Research graph
References from Lifelong caloric restriction reshapes age-related hepatic oxylipin profiles and is associated with a CYB5R3-linked epoxide–diol signature. Local targets link to admitted publications; unresolved targets remain external evidence.
Hallmarks of aging: An expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
Biomarkers of aging
10.1007/s11427-023-2305-0 · 2023 · External reference
Chronic inflammation and the hallmarks of aging
10.1016/j.molmet.2023.101755 · 2023 · External reference
Inflammation and aging-related disease: A transdisciplinary inflammaging framework
10.1007/s11357-024-01364-0 · 2025 · External reference
Hallmarks of Aging in the Liver
10.1016/j.csbj.2019.07.021 · 2019 · External reference
Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells
10.1038/s41423-025-01313-7 · 2025 · External reference
The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
10.1038/s41574-020-0386-0 · 2020 · External reference
Oxylipins Derived from PUFAs in Cardiometabolic Diseases: Mechanism of Actions and Possible Nutritional Interactions
10.3390/nu16223812 · 2024 · External reference
Eicosanoid storm in infection and inflammation
10.1038/nri3859 · 2015 · External reference
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
10.1038/s41392-020-00443-w · 2021 · External reference
Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception
10.1186/s12974-020-1703-1 · 2020 · External reference
Prostanoids and Resolution of Inflammation - Beyond the Lipid-Mediator Class Switch
10.3389/fimmu.2021.714042 · 2021 · External reference
CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro
10.1186/s12931-021-01891-w · 2021 · External reference
Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
10.1172/jci97943 · 2018 · External reference
Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice
10.1038/s41419-024-06705-7 · 2024 · External reference
Inflammation and aging: signaling pathways and intervention therapies
10.1038/s41392-023-01502-8 · 2023 · External reference
Deciphering the role of cytokines in aging: Biomarker potential and effective targeting
10.1016/j.mad.2025.112036 · 2025 · External reference
Calorie restriction in humans: An update
10.1016/j.arr.2016.08.005 · 2017 · External reference
Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: implications for senolytic clinical trial design
10.1007/s11357-023-00830-5 · 2023 · External reference
The role of nutrition in inflammaging
10.1016/j.arr.2022.101596 · 2022 · External reference
The Effects of Caloric Restriction on Inflammatory Targets in the Prostates of Aged Rats
10.3390/ijms25105236 · 2024 · External reference
Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and Lifespan
10.3389/fgene.2016.00142 · 2016 · External reference
Calorie restriction mimetics against aging and inflammation
10.1007/s10522-025-10269-0 · 2025 · External reference
Caloric restriction modulates liver transcriptomes in an age-dependent manner in C57BL/6 N mice
2026 · External reference
Caloric restriction improves health and survival of rhesus monkeys
10.1038/ncomms14063 · 2017 · External reference
Novel Benzimidazole Derivatives as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase 1 for the Potential Treatment of Inflammation, Pain, and Fever
10.1021/acs.jmedchem.4c01883 · 2024 · External reference
Cytochrome b5 reductases: Redox regulators of cell homeostasis
10.1016/j.jbc.2022.102654 · 2022 · External reference
Caloric restriction in humans reveals immunometabolic regulators of health span
10.1126/science.abg7292 · 2022 · External reference
Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice
10.1016/j.cmet.2023.05.003 · 2023 · External reference
Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE 2 trial analysis
10.1111/acel.14149 · 2024 · External reference
Tissue-specific Gene Expression Changes Are Associated with Aging in Mice
10.1016/j.gpb.2020.12.001 · 2020 · External reference
Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues
10.1016/j.celrep.2019.08.043 · 2019 · External reference
Single-cell transcriptome analysis of aging mouse liver
10.1096/fj.202302282r · 2024 · External reference
Hepatic soluble epoxide hydrolase activity regulates cerebral Abeta metabolism and the pathogenesis of Alzheimer's disease in mice
10.1016/j.neuron.2023.06.002 · 2023 · External reference
Soluble epoxide hydrolase: an emerging target for nutraceuticals against inflammation and oxidative stress
2024 · External reference
17,18-Epoxyeicosatetraenoic Acid Inhibits TNF-α-Induced Inflammation in Cultured Human Airway Epithelium and LPS-Induced Murine Airway Inflammation
10.1177/19458924211027682 · 2022 · External reference
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid
10.1038/s42255-024-01070-3 · 2024 · External reference
Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review
10.1016/j.jare.2018.02.004 · 2018 · External reference
Sex Specific Differences in Response to Calorie Restriction in Skeletal Muscle of Young Rats
10.3390/nu14214535 · 2022 · External reference
Responses to Many Anti-Aging Interventions Are Sexually Dimorphic
10.5534/wjmh.230015 · 2024 · External reference
A Clinical Perspective of Soluble Epoxide Hydrolase Inhibitors in Metabolic and Related Cardiovascular Diseases
10.2174/1874467214666210920104352 · 2022 · External reference
Calorie restriction mimetics against aging and inflammation
10.1007/s10522-025-10269-0 · ExternalCitation · doi-reference
Long-term dasatinib plus quercetin effects on aging outcomes and inflammation in nonhuman primates: implications for senolytic clinical trial design
10.1007/s11357-023-00830-5 · ExternalCitation · doi-reference
Inflammation and aging-related disease: A transdisciplinary inflammaging framework
10.1007/s11357-024-01364-0 · ExternalCitation · doi-reference
Biomarkers of aging
10.1007/s11427-023-2305-0 · ExternalCitation · doi-reference
Calorie restriction in humans: An update
10.1016/j.arr.2016.08.005 · ExternalCitation · doi-reference
The role of nutrition in inflammaging
10.1016/j.arr.2022.101596 · ExternalCitation · doi-reference
Hallmarks of aging: An expanding universe
10.1016/j.cell.2022.11.001 · ExternalCitation · doi-reference
Age-Related Gene Expression Signature in Rats Demonstrate Early, Late, and Linear Transcriptional Changes from Multiple Tissues
10.1016/j.celrep.2019.08.043 · ExternalCitation · doi-reference
Prolonged fasting times reap greater geroprotective effects when combined with caloric restriction in adult female mice
10.1016/j.cmet.2023.05.003 · ExternalCitation · doi-reference
Hallmarks of Aging in the Liver
10.1016/j.csbj.2019.07.021 · ExternalCitation · doi-reference
Tissue-specific Gene Expression Changes Are Associated with Aging in Mice
10.1016/j.gpb.2020.12.001 · ExternalCitation · doi-reference
Ageing: Is there a role for arachidonic acid and other bioactive lipids? A review
10.1016/j.jare.2018.02.004 · ExternalCitation · doi-reference
Cytochrome b5 reductases: Redox regulators of cell homeostasis
10.1016/j.jbc.2022.102654 · ExternalCitation · doi-reference
Deciphering the role of cytokines in aging: Biomarker potential and effective targeting
10.1016/j.mad.2025.112036 · ExternalCitation · doi-reference
Chronic inflammation and the hallmarks of aging
10.1016/j.molmet.2023.101755 · ExternalCitation · doi-reference
Hepatic soluble epoxide hydrolase activity regulates cerebral Abeta metabolism and the pathogenesis of Alzheimer's disease in mice
10.1016/j.neuron.2023.06.002 · ExternalCitation · doi-reference
Novel Benzimidazole Derivatives as Potent Inhibitors of Microsomal Prostaglandin E2 Synthase 1 for the Potential Treatment of Inflammation, Pain, and Fever
10.1021/acs.jmedchem.4c01883 · ExternalCitation · doi-reference
Caloric restriction improves health and survival of rhesus monkeys
10.1038/ncomms14063 · ExternalCitation · doi-reference
Eicosanoid storm in infection and inflammation
10.1038/nri3859 · ExternalCitation · doi-reference
Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets
10.1038/s41392-020-00443-w · ExternalCitation · doi-reference
Inflammation and aging: signaling pathways and intervention therapies
10.1038/s41392-023-01502-8 · ExternalCitation · doi-reference
Resolvin E1 improves efferocytosis and rescues severe aplastic anemia in mice
10.1038/s41419-024-06705-7 · ExternalCitation · doi-reference
Inflammation and immunity in liver homeostasis and disease: a nexus of hepatocytes, nonparenchymal cells and immune cells
10.1038/s41423-025-01313-7 · ExternalCitation · doi-reference
The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic
10.1038/s41574-020-0386-0 · ExternalCitation · doi-reference
The sphingosine-1-phosphate receptor 1 mediates the atheroprotective effect of eicosapentaenoic acid
10.1038/s42255-024-01070-3 · ExternalCitation · doi-reference
Single-cell transcriptome analysis of aging mouse liver
10.1096/fj.202302282r · ExternalCitation · doi-reference
Effect of long-term caloric restriction on telomere length in healthy adults: CALERIE 2 trial analysis
10.1111/acel.14149 · ExternalCitation · doi-reference
Caloric restriction in humans reveals immunometabolic regulators of health span
10.1126/science.abg7292 · ExternalCitation · doi-reference
Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators
10.1172/jci97943 · ExternalCitation · doi-reference
17,18-Epoxyeicosatetraenoic Acid Inhibits TNF-α-Induced Inflammation in Cultured Human Airway Epithelium and LPS-Induced Murine Airway Inflammation
10.1177/19458924211027682 · ExternalCitation · doi-reference
CYP2J2 and EETs protect against pulmonary arterial hypertension with lung ischemia-reperfusion injury in vivo and in vitro
10.1186/s12931-021-01891-w · ExternalCitation · doi-reference
Molecular mechanisms underlying the actions of arachidonic acid-derived prostaglandins on peripheral nociception
10.1186/s12974-020-1703-1 · ExternalCitation · doi-reference
A Clinical Perspective of Soluble Epoxide Hydrolase Inhibitors in Metabolic and Related Cardiovascular Diseases
10.2174/1874467214666210920104352 · ExternalCitation · doi-reference
Better Living through Chemistry: Caloric Restriction (CR) and CR Mimetics Alter Genome Function to Promote Increased Health and Lifespan
10.3389/fgene.2016.00142 · ExternalCitation · doi-reference
Prostanoids and Resolution of Inflammation - Beyond the Lipid-Mediator Class Switch
10.3389/fimmu.2021.714042 · ExternalCitation · doi-reference
The Effects of Caloric Restriction on Inflammatory Targets in the Prostates of Aged Rats
10.3390/ijms25105236 · ExternalCitation · doi-reference
Sex Specific Differences in Response to Calorie Restriction in Skeletal Muscle of Young Rats
10.3390/nu14214535 · ExternalCitation · doi-reference
Oxylipins Derived from PUFAs in Cardiometabolic Diseases: Mechanism of Actions and Possible Nutritional Interactions
10.3390/nu16223812 · ExternalCitation · doi-reference
Responses to Many Anti-Aging Interventions Are Sexually Dimorphic
10.5534/wjmh.230015 · ExternalCitation · doi-reference
