Research graph
References from Natural products as modulators of cuproptosis: A systematic review of mechanisms, therapeutic potential, and future directions. Local targets link to admitted publications; unresolved targets remain external evidence.
Antioxidant, anti-inflammatory and epigenetic potential of curcumin in Alzheimer's disease
10.1002/biof.2039 · 2024 · External reference
Curcumin attenuates copper-induced oxidative stress and neurotoxicity in Drosophila melanogaster
10.1016/j.toxrep.2020.01.015 · 2020 · External reference
Bioavailability of phytochemicals and its enhancement by drug delivery systems
10.1016/j.canlet.2013.02.032 · 2013 · External reference
Artemisinin kinetics and dynamics during oral and rectal treatment of uncomplicated malaria
10.1016/s0009-9236(98)90044-3 · 1998 · External reference
Divergent synthesis of a pochonin library targeting HSP90 and in vivo efficacy of an identified inhibitor
10.1002/anie.200800233 · 2008 · External reference
Blood copper levels and the occurrence of colorectal cancer in Poland
10.3390/biomedicines9111628 · 2021 · External reference
Phase I clinical trial of STA-4783 in combination with paclitaxel in patients with refractory solid tumors
10.1158/1078-0432.ccr-06-0964 · 2007 · External reference
Improving on nature: the role of nanomedicine in the development of clinical natural drugs
10.1055/s-0043-102949 · 2017 · External reference
Single-cell tracking demonstrates copper chaperone Atox1 to be required for breast cancer cell migration
10.1073/pnas.1910722117 · 2020 · External reference
Tetrathiomolybdate anticopper therapy for Wilson's disease inhibits angiogenesis, fibrosis and inflammation
10.1111/j.1582-4934.2003.tb00198.x · 2003 · External reference
Black tea polyphenols: A mechanistic treatise
10.1080/10408398.2011.623198 · 2014 · External reference
Serum copper and zinc levels and the risk of oral cancer: A new insight based on large-scale case-control study
10.1111/odi.12957 · 2019 · External reference
Copper homeostasis and cuproptosis in health and disease
10.1038/s41392-022-01229-y · 2022 · External reference
Homeostasis and metabolism of iron and other metal ions in neurodegenerative diseases
10.1038/s41392-024-02071-0 · 2025 · External reference
Artesunate alleviates Parkinson's disease by targeting astrocyte MT2A to attenuate dopamine neuronal cuproptosis
10.1016/j.phrs.2025.107895 · 2025 · External reference
Resveratrol-like Compounds as SIRT1 Activators
10.3390/ijms232315105 · 2022 · External reference
Drug delivery systems of natural products in oncology
10.3390/molecules25194560 · 2020 · External reference
Ultrasound-activated metal-polyphenol nanodroplets for tumor cuproptosis
10.1016/j.biomaterials.2026.124013 · 2026 · External reference
Natural products as non-covalent and covalent modulators of the KEAP1/NRF2 pathway exerting antioxidant effects
10.1016/j.ejmech.2024.116355 · 2024 · External reference
Wilson disease
10.1038/s41572-018-0018-3 · 2018 · External reference
Cysteine oxidation of copper transporter CTR1 drives VEGFR2 signalling and angiogenesis
10.1038/s41556-021-00822-7 · 2022 · External reference
Mitochondrial-targeted copper delivery for cuproptosis-based synergistic cancer therapy
2024 · External reference
Targeting copper in cancer therapy: ‘copper that cancer
10.1039/c5mt00149h · 2015 · External reference
Targeting cuproptosis in disease treatment: From molecular mechanisms to therapeutic interventions
10.1016/j.preme.2026.100058 · 2026 · External reference
Ferroptosis: bug or feature?
10.1111/imr.12533 · 2017 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
FDX1 regulates cellular protein lipoylation through direct binding to LIAS
10.1016/j.jbc.2023.105046 · 2023 · External reference
Copper exerts cytotoxicity through inhibition of iron-sulfur cluster biogenesis on ISCA1/ISCA2/ISCU assembly proteins
10.1016/j.freeradbiomed.2023.05.017 · 2023 · External reference
Inhibitory act of selenoprotein P on Cu(+)/Cu(2+)-induced tau aggregation and neurotoxicity
10.1021/ic501788v · 2014 · External reference
Special issue: cytotoxicity, antioxidant and anticancer activity of natural products, 2nd edition
10.3390/ijms27041623 · 2026 · External reference
Orchestrating mitochondrial catastrophe: mechanistic insights and therapeutic frontiers of cuproptosis in precision pharmacology
10.1016/j.coph.2026.102629 · 2026 · External reference
Apoptosis: a review of programmed cell death
10.1080/01926230701320337 · 2007 · External reference
Advances in drug delivery systems, challenges and future directions
10.1016/j.heliyon.2023.e17488 · 2023 · External reference
A safe saponin-based nano-strategy for manganese-mediated STING activation
10.1016/j.jconrel.2025.114303 · 2025 · External reference
Understanding the prooxidant action of plant polyphenols in the cellular microenvironment of malignant cells: role of copper and therapeutic implications
2022 · External reference
Discovery of natural resorcylic acid lactones as novel potent copper ionophores covalently targeting prdx1 to induce cuproptosis for triple-negative breast cancer therapy
10.1021/acscentsci.4c02188 · 2025 · External reference
Copper in the colorectal cancer microenvironment: pioneering a new era of cuproptosis-based therapy
2024 · External reference
Copper regulation of hypoxia-inducible factor-1 activity
10.1124/mol.108.051516 · 2009 · External reference
Mechanisms of copper ion mediated Huntington's disease progression
10.1371/journal.pone.0000334 · 2007 · External reference
Oral bioavailability comparison of artemisinin, deoxyartemisinin, and 10-deoxoartemisinin based on computer simulations and pharmacokinetics in rats
10.1021/acsomega.0c05465 · 2021 · External reference
Epigallocatechin gallate promotes cuproptosis via the MTF1/ATP7B axis in hepatocellular carcinoma
10.3390/cells14060391 · 2025 · External reference
Connecting copper and cancer: from transition metal signalling to metalloplasia
10.1038/s41568-021-00417-2 · 2022 · External reference
Characterization of chalkophomycin, a copper(II) metallophore with an unprecedented molecular architecture
10.1021/jacs.1c09311 · 2021 · External reference
Chemical evolution of natural product structure
10.1021/jacs.1c11270 · 2022 · External reference
Targeting regulated cell death: Apoptosis, necroptosis, pyroptosis, ferroptosis, and cuproptosis in anticancer immunity
10.1515/jtim-2025-0004 · 2025 · External reference
The metallochaperone Atox1 plays a critical role in perinatal copper homeostasis
10.1073/pnas.111058498 · 2001 · External reference
A paclitaxel prodrug with copper depletion for combined therapy toward triple-negative breast cancer
10.1021/acsnano.3c01792 · 2023 · External reference
Tackling cuproptosis: from metabolic rewiring to therapeutic exploitation in cancer
10.1038/s41423-026-01387-x · 2026 · External reference
Ellagic acid protects human keratinocyte (HaCaT) cells against UVA-induced oxidative stress and apoptosis through the upregulation of the HO-1 and Nrf-2 antioxidant genes
10.1016/j.fct.2012.02.020 · 2012 · External reference
The STAT1-SLC31A1 axis: potential regulation of cuproptosis in diabetic retinopathy
10.1016/j.gene.2024.148861 · 2024 · External reference
The mechanism of cuproptosis in Parkinson's disease
10.1016/j.arr.2024.102214 · 2024 · External reference
Insights into antiamyloidogenic properties of the green tea extract (-)-epigallocatechin-3-gallate toward metal-associated amyloid-β species
10.1073/pnas.1220326110 · 2013 · External reference
Enhancing curcumin oral bioavailability through nanoformulations
10.1007/s13318-019-00545-z · 2019 · External reference
Photothermal-responsive curcumin-loaded copper-based nanocomposites for targeted drug release and combined immunotherapy
10.1016/j.jcis.2025.138042 · 2025 · External reference
Unraveling colorectal cancer and pan-cancer immune heterogeneity and synthetic therapy response using cuproptosis and hypoxia regulators by multi-omic analysis and experimental validation
10.7150/ijbs.84781 · 2023 · External reference
Baicalein enhances cisplatin sensitivity in cervical cancer cells by promoting cuproptosis through the Akt pathway
10.1016/j.biopha.2024.117415 · 2024 · External reference
Advances in novel cell death mechanisms in breast cancer: intersecting perspectives on ferroptosis, cuproptosis, disulfidptosis, and pyroptosis
10.1186/s12943-025-02445-0 · 2025 · External reference
The role of redox active copper(II) on antioxidant properties of the flavonoid baicalein: DNA protection under Cu(II)-Fenton reaction and Cu(II)-ascorbate system conditions
10.1016/j.jinorgbio.2023.112244 · 2023 · External reference
Elemental quantification and analysis of structural abnormalities in neurons from Parkinson's-diseased brains by X-ray fluorescence microscopy and diffraction
10.1364/boe.389408 · 2020 · External reference
Metallothionein in brain disorders
10.1155/2017/5828056 · 2017 · External reference
Copper-induced cell death
10.1126/science.abo3959 · 2022 · External reference
Natural products against cancer angiogenesis
10.1007/s13277-016-5364-8 · 2016 · External reference
GTP Cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling
10.1021/acscentsci.9b01063 · 2020 · External reference
Trafficking of the copper-ATPases, ATP7A and ATP7B: role in copper homeostasis
10.1016/j.abb.2007.04.021 · 2007 · External reference
Polyphenols as potential metal chelation compounds against alzheimer's disease
10.3233/jad-200185 · 2021 · External reference
Copper-quercetin complexes: methods of study, relevance to cell death pathways, therapeutic applications
10.1016/j.biopha.2025.118055 · 2025 · External reference
Structure-activity assessment of flavonoids as modulators of copper transport
10.3389/fchem.2022.972198 · 2022 · External reference
Serum concentrations of selenium and copper in patients diagnosed with pancreatic cancer
10.4143/crt.2015.282 · 2016 · External reference
Cuproptosis-a potential target for the treatment of osteoporosis
2023 · External reference
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system
10.1016/j.biomaterials.2025.123201 · 2025 · External reference
From copper homeostasis to cuproptosis: a new perspective on CNS immune regulation and neurodegenerative diseases
2025 · External reference
Cuproptosis in cancer: biological implications and therapeutic opportunities
10.1186/s11658-024-00608-3 · 2024 · External reference
Combination of the cuproptosis inducer disulfiram and anti‑PD‑L1 abolishes NSCLC resistance by ATP7B to regulate the HIF‑1 signaling pathway
2024 · External reference
Hybrid cell membrane-functionalized nanoagents synergistically enhance cuproptosis-mediated immunotherapy by dual modulation of glycolytic metabolism and tumor microenvironments
10.1021/acsnano.5c10671 · 2025 · External reference
Modulation of type I interferon signaling by natural products in the treatment of immune-related diseases
2023 · External reference
Cuproptosis: lipoylated TCA cycle proteins-mediated novel cell death pathway
10.1038/s41392-022-01014-x · 2022 · External reference
AR-targeted therapies sensitize prostate cancer to cuproptosis by transcriptionally activating FDX1
2026 · External reference
Copper homeostasis: emerging target for cancer treatment
10.1002/iub.2341 · 2020 · External reference
Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death
10.1186/s12964-023-01267-1 · 2023 · External reference
GSDMD-mediated pyroptosis: molecular mechanisms, diseases and therapeutic targets
10.1186/s43556-025-00249-8 · 2025 · External reference
Metal chelating, inhibitory DNA damage, and anti-inflammatory activities of phenolics from rambutan (nephelium lappaceum) peel and the quantifications of geraniin and corilagin
2018 · External reference
Unresolved reference
2016 · External reference
Harnessing Cuproptosis resistance to advance cancer therapeutics
10.1007/s10495-026-02266-6 · 2026 · External reference
Evolocumab attenuates myocardial ischemia/reperfusion injury by blocking PCSK9/LIAS-mediated cuproptosis of cardiomyocytes
10.1007/s00395-025-01100-5 · 2025 · External reference
Methanobactin reverses acute liver failure in a rat model of Wilson disease
10.1172/jci85226 · 2016 · External reference
DLAT promotes triple-negative breast cancer progression via YAP1 activation
10.1080/15384047.2024.2421578 · 2024 · External reference
NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism
2024 · External reference
Oral bioavailability of curcumin: problems and advancements
10.3109/1061186x.2016.1157883 · 2016 · External reference
Novel strategy for cancer therapy proposal based on effects and mechanisms of targeting cuproptosis by polyphenols—a narrative review
10.3390/nu18060917 · 2026 · External reference
Targeting cuproptosis with nano material: new way to enhancing the efficacy of immunotherapy in colorectal cancer
10.3389/fphar.2024.1451067 · 2024 · External reference
Pyroptosis in health and disease: mechanisms, regulation and clinical perspective
10.1038/s41392-024-01958-2 · 2024 · External reference
Role of copper homeostasis and cuproptosis in heart failure pathogenesis: implications for therapeutic strategies
2024 · External reference
Identification of GLS as a cuproptosis-related diagnosis gene in acute myocardial infarction
10.3389/fcvm.2022.1016081 · 2022 · External reference
Harnessing cuproptosis for antitumor immunity: a review of current evidence and therapeutic strategies
10.1002/mc.70128 · 2026 · External reference
Bioactivity of dietary polyphenols: the role of metabolites
10.1080/10408398.2018.1546669 · 2020 · External reference
The contribution of copper efflux transporters ATP7A and ATP7B to chemoresistance and personalized medicine in ovarian cancer
10.1016/j.biopha.2020.110401 · 2020 · External reference
Anticancer effects and molecular target of theaflavins from black tea fermentation in vitro and in vivo
10.1021/acs.jafc.1c05313 · 2021 · External reference
Merestinib inhibits cuproptosis by targeting NRF2 to alleviate acute liver injury
10.1016/j.freeradbiomed.2025.01.029 · 2025 · External reference
Caffeic acid: a review of its potential use in medications and cosmetics
10.1039/c3ay41807c · 2014 · External reference
Copper-chelating natural products
10.1007/s00775-025-02099-9 · 2025 · External reference
Targeted treatment for osteoarthritis: drugs and delivery system
10.1080/10717544.2021.1971798 · 2021 · External reference
Copper and alzheimer's disease
10.1007/978-3-319-60189-2_10 · 2017 · External reference
Copper toxicity and deficiency: the vicious cycle at the core of protein aggregation in ALS
10.3389/fnmol.2024.1408159 · 2024 · External reference
Ellagic acid as a potent anticancer drug: a comprehensive review on in vitro, in vivo, in silico, and drug delivery studies
10.1002/bab.2288 · 2022 · External reference
Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019
10.1021/acs.jnatprod.9b01285 · 2020 · External reference
Final results of phase III SYMMETRY study: randomized, double-blind trial of elesclomol plus paclitaxel versus paclitaxel alone as treatment for chemotherapy-naive patients with advanced melanoma
10.1200/jco.2012.44.5585 · 2013 · External reference
Comparison of (-)-epigallocatechin-3-O-gallate (EGCG) and O-methyl EGCG bioavailability in rats
10.1248/bpb.b13-00349 · 2013 · External reference
NAD(H) enhances the Cu(II)-mediated inactivation of lactate dehydrogenase by increasing the accessibility of sulfhydryl groups
10.1080/10715760400023671 · 2005 · External reference
Theaflavin-3,3′-digallate enhances the inhibitory effect of cisplatin by regulating the copper transporter 1 and glutathione in human ovarian cancer cells
10.3390/ijms19010117 · 2018 · External reference
Necroptosis and its role in inflammation
10.1038/nature14191 · 2015 · External reference
Serum levels of metal ions in female patients with breast cancer
2015 · External reference
Copper-stimulated endocytosis and degradation of the human copper transporter, hCtr1
10.1074/jbc.m209455200 · 2003 · External reference
Pharmacokinetics, pharmacodynamics and formulation strategies for enhanced bioavailability of baicalein: an update
10.1007/s00210-026-05414-6 · 2026 · External reference
Retrospective analysis of natural products provides insights for future discovery trends
10.1073/pnas.1614680114 · 2017 · External reference
Quercetin alleviates toxicity induced by high levels of copper in porcine follicular granulosa cells by scavenging reactive oxygen species and improving mitochondrial function
2023 · External reference
Targeting tumor-associated macrophage polarization with traditional Chinese medicine active ingredients: Dual reversal of chemoresistance and immunosuppression in tumor microenvironment
10.1016/j.phrs.2025.107788 · 2025 · External reference
Natural products in cancer prevention and therapy: current challenges and future directions
10.1002/mco2.70585 · 2026 · External reference
Novel natural product therapeutics targeting both inflammation and cancer
2017 · External reference
Curcumin suppresses copper accumulation in non-small cell lung cancer by binding ATOX1
10.1186/s40360-024-00784-0 · 2024 · External reference
Dual-purpose isocyanides produced by Aspergillus fumigatus contribute to cellular copper sufficiency and exhibit antimicrobial activity
10.1073/pnas.2015224118 · 2021 · External reference
Cuproptosis inducers in cancer therapy: state of the art and challenges
10.1002/tcr.70179 · 2026 · External reference
A mechanistic evaluation of antioxidant nutraceuticals on their potential against age-associated neurodegenerative diseases
10.3390/antiox9101019 · 2020 · External reference
Determination of copper and other trace elements in serum samples from patients with biliary tract cancers: prospective noninterventional nonrandomized clinical study protocol
10.2478/raon-2024-0026 · 2024 · External reference
Prospective challenges for patenting and clinical trials of anticancer compounds from natural products: coherent review
10.2174/1574892818666221104113703 · 2023 · External reference
Serum levels of selenium, zinc, copper, manganese, and iron in prostate cancer patients
10.1159/000499261 · 2020 · External reference
Fluopsin C: a potential candidate against the deadly drug-resistant microbial infections in humans
10.2217/fmb-2019-0307 · 2020 · External reference
Enhancement of anticancer potential of artemisinin derivatives through n-glycosylation
10.2174/0115680266322676240724114536 · 2024 · External reference
Black tea polyphenol theaflavin as promising antioxidant and potential copper chelator
10.1002/jsfa.10347 · 2020 · External reference
The association between serum levels of selenium, copper, and magnesium with thyroid cancer: a meta-analysis
10.1007/s12011-015-0304-9 · 2015 · External reference
Quercetin attenuates acute kidney injury caused by cisplatin by inhibiting ferroptosis and cuproptosis
10.1007/s12013-024-01379-6 · 2024 · External reference
The structures of fluopsins C and F
10.7164/antibiotics.23.546 · 1970 · External reference
The roles of metallothioneins in carcinogenesis
10.1186/s13045-018-0645-x · 2018 · External reference
Low levels of copper disrupt brain amyloid-β homeostasis by altering its production and clearance
10.1073/pnas.1302212110 · 2013 · External reference
Tumor glucose reprogramming suppresses cuproptosis: a review
10.17305/bb.2025.12751 · 2025 · External reference
Emerging mechanistic insights into cuproptosis in cancer: metabolic rewiring and therapeutic targeting
10.1016/j.biopha.2026.119615 · 2026 · External reference
Cuproptosis: a copper-triggered modality of mitochondrial cell death
10.1038/s41422-022-00653-7 · 2022 · External reference
Targeting cuproplasia and cuproptosis in cancer
10.1038/s41571-024-00876-0 · 2024 · External reference
Cuproptosis: an emerging member of the immunogenic cell death family
10.1038/s41418-026-01852-0 · 2026 · External reference
Synergistic interaction of Cu(II) with caffeic acid and chlorogenic acid in α-glucosidase inhibition
10.1002/jsfa.12955 · 2024 · External reference
Challenges and opportunities for improving the druggability of natural product: why need drug delivery system?
10.1016/j.biopha.2023.114955 · 2023 · External reference
Resveratrol: a review of plant sources, synthesis, stability, modification and food application
10.1002/jsfa.10152 · 2020 · External reference
The pharmacokinetics of artemisinin after oral, intramuscular and rectal administration to volunteers
10.1111/j.2042-7158.1990.tb07030.x · 1990 · External reference
Copper homeostasis as a therapeutic target in amyotrophic lateral sclerosis with SOD1 mutations
10.3390/ijms17050636 · 2016 · External reference
Copper induces cell death by targeting lipoylated TCA cycle proteins
10.1126/science.abf0529 · 2022 · External reference
Pyroptosis-induced inflammation and tissue damage
10.1016/j.smim.2023.101781 · 2023 · External reference
Molecular mechanisms of apoptosis: an overview
10.1007/978-3-540-69184-6_2 · 1999 · External reference
Bioavailability of resveratrol
10.1111/j.1749-6632.2010.05842.x · 2011 · External reference
The molecular mechanisms of cuproptosis and its relevance to cardiovascular disease
10.1016/j.biopha.2023.114830 · 2023 · External reference
The molecular mechanisms of cuproptosis and its relevance to atherosclerosis
10.17305/bb.2024.11826 · 2025 · External reference
Enhancement of oral bioavailability of celastrol by chitosan microencapsulated porous starch carriers
10.1016/j.ijbiomac.2024.137167 · 2024 · External reference
Pyruvate metabolism enzyme DLAT promotes tumorigenesis by suppressing leucine catabolism
10.1016/j.cmet.2025.02.008 · 2025 · External reference
Ellagic acid activates the Keap1-Nrf2-ARE signaling pathway in improving Parkinson's disease: a review
10.1016/j.biopha.2022.113848 · 2022 · External reference
Comprehensive bioinformatics analysis to identify a novel cuproptosis-related prognostic signature and its ceRNA regulatory axis and candidate traditional Chinese medicine active ingredients in lung adenocarcinoma
2022 · External reference
Cuproptosis: biomarkers, mechanisms and treatments in diseases
10.3390/molecules31030394 · 2026 · External reference
Bioavailability of caffeic acid in rats and its absorption properties in the Caco-2 cell model
10.3109/13880209.2013.879906 · 2014 · External reference
First establishment of LC-MS/MS method for quantitative analysis of pharmacokinetics and tissue distribution of trilobatin-comparison of three administration modes
10.1002/bmc.70426 · 2026 · External reference
Targeting FDX1 by trilobatin to inhibit cuproptosis in doxorubicin-induced cardiotoxicity
10.1111/bph.17468 · 2025 · External reference
Mitochondrial ROS promotes susceptibility to infection via gasdermin D-mediated necroptosis
10.1016/j.cell.2022.06.038 · 2022 · External reference
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer
10.1096/fj.202300980r · 2023 · External reference
Improved oral bioavailability of artemisinin through inclusion complexation with beta- and gamma-cyclodextrins
10.1016/s0378-5173(01)00796-7 · 2001 · External reference
Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase
10.1073/pnas.040461197 · 2000 · External reference
Identification of cuproptosis-related genes in nonalcoholic fatty liver disease
10.1155/2023/9245667 · 2023 · External reference
Cuproptosis: mechanisms and links with cancers
10.1186/s12943-023-01732-y · 2023 · External reference
Cuproptosis in stroke: focusing on pathogenesis and treatment
10.3389/fnmol.2024.1349123 · 2024 · External reference
Targeting the TCA cycle through cuproptosis confers synthetic lethality on ARID1A-deficient hepatocellular carcinoma
2023 · External reference
Cuproptosis-related genes and agents: implications in tumor drug resistance and future perspectives
2025 · External reference
Nanoenabled intracellular metal ion homeostasis regulation for tumor therapy
2024 · External reference
Copper metabolism in cell death and autophagy
10.1080/15548627.2023.2200554 · 2023 · External reference
SRF/SLC31A1 signaling promotes cuproptosis induced by celastrol in NSCLC
10.1016/j.intimp.2025.114165 · 2025 · External reference
Necroptosis and tumor progression
10.1016/j.trecan.2021.09.003 · 2022 · External reference
A novel GSH depletor for simultaneous ferroptosis and cuproptosis Activation in hepatocellular carcinoma
10.1016/j.bcp.2025.117488 · 2026 · External reference
A mitochondrion–targeted natural polyphenolic copper carrier overcomes tumor resistance to cisplatin by potentiating cuproptosis
10.1186/s13046-026-03642-5 · 2026 · External reference
Copper ionophore complex ES-Cu synergizes with quercetin to target FDX1, promote cuproptosis, and reverse lenvatinib resistance in hepatocellular carcinoma cells
10.1016/j.jare.2025.08.066 · 2025 · External reference
Copper homeostasis and cuproptosis in atherosclerosis: metabolism, mechanisms and potential therapeutic strategies
10.1038/s41420-023-01796-1 · 2024 · External reference
Regulation of ferroptotic cancer cell death by GPX4
10.1016/j.cell.2013.12.010 · 2014 · External reference
Proteomics revealed the crosstalk between copper stress and cuproptosis, and explored the feasibility of curcumin as anticancer copper ionophore. Free Radic
2022 · External reference
The structural modification of natural products for novel drug discovery
10.1080/17460441.2016.1272757 · 2017 · External reference
Dextran-Catechin inhibits angiogenesis by disrupting copper homeostasis in endothelial cells
10.1038/s41598-017-07452-w · 2017 · External reference
DLAT activates EMT to promote HCC metastasis by regulating GLUT1-mediated aerobic glycolysis
10.1186/s10020-025-01125-5 · 2025 · External reference
Improving the stability and bioavailability of tea polyphenols by encapsulations: a review
10.1016/j.fshw.2021.12.011 · 2022 · External reference
Pyroptosis: mechanisms and diseases
10.1038/s41392-021-00507-5 · 2021 · External reference
Cuproptosis, the novel therapeutic mechanism for heart failure: a narrative review
10.21037/cdt-22-214 · 2022 · External reference
Targeting cuproptosis for cancer therapy: mechanistic insights and clinical perspectives
10.1186/s13045-024-01589-8 · 2024 · External reference
Oral bioavailability and gender-related pharmacokinetics of celastrol following administration of pure celastrol and its related tablets in rats
10.1016/j.jep.2012.09.005 · 2012 · External reference
Enhanced bioavailability after oral and pulmonary administration of baicalein nanocrystal
10.1016/j.ijpharm.2011.08.023 · 2011 · External reference
Copper chelation therapy attenuates periodontitis inflammation through the cuproptosis/autophagy/lysosome axis
2024 · External reference
Ellagic acid and intestinal microflora metabolite urolithin a: a review on its sources, metabolic distribution, health benefits, and biotransformation
10.1080/10408398.2022.2036693 · 2023 · External reference
Nanomedicine strategies for cuproptosis: metabolic reprogramming and tumor immunotherapy
10.1016/j.apsb.2025.07.007 · 2025 · External reference
Improved bioavailability and hepatoprotective activity of baicalein via a self-assembled solutol HS15 micelles system
10.2174/1567201820666230606163452 · 2024 · External reference
Necroptosis pathways in tumorigenesis
10.1016/j.semcancer.2022.07.007 · 2022 · External reference
Curcumin is a biologically active copper chelator with antitumor activity
10.1016/j.phymed.2015.11.005 · 2016 · External reference
Targeting ferroptosis and cuproptosis in gastrointestinal cancers: molecular mechanisms, metabolic vulnerabilities, and therapeutic interventions
10.1186/s43556-025-00347-7 · 2025 · External reference
Copper/iron bimetal phenolic networks boosted apoptosis/ferroptosis/cuproptosis combined tumor therapy through dual glutathione depletion
10.1016/j.cej.2024.157408 · 2024 · External reference
Cuproptosis and cuproptosis-related genes in rheumatoid arthritis: implication, prospects, and perspectives
2022 · External reference
Tongmai Yangxin Pill ameliorates doxorubicin-induced cardiotoxicity through m6A/ALKBH5/BNIP3 axis
10.1016/j.jep.2026.121213 · 2026 · External reference
Astragaloside IV represses the immune evasion and acidic microenvironment of oral squamous cell carcinoma
10.1186/s11658-026-00869-0 · 2026 · External reference
Complanatoside a disrupts copper homeostasis and induces cuproptosis via directly targeting ATOX1 in prostate cancer
10.1016/j.taap.2025.117257 · 2025 · External reference
Identification of tanshinone I as a natural Cu(II) ionophore
10.1016/j.freeradbiomed.2024.11.049 · 2025 · External reference
Targeting PTBP3-mediated alternative splicing of COX11 induces cuproptosis for inhibiting gastric cancer peritoneal metastasis
2025 · External reference
Oral absorption and bioavailability of tea catechins
10.1055/s-2000-8599 · 2000 · External reference
COX17 restricts renal fibrosis development by maintaining mitochondrial copper homeostasis and restoring complex IV activity
10.1038/s41401-023-01098-3 · 2023 · External reference
The role of copper in tau-related pathology in alzheimer’s disease
2020 · External reference
Elesclomol rescues mitochondrial copper deficiency in disease models without triggering cuproptosis
10.1016/j.jpet.2024.100048 · 2025 · External reference
