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References from Belumosudil improves experimental pulmonary fibrosis via the ROCK2/Smad3/CTGF pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Comparative transcriptome profile of mouse macrophages treated with the RhoA/Rock pathway inhibitors Y27632, Fingolimod (Gilenya), and Rezurock (Belumosudil, SLx-2119)
10.1016/j.intimp.2023.110017 · 2023 · External reference
Idiopathic pulmonary fibrosis (an update) and progressive pulmonary fibrosis in adults: an Official ATS/ERS/JRS/ALAT Clinical practice guideline
10.1164/rccm.202202-0399st · 2022 · External reference
Gazing into the proteomic crystal ball: predicting survival in idiopathic pulmonary fibrosis
10.1164/rccm.202311-2108ed · 2024 · External reference
Immune dysregulation as a driver of idiopathic pulmonary fibrosis
10.1172/jci143226 · 2021 · External reference
Role of ROCK signaling in virus replication
10.1016/j.virusres.2023.199105 · 2023 · External reference
Novel small-molecule ROCK2 inhibitor GNS-3595 attenuates pulmonary fibrosis in preclinical studies
10.1165/rcmb.2023-0401oc · 2024 · External reference
Identification of novel Imidazo[1,2-b]pyridazine derivatives as selective ROCK2 inhibitors for the treatment of pulmonary fibrosis
10.1021/acs.jmedchem.5c02233 · 2025 · External reference
Sapanisertib attenuates pulmonary fibrosis by modulating Wnt5a/mTOR signalling
10.1111/bcpt.13924 · 2023 · External reference
Tirbanibulin Attenuates Pulmonary Fibrosis by modulating Src/STAT3 signaling
2021 · External reference
Fibrosis: from mechanisms to medicines
10.1038/s41586-020-2938-9 · 2020 · External reference
Role of pirfenidone in the management of pulmonary fibrosis
10.2147/tcrm.s81141 · 2017 · External reference
Increased fibroblast telomerase expression precedes myofibroblast α-smooth muscle actin expression in idiopathic pulmonary fibrosis
10.6061/clinics/2012(09)10 · 2012 · External reference
Nintedanib for the treatment of idiopathic pulmonary fibrosis
10.1080/14656566.2018.1425681 · 2018 · External reference
Macrophage polarization and its impact on idiopathic pulmonary fibrosis
10.3389/fimmu.2024.1444964 · 2024 · External reference
The role of macrophage polarization and cellular crosstalk in the pulmonary fibrotic microenvironment: a review
10.1186/s12964-024-01557-2 · 2024 · External reference
Modulation of M1 and M2 macrophage polarization by metformin: implications for inflammatory diseases and malignant tumors
10.1016/j.intimp.2025.114345 · 2025 · External reference
Rho/Rock cross-talks with transforming growth factor-β/Smad pathway participates in lung fibroblast-myofibroblast differentiation
10.3892/br.2014.323 · 2014 · External reference
ROCK2, a critical regulator of immune modulation and fibrosis has emerged as a therapeutic target in chronic graft-versus-host disease
10.1016/j.clim.2021.108823 · 2021 · External reference
Smad3 signaling involved in pulmonary fibrosis and emphysema
10.1513/pats.200605-125sf · 2006 · External reference
Alveolar fibroblast lineage orchestrates lung inflammation and fibrosis
10.1038/s41586-024-07660-1 · 2024 · External reference
Connective tissue growth factor in idiopathic pulmonary fibrosis: breaking the Bridge
10.3390/ijms23116064 · 2022 · External reference