Research graph
References from Cracking the Code of Cravings: Endocannabinoids and the Hypothalamic Appetite Nexus. Local targets link to admitted publications; unresolved targets remain external evidence.
Obesity in adults
10.1016/s0140-6736(24)01210-8 · 2024 · External reference
Sleep Physiology and Traditional Nutritional Practices
2024 · External reference
Acquired hypothalamic obesity: A clinical overview and update
10.1111/dom.15530 · 2024 · External reference
Endocannabinoid system and phytocannabinoids in the main species of veterinary interest: a comparative review
10.1007/s11259-024-10509-7 · 2024 · External reference
Isolation and structure of a brain constituent that binds to the cannabinoid receptor
10.1126/science.1470919 · 1992 · External reference
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
10.1016/0006-2952(95)00109-d · 1995 · External reference
Cannabinoids and appetite: food craving and food pleasure
10.1080/09540260902782810 · 2009 · External reference
Anandamide induces overeating: mediation by central cannabinoid (CB1) receptors
10.1007/s002130050953 · 1999 · External reference
The Endocannabinoid System and Eating Behaviours: a Review of the Current State of the Evidence
2022 · External reference
Molecular characterization of a peripheral receptor for cannabinoids
10.1038/365061a0 · 1993 · External reference
Immunohistochemical localization of the neural cannabinoid receptor in rat brain
10.1002/(sici)1097-4547(19980201)51:3<391::aid-jnr12>3.0.co;2-a · 1998 · External reference
Review of the endocannabinoid system
2021 · External reference
Endocannabinoids, related compounds and their metabolic routes
10.3390/molecules191117078 · 2014 · External reference
The impact of the CB2 cannabinoid receptor in inflammatory diseases: an update
10.3390/molecules29143381 · 2024 · External reference
The novel cannabinoid CB1 receptor neutral antagonist AM4113 suppresses food intake and food-reinforced behavior but does not induce signs of nausea in rats
10.1038/sj.npp.1301476 · 2008 · External reference
O. Prospéro-Garcı́a, Anandamide modulates sleep and memory in rats
10.1016/s0006-8993(98)00969-x · 1998 · External reference
Roles of the Endocannabinoid system in learning and memory
10.1007/978-3-540-88955-7_8 · 2009 · External reference
Hypothalamic regulation of food intake and clinical therapeutic applications
10.1590/s0004-27302009000200002 · 2009 · External reference
Fine morphological evaluation of hypothalamus in patients with hyperphagia
10.1007/s00701-017-3112-5 · 2017 · External reference
Appetite regulation: hormones, peptides, and neurotransmitters and their role in obesity
10.1177/1559827617716376 · 2019 · External reference
Regulation of feeding behavior and body weight by orexigenic neurons in the arcuate nucleus
10.7570/jomes25059 · 2025 · External reference
Hypothalamic endocannabinoids in obesity: an old story with new challenges
10.1007/s00018-021-04002-6 · 2021 · External reference
The hypothalamus and the control of energy homeostasis: different circuits, different purposes
10.1016/s0031-9384(01)00612-6 · 2001 · External reference
Paraventricular nucleus–locus coeruleus VGlut2 neural circuit regulates energy metabolism in mice
10.1038/s41419-025-08238-z · 2025 · External reference
The rise, fall, and resurrection of the ventromedial hypothalamus in the regulation of feeding behavior and body weight
10.1016/j.physbeh.2005.10.007 · 2006 · External reference
Hypothalamic neuropeptides and the regulation of appetite
10.1016/j.neuropharm.2012.02.004 · 2012 · External reference
Hypothalamic obesity: from basic mechanisms to clinical perspectives
10.1016/s2213-8587(24)00283-3 · 2025 · External reference
The physiological control of eating: signals, neurons, and networks
10.1152/physrev.00028.2020 · 2022 · External reference
A brain on cannabinoids: the role of dopamine release in reward seeking and addiction
10.1101/cshperspect.a039305 · 2021 · External reference
Endocannabinoid actions on cortical terminals orchestrate local modulation of dopamine release in the nucleus accumbens
10.1016/j.neuron.2017.11.012 · 2017 · External reference
Endocannabinoid modulation of nucleus accumbens microcircuitry and terminal dopamine release
10.3389/fnsyn.2021.734975 · 2021 · External reference
Endocannabinoids shape accumbal encoding of cue-motivated behavior via CB1 receptor activation in the ventral tegmentum
10.1016/j.neuron.2011.11.018 · 2012 · External reference
Methamphetamine-induced dopamine terminal deficits in the nucleus accumbens are exacerbated by reward-associated cues and attenuated by CB1 receptor antagonism
10.1016/j.neuropharm.2012.01.013 · 2012 · External reference
Phasic dopamine release evoked by abused substances requires cannabinoid receptor activation
10.1523/jneurosci.4152-06.2007 · 2007 · External reference
Δ9-Tetrahydrocannabinol excites rat VTA dopamine neurons through activation of cannabinoid CB1 but not opioid receptors
10.1016/s0304-3940(97)00278-4 · 1997 · External reference
Mechanisms of cannabinoid CB2 receptor-mediated reduction of dopamine neuronal excitability in mouse ventral tegmental area
10.1016/j.ebiom.2019.03.040 · 2019 · External reference
Brain CB2 receptor: A new target in medication development for treating opioid use disorder in rodents
10.1038/s41380-025-03377-3 · 2026 · External reference
Unresolved reference
2012 · External reference
Regulation of brain reward by the endocannabinoid system: a critical review of behavioral studies in animals
10.2174/13816128113199990433 · 2014 · External reference
Brain cannabinoid CB2 receptors modulate cocaine’s actions in mice
10.1038/nn.2874 · 2011 · External reference
CB2 agonist mitigates cocaine-induced reinstatement of place preference and modulates the inflammatory response in mice
10.1097/fbp.0000000000000759 · 2024 · External reference
Cannabinoid type 2 receptors in dopamine neurons inhibits psychomotor behaviors, alters anxiety, depression and alcohol preference
10.1038/s41598-017-17796-y · 2017 · External reference
F. García-García, Involvement of CB1R and CB2R Ligands in Sleep Disorders and Addictive Behaviors in the Last 25 Years
10.3390/ph18020266 · 2025 · External reference
Cannabidiol inhibits sucrose self‐administration by CB 1 and CB 2 receptor mechanisms in rodents
10.1111/adb.12783 · 2020 · External reference
Cannabinoid CB2 receptors are expressed in glutamate neurons in the red nucleus and functionally modulate motor behavior in mice
10.1016/j.neuropharm.2021.108538 · 2021 · External reference
Behavioral and neurochemical changes in mesostriatal dopaminergic regions of the rat after chronic administration of the cannabinoid receptor agonist WIN55, 212-2
10.1093/ijnp/pyu097 · 2015 · External reference
Alterations in rat accumbens dopamine, endocannabinoids and GABA content during WIN55, 212-2 treatment: The role of ghrelin
10.3390/ijms22010210 · 2020 · External reference
Pharmacological characterization of the cannabinoid receptor 2 agonist, β-caryophyllene on seizure models in mice
10.1016/j.seizure.2018.03.009 · 2018 · External reference
Beta-caryophyllene, a cannabinoid receptor type 2 selective agonist, in emotional and cognitive disorders
10.3390/ijms25063203 · 2024 · External reference
The third transmembrane helix of the cannabinoid receptor plays a role in the selectivity of aminoalkylindoles for CB2, peripheral cannabinoid receptor
10.1016/s0022-3565(24)35174-2 · 1999 · External reference
Targeting cannabinoid receptors: current status and prospects of natural products
10.3390/ijms21145064 · 2020 · External reference
Localization of the CB1 cannabinoid receptor in the rat brain. An immunohistochemical study☆
10.1016/s0196-9781(00)00324-7 · 2000 · External reference
On the role of central type-1 cannabinoid receptor gene regulation in food intake and eating behaviors
10.3390/ijms22010398 · 2021 · External reference
Coexpression of the cannabinoid receptor type 1 with the corticotropin-releasing hormone receptor type 1 in distinct regions of the adult mouse forebrain
10.1016/j.neulet.2004.10.080 · 2005 · External reference
Morán, Implications of the mitochondrial CB1 receptor in the brain: from mitochondrial dysfunction to neuroprotection
10.1515/revneuro-2025-0086 · 2026 · External reference
Recent advances on type-2 cannabinoid (CB2) receptor agonists and their therapeutic potential
10.2174/0929867329666220825161603 · 2023 · External reference
The endocannabinoid system in appetite regulation and treatment of obesity
10.1002/prp2.70009 · 2024 · External reference
A. Šulcová, Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures—a short review
10.1016/j.pbb.2008.05.010 · 2008 · External reference
Prolonged activation of brain CB2 signaling modulates hypothalamic microgliosis and astrogliosis in high fat diet-fed mice
10.3390/ijms23105527 · 2022 · External reference
Cannabinoid CB2 receptors: immunohistochemical localization in rat brain
10.1016/j.brainres.2005.11.035 · 2006 · External reference
The implication of gut hormones in the regulation of energy homeostasis and their role in the pathophysiology of obesity
10.1007/s13679-020-00396-9 · 2020 · External reference
Leptin, the brain and energy homeostasis: From an apparently simple to a highly complex neuronal system
10.1007/s11154-021-09636-2 · 2022 · External reference
Anti-obesity effect of SR141716, a CB1 receptor antagonist, in diet-induced obese mice
10.1152/ajpregu.00545.2002 · 2003 · External reference
CB1 cannabinoid receptor knockout in mice leads to leanness, resistance to diet-induced obesity and enhanced leptin sensitivity
10.1038/sj.ijo.0802583 · 2004 · External reference
Targeting the endocannabinoid CB1 receptor to treat body weight disorders: a preclinical and clinical review of the therapeutic potential of past and present CB1 drugs
10.3390/biom10060855 · 2020 · External reference
Food for thought: reward mechanisms and hedonic overeating in obesity
10.1007/s13679-017-0280-9 · 2017 · External reference
Endocannabinoids and energy homeostasis: an update
10.1002/biof.1168 · 2014 · External reference
Leptin as a key regulator of the adipose organ
10.1007/s11154-021-09687-5 · 2022 · External reference
Obesity affects the microbiota–gut–brain axis and the regulation thereof by endocannabinoids and related mediators
10.3390/ijms21051554 · 2020 · External reference
The endocannabinoid system is modulated in reward and homeostatic brain regions following diet-induced obesity in rats: a cluster analysis approach
10.1007/s00394-021-02613-0 · 2021 · External reference
High fat diet increases circulating endocannabinoids accompanied by increased synthesis enzymes in adipose tissue
10.3389/fphys.2018.01913 · 2019 · External reference
60 years of POMC: regulation of feeding and energy homeostasis by α-MSH
10.1530/jme-16-0014 · 2016 · External reference
Neuropeptide y receptor selective ligands in the treatment of obesity
10.1210/er.2007-0003 · 2007 · External reference
CB1 cannabinoid receptor in SF1-expressing neurons of the ventromedial hypothalamus determines metabolic responses to diet and leptin
10.1016/j.molmet.2014.07.004 · 2014 · External reference
Overactivation of the endocannabinoid system alters the antilipolytic action of insulin in mouse adipose tissue
10.1152/ajpendo.00374.2016 · 2017 · External reference
Understanding metabolic homeostasis and imbalance: what is the role of the endocannabinoid system?
10.1016/j.amjmed.2007.06.007 · 2007 · External reference
Exploring the therapeutic potential of cannabinoid receptor antagonists in inflammation, diabetes mellitus, and obesity
1667 · External reference
New insights of SF1 neurons in hypothalamic regulation of obesity and diabetes
10.3390/ijms22126186 · 2021 · External reference
Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance
10.1016/j.cmet.2012.07.002 · 2012 · External reference
Ghrelin as a prominent endocrine factor in stress-induced obesity
10.1080/1028415x.2020.1863740 · 2022 · External reference
The CB1 receptor mediates the peripheral effects of ghrelin on AMPK activity but not on growth hormone release, The
10.1096/fj.13-232918 · 2013 · External reference
Endocannabinoids in body weight control
10.3390/ph11020055 · 2018 · External reference
The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system
10.1371/journal.pone.0001797 · 2008 · External reference
Ghrelin recruits the endocannabinoid system to modulate food reward
10.1523/jneurosci.1620-24.2024 · 2025 · External reference
Effects of the cannabinoid antagonists AM281 and AM630 on deprivation-induced intake in Lewis rats
10.1016/s0006-8993(02)04274-9 · 2003 · External reference
Behavioral effects of CB2 cannabinoid receptor activation and its influence on food and alcohol consumption
10.1196/annals.1432.035 · 2008 · External reference
Hepatic cannabinoid receptor-1 mediates diet-induced insulin resistance via inhibition of insulin signaling and clearance in mice
10.1053/j.gastro.2012.01.032 · 2012 · External reference
Therapeutical potential of CB2 receptors in immune-related diseases
10.2174/1874467207666140219122337 · 2013 · External reference
Low-grade inflammation, obesity, and diabetes
10.1007/s13679-014-0124-9 · 2014 · External reference
Effects of the CB1 receptor antagonists AM6545 and AM4113 on insulin resistance in a high-fructose high-salt rat model of metabolic syndrome
10.3390/medicina56110573 · 2020 · External reference
Deficiency of CB2 cannabinoid receptor in mice improves insulin sensitivity but increases food intake and obesity with age
10.1007/s00125-010-1894-6 · 2010 · External reference
A nonsynonymous polymorphism in cannabinoid CB2 receptor gene is associated with eating disorders in humans and food intake is modified in mice by its ligands
10.1002/syn.20714 · 2010 · External reference
Differential modulation of endogenous cannabinoid CB1 and CB2 receptors in spontaneous and splice variants of ghrelin-induced food intake in conscious rats
10.1016/j.nut.2014.06.008 · 2015 · External reference
Anti-obesity effect of the CB2 receptor agonist JWH-015 in diet-induced obese mice
10.1371/journal.pone.0140592 · 2015 · External reference
Maternal high-fat diet induces sex-specific endocannabinoid system changes in newborn rats and programs adiposity, energy expenditure and food preference in adulthood
10.1016/j.jnutbio.2017.09.019 · 2018 · External reference
Diet‐Induced Obesity in Cannabinoid‐2 Receptor Knockout Mice and Cannabinoid Receptor 1/2 Double‐Knockout Mice
10.1002/oby.22403 · 2019 · External reference
Anxiety associated with palatable food withdrawal is reversed by the selective FAAH inhibitor PF‐3845: A regional analysis of the contribution of endocannabinoid signaling machinery
10.1002/eat.23917 · 2023 · External reference
CB1 cannabinoid receptor‐mediated modulation of food intake in mice
10.1038/sj.bjp.0706157 · 2005 · External reference
Anandamide and 2-arachidonoylglycerol: Pharmacological properties, functional features, and emerging specificities of the two major endocannabinoids
10.1007/s12035-012-8299-0 · 2012 · External reference
Presynaptically located CB1 cannabinoid receptors regulate GABA release from axon terminals of specific hippocampal interneurons
10.1523/jneurosci.19-11-04544.1999 · 1999 · External reference
Cinnamaldehyde (TRPA1 agonist) protected against olanzapine-induced metabolic alterations in mice: involvement of hypothalamic energy sensing, appetite regulation and inflammatory aberrations
10.1016/j.psyneuen.2021.105525 · 2021 · External reference
Cannabinoid Receptor Type 1 Agonist ACEA Improves Cognitive Deficit on STZ-Induced Neurotoxicity Through Apoptosis Pathway and NO Modulation
10.1007/s12640-018-9991-2 · 2019 · External reference
