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References from Fibroblast phenotypic plasticity: molecular mechanisms, context-dependent regulation, and clinical translation challenges— A comprehensive review. Local targets link to admitted publications; unresolved targets remain external evidence.
The myofibroblast: paradigm for a mechanically active cell
10.1016/j.jbiomech.2009.09.020 · 2010 · External reference
The role of myofibroblasts in physiological and pathological tissue repair
10.1101/cshperspect.a041231 · 2023 · External reference
Human wound repair
1968 · External reference
Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination
10.1038/s41467-020-17740-1 · 2020 · External reference
Presence of modified fibroblasts in granulation tissue and their possible role in wound contraction
10.1007/bf02147594 · 1971 · External reference
Cross-tissue organization of the fibroblast lineage
10.1038/s41586-021-03549-5 · 2021 · External reference
Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
10.1038/s41586-018-0590-4 · 2018 · External reference
Mapping the mouse cell atlas by microwell-seq
10.1016/j.cell.2018.02.001 · 2018 · External reference
Skin cell heterogeneity in development, wound healing, and cancer
10.1016/j.tcb.2018.05.002 · 2018 · External reference
Characterizing fibroblast heterogeneity in diabetic wounds through single-cell RNA-sequencing
10.3390/biomedicines12112538 · 2024 · External reference
Single-cell RNA-seq reveals the transcriptional landscape and heterogeneity of aortic macrophages in murine atherosclerosis
10.1161/circresaha.117.312509 · 2018 · External reference
Fibroblast heterogeneity and tertiary lymphoid tissues in the kidney
10.1111/imr.12969 · 2021 · External reference
Tissue stiffness dictates development, homeostasis, and disease progression
10.1080/15476278.2015.1019687 · 2015 · External reference
Fibrotic disease and the T(H)1/T(H)2 paradigm
10.1038/nri1412 · 2004 · External reference
Fibrosis—a common pathway to organ injury and failure
10.1056/nejmra1300575 · 2015 · External reference
A framework for advancing our understanding of cancer-associated fibroblasts
10.1038/s41568-019-0238-1 · 2020 · External reference
Mechanobiology of non-small cell lung cancer: bridging tumor mechanics and therapeutic strategies
10.1007/s11033-026-11852-5 · 2026 · External reference
The cell biology of ferroptosis
10.1038/s41580-024-00703-5 · 2024 · External reference
Origin and function of myofibroblasts in kidney fibrosis
10.1038/nm.3218 · 2013 · External reference
Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation
10.1016/j.ccell.2024.08.020 · 2024 · External reference
Skin fibrosis. Identification and isolation of a dermal lineage with intrinsic fibrogenic potential
10.1126/science.aaa2151 · 2015 · External reference
Fibrosis—a common pathway to organ injury and failure
10.1056/nejmc1504848 · 2015 · External reference
Pericytes: developmental, physiological, and pathological perspectives, problems, and promises
10.1016/j.devcel.2011.07.001 · 2011 · External reference
Identification, discrimination and heterogeneity of fibroblasts
10.1038/s41467-022-30633-9 · 2022 · External reference
Signaling role of pericytes in vascular health and tissue homeostasis
10.3390/ijms25126592 · 2024 · External reference
Mesenchymal stem cells: revisiting history, concepts, and assays
10.1016/j.stem.2008.03.002 · 2008 · External reference
Fibrocytes are associated with the fibrosis of coronary heart disease
10.1016/j.prp.2012.09.012 · 2013 · External reference
Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts
10.1083/jcb.122.1.103 · 1993 · External reference
Formation and function of the myofibroblast during tissue repair
10.1038/sj.jid.5700613 · 2007 · External reference
Fibroblast-macrophage reciprocal interactions in health, fibrosis, and cancer
10.1016/j.immuni.2021.04.021 · 2021 · External reference
Epigenetic regulation of wound healing and fibrosis
10.1097/bor.0b013e32835b13e1 · 2013 · External reference
Diversity, topographic differentiation, and positional memory in human fibroblasts
10.1073/pnas.162488599 · 2002 · External reference
Distinct and complementary roles of papillary and reticular fibroblasts in skin morphogenesis and homeostasis
10.1684/ejd.2012.1693 · 2012 · External reference
Identification of a physiologic vasculogenic fibroblast state to achieve tissue repair
10.1038/s41467-023-36665-z · 2023 · External reference
Single-cell analysis reveals fibroblast heterogeneity and myeloid-derived adipocyte progenitors in murine skin wounds
10.1038/s41467-018-08247-x · 2019 · External reference
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
10.1084/jem.20162024 · 2017 · External reference
Single-cell analysis reveals fibroblast clusters linked to immunotherapy resistance in cancer
10.1158/2159-8290.cd-19-1384 · 2020 · External reference
CD34+ PI16+ fibroblast progenitors aggravate neointimal lesions of allograft arteries via CCL11/CCR3-PI3K/AKT pathway
10.7150/thno.104650 · 2025 · External reference
TGFβ signalling in context
10.1038/nrm3434 · 2012 · External reference
Redox mechanisms driving skin fibroblast-to-myofibroblast differentiation
10.3390/antiox14040486 · 2025 · External reference
Regulation of wound healing by growth factors and cytokines
10.1152/physrev.2003.83.3.835 · 2003 · External reference
Role of platelet-derived growth factors in physiology and medicine
10.1101/gad.1653708 · 2008 · External reference
Keratinocyte autophagy enables the activation of keratinocytes and fibroblastsand facilitates wound healing
10.1080/15548627.2020.1816342 · 2021 · External reference
Distinct fibroblast subsets drive inflammation and damage in arthritis
10.1038/s41586-019-1263-7 · 2019 · External reference
Highlights of strategies targeting fibroblasts for novel therapies for rheumatoid arthritis
10.3389/fmed.2022.846300 · 2022 · External reference
Balancing forces: architectural control of mechanotransduction
10.1038/nrm3112 · 2011 · External reference
Tension anisotropy drives fibroblast phenotypic transition by self-reinforcing cell-extracellular matrix mechanical feedback
10.1038/s41563-025-02162-5 · 2025 · External reference
Expression of integrin β1 by fibroblasts is required for tissue repair in vivo
10.1242/jcs.070672 · 2010 · External reference
Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation
10.1016/s0002-9440(10)61776-2 · 2001 · External reference
Organ fibrosis: beyond collagen I expression. Fibroblast phenotype and basement membrane proteins
10.1152/ajpcell.00077.2025 · 2025 · External reference
Mechanical memory and dosing influence stem cell fate
10.1038/nmat3889 · 2014 · External reference
Hypoxia-induced epigenetic modifications are associated with cardiac tissue fibrosis and the development of a myofibroblast-like phenotype
10.1093/hmg/ddt614 · 2014 · External reference
Pathological integrin signaling enhances proliferation of primary lung fibroblasts from patients with idiopathic pulmonary fibrosis
10.1084/jem.20080001 · 2008 · External reference
miR-338-3p blocks TGFβ-induced myofibroblast differentiation through the induction of PTEN
10.1152/ajplung.00251.2021 · 2022 · External reference
Epigenetic regulation of TGF-β-induced EMT by JMJD3/KDM6B histone H3K27 demethylase
10.1038/s41389-021-00307-0 · 2021 · External reference
Histone H3K27 methyltransferase EZH2 and demethylase JMJD3 regulate hepatic stellate cells activation and liver fibrosis
10.7150/thno.46360 · 2021 · External reference
Let-7d microRNA affects mesenchymal phenotypic properties of lung fibroblasts
10.1152/ajplung.00149.2013 · 2014 · External reference
Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis
10.1073/pnas.0805038105 · 2008 · External reference
miR-29 is a major regulator of genes associated with pulmonary fibrosis
10.1165/rcmb.2010-0323oc · 2011 · External reference
Fibroblast lipid metabolism through ACSL4 regulates epithelial sensitivity to ferroptosis in IBD
10.1038/s42255-025-01313-x · 2025 · External reference
The myofibroblast in pulmonary fibrosis
10.1378/chest.122.6_suppl.286s · 2002 · External reference
The role of fibroblasts in melanoma development: from tumor microenvironment remodeling to pre-metastatic niche formation
10.3390/ijms26136132 · 2025 · External reference
Structural remodeling of the human colonic mesenchyme in inflammatory bowel disease
10.1016/j.cell.2018.08.067 · 2018 · External reference
The role of the dynamic lung extracellular matrix environment on fibroblast morphology and inflammation
10.3390/cells11020185 · 2022 · External reference
Cell confinement by micropatterning induces phenotypic changes in cancer-associated fibroblasts
10.1016/j.actbio.2024.12.007 · 2025 · External reference
Fibroblasts and macrophages: collaborators in tissue homeostasis
10.1111/imr.12989 · 2021 · External reference
Protective and pathogenic functions of macrophage subsets
10.1038/nri3073 · 2011 · External reference
Pulmonary fibrosis: patterns and perpetrators
10.1172/jci60323 · 2012 · External reference
