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References from IL-1 signaling in cancer-associated fibroblasts: shaping fibroblast heterogeneity, tumor immunity, and therapeutic resistance. Local targets link to admitted publications; unresolved targets remain external evidence.
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10.1073/pnas.0308558101 · 2004 · External reference
Nonclassical IL-1β Secretion Stimulated by P2X7 Receptors Is Dependent on Inflammasome Activation and Correlated with Exosome Release in Murine Macrophages
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Identification of a key pathway required for the sterile inflammatory response triggered by dying cells
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Interleukin 1α and the inflammatory process
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NF-κB signaling in inflammation
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Tumor necrosis factor receptor-associated factor regulation of nuclear factor κB and mitogen-activated protein kinase pathways
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IL-1 receptor 2 (IL-1R2) and its role in immune regulation
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IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines
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Interleukin-1 (IL-1)
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Interleukin-1 in tumor progression, therapy, and prevention
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Endogenous Production of IL1B by Breast Cancer Cells Drives Metastasis and Colonization of the Bone Microenvironment
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Cancer‑associated fibroblast stimulates cancer cell invasion in an interleukin‑1 receptor (IL‑1R)‑dependent manner
2019 · External reference
Cancer-Associated Fibroblasts in Inflammation and Antitumor Immunity
10.1158/1078-0432.ccr-22-1031 · 2023 · External reference
The interleukin-1 family of cytokines and receptors in human breast cancer: implications for tumor progression
2003 · External reference
The Role of IL-1β in the Early Tumor Cell–Induced Angiogenic Response
10.4049/jimmunol.1202769 · 2013 · External reference
A paracrine circuit of IL-1β/IL-1R1 between myeloid and tumor cells drives genotype-dependent glioblastoma progression
10.1172/jci163802 · 2023 · External reference
Fibroblasts: Origins, definitions, and functions in health and disease
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Fibroblasts—Warriors at the intersection of wound healing and disrepair
10.3390/biom13060945 · 2023 · External reference
Human Skin Fibroblasts as an In Vitro Model Illustrating Changes in Collagen Levels and Skin Cell Migration Under the Influence of Selected Plant Hormones
10.3390/bioengineering11121188 · 2024 · External reference
Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation
1997 · External reference
FGFR signaling establishes spatial gradients of secretory cell identities along the airway proximal-distal axis
10.1038/s41467-026-70842-0 · 2026 · External reference
Dermal Fibroblasts Promote Alternative Macrophage Activation Improving Impaired Wound Healing
10.1016/j.jid.2016.11.035 · 2017 · External reference
The diverse nature of intestinal fibroblasts in development, homeostasis, and disease
10.1016/j.tcb.2023.03.007 · 2023 · External reference
Effects of embryonic origin, tissue cues and pathological signals on fibroblast diversity in humans
10.1038/s41556-025-01638-5 · 2025 · External reference
Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development
10.1016/j.devcel.2020.02.003 · 2020 · External reference
Distinct populations of crypt-associated fibroblasts act as signaling hubs to control colon homeostasis
10.1371/journal.pbio.3001032 · 2020 · External reference
Fibroblast Memory in Development, Homeostasis and Disease
10.3390/cells10112840 · 2021 · External reference
Fibroblasts in intestinal homeostasis, damage, and repair
10.3389/fimmu.2022.924866 · 2022 · External reference
Essential growth factor receptors for fibroblast homeostasis and activation: Fibroblast Growth Factor Receptor (FGFR), Platelet Derived Growth Factor Receptor (PDGFR), and Transforming Growth Factor β Receptor (TGFβR)
2024 · External reference
IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer
10.1038/s41467-023-39953-w · 2023 · External reference
Cancer-associated fibroblasts downregulate type I interferon receptor to stimulate intratumoral stromagenesis
10.1038/s41388-020-01424-7 · 2020 · External reference
The Chemokine System as a Key Regulator of Pulmonary Fibrosis: Converging Pathways in Human Idiopathic Pulmonary Fibrosis (IPF) and the Bleomycin-Induced Lung Fibrosis Model in Mice
10.3390/cells13242058 · 2024 · External reference
The biology and function of fibroblasts in cancer
10.1038/nrc.2016.73 · 2016 · External reference
Cancer-associated fibroblasts: central players in cancer hallmarks and therapeutic resistance
10.1186/s12964-025-02516-1 · 2025 · External reference
Hallmarks of cancer—Then and now, and beyond
10.1016/j.cell.2025.12.049 · 2026 · External reference
Adipose Tissue-Derived Stem Cells Differentiate into Carcinoma-Associated Fibroblast-Like Cells under the Influence of Tumor-Derived Factors
10.1155/2010/695162 · 2010 · External reference
Hematopoietic stem cell derived carcinoma-associated fibroblasts: a novel origin
2012 · External reference
search of definitions: Cancer-associated fibroblasts and their markers
10.1002/ijc.32193 · 2020 · External reference
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
10.1126/science.1254257 · 2014 · External reference
Tumour Heterogeneity: The Key Advantages of Single-Cell Analysis
10.3390/ijms17122142 · 2016 · External reference
Method of the Year: spatially resolved transcriptomics
10.1038/s41592-020-01033-y · 2021 · External reference
Integration of Single-Cell RNA-Seq Datasets: A Review of Computational Methods
10.14348/molcells.2023.0009 · 2023 · External reference
Scrublet: Computational Identification of Cell Doublets in Single-Cell Transcriptomic Data
10.1016/j.cels.2018.11.005 · 2019 · External reference
Transcription factors in fibroblast plasticity and CAF heterogeneity
10.1186/s13046-023-02934-4 · 2023 · External reference
Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment
10.1038/s41467-022-34395-2 · 2022 · External reference
Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer
10.1084/jem.20162024 · 2017 · External reference
IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma
10.1158/2159-8290.cd-18-0710 · 2019 · External reference
Spatial transcriptomic analysis of primary and metastatic pancreatic cancers highlights tumor microenvironmental heterogeneity
10.1038/s41588-024-01914-4 · 2024 · External reference
Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response
10.1186/s12943-024-02191-9 · 2025 · External reference
Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
10.1158/2159-8290.cd-19-0094 · 2019 · External reference
Antigen-presenting cancer associated fibroblasts enhance antitumor immunity and predict immunotherapy response
10.1038/s41467-025-57465-7 · 2025 · External reference
Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer
10.1016/j.ccell.2022.11.005 · 2022 · External reference
miR200-regulated CXCL12β promotes fibroblast heterogeneity and immunosuppression in ovarian cancers
10.1038/s41467-018-03348-z · 2018 · External reference
Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer
10.1016/j.ccell.2018.01.011 · 2018 · External reference
Single-Cell Analysis Reveals Fibroblast Clusters Linked to Immunotherapy Resistance in Cancer
10.1158/2159-8290.cd-19-1384 · 2020 · External reference
Deciphering the spatial landscape and plasticity of immunosuppressive fibroblasts in breast cancer
10.1038/s41467-024-47068-z · 2024 · External reference
The molecular classification of cancer-associated fibroblasts on a pan-cancer single-cell transcriptional atlas
10.1002/ctm2.1516 · 2023 · External reference
Cancer-associated fibroblast subtypes modulate the tumor-immune microenvironment and are associated with skin cancer malignancy
10.1038/s41467-024-53908-9 · 2024 · External reference
Cancer-associated fibroblasts: Recent advances and therapeutic implications
10.1016/j.ceb.2025.102601 · 2026 · External reference
Hypoxia Potentiates the Inflammatory Fibroblast Phenotype Promoted by Pancreatic Cancer Cell-Derived Cytokines
10.1158/0008-5472.can-22-2316 · 2023 · External reference
Diversity and Biology of Cancer-Associated Fibroblasts
10.1152/physrev.00048.2019 · 2021 · External reference
Roles of IL-1 in Cancer: From Tumor Progression to Resistance to Targeted Therapies
10.3390/ijms21176009 · 2020 · External reference
KrasG12D-Induced IKK2/β/NF-κB Activation by IL-1α and p62 Feedforward Loops Is Required for Development of Pancreatic Ductal Adenocarcinoma
10.1016/j.ccr.2011.12.006 · 2012 · External reference
Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer
10.1038/s41389-022-00434-2 · 2022 · External reference
SMAD4 and KRAS Status Shapes Cancer Cell–Stromal Cross-Talk and Therapeutic Response in Pancreatic Cancer
10.1158/0008-5472.can-24-2330 · 2025 · External reference
The role of hypoxia in cancer progression, angiogenesis, metastasis, and resistance to therapy
10.2147/hp.s93413 · 2015 · External reference
Hypoxic microenvironment determines the phenotypic plasticity and spatial distribution of cancer-associated fibroblasts
10.1002/ctm2.1438 · 2023 · External reference
ELF3 Mediates IL -1α Induced Differentiation of Mesenchymal Stem Cells to Inflammatory iCAFs
10.1002/stem.3455 · 2021 · External reference
The Blockade of Tumoral IL1β-Mediated Signaling in Normal Colonic Fibroblasts Sensitizes Tumor Cells to Chemotherapy and Prevents Inflammatory CAF Activation
10.3390/ijms22094960 · 2021 · External reference
IL-1β derived from mixed-polarized macrophages activates fibroblasts and synergistically forms a cancer-promoting microenvironment
10.1007/s10120-022-01352-3 · 2023 · External reference
NFAT mediates pro-tumorigenic inflammation in cancer-associated fibroblasts in pancreatic ductal adenocarcinoma
10.1016/j.celrep.2025.116849 · 2026 · External reference
IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer
10.1038/s41586-023-06685-2 · 2023 · External reference
Neutrophil-mediated fibroblast-tumor cell il-6/stat-3 signaling underlies the association between neutrophil-to-lymphocyte ratio dynamics and chemotherapy response in localized pancreatic cancer: A hybrid clinical-preclinical study
10.7554/elife.78921 · 2022 · External reference
NLRP3 inflammasome in fibroblasts links tissue damage with inflammation in breast cancer progression and metastasis
10.1038/s41467-019-12370-8 · 2019 · External reference
Fusobacterium nucleatum interacts with cancer-associated fibroblasts to promote colorectal cancer
10.1038/s44318-025-00542-w · 2025 · External reference
Intratumoral Fusobacterium nucleatum Drives Cancer-Associated Fibroblasts Enrichment and Immune Exclusion in Esophageal Squamous Cell Carcinoma
10.1002/ags3.70116 · 2026 · External reference
Fusobacterium nucleatum increases CTGF expression through TLR2-YAP signaling axis in cancer-associated fibroblasts, thereby promoting colorectal cancer progression
10.1186/s12935-025-04023-2 · 2025 · External reference
Preprint at
2025 · External reference
Hypoxia-induced Wnt5a-secreting fibroblasts promote colon cancer progression
10.1038/s41467-025-58748-9 · 2025 · External reference
TGF-β1-mediated transition of resident fibroblasts to cancer-associated fibroblasts promotes cancer metastasis in gastrointestinal stromal tumor
10.1038/s41389-021-00302-5 · 2021 · External reference
Interleukin-1 beta signaling in cancer: A double-edged sword in inflammation and tumorigenesis
10.36922/cp025310046 · 2025 · External reference
Synthetic immune niches for cancer immunotherapy
10.1038/nri.2017.89 · 2018 · External reference
Cancer cell-derived IL-1β reverses chemo-immunotherapy resistance in non-small cell lung cancer
10.1038/s41467-025-64839-4 · 2025 · External reference
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1986 · External reference
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10.1084/jem.168.6.2031 · 1988 · External reference
The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer
10.1084/jem.20100050 · 2010 · External reference
Inflammation driven by tumour-specific Th1 cells protects against B-cell cancer
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Interleukin-1 is required for cancer eradication mediated by tumor-specific Th1 cells
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The plasticity of cancer-associated fibroblasts
10.1016/j.trecan.2025.04.012 · 2025 · External reference
Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment
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Inflammatory fibroblasts mediate resistance to neoadjuvant therapy in rectal cancer
10.1016/j.ccell.2022.01.004 · 2022 · External reference
Targeting Tumor–Stromal IL6/STAT3 Signaling through IL1 Receptor Inhibition in Pancreatic Cancer
10.1158/1535-7163.mct-21-0083 · 2021 · External reference
Oncolytic virus-induced IL-1β+ monocyte-IL-6+ CAF axis suppresses dendritic cell-mediated antitumor immunity in pancreatic cancer
10.1136/jitc-2025-013175 · 2025 · External reference
IL-1R2 promotes tumorigenesis and modulates the tumor immune microenvironment in colorectal cancer
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Cancer-associated fibroblasts: Vital suppressors of the immune response in the tumor microenvironment
10.1016/j.cytogfr.2022.07.006 · 2022 · External reference
Interleukin-6 serves as a critical factor in various cancer progression and therapy
10.1007/s12032-024-02422-5 · 2024 · External reference
Pancreatic stellate cell secreted IL-6 stimulates STAT3 dependent invasiveness of pancreatic intraepithelial neoplasia and cancer cells
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Loss of P53 Function Activates JAK2-STAT3 Signaling to Promote Pancreatic Tumor Growth, Stroma Modification, and Gemcitabine Resistance in Mice and Is Associated With Patient Survival
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An Immune Gene Signature Stratifies Breast Cancer Prognosis Through iCAF-Driven Immunosuppressive Microenvironment
10.3390/biomedicines13122966 · 2025 · External reference
The IL-1/IL-1 receptor axis and tumor cell released inflammasome adaptor ASC are key regulators of TSLP secretion by cancer associated fibroblasts in pancreatic cancer
10.1186/s40425-019-0521-4 · 2019 · External reference
Precision Medicine: IL-1RA and Pancreatic Cancer Organoids
10.3390/biology14060604 · 2025 · External reference
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Unresolved reference
2026 · External reference
Neutrophils in the Tumor Microenvironment
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Interleukin-1 Receptor Type 2 Acts with c-Fos to Enhance the Expression of Interleukin-6 and Vascular Endothelial Growth Factor A in Colon Cancer Cells and Induce Angiogenesis
10.1074/jbc.m115.644823 · 2015 · External reference
IL1R2 Blockade Suppresses Breast Tumorigenesis and Progression by Impairing USP15-Dependent BMI1 Stability
2020 · External reference
Single-cell transcriptomics reveals hypoxia-driven iCAF_PLAU is associated with stemness and immunosuppression in anorectal malignant melanoma
10.1007/s00535-025-02273-5 · 2025 · External reference
A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells
10.1007/s00011-018-1145-8 · 2018 · External reference
The role of interleukin -1 family in fibrotic diseases
10.1016/j.cyto.2023.156161 · 2023 · External reference
IL-1 Mediates Tissue-Specific Inflammation and Severe Respiratory Failure in COVID-19
10.1159/000524560 · 2022 · External reference
Proinflammatory Cytokine IL-1β Promotes Tumor Growth of Lewis Lung Carcinoma by Induction of Angiogenic Factors: In Vivo Analysis of Tumor-Stromal Interaction
10.4049/jimmunol.169.1.469 · 2002 · External reference
Infiltration of COX-2–expressing macrophages is a prerequisite for IL-1β–induced neovascularization and tumor growth
10.1172/jci23298 · 2005 · External reference
Lung fibroblasts facilitate pre-metastatic niche formation by remodeling the local immune microenvironment
10.1016/j.immuni.2022.07.001 · 2022 · External reference
Interplay between cancer-associated fibroblasts and dendritic cells: implications for tumor immunity
10.3389/fimmu.2025.1515390 · 2025 · External reference
IL-1β-mediated suppression of CIITA attenuates IFN-γ-induced MHC-II expression on Fibroblasts
10.1186/s12964-025-02575-4 · 2025 · External reference
Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti-PD-1 for tumor abrogation
10.1073/pnas.1812266115 · 2019 · External reference
Tumor microenvironment and cancer therapy resistance
10.1016/j.canlet.2015.07.044 · 2016 · External reference
Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy
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Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
10.1038/nature11183 · 2012 · External reference
Intravital Imaging Reveals How BRAF Inhibition Generates Drug-Tolerant Microenvironments with High Integrin β1/FAK Signaling
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Chemotherapy activates cancer-associated fibroblasts to maintain colorectal cancer-initiating cells by IL-17A
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Targeting of cancer-associated fibroblasts enhances the efficacy of cancer chemotherapy by regulating the tumor microenvironment
10.3892/mmr.2016.4868 · 2016 · External reference
Transcriptomic Insights into the Association of IL-1 Signaling with the Senescence-Associated Secretory Phenotype in Human Fibroblasts
10.3390/genes17050527 · 2026 · External reference
IL-1 and senescence: Friends and foe of EGFR neutralization and immunotherapy
10.3389/fcell.2022.1083743 · 2023 · External reference
Cell surface-bound IL-1alpha is an upstream regulator of the senescence-associated IL-6/IL-8 cytokine network
10.1073/pnas.0905299106 · 2009 · External reference
Uncoupling the Senescence-Associated Secretory Phenotype from Cell Cycle Exit via Interleukin-1 Inactivation Unveils Its Protumorigenic Role
10.1128/mcb.00586-18 · 2019 · External reference
Hypoxia-Induced Senescent Fibroblasts Secrete IGF1 to Promote Cancer Stemness in Esophageal Squamous Cell Carcinoma
10.1158/0008-5472.can-24-1185 · 2025 · External reference
Senescence Defines a Distinct Subset of Myofibroblasts That Orchestrates Immunosuppression in Pancreatic Cancer
10.1158/2159-8290.cd-23-0428 · 2024 · External reference
TSPAN8+ myofibroblastic cancer–associated fibroblasts promote chemoresistance in patients with breast cancer
10.1126/scitranslmed.adj5705 · 2024 · External reference
PI3K and MAPK Signaling Nodes Serve as Divergent Drivers of Phenotypic Plasticity in Cancer-Associated Fibroblasts in Colorectal Cancer
10.1158/0008-5472.can-25-0766 · 2026 · External reference
Differential activity of MAPK signalling defines fibroblast subtypes in pancreatic cancer
10.1038/s41467-024-54975-8 · 2024 · External reference
Inhibition of Hedgehog Signaling Alters Fibroblast Composition in Pancreatic Cancer
10.1158/1078-0432.ccr-20-3715 · 2021 · External reference
Comparative Efficacy and Safety of Anakinra and Canakinumab in Patients With VEXAS Syndrome: An International Multicenter Study
10.1002/art.43384 · 2026 · External reference
Therapeutic Strategies for Targeting IL-1 in Cancer
10.3390/cancers13030477 · 2021 · External reference
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Reduction in C-reactive protein indicates successful targeting of the IL-1/IL-6 axis resulting in improved survival in early stage multiple myeloma
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MABp1, a first-in-class true human antibody targeting interleukin-1α in refractory cancers: an open-label, phase 1 dose-escalation and expansion study
10.1016/s1470-2045(14)70155-x · 2014 · External reference
Xilonix, a novel true human antibody targeting the inflammatory cytokine interleukin-1 alpha, in non-small cell lung cancer
10.1007/s10637-015-0226-6 · 2015 · External reference
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
10.1056/nejmoa1707914 · 2017 · External reference
Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial
10.1016/s0140-6736(17)32247-x · 2017 · External reference
Canakinumab as Adjuvant Therapy in Patients With Completely Resected Non-Small-Cell Lung Cancer: Results From the CANOPY-A Double-Blind, Randomized Clinical Trial
10.1200/jco.23.00910 · 2024 · External reference
10.1016/j.lungcan.2023.107451
10.1016/j.lungcan.2023.107451 · 2024 · External reference
Canakinumab Versus Placebo in Combination With First-Line Pembrolizumab Plus Chemotherapy for Advanced Non-Small-Cell Lung Cancer: Results From the CANOPY-1 Trial
10.1200/jco.23.00980 · 2024 · External reference
CANOPY-N: A Phase 2 Study of Canakinumab or Pembrolizumab, Alone or in Combination, as Neoadjuvant Therapy in Patients With Resectable, Stage IB-IIIA NSCLC
2025 · External reference
Harnessing the power of cancer-associated fibroblasts to revolutionize pancreatic cancer treatment
10.20892/j.issn.2095-3941.2025.0288 · 2025 · External reference
Fibroblast Activation Protein (FAP)-Targeted CAR-T Cells: Launching an Attack on Tumor Stroma
10.2147/itt.s291767 · 2021 · External reference
The Impact of the Tumor Microenvironment on the Effect of IL-1β Blockade in NSCLC: Biomarker Analyses from CANOPY-1 and CANOPY-N Trials
10.1158/2767-9764.crc-24-0490 · 2025 · External reference
Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival
10.1016/j.ccr.2014.04.005 · 2014 · External reference
Insights into the relevance of targeting fibroblasts to control cancer
2025 · External reference
αSMA+ fibroblasts suppress Lgr5+ cancer stem cells and restrain colorectal cancer progression
10.1038/s41388-021-01866-7 · 2021 · External reference
Activated fibroblasts in cancer: Perspectives and challenges
10.1016/j.ccell.2023.02.015 · 2023 · External reference
Spatial and temporal dynamics of cancer-associated fibroblast niches in breast cancer
10.1186/s13058-025-02183-7 · 2026 · External reference
Crosstalk Between Cancer-Associated Fibroblasts and Immune Cells: Mechanisms and Therapeutic Implications
2025 · External reference
A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer
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Cre reconstitution allows for DNA recombination selectively in dual-marker-expressing cells in transgenic mice
10.1093/nar/gkm559 · 2007 · External reference
Unresolved reference
2026 · External reference