Research graph
References from An HMMR-derived SHBG genetic score predicts lower type 2 diabetes risk. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/j.ebiom.2024.105447
10.1016/j.ebiom.2024.105447 · External reference
Global burden of cardiovascular diseases and risk factors, 1990–2019 update from the GBD 2019 study
10.1016/j.jacc.2020.11.010 · 2020 · External reference
Global, regional, and national burden of diabetes from 1990 to 2021,with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021
10.1016/s0140-6736(23)01301-6 · 2023 · External reference
The global epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH): a systematic review
10.1097/hep.0000000000000004 · 2023 · External reference
Molecular biomarkers for cardiometabolic disease: risk assessment in young individuals
10.1161/circresaha.123.322000 · 2023 · External reference
Sex hormone binding globulin as a potential drug candidate for liver-related metabolic disorders treatment
2022 · External reference
Sex hormone-binding globulin and type 2 diabetes mellitus
10.1016/j.tem.2011.09.005 · 2012 · External reference
Sex hormone–binding globulin and risk of type 2 diabetes in women and men
10.1056/nejmoa0804381 · 2009 · External reference
Associations of steroid sex hormones and sex hormone-binding globulin with the risk of type 2 diabetes in women: a population-based cohort study and meta-analysis
10.2337/db16-0473 · 2017 · External reference
Associations of sex steroids and sex hormone-binding globulin with non-alcoholic fatty liver disease: a population-based study and meta-analysis
10.3390/genes13060966 · 2022 · External reference
Sex hormone-binding globulin and risk of coronary heart disease in men and women
10.1093/clinchem/hvac209 · 2023 · External reference
Genetically predicted sex hormone binding globulin and ischemic heart disease in men and women: a univariable and multivariable Mendelian randomization study
10.1038/s41598-021-02510-w · 2021 · External reference
Mendelian randomization: genetic anchors for causal inference in epidemiological studies
10.1093/hmg/ddu328 · 2014 · External reference
Variation in PCSK9 and HMGCR and risk of cardiovascular disease and diabetes
10.1056/nejmoa1604304 · 2016 · External reference
Genetic variants associated with lp(a) lipoprotein level and coronary disease
10.1056/nejmoa0902604 · 2009 · External reference
10.1016/s0140-6736(12)60110-x
10.1016/s0140-6736(12)60110-x · External reference
Association between C reactive protein and coronary heart disease: Mendelian randomisation analysis based on individual participant data
10.1136/bmj.d548 · 2011 · External reference
Association between low sex hormone–binding globulin and increased risk of type 2 diabetes is mediated by increased visceral and liver fat: results from observational and Mendelian randomization analyses
10.2337/db23-0982 · 2024 · External reference
The relationship between sex hormone-binding protein and non-alcoholic fatty liver disease using Mendelian randomisation
10.1111/eci.14082 · 2024 · External reference
Genetically predicted sex hormone levels and health outcomes: phenome-wide Mendelian randomization investigation
10.1093/ije/dyac036 · 2022 · External reference
Hyaluronan mediated motility receptor (HMMR) encodes an evolutionarily conserved homeostasis, mitosis, and meiosis regulator rather than a hyaluronan receptor
10.3390/cells9040819 · 2020 · External reference
Elevated RHAMM as a biomarker for predicting diabetic kidney disease in patients with type 2 diabetes
10.1093/ckj/sfae196 · 2024 · External reference
Oleate acid-stimulated HMMR expression by CEBPα is associated with nonalcoholic steatohepatitis and hepatocellular carcinoma
10.7150/ijbs.49785 · 2020 · External reference
A variant in HMMR/HMMR-AS1 is associated with serum alanine aminotransferase levels in the Ryukyu population
10.1038/s41598-025-90195-w · 2025 · External reference
Hepatic transcriptome signature correlated with HOMA-IR explains early nonalcoholic fatty liver disease pathogenesis
10.1016/j.aohep.2020.06.009 · 2020 · External reference
Hyaluronan in adipose tissue, metabolic inflammation, and diabetes: innocent bystander or guilty party
10.2337/db22-0676 · 2023 · External reference
Using human genetics to understand the disease impacts of testosterone in men and women
10.1038/s41591-020-0751-5 · 2020 · External reference
The MR-Base platform supports systematic causal inference across the human phenome
10.7554/elife.34408 · 2018 · External reference
Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression
10.1093/ije/dyv080 · 2015 · External reference
Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
10.1038/s41588-018-0099-7 · 2018 · External reference
Consistent estimation in Mendelian randomization with some invalid instruments using a weighted Median estimator
10.1002/gepi.21965 · 2016 · External reference
Multivariable Mendelian randomization: the use of pleiotropic genetic variants to estimate causal effects
10.1093/aje/kwu283 · 2015 · External reference
Computationally efficient whole-genome regression for quantitative and binary traits
10.1038/s41588-021-00870-7 · 2021 · External reference
The UK Biobank resource with deep phenotyping and genomic data
10.1038/s41586-018-0579-z · 2018 · External reference
UK biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age
10.1371/journal.pmed.1001779 · 2015 · External reference
FinnGen provides genetic insights from a well-phenotyped isolated population
10.1038/s41586-022-05473-8 · 2023 · External reference
Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits
10.1038/ng.2213 · 2012 · External reference
O’Reilly PF. PRSice-2: polygenic Risk Score software for biobank-scale data
10.1093/gigascience/giz082 · 2019 · External reference
10.1016/j.csbj.2022.05.015 · 2022 · Admitted local publication
Cochran’s Q test was useful to assess heterogeneity in likelihood ratios in studies of diagnostic accuracy
10.1016/j.jclinepi.2014.09.005 · 2015 · External reference
MendelianRandomization: an R package for performing Mendelian randomization analyses using summarized data
10.1093/ije/dyx034 · 2017 · External reference
Sex hormone-binding globulin and sex-specific association between irritable bowel syndrome and type 2 diabetes: a prospective cohort study
10.1186/s12937-025-01155-z · 2025 · External reference
Testosterone, sex hormone-binding globulin and the metabolic syndrome: a systematic review and meta-analysis of observational studies
10.1093/ije/dyq158 · 2011 · External reference
Sex hormone binding globulin and insulin resistance
10.1111/cen.12086 · 2013 · External reference
Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone–binding globulin gene
2007 · External reference
Potential role of tumor necrosis factor-α in downregulating sex hormone–binding globulin
10.2337/db11-0727 · 2012 · External reference
Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study
10.1530/eje-13-1046 · 2014 · External reference
Association of sex hormones with non-alcoholic fatty liver disease: an observational and Mendelian randomization study
10.1111/liv.15866 · 2024 · External reference
A prospective study of sex hormone-binding globulin and fatal cardiovascular disease in Rancho Bernardo men and women
1996 · External reference
Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans
10.1530/eje.0.1320594 · 1995 · External reference
Sex hormone-binding globulin gene expression in the liver: drugs and the metabolic syndrome
10.1016/j.mce.2009.09.020 · 2010 · External reference
Human sex hormone–binding globulin variants associated with hyperandrogenism and ovarian dysfunction
10.1172/jci0214060 · 2002 · External reference
Sex differences of endogenous sex hormones and risk of type 2 diabetes: a systematic review and meta-analysis
10.1001/jama.295.11.1288 · 2006 · External reference