Research graph
References from Brain and cognitive correlates of FKBP5: methylation patterns in schizophrenia. Local targets link to admitted publications; unresolved targets remain external evidence.
Role of environmental confounding in the association between FKBP5 and first-episode psychosis
10.3389/fpsyt.2014.00084 · 2014 · External reference
Epigenetic mechanisms in schizophrenia
2014 · External reference
Unresolved reference
2000 · External reference
DNA-methylation gene network dysregulation in peripheral blood lymphocytes of schizophrenia patients
10.1016/j.schres.2013.07.030 · 2013 · External reference
Architecture of cognitive flexibility revealed by lesion mapping
10.1016/j.neuroimage.2013.05.087 · 2013 · External reference
Genome-wide mediation analysis of psychiatric and cognitive traits through imaging phenotypes
10.1002/hbm.23650 · 2017 · External reference
DNA methylation patterns and epigenetic memory
10.1101/gad.947102 · 2002 · External reference
Genetic insights into the neurodevelopmental origins of schizophrenia
10.1038/nrn.2017.125 · 2017 · External reference
No support for historical candidate gene or candidate gene-by-interaction hypotheses for major depression across multiple large samples
10.1176/appi.ajp.2018.18070881 · 2019 · External reference
Genome-wide DNA methylation comparison between live human brain and peripheral tissues within individuals
10.1038/s41398-019-0376-y · 2019 · External reference
Evidence-based umbrella review of 162 peripheral biomarkers for major mental disorders
10.1038/s41398-020-0835-5 · 2020 · External reference
Independent methylome-wide association studies of schizophrenia detect consistent case-control differences
2020 · External reference
DNA methylation and protein markers of chronic inflammation and their associations with brain and cognitive aging
10.1212/wnl.0000000000012997 · 2021 · External reference
DNA methylation of BDNF gene in schizophrenia
10.12659/msm.895896 · 2016 · External reference
Schizophrenia in the Spectrum of gene-stress interactions: the FKBP5 example
10.1093/schbul/sbu189 · 2015 · External reference
Functional annotation of the human brain methylome identifies tissue-specific epigenetic variation across brain and blood
10.1186/gb-2012-13-6-r43 · 2012 · External reference
Progressive striatal and hippocampal volume loss in initially antipsychotic-naive, first-episode schizophrenia patients treated with quetiapine: relationship to dose and symptoms
10.1017/s1461145710000817 · 2011 · External reference
Lower cortical FKBP5 DNA methylation at key enhancer sites is associated with older age and higher gene expression in schizophrenia
2025 · External reference
The global assessment scale. A procedure for measuring overall severity of psychiatric disturbance
10.1001/archpsyc.1976.01770060086012 · 1976 · External reference
Unresolved reference
External reference
Alterations in DNA methylation of Fkbp5 as a determinant of blood-brain correlation of glucocorticoid exposure
10.1016/j.psyneuen.2014.03.003 · 2014 · External reference
FKBP5 genotype and structural integrity of the posterior cingulum
10.1038/npp.2013.322 · 2014 · External reference
Evaluating historical candidate genes for schizophrenia
10.1038/mp.2015.16 · 2015 · External reference
Neuronal and brain morphological changes in animal models of schizophrenia
10.1016/j.bbr.2015.12.034 · 2016 · External reference
Association of Epigenetic Differences Screened in a few cases of monozygotic twins discordant for attention-deficit hyperactivity disorder with brain structures
10.3389/fnins.2021.799761 · 2022 · External reference
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder
10.1126/science.aat8127 · 2018 · External reference
Validation of the word accentuation test (TAP) as a means of estimating premorbid IQ in Spanish speakers
10.1016/j.schres.2010.11.016 · 2011 · External reference
The role of the right inferior frontal gyrus: inhibition and attentional control
10.1016/j.neuroimage.2009.12.109 · 2010 · External reference
Influence of FKBP5 polymorphism and DNA methylation on structural changes of the brain in major depressive disorder
2017 · External reference
Interindividual methylomic variation across blood, cortex, and cerebellum: implications for epigenetic studies of neurological and neuropsychiatric phenotypes
10.1080/15592294.2015.1100786 · 2015 · External reference
An integrated genetic-epigenetic analysis of schizophrenia: evidence for co-localization of genetic associations and differential DNA methylation
10.1186/s13059-016-1041-x · 2016 · External reference
Structural abnormalities in gyri of the prefrontal cortex in individuals with schizophrenia and their unaffected siblings
10.1192/bjp.bp.109.067314 · 2010 · External reference
Early life stress, FK506 binding protein 5 gene (FKBP5) methylation, and inhibition-related prefrontal function: a prospective longitudinal study
10.1017/s095457941700147x · 2017 · External reference
GxE effects of FKBP5 and traumatic life events on PTSD: a meta-analysis
10.1016/j.jad.2018.09.058 · 2019 · External reference
Gene expression meta-analysis of cerebellum samples supports the FKBP5 gene-environment interaction model for schizophrenia
10.3390/life11030190 · 2021 · External reference
FKBP5 genotype-dependent DNA methylation and mRNA regulation after psychosocial stress in remitted depression and healthy controls
10.1093/ijnp/pyu087 · 2015 · External reference
Role of FKBP5 in emotion processing: results on amygdala activity, connectivity and volume
10.1007/s00429-014-0729-5 · 2015 · External reference
DNA methylation-based biomarkers and the epigenetic clock theory of ageing
10.1038/s41576-018-0004-3 · 2018 · External reference
The synaptic hypothesis of schizophrenia version III: a master mechanism
10.1038/s41380-023-02043-w · 2023 · External reference
DNA methylation of the BDNF gene and its relevance to psychiatric disorders
10.1038/jhg.2013.65 · 2013 · External reference
CpG islands—‘a rough guide’
10.1016/j.febslet.2009.04.012 · 2009 · External reference
Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex
10.1038/nn.4181 · 2016 · External reference
Epigenetic alterations following early postnatal stress: a review on novel aetiological mechanisms of common psychiatric disorders
10.1186/s13148-015-0156-3 · 2015 · External reference
Co-methylation networks associated with cognition and structural brain development during adolescence
10.3389/fgene.2024.1451150 · 2025 · External reference
Brain tissue matters in the study of FKBP5 gene expression activities in schizophrenia–a meta-analysis
2017 · External reference
Regional brain atrophy and functional disconnection in Broca's area in individuals at ultra-high risk for psychosis and schizophrenia
10.1371/journal.pone.0051975 · 2012 · External reference
Schizophrenia
10.1038/nrdp.2015.67 · 2015 · External reference
Allele-specific DNA methylation level of FKBP5 is associated with post-traumatic stress disorder
10.1016/j.psyneuen.2018.12.226 · 2019 · External reference
Structural and functional brain abnormalities in schizophrenia
10.1177/0963721410377601 · 2010 · External reference
The positive and negative syndrome scale (PANSS) for schizophrenia
10.1093/schbul/13.2.261 · 1987 · External reference
Schizophrenia is associated with altered DNA methylation variance
10.1038/s41380-024-02749-5 · 2025 · External reference
Allele-specific epigenetic modification: a molecular mechanism for gene-environment interactions in stress-related psychiatric disorders?
10.2217/epi.13.11 · 2013 · External reference
Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions
10.1038/nn.3275 · 2013 · External reference
Methylation of the FKBP5 gene in association with FKBP5 genotypes, childhood maltreatment and depression
10.1038/s41386-019-0319-6 · 2019 · External reference
Multimodal associations of FKBP5 methylation with emotion-regulatory brain circuits
10.1016/j.biopsych.2024.03.003 · 2024 · External reference
The role of epigenetics for understanding mental health difficulties and its implications for psychotherapy research
10.1111/papt.12227 · 2019 · External reference
The interactive effect of genetic and epigenetic variations in FKBP5 and ApoE genes on anxiety and brain EEG parameters
10.3390/genes13020164 · 2022 · External reference
Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems
10.1186/1471-2105-12-253 · 2011 · External reference
DNA methylation in mammals
10.1101/cshperspect.a019133 · 2014 · External reference
Combining fMRI and SNP data to investigate connections between brain function and genetics using parallel ICA
10.1002/hbm.20508 · 2009 · External reference
The SFT2D2 gene is associated with the autoimmune pathology of schizophrenia in a Chinese population
10.3389/fneur.2022.1037777 · 2022 · External reference
Methylation across the central dogma in health and diseases: new therapeutic strategies
10.1038/s41392-023-01528-y · 2023 · External reference
FKBP5/FKBP51-mediated signaling pathways in neuropsychiatric diseases: insights for biomarker development and targeted therapies
10.1016/j.ynstr.2025.100762 · 2025 · External reference
DNA methylation and schizophrenia: current literature and future perspective
10.3390/cells10112890 · 2021 · External reference
Role of FKBP5 and its genetic mutations in stress-induced psychiatric disorders: an opportunity for drug discovery
10.3389/fpsyt.2023.1182345 · 2023 · External reference
Exploring the role of neuroplasticity in development, aging, and neurodegeneration
10.3390/brainsci13121610 · 2023 · External reference
Blood-based epigenome-wide analyses of cognitive abilities
10.1186/s13059-021-02596-5 · 2022 · External reference
Cognitive impairment in schizophrenia: aetiology, pathophysiology, and treatment
10.1038/s41380-023-01949-9 · 2023 · External reference
Regulatory functions of FKBP5 intronic regions associated with psychiatric disorders
10.1016/j.jpsychires.2021.08.014 · 2021 · External reference
The emerging role of the FKBP5 gene polymorphisms in vulnerability–stress model of schizophrenia: further evidence from a Serbian population
10.1007/s00406-016-0720-7 · 2017 · External reference
The FKBP5 genotype and childhood trauma effects on FKBP5 DNA methylation in patients with psychosis, their unaffected siblings, and healthy controls
10.1016/j.psyneuen.2021.105205 · 2021 · External reference
Methods and considerations for longitudinal structural brain imaging analysis across development
10.1016/j.dcn.2014.04.004 · 2014 · External reference
Interactions between variation in candidate genes and environmental factors in the etiology of schizophrenia and bipolar disorder: a systematic review
10.1007/s12035-017-0708-y · 2018 · External reference
Adverse childhood experiences and methylation of the FKBP5 gene in patients with psychotic disorders
10.3390/jcm9123792 · 2020 · External reference
Hypothalamic-pituitary-adrenal system, neurotrophic factors and clozapine response: association with FKBP5 and NTRK2 genes
10.1097/fpc.0000000000000132 · 2015 · External reference
DNA methylation and its basic function
10.1038/npp.2012.112 · 2013 · External reference
Unresolved reference
1991 · External reference
Tumor classification by partial least squares using microarray gene expression data
10.1093/bioinformatics/18.1.39 · 2002 · External reference
DNA methylation at stress-related genes is associated with exposure to early life institutionalization
10.1002/ajpa.23010 · 2016 · External reference
Schizophrenia
10.1016/s0140-6736(15)01121-6 · 2016 · External reference
Distinct genetic influences on cortical surface area and cortical thickness
10.1093/cercor/bhp026 · 2009 · External reference
Prediction of clinical outcome with microarray data: a partial least squares discriminant analysis (PLS-DA) approach
2003 · External reference
Methylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia
10.1186/s13059-014-0483-2 · 2014 · External reference
Childhood trauma in schizophrenia: current findings and research perspectives
10.3389/fnins.2019.00274 · 2019 · External reference
The effects of early life stress on the epigenome: from the womb to adulthood and even before
10.1016/j.expneurol.2014.09.001 · 2015 · External reference
PLINK: a tool set for whole-genome association and population-based linkage analyses
10.1086/519795 · 2007 · External reference
The role of BDNF methylation and Val66Met in amygdala reactivity during emotion processing
10.1002/hbm.24825 · 2019 · External reference
The epigenome in neurodevelopmental disorders
10.3389/fnins.2021.776809 · 2021 · External reference
Hpa axis related genes and response to psychological therapies: genetics and epigenetics
10.1002/da.22430 · 2015 · External reference
DNA methylation of FKBP5 and response to exposure-based psychological therapy
10.1002/ajmg.b.32650 · 2019 · External reference
Effect of interaction between a specific subtype of child abuse and the FKBP5 rs1360780 SNP on DNA methylation among patients with bipolar disorder
10.1016/j.jad.2020.03.120 · 2020 · External reference
10.1017/s0007114511003576
10.1017/s0007114511003576 · External reference
The impact of environmental factors in severe psychiatric disorders
10.3389/fnins.2014.00019 · 2014 · External reference
Dysregulation of glucocorticoid receptor co-factors FKBP5, BAG1 and PTGES3 in prefrontal cortex in psychotic illness
10.1038/srep03539 · 2013 · External reference
DNA extracted from saliva for methylation studies of psychiatric traits: evidence tissue specificity and relatedness to brain
10.1002/ajmg.b.32278 · 2015 · External reference
Neuroanatomy, Broca Area
2025 · External reference
The impact of the FKBP5 gene polymorphisms on the relationship between traumatic life events and psychotic-like experiences in non-clinical adults
10.3390/brainsci11050561 · 2021 · External reference
Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies
10.1001/archpsyc.60.12.1187 · 2003 · External reference
The early life environment and the epigenome
10.1016/j.bbagen.2009.01.009 · 2009 · External reference
The effects of childhood maltreatment on brain structure, function and connectivity
10.1038/nrn.2016.111 · 2016 · External reference
Methylation risk scores are associated with a collection of phenotypes within electronic health record systems
10.1038/s41525-022-00320-1 · 2022 · External reference
Mediation: R package for causal mediation analysis
10.18637/jss.v059.i05 · 2014 · External reference
Dynamic DNA methylation in the brain: A new epigenetic mark for experience-dependent plasticity
10.3389/fncel.2015.00331 · 2015 · External reference
Epigenetic changes of FKBP5 as a link connecting genetic and environmental risk factors with structural and functional brain changes in major depression
10.1038/npp.2017.290 · 2018 · External reference
Neurodevelopmental disorders and environmental toxicants: epigenetics as an underlying mechanism
10.1155/2017/7526592 · 2017 · External reference
Cognitive deficits in schizophrenia: understanding the biological correlates and remediation strategies
10.9758/cpn.2018.16.1.7 · 2018 · External reference
Mapping genomic loci implicates genes and synaptic biology in schizophrenia
10.1038/s41586-022-04434-5 · 2022 · External reference
Effects of the social environment and stress on glucocorticoid receptor gene methylation: a systematic review
10.1016/j.biopsych.2014.11.022 · 2016 · External reference
Childhood maltreatment and methylation of FKBP5
10.1017/s0954579415000991 · 2015 · External reference
Stress-related methylation of the catechol-O-methyltransferase Val158 allele predicts human prefrontal cognition and activity
10.1523/jneurosci.6631-10.2011 · 2011 · External reference
BDNF rs6265 methylation and genotype interact on risk for schizophrenia
10.1080/15592294.2015.1117736 · 2016 · External reference
Cortical brain abnormalities in 4474 individuals with schizophrenia and 5098 control subjects via the enhancing neuro imaging genetics through Meta analysis (ENIGMA) consortium
10.1016/j.biopsych.2018.04.023 · 2018 · External reference
Oligodendrocyte genes, white matter tract integrity, and cognition in schizophrenia
10.1093/cercor/bhs188 · 2013 · External reference
Effects of antipsychotic medication on brain structure in patients with major depressive disorder and psychotic features: neuroimaging findings in the context of a randomized placebo-controlled clinical trial
10.1001/jamapsychiatry.2020.0036 · 2020 · External reference
Correspondence of DNA methylation between blood and brain tissue and its application to schizophrenia research
10.1093/schbul/sbv074 · 2016 · External reference
Positive symptoms associate with cortical thinning in the superior temporal gyrus via the ENIGMA Schizophrenia consortium
10.1111/acps.12718 · 2017 · External reference
Prefrontal cortical thinning links to negative symptoms in schizophrenia via the ENIGMA consortium
10.1017/s0033291717001283 · 2018 · External reference
The impact of early life stress on the genetic influence on brain and cognitive development in children
2021 · External reference
Early life stress modulates the genetic influence on brain structure and cognitive function in children
2024 · External reference
Wechsler adult intelligence scale—
1997 · External reference
DNA methylation and brain structure and function across the life course: a systematic review
10.1016/j.neubiorev.2020.03.007 · 2020 · External reference
A pilot investigation of genetic and epigenetic variation of FKBP5 and response to exercise intervention in African women with obesity
10.1038/s41598-022-15678-6 · 2022 · External reference
Abnormal cortical folding patterns within Broca's area in schizophrenia: evidence from structural MRI
10.1016/j.schres.2007.03.031 · 2007 · External reference
Specificity and continuity of schizophrenia and bipolar disorder: relation to biomarkers
10.2174/1381612825666191216153508 · 2020 · External reference
Cortical thinning and flattening in schizophrenia and their unaffected parents
10.2147/ndt.s195134 · 2019 · External reference
Genetic and environmental influences on cortical thickness among 14-year-old twins
10.1097/wnr.0b013e328355a62a · 2012 · External reference
Epigenetic biomarkers as predictors and correlates of symptom improvement following psychotherapy in combat veterans with PTSD
2013 · External reference
Holocaust exposure induced intergenerational effects on FKBP5 methylation
10.1016/j.biopsych.2015.08.005 · 2016 · External reference
BA11 FKBP5 expression levels correlate with dendritic spine density in postmortem PTSD and controls
10.1016/j.ynstr.2015.07.002 · 2015 · External reference
A novel schizophrenia diagnostic model based on statistically significant changes in gene methylation in specific brain regions
10.1155/2020/8047146 · 2020 · External reference