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References from Targeting 3-mercaptopyruvate sulfurtransferase selectively eliminates colorectal cancer stem cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Hydrogen sulfide and cell signaling
10.1146/annurev-pharmtox-010510-100505 · 2011 · External reference
Signalling by hydrogen sulfide and polysulfides via protein S-sulfuration
10.1111/bph.14579 · 2020 · External reference
Physiological roles of hydrogen sulfide in mammalian cells, tissues, and organs
10.1152/physrev.00028.2021 · 2023 · External reference
Gasotransmitters in cancer: from pathophysiology to experimental therapy
10.1038/nrd.2015.1 · 2016 · External reference
Molecular functions of hydrogen sulfide in cancer
10.3390/pathophysiology28030028 · 2021 · External reference
Emerging roles of cystathionine beta-synthase in various forms of cancer
10.1016/j.redox.2022.102331 · 2022 · External reference
Role of 3-mercaptopyruvate sulfurtransferase in cancer
10.1016/j.cellsig.2025.112020 · 2025 · External reference
Cancer stem cells revisited
10.1038/nm.4409 · 2017 · External reference
Cancer stem cells—origins and biomarkers: perspectives for targeted personalized therapies
10.3389/fimmu.2020.01280 · 2020 · External reference
Cancer stem cells: advances in knowledge and implications for cancer therapy
10.1038/s41392-024-01851-y · 2024 · External reference
Cancer stem cells: landscape, challenges and emerging therapeutic innovations
10.1038/s41392-025-02360-2 · 2025 · External reference
Colorectal cancer stem cells: an overview of evolving methods and concepts
10.3390/cancers13235910 · 2021 · External reference
Molecular analysis of tumor recurrence using established cancer stem cell-line and drug discovery
10.1007/s10147-025-02948-2 · 2026 · External reference
Cancer stem cell-driven drug resistance in colorectal carcinoma: molecular aspects and therapeutic potentials
10.1186/s12943-025-02557-7 · 2026 · External reference
Proteogenomic characterization of primary colorectal cancer and metastatic progression identifies proteome-based subtypes and signatures
10.1016/j.celrep.2024.113810 · 2024 · External reference
3-Mercaptopyruvate sulfurtransferase: an enzyme at the crossroads of sulfane sulfur trafficking
10.1515/hsz-2020-0249 · 2021 · External reference
Role of 3-mercaptopyruvate sulfurtransferase (3-MST) in physiology and disease
10.3390/antiox12030603 · 2023 · External reference
Nonadhesive culture system as a model of rapid sphere formation with cancer stem cell properties
10.1371/journal.pone.0031864 · 2012 · External reference
Coaction of spheroid-derived stem-like cells and endothelial progenitor cells promotes development of colon cancer
10.1371/journal.pone.0039069 · 2012 · External reference
Pharmacological induction of mesenchymal-epithelial transition via inhibition of H2S biosynthesis and consequent suppression of ACLY activity in colon cancer cells
10.1016/j.phrs.2020.105393 · 2021 · External reference
Discovery and mechanistic characterization of selective inhibitors of H2S-producing enzyme: 3-mercaptopyruvate sulfurtransferase (3MST) targeting active-site cysteine persulfide
10.1038/srep40227 · 2017 · External reference
Role of 3-mercaptopyruvate sulfurtransferase in the regulation of proliferation, migration, and bioenergetics in murine colon cancer cells
10.3390/biom10030447 · 2020 · External reference
Novel aryl-substituted pyrimidones as inhibitors of 3-mercaptopyruvate sulfurtransferase with antiproliferative efficacy in colon cancer
10.1021/acs.jmedchem.1c00260 · 2021 · External reference
Sequential accumulation of ‘driver’ pathway mutations induces the upregulation of hydrogen-sulfide-producing enzymes in human colonic epithelial cell organoids
10.3390/antiox11091823 · 2022 · External reference
Regulation of CyR61 expression and release by 3-mercaptopyruvate sulfurtransferase in colon cancer cells
10.1016/j.redox.2022.102466 · 2022 · External reference
Hallmarks of cancer stem cell metabolism
10.1038/bjc.2016.152 · 2016 · External reference
The metabolic flexibility of quiescent CSC: implications for chemotherapy resistance
10.1038/s41419-021-04116-6 · 2021 · External reference
Intramitochondrial hydrogen sulfide production by 3-mercaptopyruvate sulfurtransferase maintains mitochondrial electron flow and supports cellular bioenergetics
10.1096/fj.12-216507 · 2013 · External reference
Effect of hydrogen sulfide on glycolysis-based energy production in mouse erythrocytes
10.1002/jcp.30544 · 2022 · External reference
3-Mercaptopyruvate sulfurtransferase regulates mitochondrial metabolism and epithelial differentiation in neonatal patient-derived airway cells
10.1152/ajplung.00418.2025 · 2026 · External reference
MPST sulfurtransferase maintains mitochondrial protein import and cellular bioenergetics to attenuate obesity
10.1084/jem.20211894 · 2022 · External reference
The assembly, regulation and function of the mitochondrial respiratory chain
10.1038/s41580-021-00415-0 · 2022 · External reference
Pulse-chase SILAC-based analyses reveal selective oversynthesis and rapid turnover of mitochondrial protein components of respiratory complexes
10.1074/jbc.ra119.011791 · 2020 · External reference
The fate of mitochondrial respiratory complexes in aging
10.1016/j.tcb.2025.02.008 · 2025 · External reference
CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system xc(−) and thereby promotes tumor growth
10.1016/j.ccr.2011.01.038 · 2011 · External reference
xCT inhibition depletes CD44v-expressing tumor cells that are resistant to EGFR-targeted therapy in head and neck squamous cell carcinoma
10.1158/0008-5472.can-12-3609-t · 2013 · External reference
Serine synthesis helps hypoxic cancer stem cells regulate redox
10.1158/0008-5472.can-16-1730 · 2016 · External reference
FASN promotes the stemness of cancer stem cells and protects colorectal cancer cells from ferroptosis by inhibiting the activation of SREBP2
2025 · External reference
Haem oxygenase-1, ferroptosis and disorders—a narrative review
10.3390/nu17243921 · 2025 · External reference
Dual role of heme oxygenase-1 in disease progression and treatment: a literature review
2025 · External reference
Activation of SAT1 engages polyamine metabolism with p53-mediated ferroptotic responses
10.1073/pnas.1607152113 · 2016 · External reference
Abundant expression of ferroptosis-related SAT1 is related to unfavorable outcome and immune cell infiltration in low-grade glioma
10.1186/s12885-022-09313-w · 2022 · External reference
FSP1 is a glutathione-independent ferroptosis suppressor
10.1038/s41586-019-1707-0 · 2019 · External reference
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
10.1038/s41586-019-1705-2 · 2019 · External reference
Exogenous monounsaturated fatty acids promote a ferroptosis-resistant cell state
10.1016/j.chembiol.2018.11.016 · 2019 · External reference
Targeting a lipid desaturation enzyme, SCD1, selectively eliminates colon cancer stem cells through the suppression of Wnt and NOTCH signaling
10.3390/cells10010106 · 2021 · External reference
PEBP1 wardens ferroptosis by enabling lipoxygenase generation of lipid death signals
10.1016/j.cell.2017.09.044 · 2017 · External reference
Upregulation of cystathionine-β-synthase in colonic epithelia reprograms metabolism and promotes carcinogenesis
10.1158/0008-5472.can-16-3480 · 2017 · External reference
Multi-pathway therapeutics in colorectal cancer: targeting EMT, CSCs, and non-apoptotic cell death for drug resistance reversal
10.1080/1061186x.2025.2600679 · 2026 · External reference
Wnt/β-catenin pathway as a link between therapy resistance-driven epithelial-mesenchymal transition and stemness in colorectal cancer
10.1002/cbin.12270 · 2025 · External reference
Lipid metabolism in cancer stem cells: reprogramming, mechanisms, crosstalk, and therapeutic approaches
10.1007/s13402-025-01081-6 · 2025 · External reference
Lipid composition of the cancer cell membrane
10.1007/s10863-020-09846-4 · 2020 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Stearoyl-CoA desaturase 1 as a therapeutic biomarker: focusing on cancer stem cells
10.3390/ijms24108951 · 2023 · External reference
