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2020 · External reference

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2018 · External reference

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Clinical efficacy and mechanism of Kunkui Baoshen Gao in patients with early- and middle-stage type 2 diabetic kidney disease from the perspective of inflammation and oxidative stress

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2024 · External reference

Effect of Huangkui extract powder on proliferation, apoptosis and cell cycle of mouse podocytes under high glucose conditions

2019 · External reference

Hyperoside ameliorates diabetic nephropathy induced by STZ via targeting the miR-499-5p/APC axis

10.1016/j.jphs.2021.02.005 · 2021 · External reference

Hyperoside ameliorates glomerulosclerosis in diabetic nephropathy by downregulating miR-21

10.1139/cjpp-2016-0066 · 2016 · External reference

Hyperoside reduces albuminuria in diabetic nephropathy at the early stage through ameliorating renal damage and podocyte injury

10.1007/s11418-016-1007-z · 2016 · External reference

Hyperoside pre-treatment prevents glomerular basement membrane damage in diabetic nephropathy by inhibiting podocyte heparanase expression

10.1038/s41598-017-06844-2 · 2017 · External reference

Total flavones of Abelmoschus manihot ameliorates podocyte pyroptosis and injury in high glucose conditions by targeting METTL3-dependent m(6)a modification-mediated NLRP3-inflammasome activation and PTEN/PI3K/Akt signaling

2021 · External reference

A single-cell profile reveals the transcriptional regulation responded for Abelmoschus manihot (L.) treatment in diabetic kidney disease

10.1016/j.phymed.2024.155642 · 2024 · External reference

Effects and mechanisms of total flavones of Abelmoschus manihot in improving insulin resistance and podocyte epithelial-mesenchymal transition in diabetic kidney disease based on IRS1/PI3K/Akt pathway

2023 · External reference

Pretreatment with the total flavone glycosides of Flos Abelmoschus manihot and hyperoside prevents glomerular podocyte apoptosis in streptozotocin-induced diabetic nephropathy

10.1089/jmf.2011.1921 · 2012 · External reference

Huangkui capsule alleviates doxorubicin-induced proteinuria via protecting against podocyte damage and inhibiting JAK/STAT signaling

10.1016/j.jep.2023.116150 · 2023 · External reference

Inhibition of Akt/mTOR/p70S6K signaling activity with Huangkui capsule alleviates the early glomerular pathological changes in diabetic nephropathy

10.3389/fphar.2018.00443 · 2018 · External reference

Inhibition of ferroptosis of renal tubular cells with total flavones of Abelmoschus manihot alleviates diabetic tubulopathy

10.1002/ar.25123 · 2023 · External reference

Effects of total flavones of Abelmoschus manihot (L.) on the treatment of diabetic nephropathy via the activation of solute carriers in renal tubular epithelial cells

10.1016/j.biopha.2023.115899 · 2023 · External reference

Effects and mechanisms of total flavones of Abelmoschus manihot combined with empagliflozin in attenuating diabetic tubulopathy through multiple targets based on mitochondrial homeostasis and ZBP1-mediated panoptosis

2025 · External reference

In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney

10.1007/s00210-011-0613-2 · 2011 · External reference

Isoquercitrin attenuates renal ischemia/reperfusion injury through antioxidation, anti-inflammation, and antiapoptosis in mice

10.1016/j.transproceed.2019.12.038 · 2020 · External reference

Isoquercitrin ameliorates cisplatin-induced nephrotoxicity via the inhibition of apoptosis, inflammation, and oxidative stress

10.3389/fphar.2020.599416 · 2020 · External reference

Isoquercitrin improves diabetes nephropathy by inhibiting the sodium-glucose co-transporter-2 pathway

10.1016/j.bbrc.2024.151142 · 2025 · External reference

Isoquercitrin alleviates diabetic nephropathy by inhibiting STAT3 phosphorylation and dimerization

2025 · External reference

Quercetin improves diabetic kidney disease by inhibiting ferroptosis and regulating the Nrf2 in streptozotocin-induced diabetic rats

10.1080/0886022x.2024.2327495 · 2024 · External reference

Quercetin alleviates folic acid-induced renal fibrosis by inhibiting tubular epithelial cell ferroptosis via EGFR/ACSL4 pathway

10.1142/s0192415x25500715 · 2025 · External reference

Huangkui capsule attenuates diabetic kidney disease through the induction of mitophagy mediated by STING1/PINK1 signaling in tubular cells

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Quercetin ameliorates kidney injury and fibrosis by modulating M1/M2 macrophage polarization

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Total flavones of Abelmoschus manihot improve diabetic nephropathy by inhibiting the iRhom2/TACE signalling pathway activity in rats

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Rutin and selenium nanoparticles protected against STZ-induced diabetic nephropathy in rats through downregulating JAK-2/STAT3 pathway and upregulating Nrf-2/HO-1 pathway

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Rutin ameliorates metabolic acidosis and fibrosis in alloxan induced diabetic nephropathy and cardiomyopathy in experimental rats

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Protective effects of rutin on kidney in type 1 diabetic mice

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Huangkui capsules regulate tryptophan metabolism to improve diabetic nephropathy through the KEAP1/Nrf2/HO-1 pathway

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Huangkui capsule, an extract from Abelmoschus manihot (L.) Medic, improves diabetic nephropathy via activating peroxisome proliferator-activated receptor (PPAR)-α/γ and attenuating endoplasmic reticulum stress in rats

10.1016/j.jep.2016.05.033 · 2016 · External reference

Quercetin inhibits kidney fibrosis and the epithelial to mesenchymal transition of the renal tubular system involving suppression of the Sonic Hedgehog signaling pathway

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Therapeutic effects of quercetin on renal fibrosis and injury

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Quercetin inhibits the amphiregulin/EGFR signaling-mediated renal tubular epithelial-mesenchymal transition and renal fibrosis in obstructive nephropathy

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Iron-quercetin complex ameliorates chronic kidney disease via inhibiting the renal TGF-β1/SMAD3/EGR1 axis-mediated kidney injury and fibrosis

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Rutin ameliorates kidney interstitial fibrosis in rats with obstructive nephropathy

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Rutin alleviates EndMT by restoring autophagy through inhibiting HDAC1 via PI3K/Akt/mTOR pathway in diabetic kidney disease

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Rutin prevents high glucose-induced renal glomerular endothelial hyperpermeability by inhibiting the ROS/RHOA/ROCK signaling pathway

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Rutin ameliorates renal fibrosis and proteinuria in 5/6-nephrectomized rats by anti-oxidation and inhibiting activation of TGFβ1-Smad signaling

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Targeting ROCK1 in diabetic kidney disease: unraveling mesangial fibrosis mechanisms and introducing myricetin as a novel antagonist

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Huangkui capsule in combination with metformin ameliorates diabetic nephropathy via the Klotho/TGF-β1/p38MAPK signaling pathway

10.1016/j.jep.2020.113548 · 2021 · External reference

Huangkui capsule ameliorates renal fibrosis in a unilateral ureteral obstruction mouse model through TRPC6 dependent signaling pathways

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Huangkui capsule in combination with leflunomide improves immunoglobulin A nephropathy by inhibiting the TGF-β1/SMAD3 signaling pathway

10.6061/clinics/2021/e2904 · 2021 · External reference

Qi-Huang-Yi-Shen formula alleviate tubular epithelial-mesenchymal tTransition in diabetic kidney disease through HIF-1a/snail signaling pathway

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Hyperoside attenuates renal aging and injury induced by D-galactose via inhibiting AMPK-ULK1 signaling-mediated autophagy

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Senolytics decrease senescent cells in humans: preliminary report from a clinical trial of dasatinib plus quercetin in individuals with diabetic kidney disease

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Senolytic combination of dasatinib and quercetin attenuates renal damage in diabetic kidney disease

10.1016/j.phymed.2024.155705 · 2024 · External reference

Senolytic combination of dasatinib and quercetin protects against diabetic kidney disease by activating autophagy to alleviate podocyte dedifferentiation via the notch pathway

10.3892/ijmm.2024.5350 · 2024 · External reference

Senolytics, dasatanib plus quercetin, reduce kidney inflammation, senescent cell abundance, and injury while restoring geroprotective factors in murine diabetic kidney disease

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Mechanistic insights into myricetin-regulated autophagy via the PI3K/Akt and PINK1/Parkin pathway in diabetic kidney disease treatment

2026 · External reference

Total flavonoids from Abelmoschus manihot (L.) improve diabetes nephropathy by regulating the gut-kidney axis

2025 · External reference

Effects of Abelmoschus manihot (L.) and its combination with irbesartan in the treatment of diabetic nephropathy via the gut-kidney axis

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Abelmoschus manihot ameliorates the levels of circulating metabolites in diabetic nephropathy by modulating gut microbiota in non-obese diabetes mice

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Broad range lipidomics and metabolomics coupled with 16s rRNA sequencing to reveal the mechanisms of Huangkui capsule against cisplatin-induced nephrotoxicity

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Integrated metabolomics and proteomics analysis elucidated the therapeutic effect of Huangkui capsule on tacrolimus-induced chronic nephrotoxicity in rats

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Quercetin ameliorates hyperuricemic nephropathy through improving gut dysfunctions and decreasing gut bacteria-derived uremic toxins

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Targeting the gut microbial metabolic pathway with small molecules decreases uremic toxin production

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Quercetin ameliorates renal injury by promoting UCP1-mediated alleviation of lipid accumulation in diabetic kidney disease

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Renoprotective effect of myricetin restrains dyslipidemia and renal mesangial cell proliferation by the suppression of sterol regulatory element binding proteins in an experimental model of diabetic nephropathy

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Efficacy of Huangkui capsules in IgA nephropathy and analysis of influencing factors

2025 · External reference

Clinical efficacy of Huangkui capsules in the treatment of targeted drug-related proteinuria in patients with hepatocellular carcinoma

2026 · External reference

New insights into the effects of individual Chinese herbal medicines on chronic kidney disease

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Therapeutic potential of Abelmoschus manihot: mechanisms of action and clinical use in traditional Chinese medicine formulas

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