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References from Pilot study of Wilms tumor 1-targeted human platelet lysate-induced antigen-presenting cells in advanced solid cancer patients. Local targets link to admitted publications; unresolved targets remain external evidence.
T-cell proliferation involving the CD28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression
1987 · External reference
CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells
10.4049/jimmunol.147.8.2461 · 1991 · External reference
Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen
10.4049/jimmunol.153.5.1990 · 1994 · External reference
Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin
10.4049/jimmunol.168.7.3484 · 2002 · External reference
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack
10.1182/blood-2012-07-446146 · 2013 · External reference
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
10.1056/nejmoa1001294 · 2010 · External reference
Efficacy and safety of autologous dendritic cell-based immunotherapy, docetaxel, and prednisone vs placebo in patients with metastatic castration-resistant prostate cancer: the VIABLE phase 3 randomized clinical trial
10.1001/jamaoncol.2021.7298 · 2022 · External reference
Research progress on dendritic cell vaccines in cancer immunotherapy
10.1186/s40164-022-00257-2 · 2022 · External reference
Association of autologous tumor lysate-loaded dendritic cell vaccination with extension of survival among patients with newly diagnosed and recurrent glioblastoma: a phase 3 prospective externally controlled cohort trial
10.1001/jamaoncol.2022.5370 · 2023 · External reference
Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes
10.1182/blood.v88.10.4029.bloodjournal88104029 · 1996 · External reference
Monocyte derived dendritic cells generated by IFN-α acquire mature dendritic and natural killer cell properties as shown by gene expression analysis
10.1186/1479-5876-5-46 · 2007 · External reference
IFN-α2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells
10.1189/jlb.71.4.669 · 2002 · External reference
IFN-α-conditioned dendritic cells are highly efficient in inducing cross-priming CD8+ T cells against exogenous viral antigens
10.1002/eji.200535579 · 2006 · External reference
Interferon-α-inducible dendritic cells matured with OK-432 exhibit TRAIL and Fas ligand pathway-mediated killer activity
10.1038/srep42145 · 2017 · External reference
IFN-α skews monocytes into CD56+-expressing dendritic cells with potent functional activities in vitro and in vivo
10.4049/jimmunol.180.3.1462 · 2008 · External reference
Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity: results from a phase I trial in advanced melanoma
10.1186/s12967-015-0473-5 · 2015 · External reference
Clinical and antitumor immune responses in relapsed/refractory follicular lymphoma patients after intranodal injections of IFNα-dendritic cells and rituximab: a phase I clinical trial
10.1158/1078-0432.ccr-19-0709 · 2019 · External reference
Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinoma
10.1111/j.1349-7006.2004.tb02490.x · 2004 · External reference
Phase I/II clinical trial of a Wilms' tumor 1-targeted dendritic cell vaccination-based immunotherapy in patients with advanced cancer
10.1007/s00262-018-2257-2 · 2019 · External reference
Phase I/II pilot study of Wilms' tumor 1 peptide-pulsed dendritic cell vaccination combined with conventional chemotherapy in patients with head and neck cancer
10.1111/1744-9987.12831 · 2019 · External reference
Baseline immunity predicts prognosis of pancreatic cancer patients treated with WT1 and/or MUC1 peptide-loaded dendritic cell vaccination and a standard chemotherapy
10.1080/21645515.2021.2003645 · 2021 · External reference
Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response
10.1007/s00262-011-1033-3 · 2011 · External reference
The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression
10.1038/ncomms6852 · 2014 · External reference
Distinct difference in tumor-infiltrating immune cells between Wilms' tumor gene 1 peptide vaccine and anti-programmed cell death-1 antibody therapies
2021 · External reference
Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer
10.4049/jimmunol.166.1.678 · 2001 · External reference
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
10.1038/nm1609 · 2007 · External reference
Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity
10.1073/pnas.1820388116 · 2019 · External reference
Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+ T-cell activation events
10.1002/eji.201343349 · 2013 · External reference
Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine
10.1200/jco.2006.08.5829 · 2007 · External reference
Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties
10.1189/jlb.0310162 · 2011 · External reference
A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells
10.1182/blood-2010-12-325753 · 2011 · External reference
Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients
10.1007/s00262-013-1475-x · 2013 · External reference
Myeloid-derived suppressor cells impair the quality of dendritic cell vaccines
10.1007/s00262-011-1143-y · 2012 · External reference
Tumor lactic acidosis: protecting tumor by inhibiting cytotoxic activity through motility arrest and bioenergetic silencing
10.3389/fonc.2020.589434 · 2020 · External reference
Interferon-α-induced dendritic cells generated with human platelet lysate exhibit elevated antigen presenting ability to cytotoxic T lymphocytes
10.3390/vaccines9010010 · 2020 · External reference
Clinical trial on the safety and tolerability of personalized cancer vaccines using human platelet lysate-induced antigen-presenting cells
10.3390/cancers15143627 · 2023 · External reference
Autologous dendritic cells pulsed with allogeneic tumor cell lysate in mesothelioma: from mouse to human
10.1158/1078-0432.ccr-17-2522 · 2018 · External reference
Impact of mature dendritic cells pulsed with a novel WT1 helper peptide on the induction of HLA-A2-restricted WT1-reactive CD8+ T cells
2020 · External reference
Dendritic cells pulsed with multifunctional Wilms' tumor 1 peptides combined with multiagent chemotherapy modulate the tumor microenvironment and enable conversion surgery in pancreatic cancer
10.1136/jitc-2024-009765 · 2024 · External reference
Dendritic cells pre-pulsed with Wilms' tumor 1 in optimized culture for cancer vaccination
10.3390/pharmaceutics12040305 · 2020 · External reference
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
10.1084/jem.20060772 · 2006 · External reference
Cisplatin inhibits frequency and suppressive activity of monocytic myeloid-derived suppressor cells in cancer patients
10.1080/2162402x.2021.1935557 · 2021 · External reference
WT1-pulsed dendritic cell vaccine combined with chemotherapy for resected pancreatic cancer in a phase I study
2018 · External reference
Immune-related adverse events of dendritic cell vaccination correlate with immunologic and clinical outcome in stage III and IV melanoma patients
10.1097/cji.0000000000000127 · 2016 · External reference
Immunohistochemical detection of WT1 protein in a variety of cancer cells
10.1038/modpathol.3800588 · 2006 · External reference
Wilms' tumor suppressor gene (WT1) is expressed in primary breast tumors despite tumor-specific promoter methylation
2001 · External reference
High expression of Wilms' tumor suppressor gene predicts poor prognosis in breast cancer patients
2002 · External reference
Dendritic cell immunotherapy: mapping the way
10.1038/nm1039 · 2004 · External reference
CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells
10.1002/1521-4141(200006)30:6<1538::aid-immu1538>3.0.co;2-x · 2000 · External reference
Generation and functional characterization of MDSC-like cells
10.1080/2162402x.2017.1295203 · 2017 · External reference
Cryopreservation affected the levels of immune responses of PBMCs and antigen-presenting cells
10.1016/j.tiv.2020.104918 · 2020 · External reference
Implication of delayed TNF-α exposure on dendritic cell maturation and expansion from cryopreserved cord blood CD34+ hematopoietic progenitors
10.1016/j.jim.2004.08.001 · 2004 · External reference
Cryopreservation of monocytes or differentiated immature DCs leads to an altered cytokine response to TLR agonists and microbial stimulation
10.1016/j.jim.2011.08.010 · 2011 · External reference
PD-L1+ lung cancer stem cells modify the metastatic lymph-node immunomicroenvironment in NSCLC patients
10.1007/s00262-020-02648-y · 2021 · External reference
Phase I pilot study of Wilms tumor gene 1 peptide-pulsed dendritic cell vaccination combined with gemcitabine in pancreatic cancer
10.1111/cas.12621 · 2015 · External reference
Expression of toll-like receptor 4 on dendritic cells is significant for anticancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432
10.1158/0008-5472.can-03-4005 · 2004 · External reference
Infiltration of alternatively activated macrophages in cancer tissue is associated with MDSC and Th2 polarization in patients with esophageal cancer
2014 · External reference
Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer
10.1038/s41590-019-0429-7 · 2019 · External reference
Circulating M-MDSC levels as an assessment marker for post-treatment tumor progression in recurrent head and neck cancer patients following radiation therapy: a case series
10.3390/jcm13175130 · 2024 · External reference
Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
10.1158/1078-0432.ccr-05-0883 · 2005 · External reference
Tumor microenvironment following gemcitabine treatment favors differentiation of immunosuppressive Ly6Chigh myeloid cells
10.4049/jimmunol.1900930 · 2020 · External reference
Efficacy and safety of autologous dendritic cell-based immunotherapy, docetaxel, and prednisone vs placebo in patients with metastatic castration-resistant prostate cancer: the VIABLE phase 3 randomized clinical trial
10.1001/jamaoncol.2021.7298 · ExternalCitation · doi-reference
Association of autologous tumor lysate-loaded dendritic cell vaccination with extension of survival among patients with newly diagnosed and recurrent glioblastoma: a phase 3 prospective externally controlled cohort trial
10.1001/jamaoncol.2022.5370 · ExternalCitation · doi-reference
CD4+CD25+ regulatory T cells down-regulate co-stimulatory molecules on antigen-presenting cells
10.1002/1521-4141(200006)30:6<1538::aid-immu1538>3.0.co;2-x · ExternalCitation · doi-reference
IFN-α-conditioned dendritic cells are highly efficient in inducing cross-priming CD8+ T cells against exogenous viral antigens
10.1002/eji.200535579 · ExternalCitation · doi-reference
Tumor-induced myeloid-derived suppressor cell subsets exert either inhibitory or stimulatory effects on distinct CD8+ T-cell activation events
10.1002/eji.201343349 · ExternalCitation · doi-reference
Gemcitabine enhances Wilms' tumor gene WT1 expression and sensitizes human pancreatic cancer cells with WT1-specific T-cell-mediated antitumor immune response
10.1007/s00262-011-1033-3 · ExternalCitation · doi-reference
Myeloid-derived suppressor cells impair the quality of dendritic cell vaccines
10.1007/s00262-011-1143-y · ExternalCitation · doi-reference
Myeloid-derived suppressor cells are associated with disease progression and decreased overall survival in advanced-stage melanoma patients
10.1007/s00262-013-1475-x · ExternalCitation · doi-reference
Phase I/II clinical trial of a Wilms' tumor 1-targeted dendritic cell vaccination-based immunotherapy in patients with advanced cancer
10.1007/s00262-018-2257-2 · ExternalCitation · doi-reference
PD-L1+ lung cancer stem cells modify the metastatic lymph-node immunomicroenvironment in NSCLC patients
10.1007/s00262-020-02648-y · ExternalCitation · doi-reference
Implication of delayed TNF-α exposure on dendritic cell maturation and expansion from cryopreserved cord blood CD34+ hematopoietic progenitors
10.1016/j.jim.2004.08.001 · ExternalCitation · doi-reference
Cryopreservation of monocytes or differentiated immature DCs leads to an altered cytokine response to TLR agonists and microbial stimulation
10.1016/j.jim.2011.08.010 · ExternalCitation · doi-reference
Cryopreservation affected the levels of immune responses of PBMCs and antigen-presenting cells
10.1016/j.tiv.2020.104918 · ExternalCitation · doi-reference
Immunohistochemical detection of WT1 protein in a variety of cancer cells
10.1038/modpathol.3800588 · ExternalCitation · doi-reference
The Wilms' tumour suppressor Wt1 is a major regulator of tumour angiogenesis and progression
10.1038/ncomms6852 · ExternalCitation · doi-reference
Dendritic cell immunotherapy: mapping the way
10.1038/nm1039 · ExternalCitation · doi-reference
Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
10.1038/nm1609 · ExternalCitation · doi-reference
Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer
10.1038/s41590-019-0429-7 · ExternalCitation · doi-reference
Interferon-α-inducible dendritic cells matured with OK-432 exhibit TRAIL and Fas ligand pathway-mediated killer activity
10.1038/srep42145 · ExternalCitation · doi-reference
Sipuleucel-T immunotherapy for castration-resistant prostate cancer
10.1056/nejmoa1001294 · ExternalCitation · doi-reference
Depletion of regulatory T cells in tumors with an anti-CD25 immunotoxin induces CD8 T cell-mediated systemic antitumor immunity
10.1073/pnas.1820388116 · ExternalCitation · doi-reference
Generation and functional characterization of MDSC-like cells
10.1080/2162402x.2017.1295203 · ExternalCitation · doi-reference
Cisplatin inhibits frequency and suppressive activity of monocytic myeloid-derived suppressor cells in cancer patients
10.1080/2162402x.2021.1935557 · ExternalCitation · doi-reference
Baseline immunity predicts prognosis of pancreatic cancer patients treated with WT1 and/or MUC1 peptide-loaded dendritic cell vaccination and a standard chemotherapy
10.1080/21645515.2021.2003645 · ExternalCitation · doi-reference
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
10.1084/jem.20060772 · ExternalCitation · doi-reference
Immune-related adverse events of dendritic cell vaccination correlate with immunologic and clinical outcome in stage III and IV melanoma patients
10.1097/cji.0000000000000127 · ExternalCitation · doi-reference
Phase I/II pilot study of Wilms' tumor 1 peptide-pulsed dendritic cell vaccination combined with conventional chemotherapy in patients with head and neck cancer
10.1111/1744-9987.12831 · ExternalCitation · doi-reference
Phase I pilot study of Wilms tumor gene 1 peptide-pulsed dendritic cell vaccination combined with gemcitabine in pancreatic cancer
10.1111/cas.12621 · ExternalCitation · doi-reference
Overexpression of the Wilms' tumor gene WT1 in pancreatic ductal adenocarcinoma
10.1111/j.1349-7006.2004.tb02490.x · ExternalCitation · doi-reference
Dendritic cells pulsed with multifunctional Wilms' tumor 1 peptides combined with multiagent chemotherapy modulate the tumor microenvironment and enable conversion surgery in pancreatic cancer
10.1136/jitc-2024-009765 · ExternalCitation · doi-reference
Expression of toll-like receptor 4 on dendritic cells is significant for anticancer effect of dendritic cell-based immunotherapy in combination with an active component of OK-432
10.1158/0008-5472.can-03-4005 · ExternalCitation · doi-reference
Gemcitabine selectively eliminates splenic Gr-1+/CD11b+ myeloid suppressor cells in tumor-bearing animals and enhances antitumor immune activity
10.1158/1078-0432.ccr-05-0883 · ExternalCitation · doi-reference
Autologous dendritic cells pulsed with allogeneic tumor cell lysate in mesothelioma: from mouse to human
10.1158/1078-0432.ccr-17-2522 · ExternalCitation · doi-reference
Clinical and antitumor immune responses in relapsed/refractory follicular lymphoma patients after intranodal injections of IFNα-dendritic cells and rituximab: a phase I clinical trial
10.1158/1078-0432.ccr-19-0709 · ExternalCitation · doi-reference
A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells
10.1182/blood-2010-12-325753 · ExternalCitation · doi-reference
Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack
10.1182/blood-2012-07-446146 · ExternalCitation · doi-reference
Generation of CD1+RelB+ dendritic cells and tartrate-resistant acid phosphatase-positive osteoclast-like multinucleated giant cells from human monocytes
10.1182/blood.v88.10.4029.bloodjournal88104029 · ExternalCitation · doi-reference
Monocyte derived dendritic cells generated by IFN-α acquire mature dendritic and natural killer cell properties as shown by gene expression analysis
10.1186/1479-5876-5-46 · ExternalCitation · doi-reference
Intratumoral injection of IFN-alpha dendritic cells after dacarbazine activates anti-tumor immunity: results from a phase I trial in advanced melanoma
10.1186/s12967-015-0473-5 · ExternalCitation · doi-reference
Research progress on dendritic cell vaccines in cancer immunotherapy
10.1186/s40164-022-00257-2 · ExternalCitation · doi-reference
Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties
10.1189/jlb.0310162 · ExternalCitation · doi-reference
IFN-α2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells
10.1189/jlb.71.4.669 · ExternalCitation · doi-reference
Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine
10.1200/jco.2006.08.5829 · ExternalCitation · doi-reference
Tumor lactic acidosis: protecting tumor by inhibiting cytotoxic activity through motility arrest and bioenergetic silencing
10.3389/fonc.2020.589434 · ExternalCitation · doi-reference
Clinical trial on the safety and tolerability of personalized cancer vaccines using human platelet lysate-induced antigen-presenting cells
10.3390/cancers15143627 · ExternalCitation · doi-reference
Circulating M-MDSC levels as an assessment marker for post-treatment tumor progression in recurrent head and neck cancer patients following radiation therapy: a case series
10.3390/jcm13175130 · ExternalCitation · doi-reference
Dendritic cells pre-pulsed with Wilms' tumor 1 in optimized culture for cancer vaccination
10.3390/pharmaceutics12040305 · ExternalCitation · doi-reference
Interferon-α-induced dendritic cells generated with human platelet lysate exhibit elevated antigen presenting ability to cytotoxic T lymphocytes
10.3390/vaccines9010010 · ExternalCitation · doi-reference
CD28 delivers a costimulatory signal involved in antigen-specific IL-2 production by human T cells
10.4049/jimmunol.147.8.2461 · ExternalCitation · doi-reference
Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen
10.4049/jimmunol.153.5.1990 · ExternalCitation · doi-reference
Increased production of immature myeloid cells in cancer patients: a mechanism of immunosuppression in cancer
10.4049/jimmunol.166.1.678 · ExternalCitation · doi-reference
Tumor-specific CTL kill murine renal cancer cells using both perforin and Fas ligand-mediated lysis in vitro, but cause tumor regression in vivo in the absence of perforin
10.4049/jimmunol.168.7.3484 · ExternalCitation · doi-reference
IFN-α skews monocytes into CD56+-expressing dendritic cells with potent functional activities in vitro and in vivo
10.4049/jimmunol.180.3.1462 · ExternalCitation · doi-reference
Tumor microenvironment following gemcitabine treatment favors differentiation of immunosuppressive Ly6Chigh myeloid cells
10.4049/jimmunol.1900930 · ExternalCitation · doi-reference
