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References from The VITAL prognostic model for cHCC-CCA after surgery: Integrating viral, inflammatory, tumor biology, and anatomic lesion. Local targets link to admitted publications; unresolved targets remain external evidence.
The 2019 WHO classification of tumours of the digestive system
10.1111/his.13975 · 2020 · External reference
Combined hepatocellular-cholangiocarcinoma: an update
10.1016/j.jhep.2021.01.035 · 2021 · External reference
Combined hepatocellular-cholangiocarcinoma: changes in the 2019 world health organization histological classification system and potential impact on imaging-based diagnosis
10.3348/kjr.2020.0091 · 2020 · External reference
Combined hepatocellular cholangiocarcinoma (cHCC-CC): an update of genetics, molecular biology, and therapeutic interventions
10.2147/jhc.s159805 · 2019 · External reference
Update on the diagnosis and treatment of combined hepatocellular cholangiocarcinoma
2024 · External reference
cHCC-CCA: consensus terminology for primary liver carcinomas with both hepatocytic and cholangiocytic differentation
10.1002/hep.29789 · 2018 · External reference
Management of locally advanced or metastatic combined hepatocellular cholangiocarcinoma
10.3390/cancers15030988 · 2023 · External reference
Genomic and transcriptomic profiling of combined hepatocellular and intrahepatic cholangiocarcinoma reveals distinct molecular subtypes
10.1016/j.ccell.2019.04.007 · 2019 · External reference
Combined hepatocellular carcinoma-cholangiocarcinoma with sarcomatoid features: new insights into a rare and aggressive tumor
10.21037/jgo-24-752 · 2024 · External reference
Combined hepatocellular-cholangiocarcinoma: an update on pathology and diagnostic approach
10.3390/biomedicines10081826 · 2022 · External reference
Prognostic significance of preoperative systemic immune-inflammation index in combined hepatocellular-cholangiocarcinoma
10.3233/cbm-200643 · 2021 · External reference
The prognostic value of peripheral blood inflammatory markers in hepatocellular carcinoma treated with lenvatinib combined with PD-1 inhibitors
10.2147/jhc.s486910 · 2025 · External reference
Prognostic biomarkers associated with immune checkpoint inhibitors in hepatocellular carcinoma
10.1111/imm.13751 · 2024 · External reference
The systemic immune-inflammation index predicts prognosis in intrahepatic cholangiocarcinoma: an international multi-institutional analysis
10.1016/j.hpb.2020.03.011 · 2020 · External reference
Evaluation of the American joint committee on cancer (AJCC) 8th edition staging system for hepatocellular carcinoma in 1,008 patients with curative resection
2020 · External reference
Intrahepatic cholangiocarcinoma: the AJCC/UICC 8th edition updates
10.21037/cco.2018.07.03 · 2018 · External reference
The threshold of alpha-fetoprotein (AFP) for the diagnosis of hepatocellular carcinoma: a systematic review and meta-analysis
2020 · External reference
Carcinoembryonic antigen in the diagnosis, treatment, and follow-up of focal liver lesions
10.4240/wjgs.v16.i4.999 · 2024 · External reference
Carbohydrate antigen 19-9—Tumor marker: past, present, and future
10.4240/wjgs.v12.i12.468 · 2020 · External reference
Intratumor heterogeneity and branched evolution revealed by multiregion sequencing
10.1056/nejmoa1113205 · 2012 · External reference
Intratumor heterogeneity: the rosetta stone of therapy resistance
10.1016/j.ccell.2020.03.007 · 2020 · External reference
Role of microvascular invasion in early recurrence of hepatocellular carcinoma after liver resection: a literature review
10.1016/j.asjsur.2024.02.115 · 2024 · External reference
Microvascular invasion of hepatocellular carcinoma predicts microvascular invasion of its recurrence: potential implications for salvage liver transplantation?
10.21037/hbsn-21-346 · 2023 · External reference
Narrow-margin hepatectomy resulted in higher recurrence and lower overall survival for R0 resection hepatocellular carcinoma
2020 · External reference
The influence of resection margin width in patients with intrahepatic cholangiocarcinoma: a meta-analysis
10.1186/s12957-023-02901-5 · 2023 · External reference
Current evidence on posthepatectomy liver failure: comprehensive review
10.1093/bjsopen/zrac142 · 2022 · External reference
Immunity, inflammation, and cancer
10.1016/j.cell.2010.01.025 · 2010 · External reference
The monocyte to lymphocyte ratio not only at baseline but also at relapse predicts poor outcomes in patients with hepatocellular carcinoma receiving locoregional therapy
10.1186/s12876-022-02180-6 · 2022 · External reference
Lymphocyte-to-monocyte ratio predicts survival of patients with hepatocellular carcinoma after curative resection
10.3748/wjg.v21.i38.10898 · 2015 · External reference
Hepatocellular carcinoma differentiation: research progress in mechanism and treatment
2021 · External reference
Dedifferentiation of hepatocellular carcinoma: molecular mechanisms and therapeutic implications
2020 · External reference
Establishment of a prognostic nomogram and risk stratification system for patients with combined hepatocellular-cholangiocarcinoma
10.1038/s41598-025-01817-2 · 2025 · External reference
Development and validation of a nomogram to predict prognosis of patients with combined hepatocellular-cholangiocarcinoma after hepatic resection
10.7150/jca.116790 · 2025 · External reference
The predictive value of staging systems and inflammation scores for patients with combined hepatocellular cholangiocarcinoma after surgical resection: a retrospective study
10.1007/s11605-018-3756-3 · 2018 · External reference
Post-resection prognosis of combined hepatocellular carcinoma-cholangiocarcinoma cannot be predicted by the 2019 world health organization classification
10.1016/j.asjsur.2021.03.002 · 2021 · External reference
Meta-analysis of prognostic factors for overall survival and disease-free survival among resected patients with combined hepatocellular carcinoma and cholangiocarcinoma
10.1016/j.ejso.2023.107279 · 2024 · External reference
Neutrophil-to-lymphocyte ratio predicts overall survival of patients with combined hepatocellular cholangiocarcinoma
2018 · External reference
Elevated neutrophil-to-lymphocyte ratio and predominance of intrahepatic cholangiocarcinoma prediction of poor hepatectomy outcomes in patients with combined hepatocellular-cholangiocarcinoma
10.1371/journal.pone.0240791 · 2020 · External reference
The systemic inflammation-based neutrophil-lymphocyte ratio: experience in patients with cancer
10.1016/j.critrevonc.2013.03.010 · 2013 · External reference
Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis
10.1093/jnci/dju124 · 2014 · External reference
Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications
10.3389/fcell.2022.938289 · 2022 · External reference
The good, the bad, and the ugly: neutrophils, angiogenesis, and cancer
10.3390/cancers14030536 · 2022 · External reference
Combined hepatocellular-cholangiocarcinoma: what the multidisciplinary team should know
10.3390/diagnostics12040890 · 2022 · External reference
Influence of cirrhosis on long-term prognosis after surgery in patients with combined hepatocellular-cholangiocarcinoma
10.1186/s12876-017-0584-y · 2017 · External reference
Resection of hepatitis B virus-related hepatocellular carcinoma: evolving strategies and emerging therapies to improve outcome
10.3748/wjg.v20.i35.12473 · 2014 · External reference
Early and late recurrence after hepatectomy in patients with low-level HBV-DNA hepatocellular carcinoma under antiviral therapy
10.1186/s13027-022-00468-6 · 2022 · External reference
The effect of antiviral therapy on patients with hepatitis B virus-related hepatocellular carcinoma after curative resection: a systematic review and meta-analysis
10.2147/ott.s150281 · 2017 · External reference
Microvascular invasion in hepatocellular carcinoma: a review of its definition, clinical significance, and comprehensive management
10.1155/2022/9567041 · 2022 · External reference
Preoperative nomogram for microvascular invasion prediction based on clinical database in hepatocellular carcinoma
2021 · External reference
Prediction of microvascular invasion in combined hepatocellular-cholangiocarcinoma based on preoperative contrast-enhanced CT and clinical data
10.1016/j.ejrad.2023.110839 · 2023 · External reference
Long-term outcome and prognostic factors of combined hepatocellular carcinoma and cholangiocarcinoma after curative resection
10.1093/gastro/goaa003 · 2020 · External reference
Patient outcomes in resected combined hepatocellular cholangiocarcinoma (cHCC-ICC) and intrahepatic cholangiocarcinoma: a single center study
10.3390/cancers16223878 · 2024 · External reference
Prognostic significance of three-tiered pathological classification for microvascular invasion in patients with combined hepatocellular-cholangiocarcinoma following hepatic resection
10.1002/cam4.5328 · 2023 · External reference
Combined hepatocellular-cholangiocarcinoma: which preoperative clinical data and conventional MRI characteristics have value for the prediction of microvascular invasion and clinical significance?
10.1007/s00330-020-06861-2 · 2020 · External reference
Combined hepatocellular-cholangiocarcinoma: an update on epidemiology, classification, diagnosis and management
10.1016/j.hbpd.2020.07.004 · 2020 · External reference
Background progenitor activation is associated with recurrence after hepatectomy of combined hepatocellular-cholangiocarcinoma
10.1002/hep.25874 · 2012 · External reference
Preoperative monocyte-to-lymphocyte ratio as a prognosis predictor after curative hepatectomy for intrahepatic cholangiocarcinoma
10.1186/s12885-024-12929-9 · 2024 · External reference
The lymphocyte-to-monocyte ratio is a superior predictor of overall survival compared to established biomarkers in HCC patients undergoing liver resection
10.1038/s41598-018-20199-2 · 2018 · External reference
Tumor-associated macrophages as major immunosuppressive cells in the tumor microenvironment
10.3390/cancers16193410 · 2024 · External reference
Concepts of extracellular matrix remodelling in tumour progression and metastasis
10.1038/s41467-020-18794-x · 2020 · External reference
Macrophages in the premetastatic and metastatic niche: key functions and therapeutic directions
10.1186/s12967-025-06556-6 · 2025 · External reference