Research graph
References from Pan-cancer splicing landscape identifies that the alternative splicing of SLK regulates cancer metastasis. Local targets link to admitted publications; unresolved targets remain external evidence.
The gene encoding the splicing factor SF2/ASF is a proto-oncogene
10.1038/nsmb1209 · 2007 · External reference
The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression
10.1016/j.ccr.2014.07.010 · 2014 · External reference
Alternative splicing and cancer: insights, opportunities, and challenges from an expanding view of the transcriptome
10.1101/gad.338962.120 · 2020 · External reference
Hallmarks of alternative splicing in cancer
10.1038/onc.2013.533 · 2014 · External reference
RNA splicing dysregulation and the hallmarks of cancer
10.1038/s41568-022-00541-7 · 2023 · External reference
Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors
10.18632/oncotarget.3145 · 2015 · External reference
A widespread length-dependent splicing dysregulation in cancer
10.1126/sciadv.abn9232 · 2022 · External reference
Induction of apoptosis by SLK, a Ste20-related kinase
10.1038/sj.onc.1203119 · 1999 · External reference
The Ste20-like kinase - a Jack of all trades?
10.1242/jcs.258269 · 2021 · External reference
Occludin S490 phosphorylation regulates vascular endothelial growth factor-induced retinal neovascularization
10.1016/j.ajpath.2016.04.018 · 2016 · External reference
Ste20-related kinase SLK phosphorylates Ser188 of RhoA to induce vasodilation in response to angiotensin II Type 2 receptor activation
10.1161/circresaha.107.164764 · 2008 · External reference
Polo-like Kinase 1 regulates vimentin phosphorylation at Ser-56 and contraction in smooth muscle
10.1074/jbc.m116.749341 · 2016 · External reference
The Ldb1 and Ldb2 transcriptional cofactors interact with the Ste20-like kinase SLK and regulate cell migration
10.1091/mbc.e08-07-0707 · 2009 · External reference
Transforming growth factor beta-induced epithelial to mesenchymal transition requires the Ste20-like kinase SLK independently of its catalytic activity
10.18632/oncotarget.21928 · 2017 · External reference
Recruitment and activation of SLK at the leading edge of migrating cells requires Src family kinase activity and the LIM-only protein 4
10.1016/j.bbamcr.2015.04.003 · 2015 · External reference
SLK-dependent activation of ERMs controls LGN-NuMA localization and spindle orientation
10.1083/jcb.201401049 · 2014 · External reference
SLK-mediated phosphorylation of paxillin is required for focal adhesion turnover and cell migration
10.1038/onc.2012.488 · 2013 · External reference
Regulation of catalytic and non-catalytic functions of the drosophila Ste20 kinase slik by activation segment phosphorylation
10.1074/jbc.m115.645952 · 2015 · External reference
The Ste20-like kinase SLK is required for ErbB2-driven breast cancer cell motility
10.1038/onc.2009.146 · 2009 · External reference
Plk1 activation by Ste20-like kinase (Slk) phosphorylation and polo-box phosphopeptide binding assayed with the substrate translationally controlled tumor protein (TCTP)
10.1021/bi702134c · 2008 · External reference
Highly accurate protein structure prediction for the human proteome
10.1038/s41586-021-03828-1 · 2021 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
The GTEx Consortium atlas of genetic regulatory effects across human tissues
10.1126/science.aaz1776 · 2020 · External reference
A perspective on cancer cell metastasis
10.1126/science.1203543 · 2011 · External reference
Association of the Ste20-like kinase (SLK) with the microtubule. Role in Rac1-mediated regulation of actin dynamics during cell adhesion and spreading
10.1074/jbc.m205899200 · 2002 · External reference
Ste20-like kinase SLK, at the crossroads
10.4161/cam.22495 · 2013 · External reference
FAK/src-family dependent activation of the Ste20-like kinase SLK is required for microtubule-dependent focal adhesion turnover and cell migration
10.1371/journal.pone.0001868 · 2008 · External reference
Lymph node colonization induces tumor-immune tolerance to promote distant metastasis
10.1016/j.cell.2022.04.019 · 2022 · External reference
Occludin phosphorylation in regulation of epithelial tight junctions
10.1111/j.1749-6632.2009.04054.x · 2009 · External reference
The tight junction protein, occludin, regulates the directional migration of epithelial cells
10.1016/j.devcel.2009.12.008 · 2010 · External reference
Loss of occludin leads to the progression of human breast cancer
10.3892/ijmm_00000519 · 2010 · External reference
A day in the life of the spliceosome
10.1038/nrm3742 · 2014 · External reference
Highly conserved cysteines are involved in the oligomerization of occludin-redox dependency of the second extracellular loop
10.1089/ars.2013.5288 · 2014 · External reference
Aberrant RNA splicing in cancer; expression changes and driver mutations of splicing factor genes
10.1038/onc.2015.318 · 2016 · External reference
Splicing dysregulation in cancer: from mechanistic understanding to a new class of therapeutic targets
10.1007/s11427-019-1605-0 · 2020 · External reference
The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor progression
10.1016/j.ccr.2014.07.010 · 2014 · External reference
An integrated encyclopedia of DNA elements in the human genome
10.1038/nature11247 · 2012 · External reference
Rbfox2 dissociation from stress granules suppresses cancer progression
10.1038/s12276-019-0246-y · 2019 · External reference
The RNA-binding protein Rbfox2: an essential regulator of EMT-driven alternative splicing and a mediator of cellular invasion
10.1038/onc.2013.50 · 2014 · External reference
RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues
10.1128/mcb.01174-12 · 2013 · External reference
Regulation of alternative pre-mRNA splicing by a novel repeated hexanucleotide element
10.1101/gad.8.13.1561 · 1994 · External reference
RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer
10.1038/s41586-023-05820-3 · 2023 · External reference
Rbfox proteins regulate splicing as part of a large multiprotein complex LASR
10.1016/j.cell.2016.03.040 · 2016 · External reference
Roles for RACK1 in cancer cell migration and invasion
10.1016/j.cellsig.2017.03.005 · 2017 · External reference
Exon skipping of Ste20-like kinase enhances glycolysis and tumor progression by activating enolase 1-mediated phosphoenolpyruvate production
10.1158/0008-5472.can-25-0523 · 2025 · External reference
Phosphorylation hotspot in the C-terminal domain of occludin regulates the dynamics of epithelial junctional complexes
10.1242/jcs.206789 · 2018 · External reference
Glycogen synthase kinase 3 (GSK-3) influences epithelial barrier function by regulating occludin, claudin-1 and E-cadherin expression
10.1016/j.bbrc.2010.05.164 · 2010 · External reference
Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins/occludin by snail
10.1242/jcs.00389 · 2003 · External reference
Systematical identification of splicing regulatory cis-elements and cognate trans-factors
2013 · External reference
Parafold: paralleling alphafold for large-scale predictions
2022 · External reference
