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References from Targeting the Ero1α-PDI oxidative protein folding pathway as a broad-spectrum strategy against coronavirus. Local targets link to admitted publications; unresolved targets remain external evidence.
A new coronavirus associated with human respiratory disease in China
10.1038/s41586-020-2008-3 · 2020 · External reference
A pneumonia outbreak associated with a new coronavirus of probable bat origin
10.1038/s41586-020-2012-7 · 2020 · External reference
Characteristics of SARS-CoV-2 and COVID-19
10.1038/s41579-020-00459-7 · 2021 · External reference
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor
10.1038/s41586-020-2180-5 · 2020 · External reference
Structural basis of receptor recognition by SARS-CoV-2
10.1038/s41586-020-2179-y · 2020 · External reference
A multibasic cleavage site in the spike protein of SARS-CoV-2 is essential for infection of human lung cells
10.1016/j.molcel.2020.04.022 · 2020 · External reference
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
10.1038/s41586-021-03237-4 · 2021 · External reference
The furin cleavage site in the SARS-CoV-2 spike protein is required for transmission in ferrets
10.1038/s41564-021-00908-w · 2021 · External reference
SARS-CoV-2 variants, spike mutations and immune escape
10.1038/s41579-021-00573-0 · 2021 · External reference
Thiol-based chemical probes exhibit antiviral activity against SARS-CoV-2 via allosteric disulfide disruption in the spike glycoprotein
10.1073/pnas.2120419119 · 2022 · External reference
SARS-coronavirus spike S2 domain flanked by cysteine residues C822 and C833 is important for activation of membrane fusion
10.1016/j.virol.2009.07.038 · 2009 · External reference
Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone
10.1016/j.freeradbiomed.2015.02.007 · 2015 · External reference
Oxidative protein folding fidelity and redoxtasis in the endoplasmic reticulum
10.1016/j.tibs.2022.06.011 · 2023 · External reference
Secretory kinase Fam20C tunes endoplasmic reticulum redox state via phosphorylation of Ero1alpha
10.15252/embj.201798699 · 2018 · External reference
SARS-CoV-2 ORF8 reshapes the ER through forming mixed disulfides with ER oxidoreductases
10.1016/j.redox.2022.102388 · 2022 · External reference
Syncytia formation by SARS-CoV-2-infected cells
10.15252/embj.2020106267 · 2020 · External reference
A novel cell culture system modeling the SARS-CoV-2 life cycle
10.1371/journal.ppat.1009439 · 2021 · External reference
An optimized high-throughput SARS-CoV-2 dual reporter trans-complementation system for antiviral screening in vitro and in vivo
10.1016/j.virs.2024.03.009 · 2024 · External reference
Oxidative protein folding by an endoplasmic reticulum-localized peroxiredoxin
10.1016/j.molcel.2010.11.010 · 2010 · External reference
Glutathione peroxidase 7 utilizes hydrogen peroxide generated by Ero1alpha to promote oxidative protein folding
10.1089/ars.2013.5236 · 2014 · External reference
Different interaction modes for protein-disulfide isomerase (PDI) as an efficient regulator and a specific substrate of endoplasmic reticulum oxidoreductin-1alpha (Ero1alpha)
10.1074/jbc.m114.602961 · 2014 · External reference
Targeting the functional interplay between endoplasmic reticulum oxidoreductin-1alpha and protein disulfide isomerase suppresses the progression of cervical cancer
10.1016/j.ebiom.2019.02.041 · 2019 · External reference
A novel disulphide switch mechanism in Ero1alpha balances ER oxidation in human cells
10.1038/emboj.2008.202 · 2008 · External reference
Low reduction potential of Ero1alpha regulatory disulphides ensures tight control of substrate oxidation
10.1038/emboj.2008.230 · 2008 · External reference
Two conserved cysteine triads in human Ero1α cooperate for efficient disulfide bond formation in the endoplasmic reticulum
10.1074/jbc.m403192200 · 2004 · External reference
A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity
10.1074/jbc.m110.126599 · 2010 · External reference
Inhibitors of protein disulfide isomerase suppress apoptosis induced by misfolded proteins
10.1038/nchembio.467 · 2010 · External reference
Discovery of an orally active small-molecule irreversible inhibitor of protein disulfide isomerase for ovarian cancer treatment
10.1073/pnas.1205226109 · 2012 · External reference
Thiol isomerases orchestrate thrombosis and hemostasis
10.1089/ars.2021.0086 · 2021 · External reference
Luminespib and AZ5104 are effective antithrombotic drugs via targeting the platelet Ero1alpha-PDI pathway
10.1126/sciadv.aeg2095 · 2026 · External reference
NVP-AUY922: a small molecule HSP90 inhibitor with potent antitumor activity in preclinical breast cancer models
10.1186/bcr1996 · 2008 · External reference
Phase I/II study of HSP90 inhibitor AUY922 and Erlotinib for EGFR-mutant lung cancer with acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors
10.1200/jco.2014.59.7328 · 2015 · External reference
Protein disulfide isomerase: a promising target for cancer therapy
10.1016/j.drudis.2013.10.017 · 2014 · External reference
Therapeutic implications of protein disulfide isomerase inhibition in thrombotic disease
10.1161/atvbaha.114.303410 · 2015 · External reference
The extracellular Ero1alpha/PDI electron transport system regulates platelet function by increasing glutathione reduction potential
10.1016/j.redox.2022.102244 · 2022 · External reference
A critical role for ERO1alpha in arterial thrombosis and ischemic stroke
10.1161/circresaha.122.322473 · 2023 · External reference
Disulfide bond formation during the folding of influenza virus hemagglutinin
10.1083/jcb.118.2.227 · 1992 · External reference
Inhibitors of protein-disulfide isomerase prevent cleavage of disulfide bonds in receptor-bound glycoprotein 120 and prevent HIV-1 entry
10.1074/jbc.m204547200 · 2002 · External reference
Targeting the human protein disulfide isomerase A3 as a broad-spectrum antiviral approach against human respiratory viruses
10.1016/j.ijantimicag.2026.107802 · 2026 · External reference
Small molecule-induced oxidation of protein disulfide isomerase is neuroprotective
10.1073/pnas.1500439112 · 2015 · External reference
