Research graph
References from Cohesin on the move: navigating genomic traffic during loop extrusion. Local targets link to admitted publications; unresolved targets remain external evidence.
Genome control by SMC complexes
10.1038/s41580-023-00609-8 · 2023 · External reference
Genome folding through loop extrusion by SMC complexes
10.1038/s41580-021-00349-7 · 2021 · External reference
Condensins, chromosome condensation protein complexes containing XCAP-C, XCAP-E and a Xenopus homolog of the Drosophila Barren protein
10.1016/s0092-8674(00)80233-0 · 1997 · External reference
Cohesin mediates DNA loop extrusion by a "swing and clamp" mechanism
10.1016/j.cell.2021.09.016 · 2021 · External reference
Genome folding principles uncovered in condensin-depleted mitotic chromosomes
10.1038/s41588-024-01759-x · 2024 · External reference
Extensive mutual influences of SMC complexes shape 3D genome folding
10.1038/s41586-025-08638-3 · 2025 · External reference
Chromosomal cohesin forms a ring
10.1016/s0092-8674(03)00162-4 · 2003 · External reference
Uniform dynamics of cohesin-mediated loop extrusion in living human cells
10.1038/s41588-025-02406-9 · 2025 · External reference
Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl
10.1038/nature22063 · 2017 · External reference
The cohesin release factor WAPL restricts chromatin loop extension
10.1016/j.cell.2017.04.013 · 2017 · External reference
DNA loop extrusion by human cohesin
10.1126/science.aaz3418 · 2019 · External reference
Full circle: a brief history of cohesin and the regulation of gene expression
10.1111/febs.16362 · 2023 · External reference
Cohesins functionally associate with CTCF on mammalian chromosome arms
10.1016/j.cell.2008.01.011 · 2008 · External reference
The structural basis for cohesin-CTCF-anchored loops
10.1038/s41586-019-1910-z · 2020 · External reference
Formation of chromosomal domains by loop extrusion
10.1016/j.celrep.2016.04.085 · 2016 · External reference
Chromatin extrusion explains key features of loop and domain formation in wild-type and engineered genomes
2015 · External reference
Wapl is an essential regulator of chromatin structure and chromosome segregation
10.1038/nature12471 · 2013 · External reference
A mechanism of cohesin-dependent loop extrusion organizes zygotic genome architecture
10.15252/embj.201798083 · 2017 · External reference
CTCF is a DNA-tension-dependent barrier to cohesin-mediated loop extrusion
10.1038/s41586-023-05961-5 · 2023 · External reference
Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization
10.1016/j.cell.2017.05.004 · 2017 · External reference
MCM complexes are barriers that restrict cohesin-mediated loop extrusion
10.1038/s41586-022-04730-0 · 2022 · External reference
Replisome passage through the cohesin ring
10.1016/j.cell.2025.08.028 · 2025 · External reference
Transcription shapes 3D chromatin organization by interacting with loop extrusion
2023 · External reference
Loop extrusion as a mechanism for formation of DNA damage repair foci
10.1038/s41586-021-03193-z · 2021 · External reference
Enhancer-promoter contact formation requires RNAPII and antagonizes loop extrusion
10.1038/s41588-023-01364-4 · 2023 · External reference
Contribution of variant subunits and associated factors to genome-wide distribution and dynamics of cohesin
10.1186/s13072-022-00469-0 · 2022 · External reference
WAPL maintains a cohesin loading cycle to preserve cell-type-specific distal gene regulation
10.1038/s41588-020-00744-4 · 2021 · External reference
Dosage sensitivity of the loop extrusion rate confers tunability to genome folding while creating vulnerability to genetic disruption
2025 · External reference
The role of cohesin loading at enhancers in the flux of loop extrusion and long-range transcriptional control
2026 · External reference
Replication fork velocities at adjacent replication origins are coordinately modified during DNA replication in human cells
10.1091/mbc.e06-08-0689 · 2007 · External reference
Signaling pathways differentially affect RNA polymerase II initiation, pausing, and elongation rate in cells
10.1016/j.molcel.2013.02.015 · 2013 · External reference
Cohesin's binding to chromosomes depends on a separate complex consisting of Scc2 and Scc4 proteins
10.1016/s1097-2765(00)80420-7 · 2000 · External reference
Scc2 is a potent activator of Cohesin's ATPase that promotes loading by binding Scc1 without Pds5
10.1016/j.molcel.2018.05.022 · 2018 · External reference
PDS5 proteins control genome architecture by limiting the lifetime of cohesin-NIPBL complexes
10.1016/j.molcel.2026.03.025 · 2026 · External reference
De novo formation of cis-regulatory contacts in the absence of NIPBL-driven chromatin loop extrusion
10.1038/s41588-026-02565-3 · 2026 · External reference
Sororin, a substrate of the Anaphase- promoting complex, is required for sister chromatid cohesion in vertebrates
10.1016/j.molcel.2005.03.017 · 2005 · External reference
Sororin actively maintains sister chromatid cohesion
10.15252/embj.201592532 · 2016 · External reference
CTCF and cohesin regulate chromatin loop stability with distinct dynamics
10.7554/elife.25776.038 · 2017 · External reference
Real-time imaging of DNA loop extrusion by condensin
10.1126/science.aar7831 · 2018 · External reference
Rules of engagement for condensins and cohesins guide mitotic chromosome formation
2025 · External reference
A unified model for cohesin function in sisterchromatid cohesion and chromatin loop formation
10.1016/j.molcel.2025.02.005 · 2025 · External reference
CTCF physically links cohesin to chromatin
10.1073/pnas.0801273105 · 2008 · External reference
Cohesin mediates transcriptional insulation by CCCTC-binding factor
10.1038/nature06634 · 2008 · External reference
Molecular basis of CTCF binding polarity in genome folding
10.1038/s41467-020-19283-x · 2020 · External reference
Binding domain mutations provide insight into CTCF's relationship with chromatin and its contribution to gene regulation
2025 · External reference
CTCF mediates chromatin looping via N-terminal domain-dependent cohesin retention
10.1073/pnas.1911708117 · 2020 · External reference
Two CTCF motifs impede cohesin-mediated DNA loop extrusion
10.1016/j.molcel.2025.11.001 · 2025 · External reference
CTCF as a boundary factor for cohesin-mediated loop extrusion: evidence for a multi-step mechanism
10.1080/19491034.2020.1782024 · 2020 · External reference
Distinct and compensatory roles of Stag1 and Stag2 in post-mitotic genome refolding
2025 · External reference
Chromatin boundary permeability is controlled by CTCF conformational ensembles
2026 · External reference
Lineage-determining transcription factors constrain cohesin to drive multi-enhancer oncogene regulation
2025 · External reference
A WIZ/Cohesin/CTCF complex anchors DNA loops to define gene expression and cell identity
2020 · External reference
Members of an array of zinc-finger proteins specify distinct Hox chromatin boundaries
10.1016/j.molcel.2024.08.007 · 2024 · External reference
CTCF and transcription influence chromatin structure re-configuration after mitosis
10.1038/s41467-021-25418-5 · 2021 · External reference
Cohesin stabilization at promoters and enhancers by common transcription factors and chromatin regulators
10.1186/s13072-025-00598-2 · 2025 · External reference
Genome-wide analyses of chromatin interactions after the loss of Pol I, Pol II, and Pol III
10.1186/s13059-020-02067-3 · 2020 · External reference
Establishment of chromatin architecture interplays with embryo hypertranscription
10.1038/s41586-025-09400-5 · 2025 · External reference
Cohesin-dependent chromosome loop extrusion is limited by transcription and stalled replication forks
2022 · External reference
Transcription-mediated supercoiling regulates genome folding and loop formation
10.1016/j.molcel.2021.06.009 · 2021 · External reference
Resolving the 3D landscape of transcription-linked Mammalian chromatin folding
10.1016/j.molcel.2020.03.002 · 2020 · External reference
Cohesin-mediated loop anchors confine the locations of human replication origins
10.1038/s41586-022-04803-0 · 2022 · External reference
Establishment of DNA-DNA interactions by the Cohesin ring
10.1016/j.cell.2017.12.021 · 2018 · External reference
A replication fork determinant for the establishment of sister chromatid cohesion
10.1016/j.cell.2022.12.044 · 2023 · External reference
Cohesin drives chromatin scanning during the RAD51-mediated homology search
2025 · External reference
Cohesin guides homology search during DNA repair using loops and sister chromatid linkages
2025 · External reference
A dual role of cohesin in DNA DSB repair
10.1038/s41467-025-56086-4 · 2025 · External reference
DNA damage signalling histone H2AX is required for tumour growth
10.1038/s41420-024-01869-9 · 2024 · External reference
Cohesin regulates homology search during recombinational DNA repair
10.1038/s41556-021-00783-x · 2021 · External reference
Cohesion is established during DNA replication utilising chromosome associated cohesin rings as well as those loaded de novo onto nascent DNAs
10.7554/elife.56611.sa2 · 2020 · External reference
Conformation of sister chromatids in the replicated human genome
10.1038/s41586-020-2744-4 · 2020 · External reference
Ovulation suppression protects against chromosomal abnormalities in mouse eggs at advanced maternal age
10.1016/j.cub.2021.06.076 · 2021 · External reference
Sister chromatid cohesion halts DNA loop expansion
10.1016/j.molcel.2024.02.004 · 2024 · External reference
Cohesin-mediated DNA loop extrusion resolves sister chromatids in G2 phase
2023 · External reference
MCPH1 inhibits condensin II during interphase by regulating its SMC2-Kleisin interface
10.7554/elife.73348.sa2 · 2021 · External reference
Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation
10.1038/s41590-018-0184-1 · 2018 · External reference
Cohesin in 3D: development, differentiation, and disease
2025 · External reference
Mutations in cohesin complex members SMC3 and SMC1A cause a mild variant of cornelia de Lange syndrome with predominant mental retardation
10.1086/511888 · 2007 · External reference
Cohesin and human disease: lessons from mouse models
10.1016/j.ceb.2015.08.003 · 2015 · External reference
Chromatid cohesion defects may underlie chromosome instability in human colorectal cancers
10.1073/pnas.0712384105 · 2008 · External reference
Mutational inactivation of STAG2 causes aneuploidy in human cancer
10.1126/science.1203619 · 2011 · External reference
Enhancer–promoter interactions and transcription are largely maintained upon acute loss of CTCF, cohesin, WAPL or YY1
10.1038/s41588-022-01223-8 · 2022 · External reference
Synergy between regulatory elements can render cohesin dispensable for distal enhancer function
2025 · External reference
An extrinsic motor directs chromatin loop formation by cohesin
2024 · External reference
