026.128007 · 2026 · External reference
Eriodictyol Inhibits RANKL-Induced Osteoclast Formation and Function Via Inhibition of NFATc1 Activity
10.1002/jcp.25304 · 2016 · External reference
Targeted inhibition of ATP5B gene prevents bone erosion in collagen-induced arthritis by inhibiting osteoclastogenesis
10.1016/j.phrs.2021.105458 · 2021 · External reference
Sexual dimorphism of osteoclast reliance on mitochondrial oxidation of energy substrates in the mouse
10.1172/jci.insight.174293 · 2023 · External reference
The Role of Autophagy and Mitophagy in Bone Metabolic Disorders
10.7150/ijbs.46627 · 2020 · External reference
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy
2019 · External reference
Platycodin D attenuates diabetic renal ischemia/reperfusion injury by enhancing mitophagy and suppressing MAPK/NF-κB signaling activation
2025 · External reference
YBX1-LDHB axis orchestrates pyruvate production from lactate to promote ICC initiation and development
10.1016/j.phrs.2026.108110 · 2026 · External reference
CDK1-mediated phosphorylation of LDHA fuels mitosis through LDHB-dependent lactate oxidation
10.1038/s44319-025-00573-8 · 2025 · External reference
LDHB Deficiency Promotes Mitochondrial Dysfunction Mediated Oxidative Stress and Neurodegeneration in Adult Mouse Brain
10.3390/antiox11020261 · 2022 · External reference
Lactate metabolism is associated with mammalian mitochondria
10.1038/nchembio.2172 · 2016 · External reference
ACT001 improves OVX-induced osteoporosis by suppressing the NF-κB/NLRP3 signaling pathway
10.1186/s10020-025-01189-3 · 2025 · External reference
The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages
10.1038/s41467-021-26987-1 · 2021 · External reference
Scoparone suppresses mitophagy-mediated NLRP3 inflammasome activation in inflammatory diseases
10.1038/s41401-022-01028-9 · 2023 · External reference
Pyroptosis leads to loss of centrosomal integrity in macrophages
10.1038/s41420-024-02093-1 · 2024 · External reference
Interleukin (IL) 18 stimulates osteoclast formation through synovial T cells in rheumatoid arthritis:: comparison with IL1β and tumour necrosis factor α
10.1136/ard.2003.018481 · 2004 · External reference
Periplogenin attenuates LPS-mediated inflammatory osteolysis through the suppression of osteoclastogenesis via reducing the NF-κB and MAPK signaling pathways
10.1038/s41420-024-01856-0 · 2024 · External reference
Inflammasomes: mechanism of action, role in disease, and therapeutics
10.1038/nm.3893 · 2015 · External reference
Mechanistic Insights into T-2 Toxin-Induced Thymic Epithelial Cell Injury and Immunotoxicity via the ROS-NF-κB-NLRP3 Signaling Axis
10.1021/acs.jafc.5c00355 · 2025 · External reference
The role of mitochondrial dynamics and mitophagy in skeletal muscle atrophy: from molecular mechanisms to therapeutic insights
10.1186/s11658-024-00572-y · 2024 · External reference
Dynamin-Related Protein 1 Inhibition Attenuates Cardiovascular Calcification in the Presence of Oxidative Stress
10.1161/circresaha.116.310293 · 2017 · External reference
RhoA signaling increases mitophagy and protects cardiomyocytes against ischemia by stabilizing PINK1 protein and recruiting Parkin to mitochondria
10.1038/s41418-022-01032-w · 2022 · External reference
The role of PINK1-Parkin in mitochondrial quality control
10.1038/s41556-024-01513-9 · 2024 · External reference
Bergapten inhibits NLRP3 inflammasome activation and pyroptosis via promoting mitophagy
10.1038/s41401-023-01094-7 · 2023 · External reference
LDHB inhibition induces mitophagy and facilitates the progression of CSFV infection
10.1080/15548627.2020.1823123 · 2021 · External reference
Cofilin-1 is a redox-sensitive guard of the NLRP3 inflammasome
10.1038/s41590-026-02477-8 · 2026 · External reference
Obacunone targets macrophage migration inhibitory factor (MIF) to impede osteoclastogenesis and alleviate ovariectomy-induced bone loss
10.1016/j.jare.2023.01.003 · 2023 · External reference
Non-pyroptotic caspase-11 activity regulates osteoclastogenesis and pathological bone loss
10.1038/s41418-025-01596-3 · 2025 · External reference
Pseurotin A Inhibits Osteoclastogenesis and Prevents Ovariectomized‑Induced Bone Loss by Suppressing Reactive Oxygen Species
10.7150/thno.30206 · 2019 · External reference
A novel BRD4 inhibitor suppresses osteoclastogenesis and ovariectomized osteoporosis by blocking RANKL‑mediated MAPK and NF‑κB pathways
10.1038/s41419-021-03939-7 · 2021 · External reference
Activated macrophage membrane-coated nanoparticles relieve osteoarthritis-induced synovitis and joint damage
10.1016/j.biomaterials.2023.122036 · 2023 · External reference
Accelerated Regeneration of Senescent Bone Injury through Age- and Sex-Independent Macrophage Polarization
10.1021/acsami.5c15449 · 2025 · External reference
STAT3/Mitophagy Axis Coordinates Macrophage NLRP3 Inflammasome Activation and Inflammatory Bone Loss
10.1002/jbmr.4756 · 2023 · External reference
Hydroxyurea blunts mitochondrial energy metabolism and osteoblast and osteoclast differentiation exacerbating trabecular bone loss in sickle cell mice
10.1038/s41419-024-07296-z · 2024 · External reference
Mitochondrial electron transport chain: Oxidative phosphorylation, oxidant production, and methods of measurement
10.1016/j.redox.2020.101674 · 2020 · External reference
Drp1 depletion protects against ferroptotic cell death by preserving mitochondrial integrity and redox homeostasis
10.1038/s41419-024-07015-8 · 2024 · External reference
ANKZF1 helps to eliminate stress-damaged mitochondria by LC3-mediated mitophagy
10.1038/s41420-025-02638-y · 2025 · External reference
Regulation of the NLRP3 inflammasome by autophagy and mitophagy
10.1111/imr.13410 · 2025 · External reference
Emodin Inhibits NLRP3 Inflammasome Activation and Protects Against Sepsis via Promoting FUNDC1-Mediated Mitophagy
10.7150/ijbs.110904 · 2025 · External reference
The lactate dehydrogenase (LDH) isoenzyme spectrum enables optimally controlling T cell glycolysis and differentiation
2023 · External reference
Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer
10.1038/s41418-024-01427-x · 2025 · External reference
Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage
10.1007/s00018-022-04453-5 · 2022 · External reference
Long noncoding RNA Malat1 protects against osteoporosis and bone metastasis
10.1038/s41467-024-46602-3 · 2024 · External reference
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
10.1038/s41413-023-00312-6 · 2024 · External reference
Unraveling the Mechanisms of Osteoporosis Triggered by Methylparaben and Monomethyl Phthalate through Integrated Mendelian Randomization, In Silico Simulations, and Experimental Validation
10.1021/acs.est.5c12267 · 2026 · External reference