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References from Environmental enrichment differentially suppresses anxiety-related behaviors, reduces passive avoidance learning, and upregulates hippocampal brain-derived neurotrophic factor expression in high- and low-avoidance Hatano rats. Local targets link to admitted publications; unresolved targets remain external evidence.
Anxiety disorders
10.1016/s0140-6736(21)00359-7 · 2021 · External reference
Epigenetics, development, and psychopathology
10.1146/annurev-clinpsy-050718-095530 · 2020 · External reference
How environmental enrichment balances out neuroinflammation in chronic pain and comorbid depression and anxiety disorders
10.1111/bph.15584 · 2022 · External reference
Environmental enrichment improves cognitive function, learning, memory and anxiety-related behaviours in rodent models of dementia: Implications for future study
10.1016/j.nlm.2023.107880 · 2024 · External reference
Environmental enrichment and physical exercise prevent stress-induced social avoidance and blood-brain barrier alterations via Fgf2
10.1038/s41467-025-68058-9 · 2026 · External reference
Enriched environment restores depressive- and anxiety-like behaviors in mice with early life stress exposure by reversing striatal function, structure and metabolism
10.1016/j.pnpbp.2025.111562 · 2025 · External reference
Hormetic pathways in environmental enrichment in animal models and humans
10.1016/bs.pbr.2025.05.007 · 2025 · External reference
A scoping review of preclinical environmental enrichment protocols in models of poststroke to set the foundations for translating the paradigm to clinical settings
10.1007/s12975-025-01335-3 · 2025 · External reference
Behavioral characteristics of rats selectively bred for high and low avoidance shuttlebox response
10.1111/j.1741-4520.1995.tb00614.x · 1995 · External reference
Alterations between high and low-avoidance lines of Hatano rats in learning behaviors, ultrasonic vocalizations, and histological characteristics in hippocampus and amygdala
10.1016/j.physbeh.2021.113670 · 2022 · External reference
Male Hatano high-avoidance rats show high avoidance and high anxiety-like behaviors as compared with male low-avoidance rats
10.1538/expanim.61.517 · 2012 · External reference
Maternal traits during lactation period reduce the anxiety-related behavior in male offspring: Results from a fostering study in Hatano rats
10.1016/j.physbeh.2020.113209 · 2021 · External reference
Possible effects of voluntary exercise intensity on anxiety-like behavior and its underlying molecular mechanisms in the hippocampus: Results from a study in Hatano rats
10.1016/j.bbr.2022.113854 · 2022 · External reference
BDNF signaling in context: From synaptic regulation to psychiatric disorders
10.1016/j.cell.2021.12.003 · 2022 · External reference
Environmental enrichment enhances autophagy signaling in the rat hippocampus
10.1016/j.brainres.2014.10.026 · 2014 · External reference
The ARRIVE guidelines 2.0: Updated guidelines for reporting animal research
2020 · External reference
Candidate anxiety-related genes in the hippocampus of Hatano male rats: Anxiolytic action of neuromedin U in the hippocampus
10.1002/npr2.70018 · 2025 · External reference
Bidirectional effects of voluntary exercise on the expression of Bdnf isoforms in the hippocampus of Hatano rat strains displaying different activity levels
10.1002/npr2.12313 · 2023 · External reference
A comparative study of puberty, and plasma gonadotropin and testicular hormone levels in two inbred strains of Hatano rats
10.1262/jrd.48.111 · 2002 · External reference
Effect of chronic handling and social isolation on emotion and cognition in adolescent rats
10.1016/j.physbeh.2021.113440 · 2021 · External reference
How stress hormones shape memories of fear and anxiety in humans
10.1016/j.neubiorev.2022.104901 · 2022 · External reference
Sex differences in the affective-cognitive dimension of neuropathic pain: Insights from the spared nerve injury rat model
10.1016/j.jpain.2024.104752 · 2025 · External reference
Environmental enrichment: dissociated effects between physical activity and changing environmental complexity on anxiety and neurogenesis in adult male Balb/C mice
10.1016/j.physbeh.2022.113878 · 2022 · External reference
Voluntary wheel-running exercise improvement of anxiety or depressive symptoms in different models of depression
10.3389/fnbeh.2024.1435891 · 2024 · External reference
Differential effects of wheel running and treadmill exercise on spatial memory, adult hippocampal neurogenesis and the cerebrospinal fluid proteome in rats
10.1016/j.neuropharm.2026.110956 · 2026 · External reference
Comparison of hair steroid levels among Wistar rats exposed to different environmental enrichment settings
10.14202/vetworld.2024.2731-2735 · 2024 · External reference
Effects of acrylic tunnel enrichment on anxiety-like behavior, neurogenesis, and physiology of C57BL/6J mice
10.30802/aalas-jaalas-19-000159 · 2021 · External reference
Effects of colored enrichment devices on circadian metabolism and physiology in male Sprague-Dawley rats
2016 · External reference
Environmental enrichment prevents depression-like behaviours induced by immune system activation in male mice
10.1016/j.neulet.2025.138450 · 2026 · External reference
Flavonoid fisetin promotes ERK-dependent long-term potentiation and enhances memory
10.1073/pnas.0607822103 · 2006 · External reference
Hydrogen sulfide and polysulfides induce GABA/glutamate/d-serine release, facilitate hippocampal LTP, and regulate behavioral hyperactivity
10.1038/s41598-023-44877-y · 2023 · External reference
LTP saturation and spatial learning disruption: effects of task variables and saturation levels
10.1523/jneurosci.14-10-05793.1994 · 1994 · External reference
Adult neurogenesis conserves hippocampal memory capacity
10.1523/jneurosci.2976-17.2018 · 2018 · External reference
Enrichment-induced forgetting is associated with white matter microstructure in mice
10.1016/j.bbr.2025.115878 · 2026 · External reference
Hippocampal neurogenesis regulates forgetting during adulthood and infancy
10.1126/science.1248903 · 2014 · External reference
More hippocampal neurons in adult mice living in an enriched environment
10.1038/386493a0 · 1997 · External reference
Influence of differential housing on emotional behaviour and neurotrophin levels in mice
10.1016/j.bbr.2005.11.024 · 2006 · External reference
Post-weaning environmental enrichment, but not chronic maternal isolation, enhanced ethanol intake during periadolescence and early adulthood
10.3389/fnbeh.2016.00195 · 2016 · External reference
Effects of environmental enrichment upon ethanol-induced conditioned place preference and pre-frontal BDNF levels in adolescent and adult mice
10.1038/s41598-017-08795-0 · 2017 · External reference
A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF
10.1016/s0896-6273(01)00561-x · 2002 · External reference
Short-term running exercise alters DNA methylation patterns in neuronal nitric oxide synthase and brain-derived neurotrophic factor genes in the mouse hippocampus and reduces anxiety-like behaviors
10.1096/fj.202100630r · 2021 · External reference
Environmental enrichment in female rodents: Considerations in the effects on behavior and biochemical markers
10.1016/j.bbr.2013.07.018 · 2013 · External reference
Environmental enrichment reduces food seeking and taking in rats: A review
10.1016/j.pbb.2020.172874 · 2020 · External reference
Environmental eustress modulates β-ARs/CCL2 axis to induce anti-tumor immunity and sensitize immunotherapy against liver cancer in mice
10.1038/s41467-021-25967-9 · 2021 · External reference
The immunological perspective of major depressive disorder: unveiling the interactions between central and peripheral immune mechanisms
10.1186/s12974-024-03312-3 · 2025 · External reference
Hatano rats are a suitable metabolic syndrome model for studying feeding behavior, blood pressure levels, and percent body fat
10.1292/jvms.18-0342 · 2019 · External reference
Male Hatano low-avoidance rats show more active sexual behavior with lower plasma testosterone than high-avoidance rats
10.1292/jvms.17-0668 · 2018 · External reference