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References from PRMT5 promotes ferroptosis in cisplatin-induced acute kidney injury through WDR5/ACSL4 pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Acute kidney injury
10.1016/s0140-6736(24)02385-7 · 2025 · External reference
Kidney physiology and susceptibility to acute kidney injury: implications for renoprotection
10.1038/s41581-021-00394-7 · 2021 · External reference
Global epidemiology and outcomes of acute kidney injury
10.1038/s41581-018-0052-0 · 2018 · External reference
Critical care nephrology: Core curriculum 2020
10.1053/j.ajkd.2019.10.010 · 2020 · External reference
Potential therapeutic targets for cisplatin-induced kidney injury: lessons from other models of AKI and fibrosis
10.1681/asn.2020101455 · 2021 · External reference
Cisplatin-induced renal injury is independently mediated by OCT2 and p53
10.1158/1078-0432.ccr-14-0319 · 2014 · External reference
Inhibition of OCT2, MATE1 and MATE2-K as a possible mechanism of drug interaction between pazopanib and cisplatin
10.1016/j.phrs.2016.05.012 · 2016 · External reference
Cisplatin nephrotoxicity: new insights and therapeutic implications
10.1038/s41581-022-00631-7 · 2023 · External reference
Mitochondrial superoxide dismutase in cisplatin-induced kidney injury
10.3390/antiox10091329 · 2021 · External reference
Regulated cell death in AKI
10.1681/asn.2014030262 · 2014 · External reference
Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases
10.7150/ijbs.85674 · 2023 · External reference
Acyl-CoA synthase ACSL4: an essential target in ferroptosis and fatty acid metabolism
10.1097/cm9.0000000000002533 · 2023 · External reference
ACSL4 deficiency confers protection against ferroptosis-mediated acute kidney injury
10.1016/j.redox.2022.102262 · 2022 · External reference
Lipid peroxidation, ferroptosis, and antioxidants
10.1016/j.freeradbiomed.2025.05.393 · 2025 · External reference
NRF2, a superstar of ferroptosis
10.3390/antiox12091739 · 2023 · External reference
NRF2 plays a critical role in mitigating lipid peroxidation and ferroptosis
10.1016/j.redox.2019.101107 · 2019 · External reference
Targeting epigenetic and posttranslational modifications regulating ferroptosis for the treatment of diseases
10.1038/s41392-023-01720-0 · 2023 · External reference
The structure and functions of PRMT5 in human diseases
10.3390/life11101074 · 2021 · External reference
Protein arginine methyltransferase PRMT5 regulates fatty acid metabolism and lipid droplet biogenesis in white adipose tissues
2020 · External reference
PRMT5 regulates ATF4 transcript splicing and oxidative stress response
10.1016/j.redox.2022.102282 · 2022 · External reference
RIPK1 senses S-adenosylmethionine scarcity to drive cell death and inflammation
10.1016/j.cmet.2025.05.014 · 2025 · External reference
Protein arginine methylation: from enigmatic functions to therapeutic targeting
10.1038/s41573-021-00159-8 · 2021 · External reference
Identification of PRMT5 as a therapeutic target in cholangiocarcinoma
10.1136/gutjnl-2024-332998 · 2024 · External reference
Arginine methylation in cancer: mechanisms and therapeutic implications
10.1186/s40364-025-00860-5 · 2025 · External reference
Prmt5 is essential for intestinal stem cell maintenance and homeostasis
10.1186/s13619-024-00216-8 · 2025 · External reference
Brg1/PRMT5 nuclear complex epigenetically regulates FOXO1 in IPF mesenchymal progenitor cells
10.1152/ajplung.00248.2023 · 2024 · External reference
Kidney disease models: tools to identify mechanisms and potential therapeutic targets
2018 · External reference
PRMT5 inhibition promotes PD-L1 expression and immuno-resistance in lung cancer
10.3389/fimmu.2021.722188 · 2022 · External reference
Identification of METTL3 and PRMT5 as an oncogenic pair for the prognosis and therapeutic targets of colorectal cancer subtype
10.1186/s13148-026-02144-7 · 2026 · External reference
Cloperastine reduces IL-6 expression via Akt/GSK3/Nrf2 signaling in monocytes/macrophages and ameliorates symptoms in a mouse sepsis model induced by lipopolysaccharide
10.1248/bpb.b24-00472 · 2024 · External reference
Cloperastine rescues impairment of passive avoidance response in mice prenatally exposed to diethylstilbestrol
10.1002/tox.21749 · 2012 · External reference
Mitochondrial damage causes inflammation via cGAS-STING signaling in acute kidney injury
10.1016/j.celrep.2019.09.050 · 2019 · External reference
Loss of cGAS facilitates angiogenesis in diabetic foot ulcer healing by suppressing the STING/Ferroptosis pathway
10.1016/j.intimp.2026.116684 · 2026 · External reference
Roles of H3K4 methylation in biology and disease
10.1016/j.tcb.2024.06.001 · 2024 · External reference
Inhibition of PRMT5 by market drugs as a novel cancer therapeutic avenue
10.1016/j.gendis.2022.04.001 · 2022 · External reference
Renal endothelial injury and microvascular dysfunction in acute kidney injury
10.1016/j.semnephrol.2015.01.010 · 2015 · External reference
Inflammation in AKI: current understanding, key questions, and knowledge gaps
10.1681/asn.2015030261 · 2015 · External reference
Macrophage-driven inflammation in acute kidney injury: therapeutic opportunities and challenges
10.1016/j.trsl.2025.02.003 · 2025 · External reference
Nonapoptotic cell death in acute kidney injury and transplantation
10.1016/j.kint.2015.10.008 · 2016 · External reference
Cell death induced by acute renal injury: a perspective on the contributions of accidental and programmed cell death
10.1152/ajprenal.00275.2023 · 2024 · External reference
Epigenetic regulation in AKI and kidney repair: mechanisms and therapeutic implications
10.1038/s41581-018-0103-6 · 2019 · External reference
Epigenetic alterations and memory: key players in the development/progression of chronic kidney disease promoted by acute kidney injury and diabetes
10.1016/j.kint.2024.10.031 · 2024 · External reference
The role and mechanism of lysine methyltransferase and arginine methyltransferase in kidney diseases
2022 · External reference
Protein arginine methyltransferase 1 mediates renal fibroblast activation and fibrogenesis through activation of Smad3 signaling
10.1152/ajprenal.00487.2019 · 2019 · External reference
Trans-omic analysis identifies the 'PRMT1-STAT3-Integrin αVβ6 Axis' as a novel therapeutic target in tacrolimus-induced chronic nephrotoxicity
10.3390/ijms262110282 · 2025 · External reference
Ubiquitination-dependent CARM1 degradation facilitates Notch1-mediated podocyte apoptosis in diabetic nephropathy
10.1016/j.cellsig.2014.04.008 · 2014 · External reference
The PRMT6/STAT1/ACSL1 axis promotes ferroptosis in diabetic nephropathy
10.1038/s41418-024-01357-8 · 2024 · External reference
FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways
10.1016/j.molcel.2023.07.004 · 2023 · External reference
The interaction between ferroptosis and necroptosis in acute and chronic kidney diseases
10.2147/jir.s559198 · 2026 · External reference
The cell biology of ferroptosis
10.1038/s41580-024-00703-5 · 2024 · External reference
Role of ACSL4 in the chemical-induced cell death in human proximal tubule epithelial HK-2 cells
10.1042/bsr20212433 · 2022 · External reference
Iron homeostasis and ferroptosis in human diseases: mechanisms and therapeutic prospects
10.1038/s41392-024-01969-z · 2024 · External reference
Antioxidant systems as modulators of ferroptosis: focus on transcription factors
10.3390/antiox13030298 · 2024 · External reference
HSF1 facilitates the multistep process of lymphatic metastasis in bladder cancer via a novel PRMT5-WDR5-dependent transcriptional program
10.1002/cac2.12284 · 2022 · External reference
Fibroblast-specific PRMT5 deficiency suppresses cardiac fibrosis and left ventricular dysfunction in male mice
10.1038/s41467-024-46711-z · 2024 · External reference
Genotoxic stress-triggered β-catenin/JDP2/PRMT5 complex facilitates reestablishing glutathione homeostasis
10.1038/s41467-019-11696-7 · 2019 · External reference
Targeting WD repeat-containing protein 5 (WDR5): a medicinal chemistry perspective
10.1021/acs.jmedchem.1c00037 · 2021 · External reference
Lateral thinking: how histone modifications regulate gene expression
10.1016/j.tig.2015.10.007 · 2015 · External reference
Unresolved reference
2025 · External reference
PRMT5-mediated arginine methylation stabilizes GPX4 to suppress ferroptosis in cancer
10.1038/s41556-025-01610-3 · 2025 · External reference
Mechanisms and models of kidney tubular necrosis and Nephron loss
10.1681/asn.2021101293 · 2022 · External reference
The road from AKI to CKD: molecular mechanisms and therapeutic targets of ferroptosis
10.1038/s41419-023-05969-9 · 2023 · External reference
Pharmacological and clinical overview of cloperastine in treatment of cough
2011 · External reference
Pharmacokinetics, bioequivalence and safety of cloperastine in Chinese healthy subjects under fasting and postprandial conditions
10.1007/s40268-022-00406-2 · 2022 · External reference
Targeting strategies for drug delivery to the kidney: from renal glomeruli to tubules
10.1002/med.21532 · 2018 · External reference