Research graph
References from Tubuloside A alleviates sepsis-associated kidney injury by modulating the mTOR-NF-κB pathway. Local targets link to admitted publications; unresolved targets remain external evidence.
Oxidative stress-driven mechanisms and biomarkers of drug-induced nephrotoxicity: translational insights and therapeutic implications
10.3390/antiox15040412 · 2026 · External reference
Galectin-3 and autophagy in renal acute tubular necrosis
10.3390/ijms25073604 · 2024 · External reference
Effects of dexamethasone on macrophage migration inhibitory factor production in sepsis
10.1097/01.shk.0000225416.27742.cb · 2006 · External reference
The role of HDAC6 in autophagy and NLRP3 inflammasome
10.3389/fimmu.2021.763831 · 2021 · External reference
SIRT1 mediates effects of FGF21 to ameliorate cisplatin-induced acute kidney injury
2020 · External reference
Autophagy in kidney disease
10.1146/annurev-physiol-021119-034658 · 2020 · External reference
Overexpression of IκB⍺ modulates NF-κB activation of inflammatory target gene expression
10.3389/fmolb.2023.1187187 · 2023 · External reference
Selective autophagy in kidney health and disease
10.1038/s41581-026-01082-0 · 2026 · External reference
Tubuloside A attenuates sepsis-induced acute lung injury by modulating the NF-κB p50-Nrf2/GPX4 axis to suppress inflammation, oxidative stress and ferroptosis
10.1016/j.bcp.2026.117934 · 2026 · External reference
Zn(2+) improves sepsis-induced acute kidney injury by upregulating SIRT7-mediated Parkin acetylation
10.1152/ajprenal.00337.2023 · 2024 · External reference
Alirocumab boosts antioxidant status and halts inflammation in rat model of sepsis-induced nephrotoxicity via modulation of Nrf2/HO-1, PCSK9/HMGB1/NF-ᴋB/NLRP3 and Fractalkine/CX3CR1 hubs
10.1016/j.biopha.2024.116929 · 2024 · External reference
Sepsis-induced AKI: from pathogenesis to therapeutic approaches
2022 · External reference
LncRNA MALAT1-deficiency restrains lipopolysaccharide (LPS)-induced pyroptotic cell death and inflammation in HK-2 cells by releasing microRNA-135b-5p
10.1080/0886022x.2021.1974037 · 2021 · External reference
Rosamultin alleviates LPS-induced acute kidney injury by promoting autophagy and inhibiting the NF-κB signaling pathway
2026 · External reference
BRD4 inhibition alleviates sepsis-associated acute kidney injury via suppression of NOX4-mediated oxidative stress and inflammation
10.1038/s41420-026-03113-y · 2026 · External reference
Molecular interactions between reactive oxygen species and autophagy in kidney disease
10.3390/ijms20153791 · 2019 · External reference
mTOR as a central hub of nutrient signalling and cell growth
10.1038/s41556-018-0205-1 · 2019 · External reference
Autophagy in the pathogenesis of disease
10.1016/j.cell.2007.12.018 · 2008 · External reference
The programmed cell death of macrophages, endothelial cells, and tubular epithelial cells in sepsis-AKI
2021 · External reference
HIF1α-BNIP3-mediated mitophagy protects against renal fibrosis by decreasing ROS and inhibiting activation of the NLRP3 inflammasome
10.1038/s41419-023-05587-5 · 2023 · External reference
Protective effect of H2S on LPS-induced AKI by promoting autophagy
10.3892/mmr.2022.12612 · 2022 · External reference
Recent advances in understanding oxidative stress in sepsis: pathogenic roles and antioxidant therapeutic prospects - a narrative review
10.3389/fphar.2025.1695992 · 2025 · External reference
The role of inflammatory response and metabolic reprogramming in sepsis-associated acute kidney injury: mechanistic insights and therapeutic potential
2024 · External reference
Metabolic reprogramming in septic acute kidney injury: pathogenesis and therapeutic implications
10.1016/j.metabol.2024.155974 · 2024 · External reference
Bioactive components, pharmacological properties, and applications of Cistanche deserticola Y. C. Ma: a comprehensive review
10.3390/nu17091501 · 2025 · External reference
Mitochondrial lipid remodeling in sepsis-associated acute kidney injury: a cardiolipin-centered convergence framework
10.1007/s00204-026-04423-x · 2026 · External reference
Oxalate-induced apoptosis through ERS-ROS-NF-κB signalling pathway in renal tubular epithelial cell
10.1186/s10020-022-00494-5 · 2022 · External reference
Acylated phenylethanoid oligoglycosides with hepatoprotective activity from the desert plant Cistanche tubulosa
10.1016/j.bmc.2010.01.047 · 2010 · External reference
Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome
10.1038/ni.1980 · 2011 · External reference
Sepsis-induced brain dysfunction: pathogenesis, diagnosis, and treatment
10.1155/2022/1328729 · 2022 · External reference
ATG5-mediated autophagy suppresses NF-κB signaling to limit epithelial inflammatory response to kidney injury
10.1038/s41419-019-1483-7 · 2019 · External reference
Sepsis, a 2020 review for the internist
2020 · External reference
Inflammation, cell death, and lncRNAs: unraveling the mechanisms of sepsis-associated acute kidney injury
2026 · External reference
Mtor signaling in growth, metabolism, and disease
10.1016/j.cell.2017.03.035 · 2017 · External reference
Analyzing real-time PCR data by the comparative CT method
10.1038/nprot.2008.73 · 2008 · External reference
The third international consensus definitions for sepsis and septic shock (Sepsis-3)
10.1001/jama.2016.0287 · 2016 · External reference
PMMA-based continuous hemofiltration modulated complement activation and renal dysfunction in LPS-induced acute kidney injury
10.3389/fimmu.2021.605212 · 2021 · External reference
p53 deacetylation alleviates sepsis-induced acute kidney injury by promoting autophagy
2021 · External reference
Tubuloside A alleviates postmyocardial infarction cardiac fibrosis by inhibiting TGM2: involvement of inflammation and mitochondrial pathway apoptosis
2024 · External reference
Immunoregulatory mechanism of acute kidney injury in sepsis: a narrative review
10.1016/j.biopha.2022.114202 · 2023 · External reference
Influence of autophagy on acute kidney injury in a murine cecal ligation and puncture sepsis model
10.1038/s41598-018-19350-w · 2018 · External reference
Hypoxic mesenchymal stem cells ameliorate acute kidney ischemia-reperfusion injury via enhancing renal tubular autophagy
10.1186/s13287-021-02374-x · 2021 · External reference
Tubuloside A, a phenylethanoid glycoside, alleviates diclofenac induced hepato-nephro oxidative injury via Nrf2/HO-1 [J]
10.1111/jcmm.17968 · 2023 · External reference
NF-κB/Apaf1/caspase-9 axis suppresses autophagy to drive tubular inflammation and apoptosis in septic acute kidney injury
10.1152/ajprenal.00489.2025 · 2026 · External reference
Dynamics of oxidative stress and antioxidant capacity in relation to renal outcomes in septic patients with acute kidney injury: a cross-sectional and follow-up study
10.1016/j.clnu.2025.07.031 · 2025 · External reference
Antioxidative effects of phenylethanoids from Cistanche deserticola
10.1248/bpb.19.1580 · 1996 · External reference
Immunological mechanisms and novel therapeutic strategies for sepsis-associated acute kidney injury (review)
10.3892/ijmm.2026.5749 · 2026 · External reference
Lupiwighteone ameliorates diabetic nephropathy-induced renal fibrosis via SIRT1/NF-κB signaling pathway-mediated inflammatory response
10.1021/acs.jafc.5c10001 · 2025 · External reference
Role of oxidative stress in sepsis: mechanisms, pathways, and therapeutic strategies
10.1016/j.jpha.2025.101452 · 2026 · External reference
Fully biocompatible tantalum-based antioxidant nanoshields for proximal tubule epithelial cells-targeted mitochondrial holistic protection in acute kidney injury
10.1002/adma.202506307 · 2026 · External reference
Self-developed NF-κB inhibitor 270 protects against LPS-induced acute kidney injury and lung injury through improving inflammation
10.1016/j.biopha.2022.112615 · 2022 · External reference
Sepsis-associated acute kidney injury: consensus report of the 28th acute disease quality initiative workgroup
10.1038/s41581-023-00683-3 · 2023 · External reference
NAT10-mediated ac(4)C modification of TNFRSF1A promotes acute kidney injury by activating NF-κB pathway
10.1186/s11658-026-00913-z · 2026 · External reference
Carboxymethyl Poria cocos polysaccharides protect against septic kidney injury by regulating the Nrf2-NF-κB signaling pathway
2025 · External reference
Epigenetic dysregulation of autophagy in sepsis-induced acute kidney injury: the underlying mechanisms for renoprotection
2023 · External reference
Immune molecular mechanisms of PANoptosis in sepsis-induced acute kidney injury
10.1186/s41232-026-00412-w · 2026 · External reference
Augmenter of liver regeneration reduces mitochondria-derived ROS and NLRP3 inflammasome activation through PINK1/Parkin-mediated mitophagy in ischemia-reperfusion-induced renal tubular injury
10.1007/s10495-022-01794-1 · 2023 · External reference
Acute kidney injury
10.1146/annurev-med-050214-013407 · 2016 · External reference
