Research graph
References from Camellioside A engages SIRT3 to promote FOXO3-PINK1/parkin dependent mitophagy and attenuate UVB-induced skin photoaging. Local targets link to admitted publications; unresolved targets remain external evidence.
Photoaging: current concepts on molecular mechanisms, prevention, and treatment
10.1007/s40257-025-00933-z · 2025 · External reference
Structural and functional changes and possible molecular mechanisms in aged skin
10.3390/ijms222212489 · 2021 · External reference
Identifying ENO1 as a protein target of chlorogenic acid to inhibit cellular senescence and prevent skin photoaging in mice
10.1111/acel.14433 · 2025 · External reference
From geroscience to precision geromedicine: understanding and managing aging
10.1016/j.cell.2025.03.011 · 2025 · External reference
Exosomes in skin photoaging: biological functions and therapeutic opportunity
10.1186/s12964-023-01451-3 · 2024 · External reference
Multi-omics analysis reveals photodynamic therapy ameliorating skin photoaging by improving cellular senescence through mitohormesis-mediated reduction of citrate content
10.1111/acel.70328 · 2026 · External reference
Mitochondrial dysfunction in aging
10.1016/j.arr.2023.101955 · 2023 · External reference
The senescence-associated secretory phenotype and its physiological and pathological implications
10.1038/s41580-024-00727-x · 2024 · External reference
18β-Glycyrrhetinic acid reduces skin damage from UVB exposure by inhibiting the MyD88/ MAPK signaling pathway
10.1016/j.intimp.2026.116212 · 2026 · External reference
Salvianolic acid B protects against UVB-induced skin aging via activation of NRF2
10.1016/j.phymed.2024.155676 · 2024 · External reference
Chlorogenic acid prevents uva-induced skin photoaging through regulating collagen metabolism and apoptosis in human dermal fibroblasts
10.3390/ijms23136941 · 2022 · External reference
Research progress on germplasm resources, chemical composition and biological activity of Camellia chekiangoleosa
2024 · External reference
Camellioside A, isolated from Camellia japonica flowers, attenuates UVA-induced production of MMP-1 in HaCaT keratinocytes via suppression of MAPK activation
2021 · External reference
Monitoring drug target engagement in cells and tissues using the cellular thermal shift assay
10.1126/science.1233606 · 2013 · External reference
Solvent-Induced Protein Precipitation for Drug Target Discovery on the Proteomic Scale
10.1021/acs.analchem.9b04531 · 2020 · External reference
Aging in the dermis: fibroblast senescence and its significance
10.1111/acel.14054 · 2024 · External reference
Silk fibroin counteracts fibroblast senescence to restore ECM homeostasis in aged skin
2026 · External reference
SPP1-ITGα5/β1 Accelerates Calcification of Nucleus Pulposus Cells by Inhibiting Mitophagy via Ubiquitin-Dependent PINK1/PARKIN Pathway Blockade
10.1002/advs.202411162 · 2025 · External reference
Mitochondrial fumarate inhibits Parkin-mediated mitophagy
10.1016/j.molcel.2025.05.021 · 2025 · External reference
Hypoxia-induced GPCPD1 depalmitoylation triggers mitophagy via regulating PRKN-mediated ubiquitination of VDAC1
10.1080/15548627.2023.2182482 · 2023 · External reference
SIRT3 deacetylates FOXO3 to protect mitochondria against oxidative damage
10.1016/j.freeradbiomed.2013.05.002 · 2013 · External reference
SIRT3 interactions with FOXO3 acetylation, phosphorylation and ubiquitinylation mediate endothelial cell responses to hypoxia
10.1042/bj20140213 · 2014 · External reference
Sanshool improves UVB-induced skin photodamage by targeting JAK2/STAT3-dependent autophagy
10.1038/s41419-018-1261-y · 2019 · External reference
Spleen tyrosine kinase regulates keratinocyte inflammasome activation and skin inflammation induced by UVB irradiation
10.1016/j.freeradbiomed.2022.01.004 · 2022 · External reference
Cordycepin inhibits UVB-induced matrix metalloproteinase expression by suppressing the NF-kappaB pathway in human dermal fibroblasts
10.3858/emm.2009.41.8.060 · 2009 · External reference
Connective tissue and fibroblast senescence in skin aging
10.1016/j.jid.2020.11.010 · 2021 · External reference
Skin aging from mechanisms to interventions: focusing on dermal aging
10.3389/fphys.2023.1195272 · 2023 · External reference
Needle-free injection of exosomes derived from human dermal fibroblast spheroids ameliorates skin photoaging
10.1021/acsnano.9b04384 · 2019 · External reference
Mitochondrial dysfunction in cell senescence and aging
10.1172/jci158447 · 2022 · External reference
Mitochondrial dynamics in health and disease: mechanisms and potential targets
10.1038/s41392-023-01547-9 · 2023 · External reference
Small extracellular vesicles derived from mesenchymal stromal cells loaded with β-nicotinamide mononucleotide activate NAD+/SIRT3 signaling pathway-mediated mitochondrial autophagy to delay skin aging.
10.1186/s13287-025-04460-w · 2025 · External reference
Elimination of damaged mitochondria during UVB-induced senescence is orchestrated by NIX-dependent mitophagy
10.1111/acel.14186 · 2024 · External reference
Unraveling mitochondrial influence on mammalian pluripotency via enforced mitophagy
10.1016/j.cell.2025.05.020 · 2025 · External reference
A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass
10.1016/j.molcel.2023.11.038 · 2024 · External reference
Emodin inhibits NLRP3 inflammasome activation and protects against sepsis via promoting FUNDC1-mediated mitophagy
10.7150/ijbs.110904 · 2025 · External reference
Impaired mitophagy causes mitochondrial DNA leakage and STING activation in ultraviolet B-irradiated human keratinocytes HaCaT
10.1016/j.abb.2023.109553 · 2023 · External reference
Human adipose-derived stem cell exosomes reduce mitochondrial DNA common deletion through PINK1/Parkin-mediated mitophagy to improve skin photoaging
10.1186/s13287-025-04475-3 · 2025 · External reference
BNIP3 upregulation via stimulation of ERK and JNK activity is required for the protection of keratinocytes from UVB-induced apoptosis
10.1038/cddis.2017.4 · 2017 · External reference
FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner
10.1016/j.jare.2023.02.012 · 2024 · External reference
Roles of SIRT3 in aging and aging-related diseases
10.7150/ijbs.115518 · 2025 · External reference
Mitochondrial Sirtuin 3: new emerging biological function and therapeutic target
10.7150/thno.45922 · 2020 · External reference
Mitochondrial proteins in heart failure: The role of deacetylation by SIRT3
10.1016/j.phrs.2021.105802 · 2021 · External reference
SIRT3 reverses aging-associated degeneration
10.1016/j.celrep.2013.01.005 · 2013 · External reference
Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation
10.1016/j.cmet.2010.11.015 · 2010 · External reference
Honokiol blocks and reverses cardiac hypertrophy in mice by activating mitochondrial Sirt3
10.1038/ncomms7656 · 2015 · External reference
2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis
10.1038/s41392-024-01816-1 · 2024 · External reference
