Research graph
References from Proteotoxic stress in stem cell therapies: The overlooked roles of senescence, EV cargo, and SOD1. Local targets link to admitted publications; unresolved targets remain external evidence.
Pluripotent stem-cell-derived therapies in clinical trial: A 2025 update
10.1016/j.stem.2024.12.005 · 2025 · External reference
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GMP-compliant manufacturing of iPSC-derived therapeutic cell products: Technologies, applications, risks and limitations
10.1016/j.addr.2025.115744 · 2026 · External reference
Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
10.3389/fcell.2021.645593 · 2021 · External reference
Identification of critical process parameters and quality attributes for bioreactor-based expansion of human MSCs
10.3389/fbioe.2025.1608194 · 2025 · External reference
Loss of regulation of protein synthesis and turnover underpins an attenuated stress response in senescent human mesenchymal stem cells
10.1073/pnas.2210745120 · 2023 · External reference
CRISPR-Cas9 screens reveal regulators of ageing in neural stem cells
10.1038/s41586-024-07972-2 · 2024 · External reference
Oxidized SOD1 accelerates cellular senescence in neural stem cells
10.1186/s13287-024-03669-5 · 2024 · External reference
Mesenchymal stromal cell-derived extracellular vesicles in regenerative medicine: Standardisation, bioengineering and clinical translation
2025 · External reference
Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
10.1038/nbt.1807 · 2011 · External reference
Extracellular vesicles production and proteomic cargo varies with incubation time and temperature
10.1016/j.yexcr.2022.113454 · 2023 · External reference
Surfaceome analysis of extracellular vesicles from senescent cells uncovers uptake repressor DPP4
10.1073/pnas.2219801120 · 2023 · External reference
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
10.1002/jev2.12404 · 2024 · External reference
MISEV and MIQE: integrating domain-specific and general standards to strengthen extracellular vesicle biomarker research
10.20517/evcna.2025.68 · 2025 · External reference
TDP-43 is intercellularly transmitted across axon terminals
10.1083/jcb.201504057 · 2015 · External reference
α-Synuclein in Extracellular Vesicles: Functional Implications and Diagnostic Opportunities
10.1007/s10571-015-0317-0 · 2016 · External reference
CNS-derived extracellular vesicles from superoxide dismutase 1 (SOD1)G93A ALS mice originate from astrocytes and neurons and carry misfolded SOD1
10.1074/jbc.ra118.004825 · 2019 · External reference
A Metal-Free, Disulfide Oxidized Form of Superoxide Dismutase 1 as a Primary Misfolded Species with Prion-Like Properties in the Extracellular Environments Surrounding Motor Neuron-Like Cells
10.3390/ijms22084155 · 2021 · External reference
Novel extracellular vesicle release pathway facilitated by toxic superoxide dismutase 1 oligomers
10.1016/j.nbd.2026.107309 · 2026 · External reference
Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS
10.1038/nn.2660 · 2010 · External reference
ALS-linked SOD1 mutations impair mitochondrial-derived vesicle formation and accelerate aging
10.1016/j.redox.2023.102972 · 2024 · External reference
Extracellular vesicles as tools and targets in therapy for diseases
10.1038/s41392-024-01735-1 · 2024 · External reference
A milestone for the therapeutic EV field: FDA approves Ryoncil, an allogeneic bone marrow-derived mesenchymal stromal cell therapy
10.20517/evcna.2025.02 · 2025 · External reference
A Novel Conductive Polypyrrole-Chitosan Hydrogel Containing Human Endometrial Mesenchymal Stem Cell-Derived Exosomes Facilitated Sustained Release for Cardiac Repair
2024 · External reference
Advances in Regenerative Medicine and Tissue Engineering: Innovation and Transformation of Medicine
10.1155/2018/2495848 · 2018 · External reference
Cellular senescence: the good, the bad and the unknown
10.1038/s41581-022-00601-z · 2022 · External reference
Intranasal administration of human mesenchymal stromal cell-derived small extracellular vesicles delays disease progression in the SOD1(G93A) mouse model
10.1186/s13041-026-01288-0 · 2026 · External reference
Case Report: Amyotrophic Lateral Sclerosis Treatment with Extracellular Vesicles derived from Mesenchymal Stromal Cells
10.18103/mra.v13i9.6930 · 2025 · External reference
Advancements and Innovative Strategies in Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cell Therapy: A Comprehensive Review
10.1155/2024/4073485 · 2024 · External reference
Wharton's jelly-derived mesenchymal stem cells: phenotypic characterization and optimizing their therapeutic potential for clinical applications
10.3390/ijms140611692 · 2013 · External reference
Rapid and Live-Cell Detection of Senescence in Mesenchymal Stem Cells by Micro Magnetic Resonance Relaxometry
10.1093/stcltm/szad014 · 2023 · External reference
Analysis and Characterization of the Extracellular Vesicles Released in Non-Cancer Diseases Using Matrix-Assisted Laser Desorption Ionization/Mass Spectrometry
10.3390/ijms25084490 · 2024 · External reference
Intercellular propagated misfolding of wild-type Cu/Zn superoxide dismutase occurs via exosome-dependent and -independent mechanisms
10.1073/pnas.1312245111 · 2014 · External reference
Intracerebroventricular infusion of monoclonal antibody or its derived Fab fragment against misfolded forms of SOD1 mutant delays mortality in a mouse model of ALS
10.1111/j.1471-4159.2010.06683.x · 2010 · External reference
Proteotoxic stress response drives T cell exhaustion and immune evasion
10.1038/s41586-025-09539-1 · 2025 · External reference
Selective removal of misfolded SOD1 delays disease onset in a mouse model of amyotrophic lateral sclerosis
10.1007/s00018-023-04956-9 · 2023 · External reference
