Research graph
References from NSAIDs in paediatric burn injury: Mechanistic insights and clinical implications for inflammation and wound healing. Local targets link to admitted publications; unresolved targets remain external evidence.
Non-steroidal anti-inflammatory drugs
10.1136/bmj.320.7241.1058 · 2000 · External reference
Oral non-steroidal anti-inflammatory drugs versus other oral analgesic agents for acute soft tissue injury
2020 · External reference
Pattern of NSAID use in the Italian general population: a questionnaire-based survey
10.1007/s00228-004-0826-0 · 2004 · External reference
Prevalence, attitudes, and behaviors related to the use of nonsteroidal anti-inflammatory drugs (NSAIDs) in student athletes
10.1016/s1054-139x(01)00325-1 · 2002 · External reference
Comparative safety evaluation of non-narcotic analgesics
10.1016/s0895-4356(98)00076-6 · 1998 · External reference
Nonsteroidal anti-inflammatory drugs and the risk of hospitalization for acute renal failure
10.1001/archinte.1996.00440200041005 · 1996 · External reference
Drug-induced bronchospasm: analysis of 187 spontaneously reported cases
10.1159/000050525 · 2001 · External reference
Evaluation of hypersensitivity reactions to nonsteroidal anti-inflammatory drugs according to the latest classification
10.1111/all.12689 · 2015 · External reference
Nonsteroidal anti-inflammatory drugs and severe psychiatric side effects
10.2190/1b32-79ea-b6h5-395v · 1996 · External reference
Basic opioid pharmacology: an update
10.1177/2049463712438493 · 2012 · External reference
Paracetamol: mechanisms and updates
2014 · External reference
Unremitting pro-inflammatory T-cell phenotypes, and macrophage activity, following paediatric burn injury
10.1002/cti2.1496 · 2024 · External reference
The time-course of the inflammatory response to major burn injury and its relation to organ failure and outcome
10.1016/j.burns.2018.09.001 · 2019 · External reference
18 high mobility group box-1 is not correlated with the persistent hyperinflammatory response after burn injury
10.1093/jbcr/irae036.018 · 2024 · External reference
Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation
10.1016/j.burns.2016.10.001 · 2017 · External reference
Burn-injured skin is marked by a prolonged local acute inflammatory response of innate immune cells and pro-inflammatory cytokines
10.3389/fimmu.2022.1034420 · 2022 · External reference
γδ T-cells: potential regulators of the post-burn inflammatory response
10.1016/j.burns.2008.08.002 · 2009 · External reference
Severity of thermal burn injury is associated with systemic neutrophil activation
10.1038/s41598-022-05768-w · 2022 · External reference
Persistent systemic inflammation in patients with severe burn injury is accompanied by influx of immature neutrophils and shifts in T cell subsets and cytokine profiles
10.3389/fimmu.2020.621222 · 2021 · External reference
Investigation and assessment of neutrophil dysfunction early after severe burn injury
10.1016/j.burns.2021.02.004 · 2021 · External reference
Anti-DAMP therapies for acute inflammation
10.3389/fimmu.2025.1579954 · 2025 · External reference
Inflammatory proteins and neutrophil extracellular traps increase in burn blister fluid 24h after burn
10.1016/j.burns.2024.02.026 · 2024 · External reference
Toll-like receptor signaling in burn wound healing and scarring
10.1089/wound.2017.0733 · 2017 · External reference
NSAIDs between past and present; a long journey towards an ideal COX-2 inhibitor lead
10.1039/d4ra04686b · 2024 · External reference
Latest advancements in the study of the relationship between NSAIDs and three prostaglandin E2 synthases
10.4155/fmc-2023-0172 · 2023 · External reference
Republished research: non-steroidal anti-inflammatory drugs (NSAIDs)
10.1136/bjsports-2013-f3195rep · 2013 · External reference
Wound healing involves induction of cyclooxygenase-2 expression in rat skin
10.1097/01.lab.0000035024.75914.39 · 2002 · External reference
Cyclooxygenase-2 mediates hydrogen peroxide-induced wound repair in human endothelial cells
10.1016/j.freeradbiomed.2009.02.026 · 2009 · External reference
Do NSAIDs really interfere with healing after surgery?
10.3390/jcm10112359 · 2021 · External reference
Nonsteroidal anti-inflammatory drugs and risk of gastrointestinal bleeding: a systematic review and meta-analysis
10.1002/cpt.70054 · 2026 · External reference
Nonsteroidal anti-inflammatory drugs: adverse effects and their prevention
10.1016/j.semarthrit.2008.08.001 · 2010 · External reference
Celecoxib to improve scar quality following acute burn injury: lessons learned after premature termination of a randomised trial
10.1016/j.burnso.2024.03.001 · 2024 · External reference
Parecoxib sodium attenuates acute lung injury following burns by regulating M1/M2 macrophage polarization through the TLR4/NF-κB pathway
10.1016/j.ejphar.2024.176407 · 2024 · External reference
Effect of celecoxib in treatment of burn-induced hypermetabolism
10.1042/bsr20191607 · 2020 · External reference
Nonsteroidal anti-inflammatory drugs may affect cytokine response and benefit healing of combat-related extremity wounds
10.1016/j.surg.2016.10.011 · 2017 · External reference
Monocyte M1/M2 profile is altered in paediatric burn patients with hypertrophic scarring
10.1111/wrr.12960 · 2021 · External reference
Pain management for pediatric burns in the outpatient setting: a changing paradigm?
10.1093/jbcr/iraa049 · 2020 · External reference
Pharmacologic management of acute pain in children: a systematic review and network meta-analysis
10.1001/jamapediatrics.2024.5920 · 2025 · External reference
An assessment of the safety of pediatric ibuprofen. A practitioner-based randomized clinical trial
10.1001/jama.1995.03520360043037 · 1995 · External reference
Safety profile of ibuprofen suspension in young children
10.1007/s10787-999-0005-0 · 1999 · External reference
Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials
10.1016/s0140-6736(13)60900-9 · 2013 · External reference
Consensus about managing gastrointestinal and cardiovascular risks of nonsteroidal anti-inflammatory drugs?
10.1186/s12916-015-0291-x · 2015 · External reference
Effect of ibuprofen on the inflammatory response to surgical wounds
10.1097/00005373-199309000-00002 · 1993 · External reference
The effects of non-steroidal anti-inflammatory drug application on incisional wound healing in rats
10.12968/jowc.2007.16.2.27001 · 2007 · External reference
Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing
10.1038/70995 · 1999 · External reference
Medications affecting healing: an evidence-based analysis
10.1111/iwj.12809 · 2017 · External reference
Nonsteroidal anti-inflammatory drugs decrease coagulopathy incidence in severe burn patients
10.3390/ebj5020009 · 2024 · External reference
Methylprednisolone and ketorolac rapidly reduce hyperalgesia around a skin burn injury and increase pressure pain thresholds
10.1111/j.1399-6576.2007.01415.x · 2007 · External reference
Inhibition of wound TGF beta-1 by celecoxib: a possible therapeutic route for scar free wound
2017 · External reference
Cox-2 inhibition potentiates mouse bone marrow stem cell engraftment and differentiation-mediated wound repair
10.1016/j.jcyt.2017.03.072 · 2017 · External reference
Examination of the effects of celecoxib on postmastectomy seroma and wound healing
2018 · External reference
Protective effects of ibuprofen against caustic esophageal burn injury in rats
10.1007/s00383-010-2618-1 · 2010 · External reference
Reduction of scar formation in full-thickness wounds with topical celecoxib treatment
2003 · External reference
Celecoxib inhibits skin fibrosis via suppressing adipocyte progenitor–myofibroblast transdifferentiation by attenuating the YAP/TAZ signaling pathway
10.1016/j.lfs.2025.123914 · 2025 · External reference
Topical application of anti-inflammatory agents on burn wounds and their effect on healing
10.1016/j.burns.2024.107290 · 2024 · External reference
Subcutaneous anti-inflammatory therapies to prevent burn progression in a swine model of contact burn injury
10.1093/milmed/usad476 · 2024 · External reference
The role of COX-2 and PGE2 in the regulation of immunomodulation and other functions of mesenchymal stromal cells
10.3390/biomedicines11020445 · 2023 · External reference
The effects of non-steroid anti-inflammatory drugs on leukocyte migration in carrageenin-induced inflammation
10.1016/0014-2999(80)90297-6 · 1980 · External reference
Ibuprofen inhibits leukocyte migration through endothelial cell monolayers
10.1016/s0024-3205(98)00139-8 · 1998 · External reference
Non-steroidal anti-inflammatory drugs inhibit the expression of cytokines and induce hsp70 in human monocytes
10.1006/cyto.1998.0437 · 1999 · External reference
Neutrophil-to-lymphocyte ratio as a predictor of short- and long-term complications in pediatric burns
10.1186/s13052-024-01834-3 · 2025 · External reference
Admission neutrophil-to-lymphocyte ratio to predict mortality in burn patients: a meta-analysis
10.1186/s40635-024-00668-x · 2024 · External reference
Effects of non-steroidal anti-inflammatory drugs on human neutrophil nadph oxidase in both whole cell and cell-free systems
10.1016/0006-2952(90)90556-z · 1990 · External reference
The role of macrophage subtypes and exosomes in immunomodulation
10.1186/s11658-022-00384-y · 2022 · External reference
A review of monocytes and monocyte-derived cells in hypertrophic scarring post burn
10.1097/bcr.0000000000000312 · 2016 · External reference
Innate immune system response to burn damage—focus on cytokine alteration
10.3390/ijms23020716 · 2022 · External reference
NSAIDs affect dendritic cell cytokine production
10.1371/journal.pone.0275906 · 2022 · External reference
Systematic study of constitutive cyclooxygenase-2 expression: role of NF-κB and NFAT transcriptional pathways
10.1073/pnas.1517642113 · 2016 · External reference
Heterotopic ossification: basic-science principles and clinical correlates
10.2106/jbjs.n.01056 · 2015 · External reference
Two new risk factors for heterotopic ossification development after severe burns
10.1371/journal.pone.0182303 · 2017 · External reference
Utility of a human–mouse xenograft model and in vivo near-infrared fluorescent imaging for studying wound healing
10.1111/iwj.12205 · 2015 · External reference
Nonsteroidal anti-inflammatory drugs in the perioperative period: current controversies and concerns
10.1016/j.bja.2024.10.018 · 2025 · External reference
Short-term use of nonsteroidal anti-inflammatory drugs and adverse effects An updated systematic review
10.1016/j.adaj.2015.07.020 · 2016 · External reference
High-dose celecoxib for pain after pediatric tonsillectomy: a randomized controlled trial
10.1177/01945998221091695 · 2023 · External reference
Celecoxib pharmacogenetics and pediatric adenotonsillectomy: a double-blinded randomized controlled study
10.1007/s12630-015-0376-1 · 2015 · External reference
Dosing celecoxib in pediatric patients with juvenile rheumatoid arthritis
10.1177/0091270011412184 · 2012 · External reference
Nanostructured lipid carriers: a groundbreaking approach for transdermal drug delivery
10.34172/apb.2020.021 · 2020 · External reference
Formulation of repurposed celecoxib-loaded nanostructured lipid carriers using Box-Behnken design, its characterization, and anticancer evaluation
10.1016/j.pharma.2025.03.005 · 2025 · External reference
