Research graph
References from Inter-domain distance analysis reveals conformational changes in the Keap1-Nrf2 stress sensor system. Local targets link to admitted publications; unresolved targets remain external evidence.
The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis
10.1152/physrev.00023.2017 · 2018 · External reference
The molecular mechanisms regulating the KEAP1-NRF2 pathway
10.1128/mcb.00099-20 · 2020 · External reference
Molecular basis of the KEAP1-NRF2 signaling pathway
10.14348/molcells.2023.0028 · 2023 · External reference
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
10.1101/gad.13.1.76 · 1999 · External reference
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-Dependent ubiquitin ligase complex
10.1128/mcb.24.24.10941-10953.2004 · 2004 · External reference
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-Based E3 ligase to regulate proteasomal degradation of Nrf2
10.1128/mcb.24.16.7130-7139.2004 · 2004 · External reference
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-Based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase
10.1128/mcb.24.19.8477-8486.2004 · 2004 · External reference
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the cullin 3-Roc1 ligase
10.1128/mcb.25.1.162-171.2005 · 2005 · External reference
An Nrf2/Small maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
10.1006/bbrc.1997.6943 · 1997 · External reference
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers
10.1073/pnas.0307301101 · 2004 · External reference
Oxidative and Electrophilic stresses activate Nrf2 through inhibition of ubiquitination activity of Keap1
10.1128/mcb.26.1.221-229.2006 · 2006 · External reference
Physiological significance of reactive cysteine residues of Keap1 in determining Nrf2 activity
10.1128/mcb.01704-07 · 2008 · External reference
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a “Tethering” mechanism
10.1074/jbc.m601119200 · 2006 · External reference
Two-site substrate recognition model for the Keap1-Nrf2 system: a Hinge and latch mechanism
10.1515/bc.2006.164 · 2006 · External reference
Different electrostatic potentials define ETGE and DLG motifs as Hinge and latch in oxidative stress response
10.1128/mcb.00753-07 · 2007 · External reference
Kinetic, thermodynamic, and structural characterizations of the association between Nrf2-DLGex degron and Keap1
10.1128/mcb.01191-13 · 2014 · External reference
Absolute amounts and status of the Nrf2-Keap1-Cul3 complex within cells
10.1128/mcb.00389-16 · 2016 · External reference
Molecular basis for the disruption of Keap1–Nrf2 interaction via Hinge & Latch mechanism
10.1038/s42003-021-02100-6 · 2021 · External reference
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
10.1073/pnas.172398899 · 2002 · External reference
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
10.1073/pnas.1007387107 · 2010 · External reference
Activation of NRF2 by nitrosative agents and H2O2 involves KEAP1 disulfide formation
10.1074/jbc.m109.051714 · 2010 · External reference
Select heterozygous Keap1 mutations have a dominant-negative effect on wild-type Keap1 in vivo
10.1158/0008-5472.can-10-2939 · 2011 · External reference
Characterizations of three major cysteine sensors of Keap1 in stress response
10.1128/mcb.00868-15 · 2016 · External reference
Crystal structure of the kelch domain of human Keap1
10.1074/jbc.m410073200 · 2004 · External reference
Structural basis for defects of Keap1 activity provoked by its point mutations in lung cancer
10.1016/j.molcel.2006.01.013 · 2006 · External reference
Structure of the BTB domain of Keap1 and its interaction with the triterpenoid antagonist CDDO
10.1371/journal.pone.0098896 · 2014 · External reference
Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
10.1073/pnas.0914036107 · 2010 · External reference
Biochemistry. The resolution revolution
10.1126/science.1251652 · 2014 · External reference
How cryo-EM is revolutionizing structural biology
10.1016/j.tibs.2014.10.005 · 2015 · External reference
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: characterization of the two-site molecular recognition model
10.1128/mcb.26.8.2887-2900.2006 · 2006 · External reference
The Keap1 BTB/POZ dimerization function is required to sequester Nrf2 in cytoplasm
10.1074/jbc.m206530200 · 2002 · External reference
Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling
10.1038/sj.emboj.7601243 · 2006 · External reference
CH7450924, a KEAP1-NRF2 interaction inhibitor, ameliorates LPS-induced multiple organ dysfunction via inflammatory pathway inhibition
10.1038/s41598-025-20350-w · 2025 · External reference
Cryo-electron tomography: a long journey to the inner space of cells
10.1016/j.cell.2022.06.034 · 2022 · External reference
Improving particle quality in cryo-EM analysis using a PEGylation method
10.1016/j.str.2021.05.004 · 2021 · External reference
Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Routine single particle CryoEM sample and grid characterization by tomography
10.7554/elife.34257 · 2018 · External reference
In situ cryo-FIB/SEM specimen preparation using the waffle method
10.21769/bioprotoc.4544 · 2022 · External reference
Discovery of potent Keap1–Nrf2 protein–protein interaction inhibitor based on molecular binding determinants analysis
10.1021/jm5000529 · 2014 · External reference
Monoacidic inhibitors of the kelch-like ECH-associated protein 1: nuclear factor erythroid 2-Related factor 2 (KEAP1:NRF2) protein–protein interaction with high cell potency identified by fragment-based discovery
10.1021/acs.jmedchem.6b00228 · 2016 · External reference
Isoquinoline kelch-like ECH-associated protein 1-Nuclear factor (Erythroid-Derived 2)-like 2 (KEAP1-NRF2) inhibitors with high metabolic stability
10.1021/acs.jmedchem.9b01074 · 2020 · External reference
Sensor systems of KEAP1 uniquely detecting oxidative and electrophilic stresses separately in vivo
10.1016/j.redox.2024.103355 · 2024 · External reference
UM171 glues asymmetric CRL3–HDAC1/2 assembly to degrade CoREST corepressors
10.1038/s41586-024-08532-4 · 2025 · External reference
Dynamic molecular architecture and substrate recruitment of cullin3–RING E3 ligase CRL3KBTBD2
10.1038/s41594-023-01182-6 · 2024 · External reference
Cryo-EM structure of the KLHL22 E3 ligase bound to an oligomeric metabolic enzyme
10.1016/j.str.2023.09.002 · 2023 · External reference
Structures of SPOP-substrate complexes: insights into molecular architectures of BTB-Cul3 ubiquitin ligases
10.1016/j.molcel.2009.09.022 · 2009 · External reference
The potential of subsampling and inpainting for fast low-dose cryo FIB-SEM imaging
10.1093/micmic/ozae005 · 2024 · External reference
Automated electron microscope tomography using robust prediction of specimen movements
10.1016/j.jsb.2005.07.007 · 2005 · External reference
Parallel cryo electron tomography on in situ lamellae
10.1038/s41592-022-01690-1 · 2023 · External reference
New tools for automated cryo-EM single-particle analysis in RELION-4.0
10.1042/bcj20210708 · 2021 · External reference
CTFFIND4: fast and accurate defocus estimation from electron micrographs
10.1016/j.jsb.2015.08.008 · 2015 · External reference
Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs
10.1038/s41592-019-0575-8 · 2019 · External reference
ColabFold: making protein folding accessible to all
10.1038/s41592-022-01488-1 · 2022 · External reference
MMseqs2 desktop and local web server app for fast, interactive sequence searches
10.1093/bioinformatics/bty1057 · 2019 · External reference
