Research graph
References from Engineering nanomedicines to reshape tertiary lymphoid structures: A new perspective on antitumor immunotherapy. Local targets link to admitted publications; unresolved targets remain external evidence.
Synthesis of nanomaterials using various top-down and bottom-up approaches, influencing factors, advantages, and disadvantages: a review
10.1016/j.cis.2021.102597 · 2022 · External reference
Advances in cancer immunotherapy: historical perspectives, current developments, and future directions
10.1186/s12943-025-02305-x · 2025 · External reference
CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors
10.1038/s41423-024-01207-0 · 2024 · External reference
Immune checkpoint inhibitors for the treatment of cancer: clinical impact and mechanisms of response and resistance
10.1146/annurev-pathol-042020-042741 · 2021 · External reference
Phase I study of lentiviral-transduced chimeric antigen receptor-modified T cells recognizing mesothelin in advanced solid cancers
10.1016/j.ymthe.2019.07.015 · 2019 · External reference
Increasing cure rates of solid tumors by immune checkpoint inhibitors
10.1186/s40164-023-00372-8 · 2023 · External reference
The immune microenvironment of colorectal cancer.
10.1038/s41568-025-00872-1 · 2025 · External reference
Linking tumour angiogenesis and tumour immunity
10.1038/s41577-025-01211-z · 2026 · External reference
Tertiary lymphoid structures in cancer
10.1126/science.abf9419 · 2022 · External reference
Tertiary lymphoid structures in the era of cancer immunotherapy
10.1038/s41568-019-0144-6 · 2019 · External reference
In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy
10.1186/s40164-025-00695-8 · 2025 · External reference
Tertiary lymphoid structures in cancer: spatiotemporal heterogeneity, immune orchestration, and translational opportunities
10.1186/s13045-025-01754-7 · 2025 · External reference
Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinoma
10.1136/jitc-2024-010173 · 2025 · External reference
Prehabilitation during neoadjuvant chemotherapy results in an enhanced immune response in esophageal adenocarcinoma tumors: A randomized controlled trial
2025 · External reference
An immune cell map of human lung adenocarcinoma development reveals an anti-tumoral role of the Tfh-dependent tertiary lymphoid structure
2024 · External reference
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer
10.1016/j.immuni.2022.02.001 · 2022 · External reference
Tertiary lymphoid structures improve immunotherapy and survival in melanoma
10.1038/s41586-019-1914-8 · 2020 · External reference
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
10.1016/j.ccell.2022.01.002 · 2022 · External reference
Tertiary lymphoid structures and B cells: An intratumoral immunity cycle
10.1016/j.immuni.2023.08.009 · 2023 · External reference
Delivery technologies for cancer immunotherapy
10.1038/s41573-018-0006-z · 2019 · External reference
Engineering precision nanoparticles for drug delivery
10.1038/s41573-020-0090-8 · 2021 · External reference
Nanomedicine Reimagined: Translational Strategies for Precision Tumor Theranostics
2026 · External reference
Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives
2026 · External reference
pH-responsive carbohydrate polymer-based nanoparticles in cancer therapy
2025 · External reference
Enhancing immunotherapy with tumour-responsive nanomaterials
10.1038/s41571-025-01000-6 · 2025 · External reference
Advances in polymer nanomaterials targeting cGAS-STING pathway for enhanced cancer immunotherapy
2025 · External reference
Tertiary lymphoid structures and cancer immunotherapy: From bench to bedside
10.1016/j.medj.2024.10.023 · 2025 · External reference
scRNA-seq of colorectal cancer shows regional immune atlas with the function of CD20(+) B cells
2024 · External reference
Tertiary lymphoid structures as a biomarker in immunotherapy and beyond: Advancing towards clinical application
2025 · External reference
Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer
10.1164/rccm.201309-1611oc · 2014 · External reference
Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer
10.1080/2162402x.2021.1900635 · 2021 · External reference
Occurrence of tertiary lymphoid tissue is associated with T-cell infiltration and predicts better prognosis in early-stage colorectal cancers
10.1158/1078-0432.ccr-13-2590 · 2014 · External reference
Artificial Tertiary Lymphoid Structures: Exploring Mesenchymal Stromal Cells as a Platform for Immune Niche Formation
10.3390/ijms252413286 · 2024 · External reference
Deciphering the maturation of tertiary lymphoid structures in cancer and inflammatory diseases of the digestive tract using imaging mass cytometry
10.3389/fimmu.2023.1147480 · 2023 · External reference
Tertiary lymphoid structures in cancers: prognostic value, regulation, and manipulation for therapeutic intervention
10.3389/fimmu.2016.00407 · 2016 · External reference
Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer
10.1158/0008-5472.can-11-0952 · 2011 · External reference
Tertiary lymphoid structures in anticancer immunity
10.1038/s41568-024-00728-0 · 2024 · External reference
An intra-tumoral niche maintains and differentiates stem-like CD8 T cells
10.1038/s41586-019-1836-5 · 2019 · External reference
Lymphatic vessels and tertiary lymphoid organs
10.1172/jci71611 · 2014 · External reference
Stromal Fibroblasts in Tertiary Lymphoid Structures: A Novel Target in Chronic Inflammation
10.3389/fimmu.2016.00477 · 2016 · External reference
Localization and density of tertiary lymphoid structures associate with molecular subtype and clinical outcome in colorectal cancer liver metastases. LID
10.1136/jitc-2022-006425 · 2023 · External reference
A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression
10.3389/fimmu.2017.00563 · 2017 · External reference
TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures
10.1016/j.immuni.2021.12.007 · 2022 · External reference
Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian Cancer
10.1158/1078-0432.ccr-15-2762 · 2016 · External reference
B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
10.1038/s41467-021-23355-x · 2021 · External reference
Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer
10.1164/rccm.201309-1611oc · 2014 · External reference
Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells
10.1158/0008-5472.can-13-1342 · 2014 · External reference
Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity
10.1038/ncomms8114 · 2015 · External reference
Tumor masses support naive T cell infiltration, activation, and differentiation into effectors
10.1084/jem.20092454 · 2010 · External reference
CD4⁺ follicular helper T cell infiltration predicts breast cancer survival
10.1172/jci67428 · 2013 · External reference
Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses
10.1016/j.immuni.2015.08.006 · 2015 · External reference
Regulatory T cells infiltrate the tumor-induced tertiary lymphoïd structures and are associated with poor clinical outcome in NSCLC
10.1038/s42003-022-04356-y · 2022 · External reference
Maturation and abundance of tertiary lymphoid structures are associated with the efficacy of neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer
10.1136/jitc-2022-005531 · 2022 · External reference
Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer
10.1158/1078-0432.ccr-14-2926 · 2015 · External reference
A Population of TIM4+FOLR2+ Macrophages Localized in Tertiary Lymphoid Structures Correlates to an Active Immune Infiltrate Across Several Cancer Types
10.1158/2326-6066.cir-22-0271 · 2022 · External reference
Deciphering the maturation of tertiary lymphoid structures in cancer and inflammatory diseases of the digestive tract using imaging mass cytometry
10.3389/fimmu.2023.1147480 · 2023 · External reference
Stromal fibroblasts in tertiary lymphoid structures: a novel target in chronic inflammation
10.3389/fimmu.2016.00477 · 2016 · External reference
Spatiotemporal architecture of immune cells and cancer-associated fibroblasts in high-grade serous ovarian carcinoma
10.1126/sciadv.adk8805 · 2024 · External reference
Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer
10.1158/0008-5472.can-11-0952 · 2011 · External reference
Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer
10.1158/0008-5472.can-11-0431 · 2011 · External reference
High endothelial venule blood vessels for tumor-infiltrating lymphocytes are associated with lymphotoxin β-producing dendritic cells in human breast cancer
10.4049/jimmunol.1300872 · 2013 · External reference
Analysis of the immune landscape of small bowel neuroendocrine tumors
10.1530/erc-18-0189 · 2019 · External reference
Tertiary lymphoid structures improve immunotherapy and survival in melanoma
10.1038/s41586-019-1914-8 · 2020 · External reference
Tertiary lymphoid structures in cancer: spatiotemporal heterogeneity, immune orchestration, and translational opportunities
10.1186/s13045-025-01754-7 · 2025 · External reference
Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas
10.1136/gutjnl-2022-328697 · 2023 · External reference
Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts
10.1016/j.celrep.2021.109422 · 2021 · External reference
The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases
10.3389/fimmu.2024.1439413 · 2024 · External reference
Lymphatic endothelial cells control initiation of lymph node organogenesis
10.1016/j.immuni.2017.05.008 · 2017 · External reference
Tertiary lymphoid structures and B lymphocytes: a promising therapeutic strategy to fight cancer
10.3389/fimmu.2023.1231315 · 2023 · External reference
Single-cell chemokine receptor profiles delineate the immune contexture of tertiary lymphoid structures in head and neck squamous cell carcinoma
2023 · External reference
High endothelial venules in cancer: Regulation, function, and therapeutic implication
2023 · External reference
Unveiling the impact of tertiary lymphoid structures on immunotherapeutic responses of clear cell renal cell carcinoma
10.1002/mco2.461 · 2024 · External reference
Heterogeneity in tertiary lymphoid structures predicts distinct prognosis and immune microenvironment characterizations of clear cell renal cell carcinoma
10.1136/jitc-2023-006667 · 2023 · External reference
CXCL13 shapes tertiary lymphoid structures and promotes response to immunotherapy in bladder cancer
10.1016/j.ejca.2021.03.054 · 2021 · External reference
PAK4 inhibition improves PD1 blockade immunotherapy in prostate cancer by increasing immune infiltration
10.1016/j.canlet.2022.216034 · 2023 · External reference
High endothelial venules and other blood vessels: critical regulators of lymphoid organ development and function
10.3389/fimmu.2017.00045 · 2017 · External reference
Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer
10.1136/jitc-2024-009243 · 2024 · External reference
TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures
10.1016/j.immuni.2021.12.007 · 2022 · External reference
Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation
10.1016/j.celrep.2016.01.038 · 2016 · External reference
Follicular helper CD4 T cells (TFH)
10.1146/annurev-immunol-031210-101400 · 2011 · External reference
Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy
10.1158/0008-5472.can-24-2274 · 2025 · External reference
Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging
10.1016/j.immuni.2018.08.025 · 2018 · External reference
Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response
10.1038/s41467-025-57465-7 · 2025 · External reference
Mature tertiary lymphoid structure associated CD103+ CD8+ Trm cells determined improved anti-tumor immune in breast cancer
2025 · External reference
M., et al, Tertiary lymphoid structures in anticancer immunity
10.1038/s41568-024-00728-0 · 2024 · External reference
Germinal centers determine the prognostic relevance of tertiary lymphoid structures and are impaired by corticosteroids in lung squamous cell carcinoma
10.1158/0008-5472.can-17-1987 · 2018 · External reference
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
10.1186/s12943-024-01980-6 · 2024 · External reference
Tertiary lymphoid structures in cancer: immune mechanisms and clinical implications
10.1002/mco2.489 · 2024 · External reference
Tertiary lymphoid structures in cancer: maturation and induction
2024 · External reference
Cancer-associated fibroblasts and tertiary lymphoid structure orchestrate the spatial architecture of tumor immunity
10.1186/s13045-026-01814-6 · 2026 · External reference
Activation of B cells in Tertiary Lymphoid Structures in cancer: anti-tumor or anti-self?
10.1016/j.smim.2022.101703 · 2023 · External reference
IgA transcytosis and antigen recognition govern ovarian cancer immunity
10.1038/s41586-020-03144-0 · 2021 · External reference
A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases
10.1158/1078-0432.ccr-16-0081 · 2017 · External reference
Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort
10.1038/s41591-022-01821-3 · 2022 · External reference
Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases
10.1158/0008-5472.can-12-1377 · 2012 · External reference
B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome
10.1038/s41571-022-00619-z · 2022 · External reference
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
10.1016/j.cell.2021.11.007 · 2021 · External reference
Characteristics and anatomic location of PD-1(+)TCF1(+) stem-like CD8 T cells in chronic viral infection and cancer
10.1073/pnas.2221985120 · 2023 · External reference
Parish, Ia, Stem-like exhausted and memory CD8(+) T cells in cancer.
10.1038/s41568-023-00615-0 · 2023 · External reference
Tfh-cell-derived interleukin 21 sustains effector CD8(+) T cell responses during chronic viral infection
10.1016/j.immuni.2022.01.018 · 2022 · External reference
Intratumoral dendritic cell-CD4(+) T helper cell niches enable CD8(+) T cell differentiation following PD-1 blockade in hepatocellular carcinoma
10.1038/s41591-023-02345-0 · 2023 · External reference
Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
10.1016/j.ccell.2023.04.010 · 2023 · External reference
Anti-CD20 rituximab IgG1, IgG3, and IgG4 but not IgG2 subclass trigger Ca(2+) mobilization and cytotoxicity in human NK cells
10.1002/jlb.5ma0620-039r · 2020 · External reference
Tertiary lymphoid structure-associated B cells enhance CXCL13(+)CD103(+)CD8(+)Trm cell response to PD-1 blockade in gastric cancer
2023 · External reference
Early Hepatic Lesions Display Immature Tertiary Lymphoid Structures and Show Elevated Expression of Immune Inhibitory and Immunosuppressive Molecules
10.1158/1078-0432.ccr-19-2929 · 2020 · External reference
Coexistence of regulatory B cells and regulatory T cells in tumor-infiltrating lymphocyte aggregates is a prognostic factor in patients with breast cancer
10.1007/s12282-018-0910-4 · 2019 · External reference
Pro-tumor Tfh2 cells induce detrimental IgG4 production and PGE(2)-dependent IgE inhibition in pancreatic cancer
10.1016/j.ebiom.2023.104819 · 2023 · External reference
IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer
10.1080/2162402x.2021.1880687 · 2021 · External reference
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
10.1038/nature24302 · 2017 · External reference
Features and clinical significance of tertiary lymphoid structure in cutaneous squamous cell carcinoma
10.1111/jdv.18464 · 2022 · External reference
Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer
10.1038/bjc.2015.145 · 2015 · External reference
Peritumor tertiary lymphoid structures are associated with infiltrating neutrophils and inferior prognosis in hepatocellular carcinoma
10.1002/cam4.5227 · 2023 · External reference
Distribution and density of tertiary lymphoid structures predict clinical outcome in intrahepatic cholangiocarcinoma
10.1016/j.jhep.2021.10.030 · 2022 · External reference
The prognostic significance of peritumoral tertiary lymphoid structures in breast cancer
10.1007/s00262-019-02407-8 · 2019 · External reference
Mesenchymal Stem/Stromal Cells Derived from Cervical Cancer Promote M2 Macrophage Polarization
10.3390/cells12071047 · 2023 · External reference
10.1002/cac2.12486
10.1002/cac2.12486 · 2023 · External reference
Predictive Value of Tertiary Lymphoid Structures Assessed by High Endothelial Venule Counts in the Neoadjuvant Setting of Triple-Negative Breast Cancer
10.4143/crt.2016.215 · 2017 · External reference
Intratumoral tertiary lymphoid structures promote patient survival and immunotherapy response in head neck squamous cell carcinoma
10.1007/s00262-022-03310-5 · 2023 · External reference
Association between the preoperative neutrophil-to-lymphocyte ratio and tertiary lymphoid structures surrounding tumor in gastric cancer
10.3892/mco.2021.2238 · 2021 · External reference
Peritumoral Tertiary Lymphoid Structures Correlate With Protective Immunity and Improved Prognosis in Patients With Hepatocellular Carcinoma
2021 · External reference
Density and maturity of peritumoral tertiary lymphoid structures in oesophageal squamous cell carcinoma predicts patient survival and response to immune checkpoint inhibitors
10.1038/s41416-023-02235-9 · 2023 · External reference
Dane, El, Enhancing cancer immunotherapy with nanomedicine.
10.1038/s41577-019-0269-6 · 2020 · External reference
Acidic tumor microenvironment-modulated nanoparticle potentiates gastric cancer photoimmunotherapy
10.1016/j.jare.2025.06.008 · 2026 · External reference
pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms
10.1080/10717544.2017.1279238 · 2017 · External reference
pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review. LID
10.3390/nano10081613 · 2020 · External reference
Rational design of cationic lipids for siRNA delivery
10.1038/nbt.1602 · 2010 · External reference
Redox imbalance and biochemical changes in cancer
10.1158/0008-5472.can-13-1117 · 2013 · External reference
Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics
10.1021/acsnano.3c06019 · 2023 · External reference
Reduction-Sensitive Dextran-Paclitaxel Polymer-Drug Conjugate: Synthesis, Self-Assembly into Nanoparticles, and In Vitro Anticancer Efficacy
10.1021/acs.bioconjchem.1c00492 · 2021 · External reference
Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery
10.1038/nbt.4181 · 2018 · External reference
Reactive oxygen species-responsive polymer drug delivery systems
2023 · External reference
MCOLN1/TRPML1 in the lysosome: a promising target for autophagy modulation in diverse diseases
10.1080/15548627.2024.2333715 · 2024 · External reference
Sensitizing ferroptotic and apoptotic cancer therapy via tailored micelles-mediated coenzyme and ATP depletion under hypoxia
10.1016/j.jconrel.2025.02.068 · 2025 · External reference
Lactylation modification in cancer: mechanisms, functions, and therapeutic strategies
10.1186/s40164-025-00622-x · 2025 · External reference
Purinergic signalling in cancer therapeutic resistance: From mechanisms to targeting strategies
10.1016/j.drup.2023.100988 · 2023 · External reference
ATP-responsive and near-infrared-emissive nanocarriers for anticancer drug delivery and real-time imaging
10.7150/thno.14843 · 2016 · External reference
Enhancing antitumor efficacy by simultaneous ATP-responsive chemodrug release and cancer cell sensitization based on a smart nanoagent
10.1002/advs.201801201 · 2018 · External reference
Reconstruction of nano-flares based on Au-Se bonds for high-fidelity detection of RNA in living cells
10.1039/d0cc01213k · 2020 · External reference
Phytochemicals and their nanoformulations for overcoming drug resistance in head and neck squamous cell carcinoma
10.1007/s11095-025-03836-0 · 2025 · External reference
MMP-responsive 'Smart' drug delivery and tumor targeting
10.1016/j.tips.2018.06.003 · 2018 · External reference
Correlation between MMP2 expression in lung cancer tissues and clinical parameters: a retrospective clinical analysis
10.1186/s12890-020-01317-1 · 2020 · External reference
Engineering stimuli-activatable boolean logic prodrug nanoparticles for combination cancer immunotherapy
10.1002/adma.201907210 · 2020 · External reference
MMP-responsive nanomaterials
10.1039/d3bm00840a · 2023 · External reference
Extracellular matrix and its therapeutic potential for cancer treatment
10.1038/s41392-021-00544-0 · 2021 · External reference
TGFβ biology in cancer progression and immunotherapy
10.1038/s41571-020-0403-1 · 2021 · External reference
Size shrinkable drug delivery nanosystems and priming the tumor microenvironment for deep intratumoral penetration of nanoparticles
10.1016/j.jconrel.2018.03.012 · 2018 · External reference
Transcytosis of nanomedicine for tumor penetration
10.1021/acs.nanolett.9b03211 · 2019 · External reference
Cell penetrating peptides: a versatile vector for co-delivery of drug and genes in cancer
10.1016/j.jconrel.2020.11.028 · 2021 · External reference
"Combo" nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy
10.1016/j.addr.2015.10.019 · 2016 · External reference
Nano-, micro-, and macroscale drug delivery systems for cancer immunotherapy
10.1016/j.actbio.2018.12.028 · 2019 · External reference
Toll-like Receptor Agonist Conjugation: A Chemical Perspective
10.1021/acs.bioconjchem.7b00808 · 2018 · External reference
Pm, bioconjugation approaches to producing subunit vaccines composed of protein or peptide antigens and covalently attached toll-like receptor ligands
10.1021/acs.bioconjchem.7b00478 · 2018 · External reference
S., S.T.N.a.T.D., Tertiary lymphoid structures in cancer.
2022 · External reference
vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity
10.1038/nbt.3371 · 2015 · External reference
Structure-based programming of lymph-node targeting in molecular vaccines
10.1038/nature12978 · 2014 · External reference
Designer vaccine nanodiscs for personalized cancer immunotherapy
10.1038/nmat4822 · 2017 · External reference
A novel nanomedicine integrating ferroptosis and photothermal therapy, well-suitable for PD-L1-mediated immune checkpoint blockade
2024 · External reference
Immunostimulatory oligonucleotides-loaded cationic graphene oxide with photothermally enhanced immunogenicity for photothermal/immune cancer therapy
10.1016/j.biomaterials.2014.08.036 · 2014 · External reference
Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy
10.1016/j.apsb.2021.08.012 · 2022 · External reference
Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response
10.1186/s12943-024-02191-9 · 2025 · External reference
Tumor microenvironment in melanoma-characteristic and clinical implications
10.3390/ijms26146778 · 2025 · External reference
Dual pH-responsive multifunctional nanoparticles for targeted treatment of breast cancer by combining immunotherapy and chemotherapy
10.1016/j.actbio.2017.11.010 · 2018 · External reference
Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges
10.1038/s41571-019-0308-z · 2020 · External reference
Tertiary lymphoid structure formation induced by LIGHT-engineered and photosensitive nanoparticles-decorated bacteria enhances immune response against colorectal cancer
10.1016/j.biomaterials.2024.122846 · 2025 · External reference
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
10.1016/j.ccell.2022.01.002 · 2022 · External reference
Innovative sarcoma therapy using multifaceted nano-PROTAC-induced EZH2 degradation and immunity enhancement
10.1016/j.biomaterials.2025.123344 · 2025 · External reference
Biodegradable nano-regulator reprograms glioblastoma immunosuppression: pyroptosis-metabolism-immunity crosstalk for cascading immune activation
10.1002/anie.202516348 · 2026 · External reference
Engineering metal-based hydrogel-mediated tertiary lymphoid structure formation via activation of the STING pathway for enhanced immunotherapy
10.1039/d3mh00748k · 2023 · External reference
Recent advances and next breakthrough in immunotherapy for cancer treatment
2022 · External reference
Chemokine/cytokine-releasing biomaterials induce in situ tertiary lymphoid-like structures and enhance antitumor immunity.
10.1073/pnas.2409560122 · 2025 · External reference
Trigger inducible tertiary lymphoid structure formation using covalent organic frameworks for cancer immunotherapy
10.1038/s41467-024-55430-4 · 2025 · External reference
The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics
10.1158/2159-8290.cd-24-0002 · 2024 · External reference
YAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches
2023 · External reference
Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors
10.1038/s41467-020-14425-7 · 2020 · External reference
Hierarchical protein nano-crystalline hydrogel with extracellular vesicles for ectopic lymphoid structure formation
10.1016/j.biomaterials.2025.123166 · 2025 · External reference
CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β
10.1016/j.apsb.2024.05.009 · 2024 · External reference
Biomimetic tertiary lymphoid structures with microporous annealed particle scaffolds for cancer postoperative therapy
10.1021/acsnano.4c01180 · 2024 · External reference
3D Printing Scaffold Vaccine for Antitumor Immunity
2021 · External reference
Self-assembled microparticle hydrogel scaffolds to construct artificial tertiary lymphoids for enhanced CAR-T cell therapy against solid tumors
10.1016/j.biomaterials.2025.123976 · 2026 · External reference
Injectable hydrogel-based drug formulation for enhancing tertiary lymphoid structure formation and cancer immunotherapy efficacy
10.1016/j.jconrel.2025.113897 · 2025 · External reference
B cells, plasma cells and antibody repertoires in the tumour microenvironment
10.1038/s41577-019-0257-x · 2020 · External reference
Dendritic cells in cancer immunology and immunotherapy
10.1038/s41577-019-0210-z · 2020 · External reference
Antigen-Clustered Nanovaccine Achieves Long-Term Tumor Remission by Promoting B/CD 4 T Cell Crosstalk
10.1021/acsnano.3c13038 · 2024 · External reference
Adaptive antitumor immune response stimulated by bio-nanoparticle based vaccine and checkpoint blockade
2022 · External reference
Targeting metabolism to improve the tumor microenvironment for cancer immunotherapy
10.1016/j.molcel.2020.05.034 · 2020 · External reference
Intratumoral antigen-presenting cell activation by a nanovesicle for the concurrent tertiary lymphoid structure de novo neogenesis
10.1126/sciadv.adr1299 · 2025 · External reference
Cognate nanovaccine promotes tertiary lymphoid structures function and strengthens immune cell cross-talk by targeting exhausted t cells in nonimmunogenic cancers
10.1021/acsnano.5c01280 · 2025 · External reference
Nanovaccines fostering tertiary lymphoid structure to attack mimicry nasopharyngeal carcinoma
10.1021/acsnano.2c09619 · 2023 · External reference
Engineered bacterial membrane biomimetic covalent organic framework as nano-immunopotentiator for cancer immunotherapy
2025 · External reference
Multiple mechanisms and applications of tertiary lymphoid structures and immune checkpoint blockade
2025 · External reference
The tumor microenvironment's role in the response to immune checkpoint blockade
10.1038/s43018-025-00986-3 · 2025 · External reference
B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity
10.1016/j.ccell.2025.12.011 · 2026 · External reference
Spatial dynamics of CD39(+)CD8(+) exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer
10.1038/s41467-024-53262-w · 2024 · External reference
CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β
10.1016/j.apsb.2024.05.009 · 2024 · External reference
CAR-T therapy in solid tumors
10.1016/j.ccell.2025.03.019 · 2025 · External reference
Frontiers in pancreatic cancer on biomarkers, microenvironment, and immunotherapy
10.1016/j.canlet.2024.217350 · 2025 · External reference
Lymph node stromal cells: cartographers of the immune system.
10.1038/s41590-020-0635-3 · 2020 · External reference
Chemo-photothermal synergy ignites antitumor immunity via ferroptosis. LID
10.1038/s41392-026-02608-5 · 2026 · External reference
Lambda phage-based vaccine induces antitumor immunity in hepatocellular carcinoma
10.1016/j.heliyon.2017.e00407 · 2017 · External reference
Bacteriophages as Solid Tumor Theragnostic Agents. LID
10.3390/ijms23010402 · 2021 · External reference
The conduit system exports locally secreted IgM from lymph nodes
10.1084/jem.20180344 · 2018 · External reference
Material design for lymph node drug delivery
10.1038/s41578-019-0110-7 · 2019 · External reference
Recent Progress and Trends in X-ray-Induced Photodynamic Therapy with Low Radiation Doses.
10.1021/acsnano.2c07286 · 2022 · External reference
Inflammatory microenvironment remodelling by tumour cells after radiotherapy
10.1038/s41568-020-0246-1 · 2020 · External reference
Trigger inducible tertiary lymphoid structure formation using covalent organic frameworks for cancer immunotherapy
10.1038/s41467-024-55430-4 · 2025 · External reference
TGF-β signaling in health, disease, and therapeutics
10.1038/s41392-024-01764-w · 2024 · External reference
Organoid Models of Tumor Immunology
10.1016/j.it.2020.06.010 · 2020 · External reference
Vitro Glioblastoma Model on a Plate for Localized Drug Release Study from a 3D-Printed Drug-Eluted Hydrogel Mesh
10.3390/cells13040363 · 2024 · External reference
Innovations, challenges, and minimal information for standardization of humanized mice
10.15252/emmm.201708662 · 2020 · External reference
Mouse models for cancer immunotherapy research
10.1158/2159-8290.cd-18-0044 · 2018 · External reference
"Smart" nanoprobes for visualization of tumor microenvironments
10.1002/adhm.201800391 · 2018 · External reference
Advances in the near-infrared Ⅱ for in vivo fluorescence imaging applications: a review
2026 · External reference
Evaluating the immunologically "cold" tumor microenvironment after treatment with immune checkpoint inhibitors utilizing PET imaging of CD4 + and CD8 + T cells in breast cancer mouse models
10.1186/s13058-024-01844-3 · 2024 · External reference
Nanomedicine for advanced cancer immunotherapy
10.1016/j.jconrel.2022.10.004 · 2022 · External reference
Design of nano-delivery systems for pancreatic cancer immunotherapy
10.1016/j.canlet.2025.218098 · 2025 · External reference
Near-infrared light-responsive nanomaterials in cancer therapeutics
10.1039/c4cs00011k · 2014 · External reference
Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications
10.1016/j.jconrel.2014.12.030 · 2015 · External reference
From lymphotoxin to tertiary lymphoid structures and beyond
10.1111/imr.70062 · 2025 · External reference
"Smart" nanoprobes for visualization of tumor microenvironments
10.1002/adhm.201800391 · ExternalCitation · doi-reference
Engineering stimuli-activatable boolean logic prodrug nanoparticles for combination cancer immunotherapy
10.1002/adma.201907210 · ExternalCitation · doi-reference
Enhancing antitumor efficacy by simultaneous ATP-responsive chemodrug release and cancer cell sensitization based on a smart nanoagent
10.1002/advs.201801201 · ExternalCitation · doi-reference
Biodegradable nano-regulator reprograms glioblastoma immunosuppression: pyroptosis-metabolism-immunity crosstalk for cascading immune activation
10.1002/anie.202516348 · ExternalCitation · doi-reference
10.1002/cac2.12486
10.1002/cac2.12486 · ExternalCitation · doi-reference
Peritumor tertiary lymphoid structures are associated with infiltrating neutrophils and inferior prognosis in hepatocellular carcinoma
10.1002/cam4.5227 · ExternalCitation · doi-reference
Anti-CD20 rituximab IgG1, IgG3, and IgG4 but not IgG2 subclass trigger Ca(2+) mobilization and cytotoxicity in human NK cells
10.1002/jlb.5ma0620-039r · ExternalCitation · doi-reference
Unveiling the impact of tertiary lymphoid structures on immunotherapeutic responses of clear cell renal cell carcinoma
10.1002/mco2.461 · ExternalCitation · doi-reference
Tertiary lymphoid structures in cancer: immune mechanisms and clinical implications
10.1002/mco2.489 · ExternalCitation · doi-reference
The prognostic significance of peritumoral tertiary lymphoid structures in breast cancer
10.1007/s00262-019-02407-8 · ExternalCitation · doi-reference
Intratumoral tertiary lymphoid structures promote patient survival and immunotherapy response in head neck squamous cell carcinoma
10.1007/s00262-022-03310-5 · ExternalCitation · doi-reference
Phytochemicals and their nanoformulations for overcoming drug resistance in head and neck squamous cell carcinoma
10.1007/s11095-025-03836-0 · ExternalCitation · doi-reference
Coexistence of regulatory B cells and regulatory T cells in tumor-infiltrating lymphocyte aggregates is a prognostic factor in patients with breast cancer
10.1007/s12282-018-0910-4 · ExternalCitation · doi-reference
Dual pH-responsive multifunctional nanoparticles for targeted treatment of breast cancer by combining immunotherapy and chemotherapy
10.1016/j.actbio.2017.11.010 · ExternalCitation · doi-reference
Nano-, micro-, and macroscale drug delivery systems for cancer immunotherapy
10.1016/j.actbio.2018.12.028 · ExternalCitation · doi-reference
"Combo" nanomedicine: Co-delivery of multi-modal therapeutics for efficient, targeted, and safe cancer therapy
10.1016/j.addr.2015.10.019 · ExternalCitation · doi-reference
Pure drug nano-assemblies: A facile carrier-free nanoplatform for efficient cancer therapy
10.1016/j.apsb.2021.08.012 · ExternalCitation · doi-reference
CCL9/CCR1 axis-driven chemotactic nanovesicles for attenuating metastasis of SMAD4-deficient colorectal cancer by trapping TGF-β
10.1016/j.apsb.2024.05.009 · ExternalCitation · doi-reference
Immunostimulatory oligonucleotides-loaded cationic graphene oxide with photothermally enhanced immunogenicity for photothermal/immune cancer therapy
10.1016/j.biomaterials.2014.08.036 · ExternalCitation · doi-reference
Tertiary lymphoid structure formation induced by LIGHT-engineered and photosensitive nanoparticles-decorated bacteria enhances immune response against colorectal cancer
10.1016/j.biomaterials.2024.122846 · ExternalCitation · doi-reference
Hierarchical protein nano-crystalline hydrogel with extracellular vesicles for ectopic lymphoid structure formation
10.1016/j.biomaterials.2025.123166 · ExternalCitation · doi-reference
Innovative sarcoma therapy using multifaceted nano-PROTAC-induced EZH2 degradation and immunity enhancement
10.1016/j.biomaterials.2025.123344 · ExternalCitation · doi-reference
Self-assembled microparticle hydrogel scaffolds to construct artificial tertiary lymphoids for enhanced CAR-T cell therapy against solid tumors
10.1016/j.biomaterials.2025.123976 · ExternalCitation · doi-reference
PAK4 inhibition improves PD1 blockade immunotherapy in prostate cancer by increasing immune infiltration
10.1016/j.canlet.2022.216034 · ExternalCitation · doi-reference
Frontiers in pancreatic cancer on biomarkers, microenvironment, and immunotherapy
10.1016/j.canlet.2024.217350 · ExternalCitation · doi-reference
Design of nano-delivery systems for pancreatic cancer immunotherapy
10.1016/j.canlet.2025.218098 · ExternalCitation · doi-reference
Tumor-associated high endothelial venules mediate lymphocyte entry into tumors and predict response to PD-1 plus CTLA-4 combination immunotherapy
10.1016/j.ccell.2022.01.002 · ExternalCitation · doi-reference
Tailoring vascular phenotype through AAV therapy promotes anti-tumor immunity in glioma
10.1016/j.ccell.2023.04.010 · ExternalCitation · doi-reference
CAR-T therapy in solid tumors
10.1016/j.ccell.2025.03.019 · ExternalCitation · doi-reference
B cells disrupt tertiary lymphoid structure formation and suppress anti-tumor immunity
10.1016/j.ccell.2025.12.011 · ExternalCitation · doi-reference
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes anti-tumor CD8 T cell responses
10.1016/j.cell.2021.11.007 · ExternalCitation · doi-reference
Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation
10.1016/j.celrep.2016.01.038 · ExternalCitation · doi-reference
Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts
10.1016/j.celrep.2021.109422 · ExternalCitation · doi-reference
Synthesis of nanomaterials using various top-down and bottom-up approaches, influencing factors, advantages, and disadvantages: a review
10.1016/j.cis.2021.102597 · ExternalCitation · doi-reference
Purinergic signalling in cancer therapeutic resistance: From mechanisms to targeting strategies
10.1016/j.drup.2023.100988 · ExternalCitation · doi-reference
Pro-tumor Tfh2 cells induce detrimental IgG4 production and PGE(2)-dependent IgE inhibition in pancreatic cancer
10.1016/j.ebiom.2023.104819 · ExternalCitation · doi-reference
CXCL13 shapes tertiary lymphoid structures and promotes response to immunotherapy in bladder cancer
10.1016/j.ejca.2021.03.054 · ExternalCitation · doi-reference
Lambda phage-based vaccine induces antitumor immunity in hepatocellular carcinoma
10.1016/j.heliyon.2017.e00407 · ExternalCitation · doi-reference
Regulatory T Cells in Tumor-Associated Tertiary Lymphoid Structures Suppress Anti-tumor T Cell Responses
10.1016/j.immuni.2015.08.006 · ExternalCitation · doi-reference
Lymphatic endothelial cells control initiation of lymph node organogenesis
10.1016/j.immuni.2017.05.008 · ExternalCitation · doi-reference
Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging
10.1016/j.immuni.2018.08.025 · ExternalCitation · doi-reference
TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures
10.1016/j.immuni.2021.12.007 · ExternalCitation · doi-reference
Tfh-cell-derived interleukin 21 sustains effector CD8(+) T cell responses during chronic viral infection
10.1016/j.immuni.2022.01.018 · ExternalCitation · doi-reference
Tertiary lymphoid structures generate and propagate anti-tumor antibody-producing plasma cells in renal cell cancer
10.1016/j.immuni.2022.02.001 · ExternalCitation · doi-reference
Tertiary lymphoid structures and B cells: An intratumoral immunity cycle
10.1016/j.immuni.2023.08.009 · ExternalCitation · doi-reference
Organoid Models of Tumor Immunology
10.1016/j.it.2020.06.010 · ExternalCitation · doi-reference
Acidic tumor microenvironment-modulated nanoparticle potentiates gastric cancer photoimmunotherapy
10.1016/j.jare.2025.06.008 · ExternalCitation · doi-reference
Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications
10.1016/j.jconrel.2014.12.030 · ExternalCitation · doi-reference
Size shrinkable drug delivery nanosystems and priming the tumor microenvironment for deep intratumoral penetration of nanoparticles
10.1016/j.jconrel.2018.03.012 · ExternalCitation · doi-reference
Cell penetrating peptides: a versatile vector for co-delivery of drug and genes in cancer
10.1016/j.jconrel.2020.11.028 · ExternalCitation · doi-reference
Nanomedicine for advanced cancer immunotherapy
10.1016/j.jconrel.2022.10.004 · ExternalCitation · doi-reference
Sensitizing ferroptotic and apoptotic cancer therapy via tailored micelles-mediated coenzyme and ATP depletion under hypoxia
10.1016/j.jconrel.2025.02.068 · ExternalCitation · doi-reference
Injectable hydrogel-based drug formulation for enhancing tertiary lymphoid structure formation and cancer immunotherapy efficacy
10.1016/j.jconrel.2025.113897 · ExternalCitation · doi-reference
Distribution and density of tertiary lymphoid structures predict clinical outcome in intrahepatic cholangiocarcinoma
10.1016/j.jhep.2021.10.030 · ExternalCitation · doi-reference
Tertiary lymphoid structures and cancer immunotherapy: From bench to bedside
10.1016/j.medj.2024.10.023 · ExternalCitation · doi-reference
Targeting metabolism to improve the tumor microenvironment for cancer immunotherapy
10.1016/j.molcel.2020.05.034 · ExternalCitation · doi-reference
Activation of B cells in Tertiary Lymphoid Structures in cancer: anti-tumor or anti-self?
10.1016/j.smim.2022.101703 · ExternalCitation · doi-reference
MMP-responsive 'Smart' drug delivery and tumor targeting
10.1016/j.tips.2018.06.003 · ExternalCitation · doi-reference
Phase I study of lentiviral-transduced chimeric antigen receptor-modified T cells recognizing mesothelin in advanced solid cancers
10.1016/j.ymthe.2019.07.015 · ExternalCitation · doi-reference
Reduction-Sensitive Dextran-Paclitaxel Polymer-Drug Conjugate: Synthesis, Self-Assembly into Nanoparticles, and In Vitro Anticancer Efficacy
10.1021/acs.bioconjchem.1c00492 · ExternalCitation · doi-reference
Pm, bioconjugation approaches to producing subunit vaccines composed of protein or peptide antigens and covalently attached toll-like receptor ligands
10.1021/acs.bioconjchem.7b00478 · ExternalCitation · doi-reference
Toll-like Receptor Agonist Conjugation: A Chemical Perspective
10.1021/acs.bioconjchem.7b00808 · ExternalCitation · doi-reference
Transcytosis of nanomedicine for tumor penetration
10.1021/acs.nanolett.9b03211 · ExternalCitation · doi-reference
Recent Progress and Trends in X-ray-Induced Photodynamic Therapy with Low Radiation Doses.
10.1021/acsnano.2c07286 · ExternalCitation · doi-reference
Nanovaccines fostering tertiary lymphoid structure to attack mimicry nasopharyngeal carcinoma
10.1021/acsnano.2c09619 · ExternalCitation · doi-reference
Stimuli-Responsive Polymer-Based Nanosystems for Cancer Theranostics
10.1021/acsnano.3c06019 · ExternalCitation · doi-reference
Antigen-Clustered Nanovaccine Achieves Long-Term Tumor Remission by Promoting B/CD 4 T Cell Crosstalk
10.1021/acsnano.3c13038 · ExternalCitation · doi-reference
Biomimetic tertiary lymphoid structures with microporous annealed particle scaffolds for cancer postoperative therapy
10.1021/acsnano.4c01180 · ExternalCitation · doi-reference
Cognate nanovaccine promotes tertiary lymphoid structures function and strengthens immune cell cross-talk by targeting exhausted t cells in nonimmunogenic cancers
10.1021/acsnano.5c01280 · ExternalCitation · doi-reference
Intratumoral tertiary lymphoid organ is a favourable prognosticator in patients with pancreatic cancer
10.1038/bjc.2015.145 · ExternalCitation · doi-reference
Structure-based programming of lymph-node targeting in molecular vaccines
10.1038/nature12978 · ExternalCitation · doi-reference
Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
10.1038/nature24302 · ExternalCitation · doi-reference
Rational design of cationic lipids for siRNA delivery
10.1038/nbt.1602 · ExternalCitation · doi-reference
vivo characterization of the physicochemical properties of polymer-linked TLR agonists that enhance vaccine immunogenicity
10.1038/nbt.3371 · ExternalCitation · doi-reference
Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery
10.1038/nbt.4181 · ExternalCitation · doi-reference
Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity
10.1038/ncomms8114 · ExternalCitation · doi-reference
Designer vaccine nanodiscs for personalized cancer immunotherapy
10.1038/nmat4822 · ExternalCitation · doi-reference
Extracellular matrix and its therapeutic potential for cancer treatment
10.1038/s41392-021-00544-0 · ExternalCitation · doi-reference
TGF-β signaling in health, disease, and therapeutics
10.1038/s41392-024-01764-w · ExternalCitation · doi-reference
Chemo-photothermal synergy ignites antitumor immunity via ferroptosis. LID
10.1038/s41392-026-02608-5 · ExternalCitation · doi-reference
Density and maturity of peritumoral tertiary lymphoid structures in oesophageal squamous cell carcinoma predicts patient survival and response to immune checkpoint inhibitors
10.1038/s41416-023-02235-9 · ExternalCitation · doi-reference
CAR-T and CAR-NK as cellular cancer immunotherapy for solid tumors
10.1038/s41423-024-01207-0 · ExternalCitation · doi-reference
Dual-mechanism based CTLs infiltration enhancement initiated by Nano-sapper potentiates immunotherapy against immune-excluded tumors
10.1038/s41467-020-14425-7 · ExternalCitation · doi-reference
B cell signatures and tertiary lymphoid structures contribute to outcome in head and neck squamous cell carcinoma
10.1038/s41467-021-23355-x · ExternalCitation · doi-reference
Spatial dynamics of CD39(+)CD8(+) exhausted T cell reveal tertiary lymphoid structures-mediated response to PD-1 blockade in esophageal cancer
10.1038/s41467-024-53262-w · ExternalCitation · doi-reference
Trigger inducible tertiary lymphoid structure formation using covalent organic frameworks for cancer immunotherapy
10.1038/s41467-024-55430-4 · ExternalCitation · doi-reference
Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response
10.1038/s41467-025-57465-7 · ExternalCitation · doi-reference
Tertiary lymphoid structures in the era of cancer immunotherapy
10.1038/s41568-019-0144-6 · ExternalCitation · doi-reference
Inflammatory microenvironment remodelling by tumour cells after radiotherapy
10.1038/s41568-020-0246-1 · ExternalCitation · doi-reference
Parish, Ia, Stem-like exhausted and memory CD8(+) T cells in cancer.
10.1038/s41568-023-00615-0 · ExternalCitation · doi-reference
M., et al, Tertiary lymphoid structures in anticancer immunity
10.1038/s41568-024-00728-0 · ExternalCitation · doi-reference
The immune microenvironment of colorectal cancer.
10.1038/s41568-025-00872-1 · ExternalCitation · doi-reference
Improving cancer immunotherapy using nanomedicines: progress, opportunities and challenges
10.1038/s41571-019-0308-z · ExternalCitation · doi-reference
TGFβ biology in cancer progression and immunotherapy
10.1038/s41571-020-0403-1 · ExternalCitation · doi-reference
B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome
10.1038/s41571-022-00619-z · ExternalCitation · doi-reference
Enhancing immunotherapy with tumour-responsive nanomaterials
10.1038/s41571-025-01000-6 · ExternalCitation · doi-reference
Delivery technologies for cancer immunotherapy
10.1038/s41573-018-0006-z · ExternalCitation · doi-reference
Engineering precision nanoparticles for drug delivery
10.1038/s41573-020-0090-8 · ExternalCitation · doi-reference
Dendritic cells in cancer immunology and immunotherapy
10.1038/s41577-019-0210-z · ExternalCitation · doi-reference
B cells, plasma cells and antibody repertoires in the tumour microenvironment
10.1038/s41577-019-0257-x · ExternalCitation · doi-reference
Dane, El, Enhancing cancer immunotherapy with nanomedicine.
10.1038/s41577-019-0269-6 · ExternalCitation · doi-reference
Linking tumour angiogenesis and tumour immunity
10.1038/s41577-025-01211-z · ExternalCitation · doi-reference
Material design for lymph node drug delivery
10.1038/s41578-019-0110-7 · ExternalCitation · doi-reference
An intra-tumoral niche maintains and differentiates stem-like CD8 T cells
10.1038/s41586-019-1836-5 · ExternalCitation · doi-reference
Tertiary lymphoid structures improve immunotherapy and survival in melanoma
10.1038/s41586-019-1914-8 · ExternalCitation · doi-reference
IgA transcytosis and antigen recognition govern ovarian cancer immunity
10.1038/s41586-020-03144-0 · ExternalCitation · doi-reference
Lymph node stromal cells: cartographers of the immune system.
10.1038/s41590-020-0635-3 · ExternalCitation · doi-reference
Pembrolizumab in soft-tissue sarcomas with tertiary lymphoid structures: a phase 2 PEMBROSARC trial cohort
10.1038/s41591-022-01821-3 · ExternalCitation · doi-reference
Intratumoral dendritic cell-CD4(+) T helper cell niches enable CD8(+) T cell differentiation following PD-1 blockade in hepatocellular carcinoma
10.1038/s41591-023-02345-0 · ExternalCitation · doi-reference
Regulatory T cells infiltrate the tumor-induced tertiary lymphoïd structures and are associated with poor clinical outcome in NSCLC
10.1038/s42003-022-04356-y · ExternalCitation · doi-reference
The tumor microenvironment's role in the response to immune checkpoint blockade
10.1038/s43018-025-00986-3 · ExternalCitation · doi-reference
Near-infrared light-responsive nanomaterials in cancer therapeutics
10.1039/c4cs00011k · ExternalCitation · doi-reference
Reconstruction of nano-flares based on Au-Se bonds for high-fidelity detection of RNA in living cells
10.1039/d0cc01213k · ExternalCitation · doi-reference
MMP-responsive nanomaterials
10.1039/d3bm00840a · ExternalCitation · doi-reference
Engineering metal-based hydrogel-mediated tertiary lymphoid structure formation via activation of the STING pathway for enhanced immunotherapy
10.1039/d3mh00748k · ExternalCitation · doi-reference
Characteristics and anatomic location of PD-1(+)TCF1(+) stem-like CD8 T cells in chronic viral infection and cancer
10.1073/pnas.2221985120 · ExternalCitation · doi-reference
Chemokine/cytokine-releasing biomaterials induce in situ tertiary lymphoid-like structures and enhance antitumor immunity.
10.1073/pnas.2409560122 · ExternalCitation · doi-reference
pH-Responsive carriers for oral drug delivery: challenges and opportunities of current platforms
10.1080/10717544.2017.1279238 · ExternalCitation · doi-reference
MCOLN1/TRPML1 in the lysosome: a promising target for autophagy modulation in diverse diseases
10.1080/15548627.2024.2333715 · ExternalCitation · doi-reference
IgG4 induces tolerogenic M2-like macrophages and correlates with disease progression in colon cancer
10.1080/2162402x.2021.1880687 · ExternalCitation · doi-reference
Germinal center reactions in tertiary lymphoid structures associate with neoantigen burden, humoral immunity and long-term survivorship in pancreatic cancer
10.1080/2162402x.2021.1900635 · ExternalCitation · doi-reference
Tumor masses support naive T cell infiltration, activation, and differentiation into effectors
10.1084/jem.20092454 · ExternalCitation · doi-reference
The conduit system exports locally secreted IgM from lymph nodes
10.1084/jem.20180344 · ExternalCitation · doi-reference
From lymphotoxin to tertiary lymphoid structures and beyond
10.1111/imr.70062 · ExternalCitation · doi-reference
Features and clinical significance of tertiary lymphoid structure in cutaneous squamous cell carcinoma
10.1111/jdv.18464 · ExternalCitation · doi-reference
Spatiotemporal architecture of immune cells and cancer-associated fibroblasts in high-grade serous ovarian carcinoma
10.1126/sciadv.adk8805 · ExternalCitation · doi-reference
Intratumoral antigen-presenting cell activation by a nanovesicle for the concurrent tertiary lymphoid structure de novo neogenesis
10.1126/sciadv.adr1299 · ExternalCitation · doi-reference
Tertiary lymphoid structures in cancer
10.1126/science.abf9419 · ExternalCitation · doi-reference
Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas
10.1136/gutjnl-2022-328697 · ExternalCitation · doi-reference
Maturation and abundance of tertiary lymphoid structures are associated with the efficacy of neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer
10.1136/jitc-2022-005531 · ExternalCitation · doi-reference
Localization and density of tertiary lymphoid structures associate with molecular subtype and clinical outcome in colorectal cancer liver metastases. LID
10.1136/jitc-2022-006425 · ExternalCitation · doi-reference
Heterogeneity in tertiary lymphoid structures predicts distinct prognosis and immune microenvironment characterizations of clear cell renal cell carcinoma
10.1136/jitc-2023-006667 · ExternalCitation · doi-reference
Mapping the complexity and diversity of tertiary lymphoid structures in primary and peritoneal metastatic gastric cancer
10.1136/jitc-2024-009243 · ExternalCitation · doi-reference
Comparative impact of tertiary lymphoid structures and tumor-infiltrating lymphocytes in cholangiocarcinoma
10.1136/jitc-2024-010173 · ExternalCitation · doi-reference
Follicular helper CD4 T cells (TFH)
10.1146/annurev-immunol-031210-101400 · ExternalCitation · doi-reference
Immune checkpoint inhibitors for the treatment of cancer: clinical impact and mechanisms of response and resistance
10.1146/annurev-pathol-042020-042741 · ExternalCitation · doi-reference
Human solid tumors contain high endothelial venules: association with T- and B-lymphocyte infiltration and favorable prognosis in breast cancer
10.1158/0008-5472.can-11-0431 · ExternalCitation · doi-reference
Characterization of chemokines and adhesion molecules associated with T cell presence in tertiary lymphoid structures in human lung cancer
10.1158/0008-5472.can-11-0952 · ExternalCitation · doi-reference
Neogenesis of lymphoid structures and antibody responses occur in human melanoma metastases
10.1158/0008-5472.can-12-1377 · ExternalCitation · doi-reference
Redox imbalance and biochemical changes in cancer
10.1158/0008-5472.can-13-1117 · ExternalCitation · doi-reference
Dendritic cells in tumor-associated tertiary lymphoid structures signal a Th1 cytotoxic immune contexture and license the positive prognostic value of infiltrating CD8+ T cells
10.1158/0008-5472.can-13-1342 · ExternalCitation · doi-reference
Germinal centers determine the prognostic relevance of tertiary lymphoid structures and are impaired by corticosteroids in lung squamous cell carcinoma
10.1158/0008-5472.can-17-1987 · ExternalCitation · doi-reference
Myeloid Cells Induce Infiltration and Activation of B Cells and CD4+ T Follicular Helper Cells to Sensitize Brain Metastases to Combination Immunotherapy
10.1158/0008-5472.can-24-2274 · ExternalCitation · doi-reference
Occurrence of tertiary lymphoid tissue is associated with T-cell infiltration and predicts better prognosis in early-stage colorectal cancers
10.1158/1078-0432.ccr-13-2590 · ExternalCitation · doi-reference
Orchestration and Prognostic Significance of Immune Checkpoints in the Microenvironment of Primary and Metastatic Renal Cell Cancer
10.1158/1078-0432.ccr-14-2926 · ExternalCitation · doi-reference
Tumor-Infiltrating Plasma Cells Are Associated with Tertiary Lymphoid Structures, Cytolytic T-Cell Responses, and Superior Prognosis in Ovarian Cancer
10.1158/1078-0432.ccr-15-2762 · ExternalCitation · doi-reference
A Strong B-cell Response Is Part of the Immune Landscape in Human High-Grade Serous Ovarian Metastases
10.1158/1078-0432.ccr-16-0081 · ExternalCitation · doi-reference
Early Hepatic Lesions Display Immature Tertiary Lymphoid Structures and Show Elevated Expression of Immune Inhibitory and Immunosuppressive Molecules
10.1158/1078-0432.ccr-19-2929 · ExternalCitation · doi-reference
Mouse models for cancer immunotherapy research
10.1158/2159-8290.cd-18-0044 · ExternalCitation · doi-reference
The Interplay between Extracellular Matrix Remodeling and Cancer Therapeutics
10.1158/2159-8290.cd-24-0002 · ExternalCitation · doi-reference
A Population of TIM4+FOLR2+ Macrophages Localized in Tertiary Lymphoid Structures Correlates to an Active Immune Infiltrate Across Several Cancer Types
10.1158/2326-6066.cir-22-0271 · ExternalCitation · doi-reference
Presence of B cells in tertiary lymphoid structures is associated with a protective immunity in patients with lung cancer
10.1164/rccm.201309-1611oc · ExternalCitation · doi-reference
CD4⁺ follicular helper T cell infiltration predicts breast cancer survival
10.1172/jci67428 · ExternalCitation · doi-reference
Lymphatic vessels and tertiary lymphoid organs
10.1172/jci71611 · ExternalCitation · doi-reference
Correlation between MMP2 expression in lung cancer tissues and clinical parameters: a retrospective clinical analysis
10.1186/s12890-020-01317-1 · ExternalCitation · doi-reference
Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application
10.1186/s12943-024-01980-6 · ExternalCitation · doi-reference
Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response
10.1186/s12943-024-02191-9 · ExternalCitation · doi-reference
Advances in cancer immunotherapy: historical perspectives, current developments, and future directions
10.1186/s12943-025-02305-x · ExternalCitation · doi-reference
Tertiary lymphoid structures in cancer: spatiotemporal heterogeneity, immune orchestration, and translational opportunities
10.1186/s13045-025-01754-7 · ExternalCitation · doi-reference
Cancer-associated fibroblasts and tertiary lymphoid structure orchestrate the spatial architecture of tumor immunity
10.1186/s13045-026-01814-6 · ExternalCitation · doi-reference
Evaluating the immunologically "cold" tumor microenvironment after treatment with immune checkpoint inhibitors utilizing PET imaging of CD4 + and CD8 + T cells in breast cancer mouse models
10.1186/s13058-024-01844-3 · ExternalCitation · doi-reference
Increasing cure rates of solid tumors by immune checkpoint inhibitors
10.1186/s40164-023-00372-8 · ExternalCitation · doi-reference
Lactylation modification in cancer: mechanisms, functions, and therapeutic strategies
10.1186/s40164-025-00622-x · ExternalCitation · doi-reference
In-depth insight into tumor-infiltrating stromal cells linked to tertiary lymphoid structures and their prospective function in cancer immunotherapy
10.1186/s40164-025-00695-8 · ExternalCitation · doi-reference
Innovations, challenges, and minimal information for standardization of humanized mice
10.15252/emmm.201708662 · ExternalCitation · doi-reference
Analysis of the immune landscape of small bowel neuroendocrine tumors
10.1530/erc-18-0189 · ExternalCitation · doi-reference
Tertiary lymphoid structures in cancers: prognostic value, regulation, and manipulation for therapeutic intervention
10.3389/fimmu.2016.00407 · ExternalCitation · doi-reference
Stromal fibroblasts in tertiary lymphoid structures: a novel target in chronic inflammation
10.3389/fimmu.2016.00477 · ExternalCitation · doi-reference
High endothelial venules and other blood vessels: critical regulators of lymphoid organ development and function
10.3389/fimmu.2017.00045 · ExternalCitation · doi-reference
A Unique Cellular and Molecular Microenvironment Is Present in Tertiary Lymphoid Organs of Patients with Spontaneous Prostate Cancer Regression
10.3389/fimmu.2017.00563 · ExternalCitation · doi-reference
Deciphering the maturation of tertiary lymphoid structures in cancer and inflammatory diseases of the digestive tract using imaging mass cytometry
10.3389/fimmu.2023.1147480 · ExternalCitation · doi-reference
Tertiary lymphoid structures and B lymphocytes: a promising therapeutic strategy to fight cancer
10.3389/fimmu.2023.1231315 · ExternalCitation · doi-reference
The role of dendritic cells in tertiary lymphoid structures: implications in cancer and autoimmune diseases
10.3389/fimmu.2024.1439413 · ExternalCitation · doi-reference
Mesenchymal Stem/Stromal Cells Derived from Cervical Cancer Promote M2 Macrophage Polarization
10.3390/cells12071047 · ExternalCitation · doi-reference
Vitro Glioblastoma Model on a Plate for Localized Drug Release Study from a 3D-Printed Drug-Eluted Hydrogel Mesh
10.3390/cells13040363 · ExternalCitation · doi-reference
Bacteriophages as Solid Tumor Theragnostic Agents. LID
10.3390/ijms23010402 · ExternalCitation · doi-reference
Artificial Tertiary Lymphoid Structures: Exploring Mesenchymal Stromal Cells as a Platform for Immune Niche Formation
10.3390/ijms252413286 · ExternalCitation · doi-reference
Tumor microenvironment in melanoma-characteristic and clinical implications
10.3390/ijms26146778 · ExternalCitation · doi-reference
pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review. LID
10.3390/nano10081613 · ExternalCitation · doi-reference
Association between the preoperative neutrophil-to-lymphocyte ratio and tertiary lymphoid structures surrounding tumor in gastric cancer
10.3892/mco.2021.2238 · ExternalCitation · doi-reference
High endothelial venule blood vessels for tumor-infiltrating lymphocytes are associated with lymphotoxin β-producing dendritic cells in human breast cancer
10.4049/jimmunol.1300872 · ExternalCitation · doi-reference
Predictive Value of Tertiary Lymphoid Structures Assessed by High Endothelial Venule Counts in the Neoadjuvant Setting of Triple-Negative Breast Cancer
10.4143/crt.2016.215 · ExternalCitation · doi-reference
ATP-responsive and near-infrared-emissive nanocarriers for anticancer drug delivery and real-time imaging
10.7150/thno.14843 · ExternalCitation · doi-reference
