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References from Circulating predictive biomarkers in preeclampsia. Local targets link to admitted publications; unresolved targets remain external evidence.
Pre-eclampsia and the hypertensive disorders of pregnancy
10.1093/bmb/ldg005 · 2003 · External reference
ACOG practice bulletin. Diagnosis and management of preeclampsia and eclampsia. Number 33, January 2002
2002 · External reference
Preeclampsia: an excessive maternal inflammatory response to pregnancy
10.1016/s0002-9378(99)70239-5 · 1999 · External reference
Latest advances in understanding preeclampsia
10.1126/science.1111726 · 2005 · External reference
Preeclampsia – more than pregnancy-induced hypertension
10.1016/0140-6736(93)90889-o · 1993 · External reference
Rheological and physiological consequences of conversion of the maternal spiral arteries for uteroplacental blood flow during human pregnancy
10.1016/j.placenta.2009.02.009 · 2009 · External reference
Unresolved reference
External reference
Risk factors for pre-eclampsia at antenatal booking: systematic review of controlled studies
10.1136/bmj.38380.674340.e0 · 2005 · External reference
Are tests for predicting pre-eclampsia good enough to make screening viable? A review of reviews and critical appraisal
10.1080/00016340903008953 · 2009 · External reference
Unresolved reference
1991 · External reference
Pregnancy-associated plasma protein-A (PAPP-A) cleaves insulin-like growth factor binding protein (IGFBP)-5 independent of IGF: implications for the mechanism of IGFBP-4 proteolysis by PAPP-A
10.1016/s0014-5793(01)02760-0 · 2001 · External reference
Identification and regulation of the IGFBP-4 protease and its physiological inhibitor in human trophoblasts and endometrial stroma: evidence for paracrine regulation of IGF-II bioavailability in the placental bed during human implantation
10.1210/jcem.87.5.8448 · 2002 · External reference
Plasma concentrations of four pregnancy proteins in complications of pregnancy
10.1016/0002-9378(77)90725-6 · 1977 · External reference
Concentration of pregnancy-associated plasma protein A (PAPP-A) in patients with pre-eclamptic toxaemia
1981 · External reference
Assay of a placental protein to determine fetal risk
10.1136/bmj.280.6215.671 · 1980 · External reference
Women with preeclampsia have increased serum levels of pregnancy-associated plasma protein A (PAPP-A), inhibin A, activin A and soluble E-selectin
10.1081/prg-120016794 · 2003 · External reference
Decreased first trimester PAPP-A is a predictor of adverse pregnancy outcome
10.1002/pd.407 · 2002 · External reference
First trimester maternal serum free beta human chorionic gonadotrophin and pregnancy associated plasma protein A as predictors of pregnancy complications
10.1111/j.1471-0528.2000.tb11618.x · 2000 · External reference
Early pregnancy levels of pregnancy-associated plasma protein A and the risk of intrauterine growth restriction, premature birth, preeclampsia, and stillbirth
10.1210/jcem.87.4.8430 · 2002 · External reference
Second- and third-trimester serum levels of placental proteins in preeclampsia and small-for-gestational age pregnancies
10.1111/j.1600-0412.2004.00277.x · 2004 · External reference
Prediction of pregnancy complications by first-trimester maternal serum PAPP-A and free beta-hCG and with second-trimester uterine artery Doppler
10.1002/pd.1251 · 2005 · External reference
Low levels of maternal serum PAPP-A in the first trimester and the risk of pre-eclampsia
10.1002/pd.1890 · 2008 · External reference
First-trimester maternal serum PAPP-A and free-beta subunit human chorionic gonadotropin concentrations and nuchal translucency are associated with obstetric complications: a population-based screening study (the FASTER Trial)
10.1016/j.ajog.2004.06.052 · 2004 · External reference
Screening for pre-eclampsia and fetal growth restriction by uterine artery Doppler and PAPP-A at 11–14 weeks’ gestation
10.1002/uog.3881 · 2007 · External reference
First-trimester maternal serum pregnancy-associated plasma protein-A and pre-eclampsia
10.1002/uog.6280 · 2009 · External reference
First-trimester maternal serum PP-13, PAPP-A and second-trimester uterine artery Doppler pulsatility index as markers of pre-eclampsia
10.1002/uog.3876 · 2007 · External reference
First-trimester prediction of hypertensive disorders in pregnancy
10.1161/hypertensionaha.108.127977 · 2009 · External reference
Low levels of maternal serum PAPP-A in early pregnancy and the risk of adverse outcomes
10.1002/pd.2116 · 2008 · External reference
First trimester serum PAPP-A and NGAL in the prediction of late-onset pre-eclampsia
10.1002/pd.2339 · 2009 · External reference
Association between birth weight and first-trimester free beta-human chorionic gonadotropin and pregnancy-associated plasma protein A
10.1016/j.fertnstert.2007.02.024 · 2008 · External reference
Inhibin and activin modulate the release of gonadotropin-releasing hormone, human chorionic gonadotropin, and progesterone from cultured human placental cells
10.1073/pnas.86.13.5114 · 1989 · External reference
Endocrine control of inhibin biosynthesis by human placenta
1985 · External reference
Serum markers for predicting pre-eclampsia
10.1016/j.mam.2007.04.002 · 2007 · External reference
Induced expression of the new cytokine, activin A, in human monocytes: inhibition by glucocorticoids and retinoic acid
10.1046/j.1365-2567.1996.d01-675.x · 1996 · External reference
Activin A and inhibin A as possible endocrine markers for pre-eclampsia
10.1016/s0140-6736(96)09264-1 · 1997 · External reference
Hypertension in pregnancy: changes in activin A maternal serum concentration
10.1016/0143-4004(95)90102-7 · 1995 · External reference
Inhibin-A and pro-alpha C are elevated in preeclamptic pregnancy and correlate with human chorionic gonadotropin
10.1111/j.1600-0897.1998.tb00386.x · 1998 · External reference
Comparison of activin A and cell-free fetal DNA levels in maternal plasma from patients at high risk for preeclampsia
10.1002/pd.1606 · 2006 · External reference
Maternal circulating levels of activin A, inhibin A, sFlt-1 and endoglin at parturition in normal pregnancy and pre-eclampsia
10.1371/journal.pone.0004453 · 2009 · External reference
Adhesion molecules, activin and inhibin—candidates for the biochemical prediction of hypertensive diseases in pregnancy?
10.1007/s00404-003-0514-9 · 2004 · External reference
Comparison of maternal serum total activin A and inhibin A in normal, preeclamptic, and nonproteinuric gestationally hypertensive pregnancies
10.1016/s0002-9378(99)70606-x · 1999 · External reference
Placental production and maternal serum and urine levels of inhibin A and activin A are modified by antihypertensive therapy in hypertensive disorders of pregnancy
10.1111/j.1365-2265.2008.03426.x · 2009 · External reference
Maternal serum inhibin A can predict pre-eclampsia
10.1111/j.1471-0528.1998.tb09943.x · 1998 · External reference
Second-trimester maternal serum inhibin A concentration as an early marker for preeclampsia
10.1016/s0002-9378(99)70448-5 · 1999 · External reference
Severe preeclampsia is associated with high inhibin A levels and normal leptin levels at 7–13weeks into pregnancy
10.1016/s0002-9378(03)00902-5 · 2003 · External reference
First trimester inhibin-A concentrations and later development of preeclampsia
2004 · External reference
Serum inhibin A and activin A are elevated prior to the onset of pre-eclampsia
10.1093/humrep/15.7.1640 · 2000 · External reference
Serum inhibin A and angiogenic factor levels in pregnancies with previous preeclampsia and/or chronic hypertension: are they useful markers for prediction of subsequent preeclampsia?
10.1016/j.ajog.2008.06.071 · 2008 · External reference
Prediction of pre-eclampsia by uterine artery Doppler ultrasonography and maternal serum pregnancy-associated plasma protein-A, free beta-human chorionic gonadotropin, activin A and inhibin A at 22+0 to 24+6 weeks’ gestation
10.1002/uog.2676 · 2006 · External reference
First trimester markers for pre-eclampsia: placental vs. non-placental protein serum levels
10.1159/000094672 · 2007 · External reference
Maternal serum activin, inhibin, human chorionic gonadotrophin and alpha-fetoprotein as second trimester predictors of pre-eclampsia
2003 · External reference
Is mid-trimester maternal serum inhibin-A a marker of preeclampsia or intrauterine growth restriction?
10.1034/j.1600-0412.2002.810611.x · 2002 · External reference
Functional analyses of placental protein 13/galectin-13
10.1111/j.1432-1033.2004.04004.x · 2004 · External reference
Placental protein 13 (PP-13): effects on cultured trophoblasts, and its detection in human body fluids in normal and pathological pregnancies
10.1016/j.placenta.2003.12.009 · 2004 · External reference
Placental protein 13 (galectin-13) has decreased placental expression but increased shedding and maternal serum concentrations in patients presenting with preterm pre-eclampsia and HELLP syndrome
10.1007/s00428-008-0658-x · 2008 · External reference
A novel approach to first-trimester screening for early pre-eclampsia combining serum PP-13 and Doppler ultrasound
10.1002/uog.2686 · 2006 · External reference
First-trimester placental protein 13 screening for preeclampsia and intrauterine growth restriction
10.1016/j.ajog.2007.02.025 · 2007 · External reference
Longitudinal determination of serum placental protein 13 during development of preeclampsia
10.1159/000151344 · 2008 · External reference
First-trimester maternal serum PP13 in the risk assessment for preeclampsia
10.1016/j.ajog.2008.01.013 · 2008 · External reference
Placental protein 13 as an early marker for pre-eclampsia: a prospective longitudinal study
10.1111/j.1471-0528.2008.01902.x · 2008 · External reference
First trimester maternal serum placental protein 13 for the prediction of pre-eclampsia in women with a priori high risk
10.1002/pd.2287 · 2009 · External reference
Second-trimester uterine artery Doppler pulsatility index and maternal serum PP13 as markers of pre-eclampsia
10.1002/pd.1664 · 2007 · External reference
Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia
10.1172/jci17189 · 2003 · External reference
Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria
10.1074/jbc.c300012200 · 2003 · External reference
Soluble endoglin contributes to the pathogenesis of preeclampsia
10.1038/nm1429 · 2006 · External reference
Soluble endoglin and other circulating antiangiogenic factors in preeclampsia
10.1056/nejmoa055352 · 2006 · External reference
Preeclampsia is associated with reduced serum levels of placenta growth factor
10.1016/s0002-9378(98)70021-3 · 1998 · External reference
Selective deficit of angiogenic growth factors characterises pregnancies complicated by pre-eclampsia
10.1111/j.1471-0528.1999.tb08107.x · 1999 · External reference
Reductions of vascular endothelial growth factor and placental growth factor concentrations in severe preeclampsia
10.1067/mob.2000.108022 · 2000 · External reference
Circulating angiogenic factors and the risk of preeclampsia
10.1056/nejmoa031884 · 2004 · External reference
Circulating concentrations of sFlt1 (soluble fms-like tyrosine kinase 1) in fetal and maternal serum during pre-eclampsia
10.1016/j.ejogrb.2004.11.015 · 2005 · External reference
Soluble fms-like tyrosine kinase 1 is increased in preeclampsia but not in normotensive pregnancies with small-for-gestational-age neonates: relationship to circulating placental growth factor
10.1210/jc.2004-1955 · 2005 · External reference
Evaluation of placenta growth factor and soluble Fms-like tyrosine kinase 1 receptor levels in mild and severe preeclampsia
10.1016/j.ajog.2005.12.049 · 2006 · External reference
Urinary podocyte excretion as a marker for preeclampsia
10.1016/j.ajog.2007.02.007 · 2007 · External reference
Placental growth factor (PlGF) is a surrogate marker in preeclamptic hypertension
10.1080/10641950701825937 · 2008 · External reference
Elevated serum soluble vascular endothelial growth factor receptor 1 (sVEGFR-1) levels in women with preeclampsia
10.1210/jc.2002-021942 · 2003 · External reference
Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences
10.1210/jc.2003-030528 · 2003 · External reference
Evidence supporting a role for blockade of the vascular endothelial growth factor system in the pathophysiology of preeclampsia. Young Investigator Award
10.1016/j.ajog.2004.03.043 · 2004 · External reference
Soluble vascular endothelial growth factor receptor-1 (sFlt-1) is increased throughout gestation in patients who have preeclampsia develop
10.1016/j.ajog.2004.03.004 · 2004 · External reference
Plasma markers of angiogenesis in pregnancy induced hypertension
10.1160/th05-03-0167 · 2005 · External reference
Elevated serum sFlt-1/Ang-2 ratio in women with preeclampsia
10.1159/000101483 · 2007 · External reference
Maternal Serum sFlt1 concentration is an early and reliable predictive marker of preeclampsia
10.1373/clinchem.2004.036715 · 2004 · External reference
Soluble fms-like tyrosine kinase 1
10.1056/nejm200411183512123 · 2004 · External reference
Circulating concentrations of soluble endoglin (CD105) in fetal and maternal serum and in amniotic fluid in preeclampsia
10.1016/j.ajog.2007.03.036 · 2007 · External reference
Longitudinal serum concentrations of placental growth factor: evidence for abnormal placental angiogenesis in pathologic pregnancies
10.1067/mob.2003.111 · 2003 · External reference
Suppression of serum vascular endothelial growth factor immunoreactivity in normal pregnancy and in pre-eclampsia
10.1111/j.1471-0528.1997.tb11050.x · 1997 · External reference
Angiogenin and vascular endothelial growth factor in pregnancies complicated by preeclampsia
10.1016/j.ijgo.2004.10.005 · 2005 · External reference
Angiogenic factors and preeclampsia
10.2741/2241 · 2007 · External reference
Second-trimester maternal serum placental growth factor and vascular endothelial growth factor for predicting severe, early-onset preeclampsia
10.1016/s0029-7844(03)00338-7 · 2003 · External reference
Low maternal serum levels of placenta growth factor as an antecedent of clinical preeclampsia
10.1067/mob.2001.113129 · 2001 · External reference
First trimester placental growth factor and soluble fms-like tyrosine kinase 1 and risk for preeclampsia
10.1210/jc.2003-031244 · 2004 · External reference
Changes in circulating level of angiogenic factors from the first to second trimester as predictors of preeclampsia
10.1016/j.ajog.2006.10.909 · 2007 · External reference
The change in concentrations of angiogenic and anti-angiogenic factors in maternal plasma between the first and second trimesters in risk assessment for the subsequent development of preeclampsia and small-for-gestational age
10.1080/14767050802034545 · 2008 · External reference
A prospective cohort study of the value of maternal plasma concentrations of angiogenic and anti-angiogenic factors in early pregnancy and midtrimester in the identification of patients destined to develop preeclampsia
10.3109/14767050902994754 · 2009 · External reference
First-trimester maternal serum levels of placenta growth factor as predictor of preeclampsia and fetal growth restriction
10.1016/s0029-7844(01)01528-9 · 2001 · External reference
Circulating angiogenic factors in early pregnancy and the risk of preeclampsia, intrauterine growth restriction, spontaneous preterm birth, and stillbirth
10.1097/01.aog.0000265804.09161.0d · 2007 · External reference
Plasma placenta growth factor levels in midtrimester pregnancies
10.1016/s0029-7844(01)01497-1 · 2001 · External reference
Decreased maternal serum placenta growth factor in early second trimester and preeclampsia
10.1016/s0029-7844(01)01341-2 · 2001 · External reference
A longitudinal study of biochemical variables in women at risk of preeclampsia
10.1067/mob.2002.122969 · 2002 · External reference
Prospective analysis of placenta growth factor (PlGF) concentrations in the plasma of women with normal pregnancy and pregnancies complicated by preeclampsia
10.1081/prg-120028286 · 2004 · External reference
Increased sFlt-1 to PlGF ratio in women who subsequently develop preeclampsia
10.3346/jkms.2007.22.5.873 · 2007 · External reference
Identification of patients at risk for early onset and/or severe preeclampsia with the use of uterine artery Doppler velocimetry and placental growth factor
10.1016/j.ajog.2006.11.002 · 2007 · External reference
Second-trimester angiogenic factors as biomarkers for future-onset preeclampsia
10.1016/j.ajog.2007.05.022 · 2007 · External reference
10.1080/14767050701830480
10.1080/14767050701830480 · 2008 · External reference
Maternal serum placental growth factor at 11+0 to 13+6 weeks of gestation in the prediction of pre-eclampsia
10.1002/uog.6244 · 2008 · External reference
Predictive value of angiogenic factors and uterine artery Doppler for early- versus late-onset pre-eclampsia and intrauterine growth restriction
10.1002/uog.5184 · 2008 · External reference
Placental growth factor: a predictive marker for preeclampsia?
10.1159/000197908 · 2009 · External reference
Placenta growth factor levels in second-trimester maternal serum in Down syndrome pregnancy and in the prediction of preeclampsia
10.1002/pd.998 · 2004 · External reference
Maternal serum placental growth factor (PlGF) in small for gestational age pregnancy at 11(+0) to 13(+6) weeks of gestation
10.1002/pd.2143 · 2008 · External reference
Angiogenic factors for the prediction of preeclampsia in high-risk women
10.1016/j.ajog.2007.06.030 · 2007 · External reference
Circulatory soluble endoglin and its predictive value for preeclampsia in second-trimester pregnancies with abnormal uterine perfusion
10.1016/j.ajog.2007.08.052 · 2008 · External reference
Predictive value of maternal angiogenic factors in second trimester pregnancies with abnormal uterine perfusion
10.1161/01.hyp.0000258404.21552.a3 · 2007 · External reference
Angiogenic factors for the prediction of pre-eclampsia in women with abnormal midtrimester uterine artery Doppler velocimetry
10.1016/j.ijgo.2008.02.016 · 2008 · External reference
Sequential changes in antiangiogenic factors in early pregnancy and risk of developing preeclampsia
10.1161/hypertensionaha.107.087700 · 2007 · External reference
Effective prediction of preeclampsia by a combined ratio of angiogenesis-related factors
10.1097/aog.0b013e3181719b7a · 2008 · External reference
Circulating angiogenic factors and placental abruption
10.1097/01.aog.0000216014.72503.09 · 2006 · External reference
Angiopoietin-1/angiopoietin-2 ratio for prediction of preeclampsia
10.1038/ajh.2009.97 · 2009 · External reference
Disturbed feto-maternal cell traffic in preeclampsia
10.1016/s0029-7844(98)00068-4 · 1998 · External reference
Elevation in erythroblast count in maternal blood before the onset of preeclampsia
10.1067/mob.2001.108861 · 2001 · External reference
Increased fetal erythroblasts in women who subsequently develop pre-eclampsia
10.1093/humrep/15.7.1624 · 2000 · External reference
Quantitative abnormalities of fetal DNA in maternal serum in preeclampsia
10.1093/clinchem/45.2.184 · 1999 · External reference
Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia
10.1093/clinchem/47.1.137 · 2001 · External reference
Circulatory fetal and maternal DNA in pregnancies at risk and those affected by preeclampsia
10.1111/j.1749-6632.2001.tb03874.x · 2001 · External reference
The levels of circulatory cell free fetal DNA in maternal plasma are elevated prior to the onset of preeclampsia
10.1081/prg-120002911 · 2002 · External reference
Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia
10.1016/j.ajog.2003.12.019 · 2004 · External reference
A microarray approach for systematic identification of placental-derived RNA markers in maternal plasma
10.1007/978-1-59745-066-9_22 · 2008 · External reference
Value of HCG and HCS measurement in clinical practice
1974 · External reference
Maternal serum human chorionic gonadotropin level at 15 weeks is a predictor for preeclampsia
10.1016/s0002-9378(96)70247-8 · 1996 · External reference
Prediction of preeclampsia or intrauterine growth restriction by second trimester serum screening and uterine Doppler velocimetry
10.1159/000081369 · 2005 · External reference
Mid-trimester beta-hCG levels incorporated in a multifactorial model for the prediction of severe pre-eclampsia
10.1002/1097-0223(200009)20:9<738::aid-pd917>3.0.co;2-r · 2000 · External reference
The value of elevated second-trimester beta-human chorionic gonadotropin in predicting development of preeclampsia
10.1016/s0002-9378(97)70512-x · 1997 · External reference
Endothelial dysfunction and raised plasma concentrations of asymmetric dimethylarginine in pregnant women who subsequently develop pre-eclampsia
10.1016/s0140-6736(03)13177-7 · 2003 · External reference
Plasma concentrations of asymmetric dimethylarginine, a natural inhibitor of nitric oxide synthase, in normal pregnancy and preeclampsia
10.1016/s0002-9378(98)70437-5 · 1998 · External reference
Asymmetric dimethylarginine (ADMA) in the maternal and fetal circulation in preeclampsia
10.1203/pdr.0b013e3181b33392 · 2009 · External reference
Increased circulating concentrations of asymmetric dimethyl arginine (ADMA), an endogenous inhibitor of nitric oxide synthesis, in preeclampsia
10.1080/j.1600-0412.1998.770805.x · 1998 · External reference
Reduced l-arginine level and decreased placental eNOS activity in preeclampsia
10.1016/j.placenta.2005.04.011 · 2006 · External reference
Plasma concentrations of asymmetric dimethylarginine (ADMA) in Colombian women with pre-eclampsia
10.1001/jama.291.7.823 · 2004 · External reference
Elevated asymmetric dimethylarginine concentrations precede clinical preeclampsia, but not pregnancies with small-for-gestational-age infants
10.1016/j.ajog.2007.05.052 · 2008 · External reference
High levels of corticotropin-releasing factor (CRF) are inversely correlated with low levels of maternal CRF-binding protein in pregnant women with pregnancy-induced hypertension
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Corticotrophin-releasing hormone and corticotrophin-releasing hormone binding protein in normal and pre-eclamptic human pregnancies
10.1111/j.1471-0528.1995.tb09063.x · 1995 · External reference
The measurement of maternal plasma corticotropin-releasing factor (CRF) and CRF-binding protein improves the early prediction of preeclampsia
10.1210/jc.2004-0186 · 2004 · External reference
The addition of activin A and inhibin A measurement to uterine artery Doppler velocimetry to improve the early prediction of pre-eclampsia
10.1002/uog.29 · 2003 · External reference
AT1-receptor autoantibodies and uteroplacental RAS in pregnancy and pre-eclampsia
10.1007/s00109-008-0332-4 · 2008 · External reference
Angiotensin receptor agonistic autoantibodies induce pre-eclampsia in pregnant mice
10.1038/nm.1856 · 2008 · External reference
Circulating and placental growth-differentiation factor 15 in preeclampsia and in pregnancy complicated by diabetes mellitus
10.1161/hypertensionaha.109.130583 · 2009 · External reference
A proof-of-principle gel-free proteomics strategy for the identification of predictive biomarkers for the onset of pre-eclampsia
10.1111/j.1471-0528.2009.02283.x · 2009 · External reference
Detection and identification of novel metabolomic biomarkers in preeclampsia
10.1177/1933719108316908 · 2008 · External reference
First trimester urinary placental growth factor and development of pre-eclampsia
10.1111/j.1471-0528.2008.02074.x · 2009 · External reference
Urinary placental growth factor and risk of preeclampsia
10.1001/jama.293.1.77 · 2005 · External reference
Low urinary placental growth factor is a marker of pre-eclampsia
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Urinary angiogenic factors cluster hypertensive disorders and identify women with severe preeclampsia
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Metabolic syndrome in early pregnancy and risk of preterm birth
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Obesity and preeclampsia: the potential role of inflammation
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