Research graph
References from A 6His-2Flag dual-tag strategy enables high-yield production of antimicrobial peptide N6 in Pichia pastoris to combat multidrug-resistant Klebsiella pneumonia. Local targets link to admitted publications; unresolved targets remain external evidence.
Klebsiella pneumoniae: going on the offense with a strong defense
10.1128/mmbr.00078-15 · 2016 · External reference
Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
10.1515/med-2023-0707 · 2023 · External reference
Epidemiological characteristics and formation mechanisms of multidrug-resistant Hypervirulent Klebsiella pneumoniae
10.3389/fmicb.2020.581543 · 2020 · External reference
A new era of antibiotics: the clinical potential of antimicrobial peptides
10.3390/ijms21197047 · 2020 · External reference
Marine invertebrate antimicrobial peptides and their potential as novel peptide antibiotics
10.3390/md21100503 · 2023 · External reference
Antibacterial and detoxifying activity of NZ17074 analogues with multi-layers of selective antimicrobial actions against Escherichia coli and Salmonella enteritidis
2017 · External reference
Deleting the first disulfide bond in an arenicin derivative enhances its expression in Pichia pastoris
10.1111/lam.12770 · 2017 · External reference
Expression and purification of antimicrobial peptide AP2 using SUMO fusion partner technology in Escherichia coli
10.1111/lam.13079 · 2018 · External reference
New developments in Pichia pastoris expression system, review and update
10.2174/1389201019666180718093037 · 2018 · External reference
High-yield preparation of American oyster defensin (AOD) via a small and acidic fusion tag and its antibacterial activity against Staphylococcus epidermidis
10.3390/md22010008 · 2024 · External reference
Characterization of an anti-FLAG antibody binding protein in V. cholerae
10.1016/j.bbrc.2020.05.169 · 2020 · External reference
Review on microbial recombination expression of antimicrobial peptides
2025 · External reference
Mechanisms of antibiotic resistance and developments in therapeutic strategies to combat Klebsiella pneumoniae infection
10.2147/idr.s453025 · 2024 · External reference
A new high-yielding antimicrobial peptide NZX and its antibacterial activity against Staphylococcus hyicus in Vitro/Vivo
10.1007/s00253-019-10313-3 · 2020 · External reference
In vitro and in vivo characterization of a new recombinant antimicrobial peptide, MP1102, against methicillin-resistant Staphylococcus aureus
2015 · External reference
Unresolved reference
2025 · External reference
High prevalence of KPC-2-producing hypervirulent Klebsiella pneumoniae causing meningitis in Eastern China
10.2147/idr.s191892 · 2019 · External reference
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances
10.1038/nprot.2007.521 · 2008 · External reference
Dermatophytic defensin with antiinfective potential
10.1073/pnas.1201263109 · 2012 · External reference
Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test
10.1128/aac.40.8.1914 · 1996 · External reference
A recombinant fungal defensin-like peptide-p2 combats multidrug-resistant Staphylococcus aureus and biofilms
10.1007/s00253-019-09785-0 · 2019 · External reference
A novel pH-responsive iron oxide core-shell magnetic mesoporous silica nanoparticle (M-MSN) system encapsulating doxorubicin (DOX) and glucose oxidase (Gox) for pancreatic cancer treatment
10.2147/ijn.s436253 · 2023 · External reference
Unlocking the power of antimicrobial peptides: advances in production, optimization, and therapeutics
10.3389/fcimb.2025.1528583 · 2025 · External reference
Designing and optimizing new antimicrobial peptides: all targets are not the same
10.1080/10408363.2019.1631249 · 2019 · External reference
The One Health stewardship of colistin as an antibiotic of last resort for human health in South Africa
10.1016/s1473-3099(18)30119-1 · 2018 · External reference
In vitro pharmacodynamics of colistin against multidrug-resistant Klebsiella pneumoniae
10.1093/jac/dkn425 · 2008 · External reference
Detection of colistin-resistant populations prior to antibiotic exposure in KPC-2-producing Klebsiella pneumoniae clinical isolates
10.1007/s12275-021-0610-1 · 2021 · External reference
Antimicrobial activity of two novel antimicrobial peptides AA139 and SET-M33 against clinically and genotypically diverse Klebsiella pneumoniae isolates with differing antibiotic resistance profiles
10.1016/j.ijantimicag.2019.05.019 · 2019 · External reference
Unveiling a new antimicrobial peptide with efficacy against P. aeruginosa and K. pneumoniae from mangrove-derived Paenibacillus thiaminolyticus NNS5-6 and genomic analysis
10.3390/antibiotics13090846 · 2024 · External reference
Gentamicin in 1978
10.7326/0003-4819-89-4-528 · 1978 · External reference
How macrolide antibiotics work
10.1016/j.tibs.2018.06.011 · 2018 · External reference
Improved stability and activity of a marine peptide-N6NH2 against Edwardsiella tarda and its preliminary application in fish
10.3390/md18120650 · 2020 · External reference
An experimental study to evaluate the effect of polymixin E (Colistin) alone or in combination with gentamicin in McCarey-Kaufman corneal preservation medium on various drug resistant bacterial and fungal isolates
10.4103/ijo.ijo_12_22 · 2022 · External reference
SPR741, Double- or triple-combined with Erythromycin and Clarithromycin, combats drug-resistant Klebsiella pneumoniae, its biofilms, and persister cells
10.3389/fcimb.2022.858606 · 2022 · External reference
Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis
10.1073/pnas.2409655121 · 2024 · External reference
Biofilm formation in a hydrodynamic environment by novel fimh variants and ramifications for virulence
10.1128/iai.69.3.1322-1328.2001 · 2001 · External reference
Enterobactin biosynthesis in Escherichia coli: isochorismate lyase (entB) is a bifunctional enzyme that is phosphopantetheinylated by entD and then acylated by entE using ATP and 2,3-dihydroxybenzoate
10.1021/bi970453p · 1997 · External reference
An assessment of siderophore production, mucoviscosity, and mouse infection models for defining the virulence spectrum of hypervirulent Klebsiella pneumoniae
10.1128/msphere.00045-21 · 2021 · External reference
RmpA regulation of capsular polysaccharide biosynthesis in Klebsiella pneumoniae CG43
10.1128/jb.00031-10 · 2010 · External reference
Characterization of integrative and conjugative element ICEKp1-associated genomic heterogeneity in a Klebsiella pneumoniae strain isolated from a primary liver abscess
2007 · External reference
Analysis of antibiotic-induced drug resistance of Salmonella enteritidis and its biofilm formation mechanism
10.1080/21655979.2021.1988251 · 2021 · External reference
The influence of biofilms in the biology of plasmids
10.1128/microbiolspec.plas-0012-2013 · 2014 · External reference
Exploration of antimicrobial peptides in the treatment of gentamicin-resistant Klebsiella pneumoniae infection
10.2147/idr.s462653 · 2024 · External reference
The impact of PM2.5 on the host defense of respiratory system
2020 · External reference
Functional insights from KpfR, a new transcriptional regulator of fimbrial expression that is crucial for Klebsiella pneumoniae pathogenicity
10.3389/fmicb.2020.601921 · 2021 · External reference
Klebsiella pneumoniae-OMVs activate death-signaling pathways in human bronchial epithelial host cells (BEAS-2B)
10.1016/j.heliyon.2024.e29017 · 2024 · External reference
High BMP7 expression May worsen airway disease in COPD by altering epithelial cell behavior
10.2147/copd.s490537 · 2025 · External reference
Colibactin contributes to the hypervirulence of pks+ K1 CC23 Klebsiella pneumoniae in mouse meningitis infections
10.3389/fcimb.2017.00103 · 2017 · External reference
Outer membrane protein A mediates Klebsiella pneumoniae penetration of the blood-brain barrier and induces bacterial meningitis
2025 · External reference
Interactions of polymyxin B with lipopolysaccharide-containing membranes
10.1039/d1fd00036e · 2021 · External reference
The transcriptomic response of Acinetobacter baumannii to colistin and doripenem alone and in combination in an in vitro pharmacokinetics/pharmacodynamics model
10.1093/jac/dku536 · 2015 · External reference
C-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo
10.1186/s12866-022-02534-w · 2022 · External reference
Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens
10.1016/j.csbj.2020.08.008 · 2020 · External reference
A recombinant fungal defensin-like peptide-p2 combats multidrug-resistant Staphylococcus aureus and biofilms
10.1007/s00253-019-09785-0 · ExternalCitation · doi-reference
A new high-yielding antimicrobial peptide NZX and its antibacterial activity against Staphylococcus hyicus in Vitro/Vivo
10.1007/s00253-019-10313-3 · ExternalCitation · doi-reference
Detection of colistin-resistant populations prior to antibiotic exposure in KPC-2-producing Klebsiella pneumoniae clinical isolates
10.1007/s12275-021-0610-1 · ExternalCitation · doi-reference
Characterization of an anti-FLAG antibody binding protein in V. cholerae
10.1016/j.bbrc.2020.05.169 · ExternalCitation · doi-reference
Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens
10.1016/j.csbj.2020.08.008 · ExternalCitation · doi-reference
Klebsiella pneumoniae-OMVs activate death-signaling pathways in human bronchial epithelial host cells (BEAS-2B)
10.1016/j.heliyon.2024.e29017 · ExternalCitation · doi-reference
Antimicrobial activity of two novel antimicrobial peptides AA139 and SET-M33 against clinically and genotypically diverse Klebsiella pneumoniae isolates with differing antibiotic resistance profiles
10.1016/j.ijantimicag.2019.05.019 · ExternalCitation · doi-reference
How macrolide antibiotics work
10.1016/j.tibs.2018.06.011 · ExternalCitation · doi-reference
The One Health stewardship of colistin as an antibiotic of last resort for human health in South Africa
10.1016/s1473-3099(18)30119-1 · ExternalCitation · doi-reference
Enterobactin biosynthesis in Escherichia coli: isochorismate lyase (entB) is a bifunctional enzyme that is phosphopantetheinylated by entD and then acylated by entE using ATP and 2,3-dihydroxybenzoate
10.1021/bi970453p · ExternalCitation · doi-reference
Agar and broth dilution methods to determine the minimal inhibitory concentration (MIC) of antimicrobial substances
10.1038/nprot.2007.521 · ExternalCitation · doi-reference
Interactions of polymyxin B with lipopolysaccharide-containing membranes
10.1039/d1fd00036e · ExternalCitation · doi-reference
Dermatophytic defensin with antiinfective potential
10.1073/pnas.1201263109 · ExternalCitation · doi-reference
Conformational ensembles in Klebsiella pneumoniae FimH impact uropathogenesis
10.1073/pnas.2409655121 · ExternalCitation · doi-reference
Designing and optimizing new antimicrobial peptides: all targets are not the same
10.1080/10408363.2019.1631249 · ExternalCitation · doi-reference
Analysis of antibiotic-induced drug resistance of Salmonella enteritidis and its biofilm formation mechanism
10.1080/21655979.2021.1988251 · ExternalCitation · doi-reference
In vitro pharmacodynamics of colistin against multidrug-resistant Klebsiella pneumoniae
10.1093/jac/dkn425 · ExternalCitation · doi-reference
The transcriptomic response of Acinetobacter baumannii to colistin and doripenem alone and in combination in an in vitro pharmacokinetics/pharmacodynamics model
10.1093/jac/dku536 · ExternalCitation · doi-reference
Deleting the first disulfide bond in an arenicin derivative enhances its expression in Pichia pastoris
10.1111/lam.12770 · ExternalCitation · doi-reference
Expression and purification of antimicrobial peptide AP2 using SUMO fusion partner technology in Escherichia coli
10.1111/lam.13079 · ExternalCitation · doi-reference
Comparison of three different in vitro methods of detecting synergy: time-kill, checkerboard, and E test
10.1128/aac.40.8.1914 · ExternalCitation · doi-reference
Biofilm formation in a hydrodynamic environment by novel fimh variants and ramifications for virulence
10.1128/iai.69.3.1322-1328.2001 · ExternalCitation · doi-reference
RmpA regulation of capsular polysaccharide biosynthesis in Klebsiella pneumoniae CG43
10.1128/jb.00031-10 · ExternalCitation · doi-reference
The influence of biofilms in the biology of plasmids
10.1128/microbiolspec.plas-0012-2013 · ExternalCitation · doi-reference
Klebsiella pneumoniae: going on the offense with a strong defense
10.1128/mmbr.00078-15 · ExternalCitation · doi-reference
An assessment of siderophore production, mucoviscosity, and mouse infection models for defining the virulence spectrum of hypervirulent Klebsiella pneumoniae
10.1128/msphere.00045-21 · ExternalCitation · doi-reference
C-terminal mini-PEGylation of a marine peptide N6 had potent antibacterial and anti-inflammatory properties against Escherichia coli and Salmonella strains in vitro and in vivo
10.1186/s12866-022-02534-w · ExternalCitation · doi-reference
Characteristics of antibiotic resistance mechanisms and genes of Klebsiella pneumoniae
10.1515/med-2023-0707 · ExternalCitation · doi-reference
High BMP7 expression May worsen airway disease in COPD by altering epithelial cell behavior
10.2147/copd.s490537 · ExternalCitation · doi-reference
High prevalence of KPC-2-producing hypervirulent Klebsiella pneumoniae causing meningitis in Eastern China
10.2147/idr.s191892 · ExternalCitation · doi-reference
Mechanisms of antibiotic resistance and developments in therapeutic strategies to combat Klebsiella pneumoniae infection
10.2147/idr.s453025 · ExternalCitation · doi-reference
Exploration of antimicrobial peptides in the treatment of gentamicin-resistant Klebsiella pneumoniae infection
10.2147/idr.s462653 · ExternalCitation · doi-reference
A novel pH-responsive iron oxide core-shell magnetic mesoporous silica nanoparticle (M-MSN) system encapsulating doxorubicin (DOX) and glucose oxidase (Gox) for pancreatic cancer treatment
10.2147/ijn.s436253 · ExternalCitation · doi-reference
New developments in Pichia pastoris expression system, review and update
10.2174/1389201019666180718093037 · ExternalCitation · doi-reference
Colibactin contributes to the hypervirulence of pks+ K1 CC23 Klebsiella pneumoniae in mouse meningitis infections
10.3389/fcimb.2017.00103 · ExternalCitation · doi-reference
SPR741, Double- or triple-combined with Erythromycin and Clarithromycin, combats drug-resistant Klebsiella pneumoniae, its biofilms, and persister cells
10.3389/fcimb.2022.858606 · ExternalCitation · doi-reference
Unlocking the power of antimicrobial peptides: advances in production, optimization, and therapeutics
10.3389/fcimb.2025.1528583 · ExternalCitation · doi-reference
Epidemiological characteristics and formation mechanisms of multidrug-resistant Hypervirulent Klebsiella pneumoniae
10.3389/fmicb.2020.581543 · ExternalCitation · doi-reference
Functional insights from KpfR, a new transcriptional regulator of fimbrial expression that is crucial for Klebsiella pneumoniae pathogenicity
10.3389/fmicb.2020.601921 · ExternalCitation · doi-reference
Unveiling a new antimicrobial peptide with efficacy against P. aeruginosa and K. pneumoniae from mangrove-derived Paenibacillus thiaminolyticus NNS5-6 and genomic analysis
10.3390/antibiotics13090846 · ExternalCitation · doi-reference
A new era of antibiotics: the clinical potential of antimicrobial peptides
10.3390/ijms21197047 · ExternalCitation · doi-reference
Improved stability and activity of a marine peptide-N6NH2 against Edwardsiella tarda and its preliminary application in fish
10.3390/md18120650 · ExternalCitation · doi-reference
Marine invertebrate antimicrobial peptides and their potential as novel peptide antibiotics
10.3390/md21100503 · ExternalCitation · doi-reference
High-yield preparation of American oyster defensin (AOD) via a small and acidic fusion tag and its antibacterial activity against Staphylococcus epidermidis
10.3390/md22010008 · ExternalCitation · doi-reference
An experimental study to evaluate the effect of polymixin E (Colistin) alone or in combination with gentamicin in McCarey-Kaufman corneal preservation medium on various drug resistant bacterial and fungal isolates
10.4103/ijo.ijo_12_22 · ExternalCitation · doi-reference
Gentamicin in 1978
10.7326/0003-4819-89-4-528 · ExternalCitation · doi-reference
