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References from Disrupting the BEX4-Mediated DNA repair rheostat with a novel inhibitor suppresses stemness and enhances chemosensitivity in hepatoblastoma. Local targets link to admitted publications; unresolved targets remain external evidence.
The epidemiology of hepatoblastoma
10.1002/pbc.24215 · 2012 · External reference
Mechanism of cancer stemness maintenance in human liver cancer
10.1038/s41419-022-04848-z · 2022 · External reference
Malignant hepatoblast-like cells sustain stemness via IGF2-dependent cholesterol accumulation in hepatoblastoma
2025 · External reference
Hepatoblastoma
10.1038/s41572-025-00620-7 · 2025 · External reference
Birth weight and neonatal morbidity as early-life risk factors for childhood cancer: a nationwide cohort study
10.1186/s12887-025-06382-1 · 2025 · External reference
Prognostic factors and treatment outcomes of hepatoblastoma in children: a SEER database analysis
10.1007/s00431-025-06498-7 · 2025 · External reference
Inhibiting glutamine-dependent mTORC1 activation ameliorates liver cancers driven by β-catenin mutations
10.1016/j.cmet.2019.01.002 · 2019 · External reference
Targeting ATR to overcome cisplatin resistance in hepatoblastoma
2025 · External reference
Targeting DNA damage response pathways in tumor drug resistance: Mechanisms, clinical implications, and future directions
10.1016/j.drup.2025.101287 · 2025 · External reference
Liquid-liquid phase separation in DNA double-strand breaks repair
10.1038/s41419-023-06267-0 · 2023 · External reference
SOX2 and p53 expression control converges in PI3K/AKT signaling with versatile implications for stemness and cancer
10.3390/ijms21144902 · 2020 · External reference
Cisplatin-mediated activation of NF-κB promotes lung cancer stem cell formation via DNA repair pathways
10.1186/s12967-025-07282-9 · 2025 · External reference
The interplay of DNA damage, epigenetics and tumour heterogeneity in driving cancer cell fitness
10.1038/s41467-025-64445-4 · 2025 · External reference
Targeting the interactions between lymphocytes and liver cancer stem cells in combination with immunotherapy is a promising therapeutic strategy
10.20517/2394-5079.2022.52 · 2023 · External reference
DNMT1-mediated methylation of BEX1 regulates stemness and tumorigenicity in liver cancer
10.1016/j.jhep.2021.06.025 · 2021 · External reference
BEX1 supports the stemness of hepatoblastoma by facilitating Warburg effect in a PPARγ/PDK1 dependent manner
10.1038/s41416-023-02418-4 · 2023 · External reference
Oncogenic potential of BEX4 is conferred by Polo-like kinase 1-mediated phosphorylation
2018 · External reference
Decreased brain-expressed X-linked 4 (BEX4) expression promotes growth of oral squamous cell carcinoma
10.1186/s13046-016-0355-6 · 2016 · External reference
BEX4 inhibits the progression of clear cell renal cell carcinoma by stabilizing SH2D4A, which is achieved by blocking SIRT2 activity
10.1038/s41388-024-03235-6 · 2025 · External reference
BEX1 and BEX4 Induce GBM progression through regulation of actin polymerization and activation of YAP/TAZ signaling
10.3390/ijms22189845 · 2021 · External reference
SUMOylation-stabilized G6PD orchestrates metabolic rewiring for oxidative stress survival and chemoresistance in HCC via a PKCδ-phosphorylation trigger
10.1038/s41418-026-01802-w · 2026 · External reference
Upregulation of SQLE Contributes to Poor Survival in Head and Neck Squamous Cell Carcinoma
10.7150/ijbs.68216 · 2022 · External reference
Inhibition of PI3K by copanlisib exerts potent antitumor effects on Merkel cell carcinoma cell lines and mouse xenografts
10.1038/s41598-020-65637-2 · 2020 · External reference
OCTN2 enhances PGC-1α-mediated fatty acid oxidation and OXPHOS to support stemness in hepatocellular carcinoma
10.1016/j.metabol.2023.155628 · 2023 · External reference
Hydrodynamic transfection for generation of novel mouse models for liver cancer research
10.1016/j.ajpath.2013.12.002 · 2014 · External reference
ELDA: extreme limiting dilution analysis for comparing depleted and enriched populations in stem cell and other assays
10.1016/j.jim.2009.06.008 · 2009 · External reference
Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair
10.1371/journal.pgen.1000110 · 2008 · External reference
The emerging role of RNAs in DNA damage repair
10.1038/cdd.2017.16 · 2017 · External reference
HDOCK: a web server for protein-protein and protein-DNA/RNA docking based on a hybrid strategy
10.1093/nar/gkx407 · 2017 · External reference
Xrcc5/Ku80 is required for the repair of DNA damage in fully grown meiotically arrested mammalian oocytes
10.1038/s41419-023-05886-x · 2023 · External reference
Plasmodium falciparum DNA repair dynamics reveal unique roles for TLS polymerases and PfRad51 in genome diversification
10.1093/nar/gkaf1275 · 2025 · External reference
GPS 5.0: an update on the prediction of kinase-specific phosphorylation sites in proteins
10.1016/j.gpb.2020.01.001 · 2020 · External reference
Aberrant brain-expressed X-linked 4 (BEX4) expression is a novel prognostic biomarker in gastric cancer
10.1097/md.0000000000023133 · 2020 · External reference
Sex differences in hepatocellular carcinoma indicated BEX4 as a potential target to improve efficacy of lenvatinib plus immune checkpoint inhibitors
10.7150/jca.73051 · 2022 · External reference
Targeting DNA damage in ageing: towards supercharging DNA repair
10.1038/s41573-025-01212-6 · 2025 · External reference
Alternative splicing of FBP-interacting repressor coordinates c-Myc, P27Kip1/cyclinE and Ku86/XRCC5 expression as a molecular sensor for bleomycin-induced DNA damage pathway
10.18632/oncotarget.1650 · 2014 · External reference
Isoorientin triggers apoptosis of hepatoblastoma by inducing DNA double-strand breaks and suppressing homologous recombination repair
10.1016/j.biopha.2018.02.142 · 2018 · External reference
Knockdown of NRAGE impairs homologous recombination repair and sensitizes hepatoblastoma cells to ionizing radiation
2020 · External reference
Ginsenoside Rg1 impairs homologous recombination repair by targeting CtBP-interacting protein and sensitizes hepatoblastoma cells to DNA damage
10.1097/cad.0000000000000646 · 2018 · External reference
Intratumoral erythroblastic islands restrain anti-tumor immunity in hepatoblastoma
2023 · External reference
Single-cell transcriptomics uncovers cellular architecture and developmental trajectories in hepatoblastoma
10.1002/hep.32775 · 2023 · External reference
From preneoplastic lesion to heterogenous tumor: recent insights into hepatoblastoma biology and therapeutic opportunities
10.1186/s12943-025-02405-8 · 2025 · External reference
Dormant and activated polyploid giant cancer cells: from chemoradiotherapy resistance to cancer progression
10.1016/j.canlet.2025.218137 · 2026 · External reference
p53 mutation biases squamocolumnar junction progenitor cells towards dysplasia rather than metaplasia in Barrett's oesophagus
10.1136/gutjnl-2024-332095 · 2025 · External reference
Contributions of the distinct biophysical phenotype of polyploidal giant cancer cells to cancer progression
10.1016/j.semcancer.2021.05.014 · 2022 · External reference
Human aneuploid cells depend on the RAF/MEK/ERK pathway for overcoming increased DNA damage
10.1038/s41467-024-52176-x · 2024 · External reference
RAD21 promotes oncogenesis and lethal progression of prostate cancer
10.1073/pnas.2405543121 · 2024 · External reference
Oncogenic microtubule hyperacetylation through BEX4-mediated sirtuin 2 inhibition
10.1038/cddis.2016.240 · 2016 · External reference
