Contact and support
Need help, have a question, or want to contact the ResearchHub team?
© 2026 ResearchHub. Built for responsible scholarly connection.
Research graph
References from Targeting tryptophan metabolism in cardiovascular disease: From immune-metabolic crosstalk to precision therapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study
10.1016/s0140-6736(19)32008-2 · 2020 · External reference
Epidemiology of cardiovascular disease in Europe
10.1038/s41569-021-00607-3 · 2021 · External reference
Metabolic reprogramming: a byproduct or a driver of cardiomyocyte proliferation?
10.1161/circulationaha.123.065880 · 2024 · External reference
Cardio-onco-metabolism: metabolic remodelling in cardiovascular disease and cancer
10.1038/s41569-022-00698-6 · 2022 · External reference
Host-microbe tryptophan partitioning in cardiovascular diseases
10.1016/j.phrs.2023.106994 · 2023 · External reference
Microbial tryptophan catabolites in health and disease
10.1038/s41467-018-05470-4 · 2018 · External reference
Kynurenines: tryptophan’s metabolites in exercise, inflammation, and mental health
10.1126/science.aaf9794 · 2017 · External reference
Gut microbiota regulation of tryptophan metabolism in health and disease
10.1016/j.chom.2018.05.003 · 2018 · External reference
Tryptophan and indole metabolism in immune regulation
10.1016/j.coi.2020.12.001 · 2021 · External reference
Tryptophan: from diet to cardiovascular diseases
10.3390/ijms22189904 · 2021 · External reference
Tryptophan metabolism in health and disease
10.1016/j.cmet.2023.06.004 · 2023 · External reference
Modulation of T cells by tryptophan metabolites in the kynurenine pathway
10.1016/j.tips.2023.04.006 · 2023 · External reference
Dietary fibre directs microbial tryptophan metabolism via metabolic interactions in the gut microbiota
10.1038/s41564-024-01737-3 · 2024 · External reference
Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury
10.1136/gutjnl-2020-321565 · 2021 · External reference
Pregnane X Receptor and the Gut-Liver Axis: A Recent Update
10.1124/dmd.121.000415 · 2022 · External reference
Serotonin 3 receptor antagonism reduces angiotensin II–induced abdominal aortic aneurysms: Contribution of periaortic fat–derived serotonin
10.1016/j.jpet.2024.100533 · 2025 · External reference
Harnessing intestinal tryptophan catabolism to relieve atherosclerosis in mice
10.1038/s41467-024-50807-x · 2024 · External reference
Prognostic value of tryptophan catabolism-base scores in acute myocardial infarction patients
10.1016/j.jare.2025.03.025 · 2026 · External reference
Indole-3-Propionic Acid Protects Against Heart Failure With Preserved Ejection Fraction
10.1161/circresaha.123.322381 · 2024 · External reference
Developmental Programming and Reprogramming of Hypertension and Kidney Disease: Impact of Tryptophan Metabolism
10.3390/ijms21228705 · 2020 · External reference
Metabolomics of the tryptophan–kynurenine degradation pathway and risk of atrial fibrillation and heart failure: potential modification effect of Mediterranean diet
10.1093/ajcn/nqab238 · 2021 · External reference
Prebiotic and probiotic supplementation and the tryptophan-kynurenine pathway: a systematic review and meta analysis
10.1016/j.neubiorev.2020.12.026 · 2021 · External reference
Exploring tryptophan metabolism in cardiometabolic diseases
10.1016/j.tem.2024.11.009 · 2025 · External reference
Modulation of immunity by tryptophan microbial metabolites
2023 · External reference
Immune regulation through tryptophan metabolism
10.1038/s12276-023-01028-7 · 2023 · External reference
Kynurenine pathway metabolites and enzymes involved in redox reactions
10.1016/j.neuropharm.2016.03.013 · 2017 · External reference
Molecular mechanisms and therapeutic significance of Tryptophan Metabolism and signaling in cancer
10.1186/s12943-024-02164-y · 2024 · External reference
Gut Microbiota-derived tryptophan metabolites maintain gut and systemic homeostasis
10.3390/cells11152296 · 2022 · External reference
Dysbiosis of the gut microbiota is associated with HIV disease progression and tryptophan catabolism
10.1126/scitranslmed.3006438 · 2013 · External reference
Butyrate produced by commensal bacteria down-regulates indolamine 2,3-dioxygenase 1 (IDO-1) expression via a dual mechanism in human intestinal epithelial cells
10.3389/fimmu.2018.02838 · 2018 · External reference
Exploring tryptophan metabolism: the transition from disturbed balance to diagnostic and therapeutic potential in metabolic diseases
2024 · External reference
Peripheral Serotonin Synthesis as a New Drug Target
10.1016/j.tips.2018.03.004 · 2018 · External reference
The Microbiota-Gut-Brain Axis
10.1152/physrev.00018.2018 · 2019 · External reference
Serotonin signalling in the gut—functions, dysfunctions and therapeutic targets
10.1038/nrgastro.2013.105 · 2013 · External reference
Enterochromaffin cells are gut chemosensors that couple to sensory neural pathways
10.1016/j.cell.2017.05.034 · 2017 · External reference
Microbiota-derived tryptophan metabolites in vascular inflammation and cardiovascular disease
10.1007/s00726-022-03161-5 · 2022 · External reference
Tryptophan Metabolic Enzyme IL4I1 Inhibits Ferroptosis by Decreasing Ubiquitination of Nrf2 via I3P in Glioblastoma
10.1111/cpr.13816 · 2025 · External reference
IL4i1 and IDO1: oxidases that control a tryptophan metabolic nexus in cancer
10.1016/j.jbc.2023.104827 · 2023 · External reference
IL4I1 is a metabolic immune checkpoint that activates the AHR and promotes tumor progression
10.1016/j.cell.2020.07.038 · 2020 · External reference
The aryl hydrocarbon receptor: structure, signaling, physiology and pathology
10.1038/s41392-025-02500-8 · 2026 · External reference
The aryl hydrocarbon receptor as a mediator of host-microbiota interplay
10.1080/19490976.2020.1859812 · 2020 · External reference
Aryl Hydrocarbon Receptor in Keratinocytes Is Essential for Murine Skin Barrier Integrity
10.1016/j.jid.2016.06.627 · 2016 · External reference
Novel Cellular Targets of AhR Underlie Alterations in Neutrophilic Inflammation and Inducible Nitric Oxide Synthase Expression during Influenza Virus Infection
10.4049/jimmunol.1201341 · 2013 · External reference
The aryl hydrocarbon receptor interacts with c-Maf to promote the differentiation of type 1 regulatory T cells induced by IL-27
10.1038/ni.1912 · 2010 · External reference
Activation of the aryl hydrocarbon receptor induces human type 1 regulatory T cell–like and Foxp3+ regulatory T cells
10.1038/ni.1915 · 2010 · External reference
IL-21 induces IL-22 production in CD4+ T cells
10.1038/ncomms4753 · 2014 · External reference
RelB, a New Partner of Aryl Hydrocarbon Receptor-Mediated Transcription
10.1210/me.2007-0211 · 2007 · External reference
The AhR and NF-κB/Rel Proteins Mediate the Inhibitory Effect of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin on the 3′ Immunoglobulin Heavy Chain Regulatory Region
10.1093/toxsci/kfv193 · 2015 · External reference
Aryl hydrocarbon receptor control of a disease tolerance defence pathway
10.1038/nature13323 · 2014 · External reference
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
10.1038/nm.4106 · 2016 · External reference
The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins
10.1038/nature06881 · 2008 · External reference
Aryl hydrocarbon receptor regulates Stat1 activation and participates in the development of Th17 cells
10.1073/pnas.0804231105 · 2008 · External reference
An endogenous aryl hydrocarbon receptor ligand acts on dendritic cells and T cells to suppress experimental autoimmune encephalomyelitis
10.1073/pnas.1009201107 · 2010 · External reference
Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes
10.1136/jitc-2023-006728 · 2023 · External reference
Aryl Hydrocarbon Receptor Contributes to the Transcriptional Program of IL-10-Producing Regulatory B Cells
10.1016/j.celrep.2019.10.018 · 2019 · External reference
Microbial tryptophan metabolites regulate gut barrier function via the aryl hydrocarbon receptor
10.1073/pnas.2000047117 · 2020 · External reference
Commensal microbiota regulates skin barrier function and repair via signaling through the aryl hydrocarbon receptor
10.1016/j.chom.2021.05.011 · 2021 · External reference
The IL-20 subfamily of cytokines — from host defence to tissue homeostasis
10.1038/nri3766 · 2014 · External reference
The microbiome-gut-brain axis during early life regulates the hippocampal serotonergic system in a sex-dependent manner
10.1038/mp.2012.77 · 2012 · External reference
Kynurenine pathway, NAD+ synthesis, and mitochondrial function: targeting tryptophan metabolism to promote longevity and healthspan
10.1016/j.exger.2020.110841 · 2020 · External reference
Serotonin: a platelet hormone modulating cardiovascular disease
10.1007/s11239-020-02331-0 · 2020 · External reference
Exploring the role of serotonin as an immune modulatory component in cardiovascular diseases
10.3390/ijms24021549 · 2023 · External reference
Serotonin (5-Hydroxytryptamine): metabolism, signaling, biological functions, diseases, and emerging therapeutic opportunities
10.1002/mco2.70383 · 2025 · External reference
Cardiovascular mechanisms of SSRI drugs and their benefits and risks in ischemic heart disease and heart failure
10.1097/yic.0b013e32835d735d · 2013 · External reference
Chronic intake of the selective serotonin reuptake inhibitor fluoxetine enhances atherosclerosis
10.1161/atvbaha.117.310536 · 2018 · External reference
Serotonin skews human macrophage polarization through HTR2B and HTR7
10.4049/jimmunol.1201133 · 2013 · External reference
Serotonin (5-HT) Shapes the Macrophage Gene Profile through the 5-HT2B–Dependent Activation of the Aryl Hydrocarbon Receptor
10.4049/jimmunol.1901531 · 2020 · External reference
Platelet serotonin aggravates myocardial ischemia/reperfusion injury via neutrophil degranulation
10.1161/circulationaha.118.033942 · 2019 · External reference
Antidepressant in treating myocardial infarction complicated with depression via 5-HT/inflammation from heart to brain
10.1016/j.jad.2025.120048 · 2025 · External reference
The cardiac ventricular 5-HT4 receptor is functional in late foetal development and is reactivated in heart failure
2012 · External reference
New therapeutic opportunities for 5-HT(2) receptor ligands
10.1016/j.pharmthera.2016.10.008 · 2017 · External reference
Serotonin and valvular heart disease
10.1080/14728222.2022.2158082 · 2022 · External reference
Long-Term Serotonin Administration Induces Heart Valve Disease in Rats
10.1161/01.cir.0000159356.42064.48 · 2005 · External reference
Serotonin mechanisms in heart valve disease I
10.1016/s0002-9440(10)64489-6 · 2002 · External reference
Endothelial serotonin receptor 1B acts as a mechanosensor to drive atherosclerosis
10.1161/circresaha.124.325453 · 2025 · External reference
Down-regulation of the serotonin transporter in hyperreactive platelets counteracts the pro-thrombotic effect of serotonin
10.1016/j.yjmcc.2012.02.004 · 2012 · External reference
A serotonin-induced N-glycan switch regulates platelet aggregation
10.1038/srep02795 · 2013 · External reference
Serotonin: a different player in hypertension-associated thrombosis
10.1161/hypertensionaha.114.05061 · 2015 · External reference
TPT-004, a next-generation inhibitor of tryptophan hydroxylase, ameliorates pulmonary arterial hypertension in rats
10.1161/jaha.124.034240 · 2024 · External reference
GPR35: from enigma to therapeutic target
10.1016/j.tips.2023.03.001 · 2023 · External reference
Mitochondrial remodeling and ischemic protection by G protein-coupled receptor 35 agonists
10.1126/science.abm1638 · 2022 · External reference
Kynurenic Acid/GPR35 Signaling Protects the Infarcted Heart by Suppressing Macrophage mtDNA-Triggered cGAS-STING Activation
10.3390/antiox15030300 · 2026 · External reference
An expanding range of targets for kynurenine metabolites of tryptophan
10.1016/j.tips.2012.09.006 · 2013 · External reference
Kynurenic Acid Protects Against Myocardial Ischemia/Reperfusion Injury by Activating GPR35 Receptors and Preserving Mitochondrial Structure and Function
10.3390/biom15101481 · 2025 · External reference
Novel Role of GPR35 (G-Protein–Coupled Receptor 35) in the Regulation of Endothelial Cell Function and Blood Pressure
10.1161/hypertensionaha.120.15423 · 2021 · External reference
The intestinal functions of PXR and CAR
10.1016/j.phrs.2025.107779 · 2025 · External reference
Intermittent fasting inhibits platelet activation and thrombosis through the intestinal metabolite indole-3-propionate
10.1093/lifemeta/loaf002 · 2025 · External reference
The pregnane X receptor and its microbiota-derived ligand indole 3-propionic acid regulate endothelium-dependent vasodilation
10.1152/ajpendo.00572.2018 · 2019 · External reference
Glutamate Receptor Ion Channels: Structure, Regulation, and Function
10.1124/pr.109.002451 · 2010 · External reference
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond
10.1038/s41573-019-0016-5 · 2019 · External reference
The kynurenine pathway: a finger in every pie
10.1038/s41380-019-0414-4 · 2019 · External reference
Kynurenines in the CNS: recent advances and new questions
10.1038/nrd3793 · 2012 · External reference
Kynurenic acid selectively reduces heart rate in spontaneously hypertensive rats
10.1007/s00210-019-01771-7 · 2019 · External reference
Melatonin receptor structure and signaling
10.1111/jpi.12952 · 2024 · External reference
Aryl hydrocarbon receptor pathway: Role, regulation and intervention in atherosclerosis therapy (Review)
2019 · External reference
Structural insight into the ligand binding mechanism of aryl hydrocarbon receptor
10.1038/s41467-022-33858-w · 2022 · External reference
Exogenous dendritic cell-derived exosomes promote Treg differentiation via IDO1-Kyn-AhR axis and improve cardiac function after myocardial infarction
10.1016/j.intimp.2026.116253 · 2026 · External reference
Dendritic cell-expressed IDO alleviates atherosclerosis by expanding CD4+CD25+Foxp3+Tregs through IDO-Kyn-AHR axis
10.1016/j.intimp.2023.109758 · 2023 · External reference
Reprogramming of the kynurenine pathway impairs NAD+ homeostasis and mediates doxorubicin-induced cardiotoxicity in mice
10.1016/j.redox.2025.103957 · 2026 · External reference
The role of the kynurenine pathway in cardiovascular disease
10.3389/fcvm.2024.1406856 · 2024 · External reference
Endothelial Cell Indoleamine 2, 3-Dioxygenase 1 Alters Cardiac Function After Myocardial Infarction Through Kynurenine
10.1161/circulationaha.120.050301 · 2021 · External reference
Indoleamine 2,3-Dioxygenase 1 Deletion-Mediated Kynurenine Insufficiency Inhibits Pathological Cardiac Hypertrophy
10.1161/hypertensionaha.122.20809 · 2023 · External reference
Untargeted metabolomics identified kynurenine as a predictive prognostic biomarker in acute myocardial infarction
2022 · External reference
L-Kynurenine regulates immune response in ICIs-associated myocarditis via JAK/STAT pathway
10.1016/j.intimp.2025.114676 · 2025 · External reference
Protocatechuic acid prevents isoproterenol-induced heart failure in mice by downregulating kynurenine-3-monooxygenase
10.1111/jcmm.17869 · 2023 · External reference
Inhibition of KMO Ameliorates Myocardial Ischemia Injury via Maintaining Mitochondrial Fusion and Fission Balance
10.7150/ijbs.83392 · 2023 · External reference
Effects of Kynurenic Acid on the Rat Aorta Ischemia—Reperfusion Model: Pharmacological Characterization and Proteomic Profiling
10.3390/molecules26102845 · 2021 · External reference
Indoleamine 2,3-dioxygenase-1 is protective in atherosclerosis and its metabolites provide new opportunities for drug development
10.1073/pnas.1517820112 · 2015 · External reference
Brain Kynurenine Pathway and Functional Outcome of Rats Resuscitated From Cardiac Arrest
10.1161/jaha.121.021071 · 2021 · External reference
The tryptophan metabolite 3-hydroxyanthranilic acid lowers plasma lipids and decreases atherosclerosis in hypercholesterolaemic mice
10.1093/eurheartj/ehs175 · 2012 · External reference
Microbiota-indole-3-propionic acid-heart axis mediates the protection of leflunomide against αPD1-induced cardiotoxicity in mice
10.1038/s41467-025-58107-8 · 2025 · External reference
Pretreatment with Indole-3-Propionic Acid Attenuates Lipopolysaccharide-Induced Cardiac Dysfunction and Inflammation Through the AhR/NF-κB/NLRP3 Pathway
10.2147/jir.s466777 · 2024 · External reference
Role of Gut Microbial Metabolites in Ischemic and Non-Ischemic Heart Failure
10.3390/ijms26052242 · 2025 · External reference
From Gut to Heart: Role of Indole-3-Propionic Acid in HFpEF
10.1161/circresaha.123.323947 · 2024 · External reference
Gut Microbiota-Derived Metabolites in Atherosclerosis: Pathways, Biomarkers, and Targets
10.3390/ijms26178488 · 2025 · External reference
Gut-Derived Metabolite Indole-3-Propionic Acid Modulates Mitochondrial Function in Cardiomyocytes and Alters Cardiac Function
10.3389/fmed.2021.648259 · 2021 · External reference
Indole-3-propionic acid, a tryptophan-derived bacterial metabolite, increases blood pressure via cardiac and vascular mechanisms in rats
10.1152/ajpregu.00142.2021 · 2021 · External reference
Gut Microbiota-Derived Tryptophan Metabolite Indole-3-aldehyde Ameliorates Aortic Dissection
10.3390/nu15194150 · 2023 · External reference
Vasoconstrictor and vasodilator responses to tryptamine of rat-isolated perfused mesentery: comparison with tyramine and β-phenylethylamine
10.1111/j.1476-5381.2011.01706.x · 2012 · External reference
Saikosaponin A protects against uremic toxin indole‑3 acetic acid‑induced damage to the myocardium
10.3892/mmr.2023.13046 · 2023 · External reference
Impact of uremic toxins on endothelial dysfunction in chronic kidney disease: a systematic review
10.3390/ijms23010531 · 2022 · External reference
The metabolite indole-3-acetic acid of bacteroides ovatus improves atherosclerosis by restoring the polarisation balance of M1/M2 macrophages and inhibiting inflammation
10.1002/advs.202413010 · 2025 · External reference
Mechanisms of tissue factor induction by the uremic toxin indole-3 acetic acid through aryl hydrocarbon receptor/nuclear factor-kappa B signaling pathway in human endothelial cells
10.1007/s00204-018-2328-3 · 2018 · External reference
The cardiovascular effect of the uremic solute indole-3 acetic acid
10.1681/asn.2013121283 · 2015 · External reference
Exploring the Relationship between Gut Microbiome Composition and Blood Indole-3-acetic Acid in Hemodialysis Patients
10.3390/biomedicines12010148 · 2024 · External reference
The Impact of Uremic Toxins on Vascular Smooth Muscle Cell Function
10.3390/toxins10060218 · 2018 · External reference
Cardiorenal disease connection during post-menopause: The protective role of estrogen in uremic toxins induced microvascular dysfunction
10.1016/j.ijcard.2017.03.050 · 2017 · External reference
Podocyte injury caused by indoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand
10.1371/journal.pone.0108448 · 2014 · External reference
Cardiac roles of serotonin (5-HT) and 5-HT-receptors in health and disease
10.3390/ijms24054765 · 2023 · External reference
Pulmonary hypertension induces serotonin hyperreactivity and metabolic reprogramming in coronary arteries via NOX1/4-TRPM2 signaling pathway
10.1161/hypertensionaha.123.21345 · 2024 · External reference
Peripheral 5-HT/HTR6 axis is responsible for obesity-associated hypertension
10.1016/j.bbamcr.2023.119651 · 2024 · External reference
Serotonin and Atheroscelotic Cardiovascular Disease
10.5551/jat.ed182 · 2022 · External reference
5-Hydroxytryptophan acts as a gap junction inhibitor to limit the spread of chemotherapy-induced cardiomyocyte injury and mitochondrial dysfunction
2024 · External reference
Site-specific 5-hydroxytryptophan incorporation into apolipoprotein A-I impairs cholesterol efflux activity and high-density lipoprotein biogenesis
10.1074/jbc.ra119.012092 · 2020 · External reference
Impact of plasma kynurenine level on functional capacity and outcome in heart failure ― results from studies investigating co-morbidities aggravating heart failure (SICA-HF)
10.1253/circj.cj-16-0791 · 2017 · External reference
Plasma kynurenine predicts severity and complications of heart failure and associates with established biochemical and clinical markers of disease
10.1159/000501483 · 2019 · External reference
Kynurenines in heart failure with preserved ejection fraction: an influence of type 2 diabetes
2024 · External reference
Activation of the kynurenine pathway predicts mortality and neurological outcome in cardiac arrest patients: A validation study
10.1016/j.jcrc.2021.09.025 · 2022 · External reference
Early Activation of the Kynurenine Pathway Predicts Early Death and Long-term Outcome in Patients Resuscitated From Out-of-Hospital Cardiac Arrest
10.1161/jaha.114.001094 · 2014 · External reference
Evaluation of neopterin levels and kynurenine pathway in patients with acute coronary syndrome
10.4266/acc.2023.00024 · 2023 · External reference
Indoleamine 2,3-dioxygenase and ischemic heart disease: a Mendelian Randomization study
10.1038/s41598-019-44819-7 · 2019 · External reference
Associations of plasma kynurenines with risk of acute myocardial infarction in patients with stable angina pectoris
10.1161/atvbaha.114.304674 · 2015 · External reference
Kynurenic Acid Is a Predictive Prognostic Metabolic Marker in ST-Elevation Myocardial Infarction
10.1155/cdr/9123654 · 2025 · External reference
Targeted metabolomic profiling of acute ST-segment elevation myocardial infarction
10.1038/s41598-024-75635-3 · 2024 · External reference
Plasma microbiome-modulated indole- and phenyl-derived metabolites associate with advanced atherosclerosis and postoperative outcomes
10.1016/j.jvs.2017.09.029 · 2018 · External reference
Plasma Gut Microbe-Derived Metabolites Associated with Peripheral Artery Disease and Major Adverse Cardiac Events
10.3390/microorganisms10102065 · 2022 · External reference
Tryptophan metabolites and incident cardiovascular disease: the EPIC-Norfolk prospective population study
10.1016/j.atherosclerosis.2023.117344 · 2023 · External reference
Molecular mechanisms underlying uremic toxin-related systemic disorders in chronic kidney disease: focused on β2-microglobulin-related amyloidosis and indoxyl sulfate-induced atherosclerosis—Oshima Award Address 2016
10.1007/s10157-018-1588-9 · 2018 · External reference
Prognostic Significance of Serum Indoxyl Sulfate and Albumin for Patients with Cardiovascular Disease
10.1536/ihj.18-116 · 2019 · External reference
AST-120 Improves Microvascular Endothelial Dysfunction in End-Stage Renal Disease Patients Receiving Hemodialysis
10.3349/ymj.2016.57.4.942 · 2016 · External reference
Uremic Retention Solute Indoxyl Sulfate Level Is Associated with Prolonged QTc Interval in Early CKD Patients
2015 · External reference
Gut microbiome and atrial fibrillation: mechanistic insights metabolites and comorbidities. Systematic review
10.1080/19490976.2025.2570423 · 2025 · External reference
Thrombolome and its emerging role in chronic kidney diseases
10.3390/toxins13030223 · 2021 · External reference
High-flux hemodialysis with polymethylmethacrylate membranes reduces soluble CD40L, a mediator of cardiovascular disease in uremia
10.1093/ndt/gfaf101 · 2025 · External reference
Results of the HEMO Study suggest that p-cresol sulfate and indoxyl sulfate are not associated with cardiovascular outcomes
10.1016/j.kint.2017.05.012 · 2017 · External reference
Differences in Dialysis Efficacy Have Limited Effects on Protein-Bound Uremic Toxins Plasma Levels over Time
10.3390/toxins11010047 · 2019 · External reference
Diet-gut microbiota-epigenetics in metabolic diseases: From mechanisms to therapeutics
10.1016/j.biopha.2022.113290 · 2022 · External reference
Increases in plasma tryptophan are inversely associated with incident cardiovascular disease in the prevención con dieta mediterránea (PREDIMED) study
10.3945/jn.116.241711 · 2017 · External reference
Mixed nuts as healthy snacks: effect on tryptophan metabolism and cardiovascular risk factors
10.3390/nu15030569 · 2023 · External reference
Interplay between diet, circulating indolepropionate concentrations and cardiometabolic health in US populations
10.1136/gutjnl-2023-330410 · 2023 · External reference
Host and gut microbial tryptophan metabolism and type 2 diabetes: an integrative analysis of host genetics, diet, gut microbiome and circulating metabolites in cohort studies
10.1136/gutjnl-2021-324053 · 2022 · External reference
The impact of dietary nutrient intake on gut microbiota in the progression and complications of chronic kidney disease
10.1016/j.kint.2022.06.025 · 2022 · External reference
Safety and efficacy of rodatristat ethyl for the treatment of pulmonary arterial hypertension (ELEVATE-2): a dose-ranging, randomised, multicentre, phase 2b trial
10.1016/s2213-2600(24)00226-1 · 2024 · External reference
Novel Tryptophan Hydroxylase Inhibitor TPT-001 Reverses PAH, Vascular Remodeling, and Proliferative-Proinflammatory Gene Expression
10.1016/j.jacbts.2024.04.006 · 2024 · External reference
IDO-1 Promotes Pulmonary Vascular Remodeling Via Kynurenine Pathway in Pulmonary Arterial Hypertension
10.1161/jaha.124.040896 · 2025 · External reference
IDO1 depletion induces an anti-inflammatory response in macrophages in mice with chronic viral myocarditis
10.1080/15384101.2019.1652471 · 2019 · External reference
Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme
10.1021/acs.jmedchem.1c00679 · 2021 · External reference
Identification and experimental validation of KMO as a critical immune-associated mitochondrial gene in unstable atherosclerotic plaque
10.1186/s12967-024-05464-5 · 2024 · External reference
UPF 648, a Selective KMO Inhibitor, Attenuates Psychomotor and Cognitive Impairment in Chronic Kidney Disease
10.1021/acschemneuro.4c00844 · 2025 · External reference
The novel KMO inhibitor CHDI-340246 leads to a restoration of electrophysiological alterations in mouse models of Huntington's disease
10.1016/j.expneurol.2016.05.005 · 2016 · External reference
Therapeutic Potentials of Sarpogrelate in Cardiovascular Disease
10.1111/j.1527-3466.2004.tb00130.x · 2006 · External reference
Sarpogrelate hydrochloride, a selective 5-HT2A antagonist, improves vascular function in patients with peripheral arterial disease
10.1097/fjc.0b013e3180325af3 · 2007 · External reference
Inhibition of 5-Hydroxytryptamine Receptor 2B Reduced Vascular Restenosis and Mitigated the β-Arrestin2–Mammalian Target of Rapamycin/p70S6K Pathway
10.1161/jaha.117.006810 · 2018 · External reference
Specific serotonin receptor antagonist reduces murine calcific atherosclerosis
10.1016/j.atherosclerosis.2026.120649 · 2026 · External reference
Kynurenic Acid/AhR Signaling at the Junction of Inflammation and Cardiovascular Diseases
10.3390/ijms25136933 · 2024 · External reference
Control of arterial hypertension by the AhR Blocker CH-223191: a chronopharmacological study in chronic intermittent hypoxia conditions
10.1007/978-3-031-32371-3_4 · 2023 · External reference
Activation of AHR by ITE Improves Cardiac Remodelling and Function in Rats After Myocardial Infarction
10.1002/ehf2.14532 · 2023 · External reference
Beneficial effects of aryl hydrocarbon receptor activation on post-infarction myocardial metabolism, inflammation and fibrosis: implications from multi-omics
10.1016/j.yjmcc.2025.10.006 · 2025 · External reference
Structural basis for the ligand-dependent activation of heterodimeric AHR-ARNT complex
10.1038/s41467-025-56574-7 · 2025 · External reference
SGLT2 inhibitor Dapagliflozin alleviates cardiac dysfunction and fibrosis after myocardial infarction by activating PXR and promoting angiogenesis
10.1016/j.biopha.2024.116994 · 2024 · External reference
Uncovering the Anti-Atherosclerotic Effect of Isoquercitrin via Microbiome Metabolic Modulation and Network Pharmacology
10.1021/acs.jafc.5c09903 · 2025 · External reference
Berberine alleviates diabetic retinopathy by regulating the Th17/Treg ratio
2024 · External reference
Sinomenine ameliorates rheumatoid arthritis by modulating tryptophan metabolism and activating aryl hydrocarbon receptor via gut microbiota regulation
10.1016/j.scib.2023.06.027 · 2023 · External reference
Gut-microbiota-derived indole sulfate promotes heart failure in chronic kidney disease
10.1016/j.chom.2025.08.014 · 2025 · External reference
Role of Akkermansia in Human Diseases: From Causation to Therapeutic Properties
10.3390/nu15081815 · 2023 · External reference
Akkermansia muciniphila ameliorates doxorubicin-induced cardiotoxicity by regulating PPARα-dependent mitochondrial biogenesis
10.1038/s41522-025-00712-y · 2025 · External reference
Akkermansia muciniphila supplementation in patients with overweight/obese type 2 diabetes: Efficacy depends on its baseline levels in the gut
10.1016/j.cmet.2024.12.010 · 2025 · External reference
Fecal microbiota transplantation for hypertension: an exploratory, multicenter, randomized, blinded, placebo-controlled trial
10.1186/s40168-025-02118-6 · 2025 · External reference
Rewiring Tryptophan Metabolism via Programmable Probiotic Integrated by Dual-Layered Microcapsule Protects against Inflammatory Bowel Disease in Mice
10.1021/acsnano.4c12801 · 2024 · External reference
Symphony of Digestion: Coordinated Host-Microbiome Enzymatic Interplay in Gut Ecosystem
10.3390/biom15081151 · 2025 · External reference
Kynurenine importation by SLC7A11 propagates anti-ferroptotic signaling
10.1016/j.molcel.2022.02.007 · 2022 · External reference
Indigenous Bacteria from the Gut Microbiota Regulate Host Serotonin Biosynthesis
10.1016/j.cell.2015.02.047 · 2015 · External reference
Emerging chemophysiological diversity of gut microbiota metabolites
10.1016/j.tips.2024.07.006 · 2024 · External reference
Gut microbiota-derived metabolites as central regulators in metabolic disorders
10.1136/gutjnl-2020-323071 · 2021 · External reference
Indoxyl Sulfate and Autism Spectrum Disorder: A Literature Review
10.3390/ijms252312973 · 2024 · External reference
Kynurenic acid protects against ischemia/reperfusion injury by modulating apoptosis in cardiomyocytes
10.1007/s10495-024-02004-w · 2024 · External reference
Kynurenic Acid: A Novel Player in Cardioprotection against Myocardial Ischemia/Reperfusion Injuries
10.3390/ph16101381 · 2023 · External reference
Gut Metabolite Indole-3-Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging-Related Myocardial Fibrosis
10.1002/advs.202501070 · 2025 · External reference
p-Cresyl sulfate predicts clinical outcomes in sustained peritoneal dialysis: a 5-year follow-up cohort study and meta-analysis
10.1080/0886022x.2022.2136528 · 2022 · External reference
Inhibition of gut- and lung-derived serotonin attenuates pulmonary hypertension in mice
10.1152/ajplung.00049.2012 · 2012 · External reference
Biochemistry and structural studies of kynurenine 3-monooxygenase reveal allosteric inhibition by Ro 61-8048
10.1096/fj.201700397rr · 2018 · External reference
Terguride ameliorates monocrotaline-induced pulmonary hypertension in rats
10.1183/09031936.00126010 · 2011 · External reference