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References from Stem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies. Local targets link to admitted publications; unresolved targets remain external evidence.
10.1016/s0140-6736(24)00757-8
10.1016/s0140-6736(24)00757-8 · 2024 · External reference
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Global, regional, and national burden of osteoarthritis, 1990-2020 and projections to 2050: a systematic analysis for the global burden of disease study 2021
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Fragility fractures in Europe: burden, management and opportunities
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Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement
10.1080/14653240600855905 · 2006 · External reference
Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
10.1016/j.cell.2007.08.025 · 2007 · External reference
Identification and specification of the mouse skeletal stem cell
10.1016/j.cell.2014.12.002 · 2015 · External reference
Gremlin 1 identifies a skeletal stem cell with bone, cartilage, and reticular stromal potential
10.1016/j.cell.2014.11.042 · 2015 · External reference
Discovery of a periosteal stem cell mediating intramembranous bone formation
10.1038/s41586-018-0554-8 · 2018 · External reference
Resting zone of the growth plate houses a unique class of skeletal stem cells
10.1038/s41586-018-0662-5 · 2018 · External reference
A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia
10.1016/j.cell.2019.04.040 · 2019 · External reference
The bone marrow microenvironment at single-cell resolution
10.1038/s41586-019-1104-8 · 2019 · External reference
Combined single-cell and spatial transcriptomics reveal the molecular, cellular and spatial bone marrow niche organization
10.1038/s41556-019-0439-6 · 2020 · External reference
Mapping distinct bone marrow niche populations and their differentiation paths
10.1016/j.celrep.2019.06.031 · 2019 · External reference
Aged skeletal stem cells generate an inflammatory degenerative niche
10.1038/s41586-021-03795-7 · 2021 · External reference
Age-related changes in human bone marrow mesenchymal stem cells: morphology, molecular features and functional properties
2023 · External reference
Mesenchymal stem versus stromal cells: International society for cell & gene therapy (ISCT) mesenchymal stromal cell committee position statement on nomenclature
10.1016/j.jcyt.2019.08.002 · 2019 · External reference
Identification of the human skeletal stem cell
10.1016/j.cell.2018.07.029 · 2018 · External reference
Premature aging of skeletal stem/progenitor cells rather than osteoblasts causes bone loss with decreased mechanosensation
10.1038/s41413-023-00269-6 · 2023 · External reference
Senescence of skeletal stem cells and their contribution to age-related bone loss
2024 · External reference
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age
10.1073/pnas.1116110108 · 2011 · External reference
Single-cell RNA sequencing reveals molecular and functional platelet bias of aged hematopoietic stem cells
10.1038/ncomms11075 · 2016 · External reference
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan
10.1038/nature16932 · 2016 · External reference
Senolytics improve physical function and increase lifespan in old age
10.1038/s41591-018-0092-9 · 2018 · External reference
Targeting cellular senescence prevents age-related bone loss in mice
10.1038/nm.4385 · 2017 · External reference
Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment
10.1038/nm.4324 · 2017 · External reference
Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline
10.1038/s41586-018-0543-y · 2018 · External reference
Mitochondrial metabolic failure in telomere attrition-provoked aging of bone marrow mesenchymal stem cells
10.1007/s10522-015-9609-5 · 2016 · External reference
MicroRNA-183-5p increases with age in bone-derived extracellular vesicles, suppresses bone marrow stromal cell proliferation, and induces stem cell senescence
10.1089/ten.tea.2016.0525 · 2017 · External reference
Aged bone matrix-derived extracellular vesicles as a messenger for calcification paradox
10.1038/s41467-022-29191-x · 2022 · External reference
S-sulfhydration of SIRT3 combats BMSC senescence and alleviates age-related osteoporosis
2023 · External reference
miR-203-3p promotes senescence of mouse bone marrow mesenchymal stem cells via downregulation of Pbk
10.1111/acel.14293 · 2024 · External reference
NAP1L2 drives mesenchymal stem cell senescence and suppresses osteogenic differentiation
10.1111/acel.13551 · 2022 · External reference
Autophagy receptor OPTN regulates mesenchymal stem cell senescence and bone-fat imbalance during aging by clearing FABP3
10.1080/15548627.2020.1839286 · 2021 · External reference
Cadmium exposure induces osteoporosis through cellular senescence, associated with activation of NF-kappaB pathway and mitochondrial dysfunction
10.1016/j.envpol.2021.118043 · 2021 · External reference
Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cells and promotes bone defect healing
10.1186/s13287-020-01704-9 · 2020 · External reference
The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence
10.1111/acel.12756 · 2018 · External reference
Surface topography regulates osteogenic differentiation of MSCs via crosstalk between FAK/MAPK and ILK/beta-catenin pathways in a hierarchically porous environment
10.1021/acsbiomaterials.7b00315 · 2017 · External reference
Integrin-linked kinase controls dental pulp stem cell senescence via the mTOR signaling pathway
10.1093/stmcls/sxae047 · 2024 · External reference
Activation of BMP4/SMAD pathway by HIF-1alpha in hypoxic environment promotes osteogenic differentiation of BMSCs and leads to ectopic bone formation
10.1016/j.tice.2024.102376 · 2024 · External reference
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
10.1038/s41580-020-00314-w · 2021 · External reference
Hallmarks of aging: an expanding universe
10.1016/j.cell.2022.11.001 · 2023 · External reference
A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues
10.1038/s41467-022-32552-1 · 2022 · External reference
Hallmarks of stem cell aging
10.1016/j.stem.2025.06.004 · 2025 · External reference
Multi-omics analysis of bone marrow mesenchymal stem cell differentiation differences in osteoporosis
10.1016/j.ygeno.2023.110668 · 2023 · External reference
A novel molecular regulatory network in bone marrow mesenchymal stem cells for age-related osteoporosis
10.1111/cen.15239 · 2025 · External reference
Multiomic identification of senescent stem cell populations critical for osteoarthritis progression and therapy in subchondral bones
2025 · External reference
Curcumin controls the senescence of adipose-derived mesenchymal stem cells via the FoxO3/autophagy signaling pathway to enhance joint repair
2025 · External reference
Embryonic stem cell-derived small extracellular vesicles alleviate non-early-stage osteoarthritis by reducing senescence and cartilage destruction
2024 · External reference
MSC-EVs alleviate osteoarthritis by regulating microenvironmental cells in the articular cavity and maintaining cartilage matrix homeostasis
2023 · External reference
Dual-engineered cartilage-targeting extracellular vesicles ameliorate osteoarthritis by promoting cartilage repair
2023 · External reference
Anti-aging effect of extracellular vesicles from mesenchymal stromal cells on senescence-induced chondrocytes in osteoarthritis
2024 · External reference
Alleviating osteoarthritis-induced damage through extracellular vesicles derived from inflammatory chondrocytes
10.1016/j.intimp.2024.113829 · 2025 · External reference
Human umbilical cord mesenchymal stem cells for treating osteoarthritis in a rabbit model: injection strategies
10.1016/j.heliyon.2024.e38384 · 2024 · External reference
Enhanced cartilage regeneration by icariin and mesenchymal stem cell-derived extracellular vesicles in osteoarthritis
10.1186/s12951-024-02317-7 · 2024 · External reference
Membrane-free stem cell components inhibit interleukin-1alpha-stimulated inflammation and cartilage degradation in vitro and in vivo: a rat model of osteoarthritis
10.3390/ijms20194869 · 2019 · External reference
Small extracellular vesicles from human adipose-derived stem cells attenuate cartilage degeneration
2020 · External reference
Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis
10.1038/s41598-017-15376-8 · 2017 · External reference
Exosomes derived from human embryonic mesenchymal stem cells promote osteochondral regeneration
10.1016/j.joca.2016.06.022 · 2016 · External reference
Single-cell transcriptomic analysis identifies senescence-associated stromal and immune niches in osteoarthritic synovium
2024 · External reference
Nucleus pulposus mesenchymal stem cells in acidic conditions mimicking degenerative intervertebral discs give better performance than adipose tissue-derived mesenchymal stem cells
10.1159/000369452 · 2014 · External reference
Intervertebral disc-derived stem/progenitor cells as a promising cell source for intervertebral disc regeneration
10.1155/2018/7412304 · 2018 · External reference
Mesenchymal stem cells may alleviate intervertebral disc degeneration by reducing oxidative stress and restoring autophagy
2022 · External reference
M1 macrophage-derived exosomes promote intervertebral disc degeneration by enhancing nucleus pulposus cell senescence through LCN2/NF-kappaB signaling
10.1186/s12951-024-02556-8 · 2024 · External reference
TMT-based proteomics analysis of senescent nucleus pulposus tissue in intervertebral disc degeneration
2023 · External reference
Intervertebral disc human nucleus pulposus cells associated with back pain and disc degeneration: single-cell transcriptomic and functional analysis
2023 · External reference
ISSLS prize in basic science 2024: superiority of nucleus pulposus cell-derived extracellular vesicles for intervertebral disc regeneration
10.1007/s00586-024-08163-3 · 2024 · External reference
Rejuvenation modulation of nucleus pulposus progenitor cells restores regenerative capacity in intervertebral disc degeneration
2025 · External reference
Hypoxia effects in intervertebral disc-derived stem cells and disc secretomes: an in vitro study
2022 · External reference
CD137 regulates bone loss via the p53 Wnt/beta-catenin signaling pathway in aged mice
2022 · External reference
MicroRNA-31a-5p from aging bone marrow mesenchymal stem cells promotes osteoclastic differentiation and bone resorption
10.1111/acel.12794 · 2018 · External reference
Long noncoding RNA Bmncr regulates mesenchymal stem cell fate during skeletal aging
10.1172/jci99044 · 2018 · External reference
Conditioned medium of human mesenchymal stem cells affects stem cell senescence in osteoporosis
10.1016/j.bbrc.2024.149858 · 2024 · External reference
Melatonin enhances osteoblastogenesis of senescent bone marrow mesenchymal stem cells through autophagy and mitochondrial regulation
2022 · External reference
Icariin has the potential to induce the differentiation of bone marrow mesenchymal stem cells into brown fat cells via PDE5A inhibition
10.1016/j.heliyon.2023.e22487 · 2023 · External reference
Dimethyloxaloylglycine-stimulated human bone marrow mesenchymal stem cell-derived exosomes enhance bone regeneration through angiogenesis by targeting the AKT/mTOR pathway
10.1186/s13287-019-1410-y · 2019 · External reference
Harnessing engineered exosomes as METTL3 carriers: enhancing osteogenesis and suppressing lipogenesis in bone marrow mesenchymal stem cells for postmenopausal osteoporosis treatment
2025 · External reference
Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice
10.1038/s41536-021-00145-z · 2021 · External reference
Bone-targeted delivery of senolytics to eliminate senescent cells increases bone formation in senile osteoporosis
10.1016/j.actbio.2022.11.056 · 2023 · External reference
Mechanical rejuvenation of senescent stem cells and aged bone via chromatin remodeling
10.1038/s41467-026-68387-3 · 2026 · External reference
Rejuvenation of BMSC senescence by pharmacological enhancement of TFEB-mediated autophagy alleviates age-related bone loss and extends lifespan in middle-aged mice
10.1038/s41413-024-00351-7 · 2024 · External reference
Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: a proof-of-concept clinical trial
10.1002/stem.1634 · 2014 · External reference
Intra-articular injection of two different doses of autologous bone marrow mesenchymal stem cells in knee osteoarthritis: a randomized controlled clinical trial
10.1186/s12967-016-0998-2 · 2016 · External reference
Adipose-derived mesenchymal stem cell therapy in the treatment of knee osteoarthritis: a randomized controlled trial
10.2217/rme-2018-0161 · 2019 · External reference
Umbilical cord-derived mesenchymal stromal cells in knee osteoarthritis: a phase I/II randomized controlled trial
10.1002/sctm.18-0053 · 2019 · External reference
Single-cell sequencing reveals a senescent immune landscape in bone marrow lesions inducing articular cartilage damage in osteoarthritis
10.1038/s41413-025-00467-4 · 2025 · External reference
Senescent bone marrow mesenchymal stem cells exacerbate subchondral bone sclerosis and osteoarthritis via the senescence-associated secretory phenotype
10.1186/s13287-025-04833-1 · 2025 · External reference
Cross-talk of inflammation and cellular senescence: a new insight into the occurrence and progression of osteoarthritis
10.1038/s41413-024-00375-z · 2024 · External reference
Aging and the emerging role of cellular senescence in osteoarthritis
10.1016/j.joca.2023.11.018 · 2024 · External reference
Umbilical cord mesenchymal stem cells for regenerative treatment of intervertebral disc degeneration
10.3389/fcell.2023.1215698 · 2023 · External reference
Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study
10.1097/tp.0b013e3182298a15 · 2011 · External reference
Intervertebral disc repair by allogeneic mesenchymal bone marrow cells: a randomized controlled trial
10.1097/tp.0000000000001484 · 2017 · External reference
Fibroblast growth factor-2 ameliorates tumor necrosis factor-alpha-induced osteogenic damage of human bone mesenchymal stem cells by improving oxidative phosphorylation
10.1016/j.mcp.2020.101538 · 2020 · External reference
Degenerative nucleus pulposus cells-derived exosomes induce apoptosis of cartilage endplate cells and aggravate intervertebral disc degeneration
10.3389/fmolb.2022.835976 · 2022 · External reference
Molecular mechanism of macrophage polarization regulating the cell senescence of nucleus pulposus during intervertebral disc degeneration
10.1016/j.intimp.2025.114131 · 2025 · External reference
Human iPSCs derived MSCs-secreted exosomes modulate senescent nucleus pulposus cells induced macrophage polarization via metabolic reprogramming to mitigate intervertebral disc degeneration
10.1002/advs.202504347 · 2025 · External reference
Biomaterials targeting senescent cells for bone regeneration: state-of-the-art and future perspectives
2025 · External reference
Functionality of decellularized matrix in cartilage regeneration: a comparison of tissue versus cell sources
10.1016/j.actbio.2018.04.048 · 2018 · External reference
A protocol to prepare decellularized stem cell matrix for rejuvenation of cell expansion and cartilage regeneration
10.1007/7651_2017_27 · 2018 · External reference
Nanomorphological and mechanical reconstruction of mesenchymal stem cells during early apoptosis detected by atomic force microscopy
2020 · External reference
Physiological mechanical loading is crucial for chondrogenesis and cartilage formation by human synovium-derived stem cells stimulated by kartogenin
10.1021/acsbiomaterials.5c00877 · 2026 · External reference
Effect of low-intensity pulsed ultrasound on osteogenic human mesenchymal stem cell commitment in a new bone scaffold
2017 · External reference
Mesenchymal stem cell-derived exosomes and intervertebral disc regeneration
10.3390/ijms23137306 · 2022 · External reference
Immunoregulatory orchestrations in osteoarthritis and mesenchymal stromal cells for therapy
10.1016/j.jot.2025.08.009 · 2025 · External reference
The Achilles' heel of senescent cells: from transcriptome to senolytic drugs
10.1111/acel.12344 · 2015 · External reference
Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
10.1038/nm.4010 · 2016 · External reference
Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL
10.1038/ncomms11190 · 2016 · External reference
Identification of HSP90 inhibitors as a novel class of senolytics
10.1038/s41467-017-00314-z · 2017 · External reference
Regulation of osteogenic and chondrogenic differentiation of tendon-derived stem cells for tendon-bone healing
10.1111/os.14152 · 2024 · External reference
HIF-1alpha-enhanced bone marrow mesenchymal stem cells improve mitochondrial function and repair capacity in glucocorticoid-induced osteonecrosis
2022 · External reference
Engineered extracellular vesicles carrying METTL3 promote osteochondral regeneration through epitranscriptomic regulation
2025 · External reference
Scalable production of human mesenchymal stromal cell-derived extracellular vesicles under serum-/xeno-free conditions in a microcarrier-based bioreactor culture system
10.3389/fcell.2020.553444 · 2020 · External reference
Exosomes: large-scale production, isolation, drug loading efficiency, and biodistribution and uptake
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Extracellular vesicles derived from human embryonic stem cell-derived MSCs ameliorate hepatic fibrosis in a mouse model
10.1002/jcp.26413 · 2018 · External reference
Stem cell aging and gene-based rejuvenation: opportunities and safety challenges
10.1007/5584_2021_624 · 2021 · External reference
Biomarker-guided imaging and AI-augmented diagnosis of degenerative joint disease
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Profiling joint tissues at single-cell resolution: advances and insights
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Organoid and organ-on-chip models for skeletal tissue degeneration and regeneration
2023 · External reference
Intelligent manufacturing for osteoarthritis organoids
10.1111/cpr.70043 · 2025 · External reference
Challenges and future perspectives in using mesenchymal stem cells for efficient bone fracture healing
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