Research graph
References from Reprogramming NAD+ homeostasis and FOXO3a–Nrf2 signaling mitigates bleomycin-driven pulmonary fibrosis. Local targets link to admitted publications; unresolved targets remain external evidence.
Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal bleomycin rat model
10.1016/j.biopha.2023.114553 · 2023 · External reference
Anti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications
10.1177/20420188231222367 · 2024 · External reference
The multifaceted effects of semaglutide: exploring its broad therapeutic applications
10.1080/20565623.2025.2483607 · 2025 · External reference
Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats
10.1016/j.ebiom.2023.104642 · 2023 · External reference
Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis
10.1164/ajrccm.163.7.2006132 · 2001 · External reference
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
10.1124/pr.110.003905 · 2012 · External reference
Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure
10.1152/ajprenal.00126.2009 · 2009 · External reference
A new era in the treatment of progressive fibrosing interstitial lung diseases
10.1183/20734735.0259-2024 · 2025 · External reference
SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro
10.3892/ijmm.2016.2503 · 2016 · External reference
Activation of AMPK/SIRT1/FOXO3a signaling by BMS-477118 (saxagliptin) mitigates chronic colitis in rats: uncovering new anti-inflammatory and antifibrotic roles
2024 · External reference
E1231/NMN protects against experimental metabolic syndrome: the central role of SIRT1 in modulating AKT/Nrf2/NFκB signaling
2025 · External reference
Activation of SIRT1 by SRT1720 alleviates dyslipidemia, improves insulin sensitivity and exhibits liver-protective effects in diabetic rats on a high-fat diet: new insights into the SIRT1/Nrf2/NFκB signaling pathway
10.1016/j.ejps.2025.107002 · 2025 · External reference
Activation of nicotinamide phosphoribosyltransferase protects against unilateral renal ischemia-reperfusion injury via the NAD+/SIRT1/PGC-1α signaling pathway and modulation of NFκB/TNF-α/IL-6
10.1016/j.ejps.2025.107302 · 2025 · External reference
GLP-1 receptor agonist ameliorates experimental lung fibrosis
10.1038/s41598-020-74912-1 · 2020 · External reference
Natural compounds for SIRT1-mediated oxidative stress and neuroinflammation in stroke: a potential therapeutic target in the future
10.1155/2022/1949718 · 2022 · External reference
Combination therapy with pirfenidone and nintedanib in idiopathic pulmonary fibrosis: a systematic review and meta-analysis
10.1016/j.chest.2023.07.1984 · 2023 · External reference
Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s)
10.1016/j.nano.2017.04.005 · 2017 · External reference
Hyperoside attenuates bleomycin-induced pulmonary fibrosis development in mice
10.3389/fphar.2020.550955 · 2020 · External reference
Immune mechanisms of pulmonary fibrosis with bleomycin
10.3390/ijms24043149 · 2023 · External reference
Pexidartinib and nintedanib combination therapy targets macrophage polarization to reverse pulmonary fibrosis: a preclinical study
10.3390/ijms26157570 · 2025 · External reference
A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis
10.1056/nejmoa1402582 · 2014 · External reference
Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes
10.1007/s00125-010-2028-x · 2011 · External reference
The importance of interventional timing in the bleomycin model of pulmonary fibrosis
10.1183/13993003.01105-2019 · 2020 · External reference
Semaglutide alleviates ovary inflammation via the AMPK/SIRT1/NF-κB signaling pathway in polycystic ovary syndrome mice
10.2147/dddt.s484531 · 2024 · External reference
Comprehensive review of potential drugs with anti-pulmonary fibrosis properties
10.1016/j.biopha.2024.116282 · 2024 · External reference
Modulation of bleomycin-induced oxidative stress and pulmonary fibrosis by N-acetylcysteine in rats via AMPK/SIRT1/NF-κβ
10.1111/1440-1681.13378 · 2020 · External reference
Neuroprotective effect of niacin in a rat model of obesity induced by high-fat-rich diet
10.1007/s00210-024-03687-3 · 2025 · External reference
The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
10.1016/j.biocel.2007.08.011 · 2008 · External reference
Alvespimycin exhibits potential anti-TGF-β signaling in the setting of a proteasome activator in rats with bleomycin-induced pulmonary fibrosis: a promising novel approach
10.3390/ph16081123 · 2023 · External reference
NAD+ metabolism, stemness, the immune response, and cancer
10.1038/s41392-020-00354-w · 2021 · External reference
Adjunctive therapies in idiopathic pulmonary fibrosis—where do we stand?
10.21037/jtd.2018.11.131 · 2018 · External reference
Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial
10.1038/s43587-024-00758-1 · 2024 · External reference
Oxidative stress and inflammation regulation of sirtuins: new insights into common oral diseases
2022 · External reference
The role of NAD(+) and NAD(+)-boosting therapies in inflammatory response by IL-13
10.3390/ph17020226 · 2024 · External reference
GLP-1 receptor agonists in heart failure
10.3390/biom15101403 · 2025 · External reference
The role of different SIRT1-mediated signaling pathways in toxic injury
10.1186/s11658-019-0158-9 · 2019 · External reference
Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis
10.1056/nejmoa1402584 · 2014 · External reference
Nifuroxazide-loaded cubosomes exhibit an advancement in pulmonary delivery and attenuate bleomycin-induced lung fibrosis by regulating the STAT3 and NF-κB signaling: a new challenge for unmet therapeutic needs
10.1016/j.biopha.2022.112731 · 2022 · External reference
E1231/SR647 protects against unilateral renal ischemia-reperfusion injury by modulating SIRT1/FOXO3 interactions with Nrf2 and NFκB pathways
10.1016/j.ejps.2025.107099 · 2025 · External reference
Protective effects of niacin following high fat rich diet: an in-vivo and in-silico study
10.1038/s41598-023-48566-8 · 2023 · External reference
Targeting CD38-dependent NAD(+) metabolism to mitigate multiple organ fibrosis
10.1016/j.isci.2020.101902 · 2021 · External reference
Mechanisms of the NAD+ salvage pathway in enhancing skeletal muscle function
2024 · External reference
Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo
10.1016/j.jaci.2017.11.043 · 2018 · External reference
Niacin modulates SIRT1-driven signaling to counteract radiation-induced neurocognitive and behavioral impairments
10.3390/ijms26115285 · 2025 · External reference
Glucagon-like peptide-1 (GLP-1) mediates the protective effects of dipeptidyl peptidase IV inhibition on pulmonary hypertension
10.1186/s12929-019-0496-y · 2019 · External reference
The role of Nrf2 in pulmonary fibrosis: molecular mechanisms and treatment approaches
2022 · External reference
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway
10.1016/j.neuropharm.2023.109716 · 2023 · External reference
Pulmonary fibrosis: pathogenesis and therapeutic strategies
10.1002/mco2.744 · 2024 · External reference
Integrated spatial and single-cell transcriptomics reveal PAK kinase as a therapeutic target in fibroblastic foci and dense fibrosis of idiopathic pulmonary fibrosis
10.1183/13993003.00022-2025 · 2025 · External reference
Unresolved reference
2025 · External reference
Effects of glucagon-like peptide-1 receptor agonists on gut microbiota in dehydroepiandrosterone-induced polycystic ovary syndrome mice: compared evaluation of liraglutide and semaglutide intervention
10.2147/dmso.s451129 · 2024 · External reference
SIRT1 activators suppress inflammatory responses through promotion of p65 deacetylation and inhibition of NF-κB activity
2012 · External reference
Regulation of SIRT1 and its roles in inflammation
2022 · External reference
Exploring the antioxidant properties of semaglutide: a comprehensive review
10.1016/j.jdiacomp.2024.108906 · 2024 · External reference
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
10.1038/sj.emboj.7600244 · 2004 · External reference
The expanding role of semaglutide: beyond glycemic control
10.1007/s40200-025-01663-z · 2025 · External reference
GLP-1RAs regulate lipid metabolism and induce autophagy through AMPK/SIRT1 pathway to improve NAFLD
10.1016/j.prostaglandins.2025.106987 · 2025 · External reference
Glucagon-like peptide-1 receptor: mechanisms and advances in therapy
10.1038/s41392-024-01931-z · 2024 · External reference
Refined murine model of idiopathic pulmonary fibrosis
10.3791/68484 · 2025 · External reference
Coomassie brilliant blue G-250 dye attenuates bleomycin-induced lung fibrosis by regulating the NF-κB and NLRP3 crosstalk: a novel approach for filling an unmet medical need
10.1016/j.biopha.2022.112723 · 2022 · External reference
Pulmonary fibrosis: pathogenesis and therapeutic strategies
10.1002/mco2.744 · ExternalCitation · doi-reference
Glucagon-like peptide-1 receptor agonist ameliorates renal injury through its anti-inflammatory action without lowering blood glucose level in a rat model of type 1 diabetes
10.1007/s00125-010-2028-x · ExternalCitation · doi-reference
Neuroprotective effect of niacin in a rat model of obesity induced by high-fat-rich diet
10.1007/s00210-024-03687-3 · ExternalCitation · doi-reference
The expanding role of semaglutide: beyond glycemic control
10.1007/s40200-025-01663-z · ExternalCitation · doi-reference
The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis?
10.1016/j.biocel.2007.08.011 · ExternalCitation · doi-reference
Coomassie brilliant blue G-250 dye attenuates bleomycin-induced lung fibrosis by regulating the NF-κB and NLRP3 crosstalk: a novel approach for filling an unmet medical need
10.1016/j.biopha.2022.112723 · ExternalCitation · doi-reference
Nifuroxazide-loaded cubosomes exhibit an advancement in pulmonary delivery and attenuate bleomycin-induced lung fibrosis by regulating the STAT3 and NF-κB signaling: a new challenge for unmet therapeutic needs
10.1016/j.biopha.2022.112731 · ExternalCitation · doi-reference
Mirtazapine, an atypical antidepressant, mitigates lung fibrosis by suppressing NLPR3 inflammasome and fibrosis-related mediators in endotracheal bleomycin rat model
10.1016/j.biopha.2023.114553 · ExternalCitation · doi-reference
Comprehensive review of potential drugs with anti-pulmonary fibrosis properties
10.1016/j.biopha.2024.116282 · ExternalCitation · doi-reference
Combination therapy with pirfenidone and nintedanib in idiopathic pulmonary fibrosis: a systematic review and meta-analysis
10.1016/j.chest.2023.07.1984 · ExternalCitation · doi-reference
Semaglutide reduces alcohol intake and relapse-like drinking in male and female rats
10.1016/j.ebiom.2023.104642 · ExternalCitation · doi-reference
Activation of SIRT1 by SRT1720 alleviates dyslipidemia, improves insulin sensitivity and exhibits liver-protective effects in diabetic rats on a high-fat diet: new insights into the SIRT1/Nrf2/NFκB signaling pathway
10.1016/j.ejps.2025.107002 · ExternalCitation · doi-reference
E1231/SR647 protects against unilateral renal ischemia-reperfusion injury by modulating SIRT1/FOXO3 interactions with Nrf2 and NFκB pathways
10.1016/j.ejps.2025.107099 · ExternalCitation · doi-reference
Activation of nicotinamide phosphoribosyltransferase protects against unilateral renal ischemia-reperfusion injury via the NAD+/SIRT1/PGC-1α signaling pathway and modulation of NFκB/TNF-α/IL-6
10.1016/j.ejps.2025.107302 · ExternalCitation · doi-reference
Targeting CD38-dependent NAD(+) metabolism to mitigate multiple organ fibrosis
10.1016/j.isci.2020.101902 · ExternalCitation · doi-reference
Glucagon-like peptide 1 signaling inhibits allergen-induced lung IL-33 release and reduces group 2 innate lymphoid cell cytokine production in vivo
10.1016/j.jaci.2017.11.043 · ExternalCitation · doi-reference
Exploring the antioxidant properties of semaglutide: a comprehensive review
10.1016/j.jdiacomp.2024.108906 · ExternalCitation · doi-reference
Combinatorial treatment of idiopathic pulmonary fibrosis using nanoparticles with prostaglandin E and siRNA(s)
10.1016/j.nano.2017.04.005 · ExternalCitation · doi-reference
Semaglutide ameliorates cognition and glucose metabolism dysfunction in the 3xTg mouse model of Alzheimer's disease via the GLP-1R/SIRT1/GLUT4 pathway
10.1016/j.neuropharm.2023.109716 · ExternalCitation · doi-reference
GLP-1RAs regulate lipid metabolism and induce autophagy through AMPK/SIRT1 pathway to improve NAFLD
10.1016/j.prostaglandins.2025.106987 · ExternalCitation · doi-reference
NAD+ metabolism, stemness, the immune response, and cancer
10.1038/s41392-020-00354-w · ExternalCitation · doi-reference
Glucagon-like peptide-1 receptor: mechanisms and advances in therapy
10.1038/s41392-024-01931-z · ExternalCitation · doi-reference
GLP-1 receptor agonist ameliorates experimental lung fibrosis
10.1038/s41598-020-74912-1 · ExternalCitation · doi-reference
Protective effects of niacin following high fat rich diet: an in-vivo and in-silico study
10.1038/s41598-023-48566-8 · ExternalCitation · doi-reference
Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial
10.1038/s43587-024-00758-1 · ExternalCitation · doi-reference
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
10.1038/sj.emboj.7600244 · ExternalCitation · doi-reference
A phase 3 trial of pirfenidone in patients with idiopathic pulmonary fibrosis
10.1056/nejmoa1402582 · ExternalCitation · doi-reference
Efficacy and safety of nintedanib in idiopathic pulmonary fibrosis
10.1056/nejmoa1402584 · ExternalCitation · doi-reference
The multifaceted effects of semaglutide: exploring its broad therapeutic applications
10.1080/20565623.2025.2483607 · ExternalCitation · doi-reference
Modulation of bleomycin-induced oxidative stress and pulmonary fibrosis by N-acetylcysteine in rats via AMPK/SIRT1/NF-κβ
10.1111/1440-1681.13378 · ExternalCitation · doi-reference
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)?
10.1124/pr.110.003905 · ExternalCitation · doi-reference
Niacin ameliorates oxidative stress, inflammation, proteinuria, and hypertension in rats with chronic renal failure
10.1152/ajprenal.00126.2009 · ExternalCitation · doi-reference
Natural compounds for SIRT1-mediated oxidative stress and neuroinflammation in stroke: a potential therapeutic target in the future
10.1155/2022/1949718 · ExternalCitation · doi-reference
Bleomycin-induced chronic lung damage does not resemble human idiopathic pulmonary fibrosis
10.1164/ajrccm.163.7.2006132 · ExternalCitation · doi-reference
Anti-inflammatory role of glucagon-like peptide 1 receptor agonists and its clinical implications
10.1177/20420188231222367 · ExternalCitation · doi-reference
Integrated spatial and single-cell transcriptomics reveal PAK kinase as a therapeutic target in fibroblastic foci and dense fibrosis of idiopathic pulmonary fibrosis
10.1183/13993003.00022-2025 · ExternalCitation · doi-reference
The importance of interventional timing in the bleomycin model of pulmonary fibrosis
10.1183/13993003.01105-2019 · ExternalCitation · doi-reference
A new era in the treatment of progressive fibrosing interstitial lung diseases
10.1183/20734735.0259-2024 · ExternalCitation · doi-reference
The role of different SIRT1-mediated signaling pathways in toxic injury
10.1186/s11658-019-0158-9 · ExternalCitation · doi-reference
Glucagon-like peptide-1 (GLP-1) mediates the protective effects of dipeptidyl peptidase IV inhibition on pulmonary hypertension
10.1186/s12929-019-0496-y · ExternalCitation · doi-reference
Adjunctive therapies in idiopathic pulmonary fibrosis—where do we stand?
10.21037/jtd.2018.11.131 · ExternalCitation · doi-reference
Semaglutide alleviates ovary inflammation via the AMPK/SIRT1/NF-κB signaling pathway in polycystic ovary syndrome mice
10.2147/dddt.s484531 · ExternalCitation · doi-reference
Effects of glucagon-like peptide-1 receptor agonists on gut microbiota in dehydroepiandrosterone-induced polycystic ovary syndrome mice: compared evaluation of liraglutide and semaglutide intervention
10.2147/dmso.s451129 · ExternalCitation · doi-reference
Hyperoside attenuates bleomycin-induced pulmonary fibrosis development in mice
10.3389/fphar.2020.550955 · ExternalCitation · doi-reference
GLP-1 receptor agonists in heart failure
10.3390/biom15101403 · ExternalCitation · doi-reference
Immune mechanisms of pulmonary fibrosis with bleomycin
10.3390/ijms24043149 · ExternalCitation · doi-reference
Niacin modulates SIRT1-driven signaling to counteract radiation-induced neurocognitive and behavioral impairments
10.3390/ijms26115285 · ExternalCitation · doi-reference
Pexidartinib and nintedanib combination therapy targets macrophage polarization to reverse pulmonary fibrosis: a preclinical study
10.3390/ijms26157570 · ExternalCitation · doi-reference
Alvespimycin exhibits potential anti-TGF-β signaling in the setting of a proteasome activator in rats with bleomycin-induced pulmonary fibrosis: a promising novel approach
10.3390/ph16081123 · ExternalCitation · doi-reference
The role of NAD(+) and NAD(+)-boosting therapies in inflammatory response by IL-13
10.3390/ph17020226 · ExternalCitation · doi-reference
Refined murine model of idiopathic pulmonary fibrosis
10.3791/68484 · ExternalCitation · doi-reference
SIRT1 exerts protective effects against paraquat-induced injury in mouse type II alveolar epithelial cells by deacetylating NRF2 in vitro
10.3892/ijmm.2016.2503 · ExternalCitation · doi-reference
