Research graph
References from T cell-derived CCL5 drives macrophage immunometabolic remodeling in chronic prostatitis via the CCR5-ERK-PKM2/HIF-1α axis. Local targets link to admitted publications; unresolved targets remain external evidence.
NIH consensus definition and classification of prostatitis
10.1001/jama.282.3.236 · 1999 · External reference
Prostatitis: a review
10.1001/jama.2025.11499 · 2025 · External reference
Male chronic pelvic pain: AUA guideline: part I evaluation and management approach
10.1097/ju.0000000000004564 · 2025 · External reference
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS): look to the future
10.1038/s41391-023-00645-7 · 2024 · External reference
Chronic Prostatitis/Chronic pelvic pain syndrome: a disease or symptom? Current perspectives on diagnosis, treatment, and prognosis
10.1177/1557988320903200 · 2020 · External reference
Male chronic pelvic pain: AUA guideline: part II treatment of chronic Prostatitis/Chronic pelvic pain syndrome
10.1097/ju.0000000000004565 · 2025 · External reference
A Chinese expert consensus on prostate-pelvic syndrome
10.1097/cu9.0000000000000319 · 2026 · External reference
NLRP3-mediated IL-1β in regulating the imbalance between Th17 and Treg in experimental autoimmune prostatitis
2024 · External reference
Activated autophagy restored the impaired frequency and function of regulatory T cells in chronic prostatitis
10.1002/pros.24073 · 2021 · External reference
High-salt-driven gut microbiota dysfunction aggravates prostatitis by promoting AHR/SGK1/FOXO1 axis-mediated Th17 cell differentiation
10.1186/s40779-025-00607-1 · 2025 · External reference
Epithelial redox stress programs macrophage immunometabolism through a ZNF24-MIF-NF-κB pathway in chronic nonbacterial prostatitis
10.1016/j.redox.2026.104042 · 2026 · External reference
Human airway macrophages are metabolically reprogrammed by IFN-γ resulting in glycolysis-dependent functional plasticity
10.7554/elife.98449.4 · 2024 · External reference
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
10.1038/cr.2015.68 · 2015 · External reference
HIF1α and metabolic reprogramming in inflammation
10.1172/jci84431 · 2016 · External reference
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
10.1038/nature11986 · 2013 · External reference
Regulation of the hypoxia-inducible factor (HIF) by pro-inflammatory cytokines
10.3390/cells10092340 · 2021 · External reference
Pyruvate kinase M2 regulates Hif-1α activity and IL-1β induction and is a critical determinant of the warburg effect in LPS-activated macrophages
10.1016/j.cmet.2014.12.005 · 2015 · External reference
Pyruvate kinase M2 regulates gene transcription by acting as a protein kinase
10.1016/j.molcel.2012.01.001 · 2012 · External reference
Nuclear PKM2: a signal receiver, a gene programmer, and a metabolic modulator
10.1186/s12929-025-01170-6 · 2025 · External reference
SIRT5 desuccinylates and Activates pyruvate kinase M2 to block macrophage IL-1β production and to prevent DSS-Induced colitis in mice
10.1016/j.celrep.2017.05.065 · 2017 · External reference
CCL5/CCR5 axis in human diseases and related treatments
10.1016/j.gendis.2021.08.004 · 2022 · External reference
Interfering with CCL5/CCR5 at the Tumor-Stroma Interface
10.1016/j.ccell.2016.03.019 · 2016 · External reference
Bone marrow hematopoiesis drives multiple sclerosis progression
10.1016/j.cell.2022.05.020 · 2022 · External reference
The CCL5/CCR5/SHP2 axis sustains Stat1 phosphorylation and activates NF-κB signaling promoting M1 macrophage polarization and exacerbating chronic prostatic inflammation
10.1186/s12964-024-01943-w · 2024 · External reference
The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis
10.1074/jbc.m112.348946 · 2012 · External reference
MIF regulates T helper 17 cell differentiation by activating the p38 MAPK signaling pathway to drive the pathogenesis of EAP
10.1016/j.intimp.2025.114959 · 2025 · External reference
TNF is a potential therapeutic target to suppress prostatic inflammation and hyperplasia in autoimmune disease
10.1038/s41467-022-29719-1 · 2022 · External reference
Single-cell analysis of mouse and human prostate reveals novel fibroblasts with specialized distribution and microenvironment interactions
10.1002/path.5751 · 2021 · External reference
5-Alpha reductase inhibitors induce a prostate luminal to club cell transition in human benign prostatic hyperplasia
10.1002/path.5857 · 2022 · External reference
Immune cell single-cell RNA sequencing analyses link an age-associated T cell subset to symptomatic benign prostatic hyperplasia
10.3389/fimmu.2025.1585446 · 2025 · External reference
Rapamycin and low-dose IL-2 mediate an immunosuppressive microenvironment to inhibit benign prostatic hyperplasia
10.7150/ijbs.85089 · 2023 · External reference
Cell2location maps fine-grained cell types in spatial transcriptomics
10.1038/s41587-021-01139-4 · 2022 · External reference
Screening cell–cell communication in spatial transcriptomics via collective optimal transport
10.1038/s41592-022-01728-4 · 2023 · External reference
Dictionary learning for integrative, multimodal and scalable single-cell analysis
10.1038/s41587-023-01767-y · 2024 · External reference
Metabolic modeling of single Th17 cells reveals regulators of autoimmunity
10.1016/j.cell.2021.05.045 · 2021 · External reference
Irf7 aggravates prostatitis by promoting Hif-1α-mediated glycolysis to facilitate M1 polarization
10.1007/s00018-025-05608-w · 2025 · External reference
Eriocalyxin B ameliorated experimental autoimmune prostatitis via modulation of macrophage polarization through gut microbiota-mediated vitamin D(3) alteration
10.1016/j.phymed.2024.156191 · 2024 · External reference
ESM1 enhances fatty acid synthesis and vascular mimicry in ovarian cancer by utilizing the PKM2-dependent warburg effect within the hypoxic tumor microenvironment
10.1186/s12943-024-02009-8 · 2024 · External reference
ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect
10.1038/ncb2629 · 2012 · External reference
M2 macrophage exosome-derived lncRNA AK083884 protects mice from CVB3-induced viral myocarditis through regulating PKM2/HIF-1α axis mediated metabolic reprogramming of macrophages
10.1016/j.redox.2023.103016 · 2024 · External reference
F13A1-Mediated macrophage activation promotes MASH progression via the PKM2/HIF1A pathway
2026 · External reference
PKM2-mediated STAT3 phosphorylation promotes acute liver failure via regulating NLRP3-dependent pyroptosis
10.1038/s42003-024-07227-w · 2024 · External reference
Immunometabolism governs dendritic cell and macrophage function
10.1084/jem.20151570 · 2016 · External reference
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
10.1038/nchembio.1060 · 2012 · External reference
CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection
10.1038/nm1303 · 2005 · External reference
Induction of copper/zinc-superoxide dismutase by CCL5/CCR5 activation causes tumour necrosis factor-alpha and reactive oxygen species production in macrophages
10.1111/j.1365-2567.2008.02966.x · 2009 · External reference
CCL5 deficiency promotes liver repair by improving inflammation resolution and liver regeneration through M2 macrophage polarization
10.1038/s41423-019-0279-0 · 2020 · External reference
A natural CCL5/RANTES variant antagonist for CCR1 and CCR3
10.1007/s00251-006-0133-2 · 2006 · External reference
CRAF methylation by PRMT6 regulates aerobic glycolysis-driven hepatocarcinogenesis via ERK-Dependent PKM2 nuclear relocalization and activation
10.1002/hep.30923 · 2020 · External reference
PP4R1 promotes glycolysis and gallbladder cancer progression through facilitating ERK1/2 mediated PKM2 nuclear translocation
10.1016/j.canlet.2024.216677 · 2024 · External reference
Maraviroc: a review of its use in HIV infection and beyond
2015 · External reference
Targeting HIF-1 alpha transcriptional activity drives cytotoxic immune effector cells into melanoma and improves combination immunotherapy
10.1038/s41388-021-01846-x · 2021 · External reference
Acriflavine, a potent inhibitor of HIF-1α, disturbs glucose metabolism and suppresses ATF4-Protective pathways in Melanoma under non-hypoxic conditions
10.3390/cancers13010102 · 2020 · External reference
