Research graph
References from Reticulon-3 in endoplasmic reticulum remodeling and cardiometabolic-fibrotic disease. Local targets link to admitted publications; unresolved targets remain external evidence.
A class of membrane proteins shaping the tubular endoplasmic reticulum
10.1016/j.cell.2005.11.047 · 2006 · External reference
Membrane proteins of the endoplasmic reticulum induce high-curvature tubules
10.1126/science.1153634 · 2008 · External reference
Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13
10.1006/geno.1999.5807 · 1999 · External reference
The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1
10.1074/jbc.m704181200 · 2007 · External reference
Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes
10.1007/s10495-006-0082-0 · 2006 · External reference
Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress
10.1007/s10495-006-0574-y · 2007 · External reference
Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi
10.1016/j.bbrc.2005.07.012 · 2005 · External reference
Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation
10.1038/nm1088 · 2004 · External reference
Increased reticulon 3 leads to obesity and hypertriglyceridemia by interacting with heat shock protein family A member 5
10.1161/circulationaha.117.030718 · 2018 · External reference
Increased RTN3 phenocopies nonalcoholic fatty liver disease by inhibiting the AMPK-IDH2 pathway
2023 · External reference
Lipid overload-induced RTN3 activation leads to cardiac dysfunction by promoting lipid droplet biogenesis
10.1038/s41418-023-01241-x · 2024 · External reference
Reticulon 3 deficiency ameliorates post-myocardial infarction heart failure by alleviating mitochondrial dysfunction and inflammation
2024 · External reference
Loss of RTN3 phenocopies chronic kidney disease and results in activation of the IGF2-JAK2 pathway in proximal tubular epithelial cells
10.1038/s12276-022-00763-7 · 2022 · External reference
Single-cell transcriptomic profiling reveals decreased ER protein Reticulon3 drives the progression of renal fibrosis
10.1186/s43556-024-00187-x · 2024 · External reference
RTN3 deficiency exacerbates cisplatin-induced acute kidney injury through the disruption of mitochondrial stability
10.1016/j.mito.2024.101851 · 2024 · External reference
RTN3 regulates collagen biosynthesis and profibrotic macrophage differentiation to promote pulmonary fibrosis via interacting with CRTH2
10.1186/s10020-025-01119-3 · 2025 · External reference
Reticulon 3 binds the 2C protein of enterovirus 71 and is required for efficient viral replication
10.1074/jbc.m611145200 · 2007 · External reference
The host protein reticulon 3.1A is utilized by flaviviruses to facilitate replication organelle formation
10.1016/j.celrep.2017.10.055 · 2017 · External reference
RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination
2021 · External reference
Reticulon 3-mediated Chk2/p53 activation suppresses hepatocellular carcinogenesis and is blocked by hepatitis B virus
10.1136/gutjnl-2020-321386 · 2021 · External reference
Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain
10.1016/j.molbrainres.2005.04.020 · 2005 · External reference
Full-length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy
10.7554/elife.25555 · 2017 · External reference
Reticulon 3 regulates very low density lipoprotein secretion by controlling very low density lipoprotein transport vesicle biogenesis
10.1139/cjpp-2018-0077 · 2018 · External reference
Reticulon 3 regulates sphingosine-1-phosphate synthesis in endothelial cells to control blood pressure
2024 · External reference
Increased expression of reticulon 3 in neurons leads to reduced axonal transport of beta-site amyloid precursor protein-cleaving enzyme 1
10.1074/jbc.m113.480079 · 2013 · External reference
Impact of RTN3 deficiency on expression of BACE1 and amyloid deposition during Alzheimer's disease pathogenesis
10.1523/jneurosci.1588-14.2014 · 2014 · External reference
Transgenic mice overexpressing reticulon 3 develop neuritic abnormalities
10.1038/sj.emboj.7601707 · 2007 · External reference
Identification of rare RTN3 variants in Alzheimer's disease in Han Chinese
10.1007/s00439-018-1868-1 · 2018 · External reference
Widespread distribution of reticulon-3 in various neurodegenerative diseases
10.1111/j.1440-1789.2010.01107.x · 2010 · External reference
Identification of four novel T cell autoantigens and personal autoreactive profiles in multiple sclerosis
10.1126/sciadv.abn1823 · 2022 · External reference
Reticulon 3 attenuates the clearance of cytosolic prion aggregates via inhibiting autophagy
10.4161/auto.7.2.14197 · 2011 · External reference
