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References from Selective targeting of the oligodendroglial GPR17 receptor improves myelin integrity and motor function in female SOD1G93A mice. Local targets link to admitted publications; unresolved targets remain external evidence.
Amyotrophic lateral sclerosis
10.1056/nejmra1603471 · 2017 · External reference
Amyotrophic lateral sclerosis: a neurodegenerative disorder poised for successful therapeutic translation
10.1038/s41573-022-00612-2 · 2023 · External reference
Towards an integrated approach for understanding glia in Amyotrophic Lateral Sclerosis
10.1002/glia.24622 · 2025 · External reference
Oligodendrocyte Dysfunction in Amyotrophic Lateral Sclerosis: Mechanisms and Therapeutic Perspectives
10.3390/cells10030565 · 2021 · External reference
Revisiting oligodendrocytes in amyotrophic lateral sclerosis using human multicellular stem cell models
2025 · External reference
Oligodendrocytes in amyotrophic lateral sclerosis and frontotemporal dementia: the new players on stage
10.3389/fnmol.2024.1375330 · 2024 · External reference
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis
10.1038/nn.3357 · 2013 · External reference
Oligodendrocyte dysfunction in the pathogenesis of amyotrophic lateral sclerosis
10.1093/brain/aws339 · 2013 · External reference
Abnormal Upregulation of GPR17 Receptor Contributes to Oligodendrocyte Dysfunction in SOD1 G93A Mice
10.3390/ijms21072395 · 2020 · External reference
Regulation and signaling of the GPR17 receptor in oligodendroglial cells
2020 · External reference
GPR17 – orphan G protein-coupled receptor with therapeutic potential
10.1016/j.tips.2025.05.001 · 2025 · External reference
Phenotypic changes, signaling pathway, and functional correlates of GPR17-expressing neural precursor cells during oligodendrocyte differentiation
10.1074/jbc.m110.162867 · 2011 · External reference
Rewiring of Glucose and Lipid Metabolism Induced by G Protein-Coupled Receptor 17 Silencing Enables the Transition of Oligodendrocyte Progenitors to Myelinating Cells
10.3390/cells11152369 · 2022 · External reference
G protein-coupled receptor 17 is regulated by WNT pathway during oligodendrocyte precursor cell differentiation
10.1016/j.nbd.2023.106315 · 2023 · External reference
The oligodendrocyte-specific G protein-coupled receptor GPR17 is a cell-intrinsic timer of myelination
10.1038/nn.2410 · 2009 · External reference
The ubiquitin ligase Mdm2 controls oligodendrocyte maturation by intertwining mTOR with G protein-coupled receptor kinase 2 in the regulation of GPR17 receptor desensitization
10.1002/glia.22896 · 2015 · External reference
The orphan receptor GPR17 identified as a new dual uracil nucleotides/cysteinyl-leukotrienes receptor
10.1038/sj.emboj.7601341 · 2006 · External reference
Oxysterols act as promiscuous ligands of class-A GPCRs: In silico molecular modeling and in vitro validation
10.1016/j.cellsig.2014.08.003 · 2014 · External reference
Identification and characterization of select oxysterols as ligands for GPR17
10.1111/bph.15969 · 2023 · External reference
Montelukast improves disease outcome in SOD1 G93A female mice by counteracting oligodendrocyte dysfunction and aberrant glial reactivity
10.1111/bph.16408 · 2024 · External reference
Agonist-induced desensitization/resensitization of human G protein-coupled receptor 17: A functional cross-talk between purinergic and cysteinyl- leukotriene ligands
10.1124/jpet.110.178715 · 2011 · External reference
Does GRK-β arrestin machinery work as a “switch on” for GPR17-mediated activation of intracellular signaling pathways?
10.1016/j.cellsig.2014.02.016 · 2014 · External reference
Surface Plasmon Resonance as a Tool for Ligand Binding Investigation of Engineered GPR17 Receptor, a G Protein Coupled Receptor Involved in Myelination
10.3389/fchem.2019.00910 · 2020 · External reference
Development of the first in vivo GPR17 ligand through an iterative drug discovery pipeline: A novel disease-modifying strategy for multiple sclerosis
10.1371/journal.pone.0231483 · 2020 · External reference
Integrative transcriptomic analysis of the amyotrophic lateral sclerosis spinal cord implicates glial activation and suggests new risk genes
10.1038/s41593-022-01205-3 · 2023 · External reference
Single-cell transcriptomic and functional studies identify glial state changes and a role for inflammatory RIPK1 signaling in ALS pathogenesis
10.1016/j.immuni.2025.02.024 · 2025 · External reference
Characterisation of <scp>GPR17</scp> -expressing oligodendrocyte precursors in human ischaemic lesions and correlation with reactive glial responses
10.1002/path.6381 · 2025 · External reference
Characterization of the TNF and IL-1 systems in human brain and blood after ischemic stroke
10.1186/s40478-020-00957-y · 2020 · External reference
Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
1994 · External reference
In-vivo genetic ablation of metabotropic glutamate receptor type 5 slows down disease progression in the SOD1G93A mouse model of amyotrophic lateral sclerosis
10.1016/j.nbd.2019.05.007 · 2019 · External reference
State of the field: An informatics-based systematic review of the SOD1-G93A amyotrophic lateral sclerosis transgenic mouse model
10.3109/21678421.2015.1047455 · 2016 · External reference
Altered mechanisms underlying the abnormal glutamate release in amyotrophic lateral sclerosis at a pre-symptomatic stage of the disease
10.1016/j.nbd.2016.07.011 · 2016 · External reference
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
10.1111/bph.15193 · 2020 · External reference
One universal common endpoint in mouse models of amyotrophic lateral sclerosis
10.1371/journal.pone.0020582 · 2011 · External reference
Blocking glutamate mGlu5 receptors with the negative allosteric modulator CTEP improves disease course in SOD1G93A mouse model of amyotrophic lateral sclerosis
10.1111/bph.15515 · 2021 · External reference
Guidelines for the preclinical in vivo evaluation of pharmacological active drugs for ALS/MND: Report on the 142nd ENMC international workshop
10.1080/17482960701292837 · 2007 · External reference
Assessment of motor balance and coordination in mice using the balance beam
10.3791/2376 · 2011 · External reference
Microglial vesicles improve post-stroke recovery by preventing immune cell senescence and favoring oligodendrogenesis
10.1016/j.ymthe.2020.12.009 · 2021 · External reference
TNFR2 signaling shapes the sex-specific remyelinating properties of microglia after experimental stroke
10.1016/j.neurot.2025.e00745 · 2025 · External reference
Prenatal Stress Impairs Spinal Cord Oligodendrocyte Maturation via BDNF Signaling in the Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis
10.1007/s10571-020-01014-x · 2022 · External reference
Label-free and fluorescence imaging of oligodendrocytes and myelin
10.1038/s44303-025-00098-8 · 2025 · External reference
Reflective imaging of myelin integrity in the human and mouse central nervous systems
10.3389/fncel.2024.1408182 · 2024 · External reference
silico identification of new ligands for GPR17: A promising therapeutic target for neurodegenerative diseases
10.1007/s10822-011-9455-8 · 2011 · External reference
Disease-associated oligodendroglia: a putative nexus in neurodegeneration
10.1016/j.it.2024.08.003 · 2024 · External reference
The distribution of gpr17-expressing cells correlates with white matter inflammation status in brain tissues of multiple sclerosis patients
10.3390/ijms22094574 · 2021 · External reference
Improvement of fiber connectivity and functional recovery after stroke by montelukast, an available and safe anti-asthmatic drug
10.1016/j.phrs.2019.02.025 · 2019 · External reference
Discovery of Anthranilic Acid Derivatives as Antagonists of the Pro-Inflammatory Orphan G Protein-Coupled Receptor GPR17
10.1021/acs.jmedchem.4c01755 · 2024 · External reference
Robust Myelination of Regenerated Axons Induced by Combined Manipulations of GPR17 and Microglia
10.1016/j.neuron.2020.09.016 · 2020 · External reference
Design, synthesis and biological evaluation of suramin-derived dual antagonists of the proinflammatory G protein-coupled receptors P2Y2 and GPR17
10.1016/j.ejmech.2019.111789 · 2020 · External reference
Repurposing HAMI3379 to Block GPR17 and Promote Rodent and Human Oligodendrocyte Differentiation
10.1016/j.chembiol.2018.03.012 · 2018 · External reference
Olig2-targeted G-protein-coupled receptor Gpr17 regulates oligodendrocyte survival in response to lysolecithin-induced demyelination
10.1523/jneurosci.0898-16.2016 · 2016 · External reference
Barcoding of GPCR trafficking and signaling through the various trafficking roadmaps by compartmentalized signaling networks
10.1016/j.cellsig.2017.04.015 · 2017 · External reference
The GPR17 agonist galinex restores oligodendrocyte maturation under inflammatory conditions
10.3389/fphar.2026.1838997 · 2026 · External reference
GnRH and GnRH receptors in the pathophysiology of the human female reproductive system
10.1093/humupd/dmv059 · 2016 · External reference
Fingolimod in multiple sclerosis: Mechanisms of action and clinical efficacy
10.1016/j.clim.2011.05.005 · 2012 · External reference
Fingolimod for Multiple Sclerosis
10.1056/nejmct1101691 · 2012 · External reference
Investigating the molecular mechanisms through which <scp>FTY</scp> 720- <scp>P</scp> causes persistent <scp> S1P 1 </scp> receptor internalization
10.1111/bph.12620 · 2014 · External reference
Constitutive activity among orphan G protein-coupled receptors: Molecular mechanisms and pharmacological perspectives
10.1016/j.molpha.2025.100100 · 2026 · External reference
Gpr17 deficiency in POMC neurons ameliorates the metabolic derangements caused by long-term high-fat diet feeding
10.1038/s41387-019-0096-7 · 2019 · External reference
Leanness and Low Plasma Leptin in GPR17 Knockout Mice Are Dependent on Strain and Associated With Increased Energy Intake That Is Not Suppressed by Exogenous Leptin
10.3389/fendo.2021.698115 · 2021 · External reference
A GPR17-cAMP-Lactate Signaling Axis in Oligodendrocytes Regulates Whole-Body Metabolism
10.1016/j.celrep.2019.02.060 · 2019 · External reference
Sex differences of microglia in the healthy brain from embryonic development to adulthood and across lifestyle influences
10.1016/j.brainresbull.2023.110752 · 2023 · External reference
Sex and age differences in glia and myelin in nonhuman primate and human spinal cords: implications for pathology
10.1038/s41420-025-02425-9 · 2025 · External reference
Sex-specific differences in transcriptomic profiles and cellular characteristics of oligodendrocyte precursor cells
10.1016/j.scr.2020.101866 · 2020 · External reference
GPCRs in context: sexual dimorphism in the cardiovascular system
10.1111/bph.14160 · 2018 · External reference
Characterization of the Contribution of Genetic Background and Gender to Disease Progression in the SOD1 G93A Mouse Model of Amyotrophic Lateral Sclerosis: A Meta-Analysis
10.3233/jnd-140068 · 2015 · External reference
Pre-symptomatic detection of chronic motor deficits and genotype prediction in congenic B6.SOD1 ALS mouse model
10.1016/j.neuroscience.2009.08.031 · 2009 · External reference
Epidemiology of amyotrophic lateral sclerosis: A review of literature
10.1016/j.neurol.2015.11.002 · 2016 · External reference
Effects of gender in amyotrophic lateral sclerosis
10.1016/j.genm.2010.11.010 · 2010 · External reference
The effects of diet and sex in amyotrophic lateral sclerosis
10.1016/j.neurol.2019.09.008 · 2020 · External reference
Neuroinflammation and Oxidative Stress in SOD1 Animal Models of ALS: A Meta-analysis Study of Their Effects on Disease Onset and Progression
10.1007/s12035-026-05773-4 · 2026 · External reference
Myelin debris phagocytosis in demyelinating disease
10.1002/glia.24602 · 2024 · External reference
The roles of microglia and astrocytes in myelin phagocytosis in the central nervous system
10.1177/0271678x221137762 · 2023 · External reference
Inefficient clearance of myelin debris by microglia impairs remyelinating processes
10.1084/jem.20141656 · 2015 · External reference
TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis
10.1007/s00401-020-02193-z · 2020 · External reference
Myelin phagocytosis by astrocytes after myelin damage promotes lesion pathology
10.1093/brain/aww298 · 2017 · External reference
Not only myelination: the immune- inflammatory functions of oligodendrocytes
10.4103/1673-5374.342678 · 2022 · External reference
Changes in glial cell activation and extracellular vesicles production precede the onset of disease symptoms in transgenic hSOD1G93A pigs
10.1016/j.expneurol.2024.114716 · 2024 · External reference
Emerging insights into the complex genetics and pathophysiology of amyotrophic lateral sclerosis
10.1016/s1474-4422(21)00414-2 · 2022 · External reference
