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References from METTL3-mediated m6A modification of PARP2 accelerates hepatocellular carcinoma progression. Local targets link to admitted publications; unresolved targets remain external evidence.
The role of PARP-1 and PARP-2 enzymes in metabolic regulation and disease
10.1016/j.cmet.2012.06.016 · 2012 · External reference
The global epidemiology of hepatocellular carcinoma
10.1097/hc9.0000000000000932 · 2026 · External reference
Novel insights into the m6A-RNA methyltransferase METTL3 in cancer
10.1186/s40364-021-00278-9 · 2021 · External reference
CircRNA ZFR stimulates the proliferation of hepatocellular carcinoma through upregulating MAP2K1
2020 · External reference
RNA N6-methyladenosine methyltransferase-like 3 promotes liver cancer progression through YTHDF2-dependent posttranscriptional silencing of SOCS2
10.1002/hep.29683 · 2018 · External reference
The role of m6A RNA methylation in human cancer
10.1186/s12943-019-1033-z · 2019 · External reference
N6-methyladenosine links RNA metabolism to cancer progression
10.1038/s41419-017-0129-x · 2018 · External reference
RNA N6-methyladenosine modification in cancers: current status and perspectives
10.1038/s41422-018-0034-6 · 2018 · External reference
METTL3-mediated m6A modification of FMRP drives hepatocellular carcinoma progression and indicates poor prognosis
2024 · External reference
Development of a four-gene prognostic signature for hepatocellular carcinoma using TCGA and GEO datasets
2026 · External reference
Integrative bioinformatics analysis for targeting hub genes in hepatocellular carcinoma treatment
10.2174/0113892029308243240709073945 · 2025 · External reference
The diagnosis and treatment of hepatocellular carcinoma
10.1053/j.semdp.2016.12.011 · 2017 · External reference
METTL3 confers oxaliplatin resistance through the activation of G6PD-enhanced pentose phosphate pathway in hepatocellular carcinoma
10.1038/s41418-024-01406-2 · 2025 · External reference
Epidemiology of liver cancer in South Korea
10.3350/cmh.2017.0112 · 2018 · External reference
Clinical PARP inhibitors allosterically induce PARP2 retention on DNA
10.1126/sciadv.adf7175 · 2023 · External reference
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
10.1038/nchembio.1432 · 2014 · External reference
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancer
10.1038/s41556-018-0174-4 · 2018 · External reference
Link between m6A modification and cancers
10.3389/fbioe.2018.00089 · 2018 · External reference
METTL3-mediated m6A methylation in cardiac diseases: pathogenic roles and therapeutic potential
10.1007/s10565-025-10039-1 · 2025 · External reference
Emerging role of RNA modification N6-methyladenosine in immune evasion
10.1038/s41419-021-03585-z · 2021 · External reference
ADP-ribosyltransferases, an update on function and nomenclature
10.1111/febs.16142 · 2022 · External reference
PARP inhibitors for breast cancer treatment: a review
10.1001/jamaoncol.2023.7322 · 2024 · External reference
Selective degradation of PARP2 by PROTACs via recruiting DCAF16 for triple-negative breast cancer
10.1016/j.ejmech.2022.114321 · 2022 · External reference
A pilot trial evaluating stereotactic body radiation therapy to induce hyperemia in combination with transarterial chemoembolization for hepatocellular carcinoma
10.1016/j.ijrobp.2020.07.033 · 2020 · External reference
Mechanism, potential, and concerns of immunotherapy for hepatocellular carcinoma and liver transplantation
10.2174/0118761429310703240823045808 · 2024 · External reference
PARPi treatment enhances radiotherapy-induced ferroptosis and antitumor immune responses via the cGAS signaling pathway in colorectal cancer
10.1016/j.canlet.2022.215919 · 2022 · External reference
Reduced expression of METTL3 promotes metastasis of triple-negative breast cancer by m6A methylation-mediated COL3A1 up-regulation
10.3389/fonc.2020.01126 · 2020 · External reference
PARP and PARG inhibitors in cancer treatment
10.1101/gad.334516.119 · 2020 · External reference
Five-year survival post hepatectomy for colorectal liver metastases in a real-world Chinese cohort: recurrence patterns and prediction for potential cure
10.1002/cam4.5732 · 2023 · External reference
The role of insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs) as m6A readers in cancer
10.7150/ijbs.70458 · 2022 · External reference
The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cells
2018 · External reference
GEPIA: a web server for cancer and normal gene expression profiling and interactive analyses
10.1093/nar/gkx247 · 2017 · External reference
Identification of candidate substrates for poly(ADP-ribose) polymerase-2 (PARP2) in the absence of DNA damage using high-density protein microarrays
10.1111/j.1742-4658.2011.08286.x · 2011 · External reference
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells
10.1038/nm.4416 · 2017 · External reference
N6-methyladenosine modulates messenger RNA translation efficiency
10.1016/j.cell.2015.05.014 · 2015 · External reference
Metronomic chemotherapy remodel cancer-associated fibroblasts to decrease chemoresistance of gastric cancer in nude mice
2017 · External reference
Circulating tumor cells are an indicator for the administration of adjuvant transarterial chemoembolization in hepatocellular carcinoma: a single-center, retrospective, propensity-matched study
10.1002/ctm2.137 · 2020 · External reference
Loss of Mettl3 enhances liver tumorigenesis by inducing hepatocyte dedifferentiation and hyperproliferation
10.1016/j.celrep.2023.112704 · 2023 · External reference
METTL3-mediated m6A methylation on lncRNA H19 inhibits intrahepatic cholangiocarcinoma progression through PPARγ downregulation
10.7150/ijbs.120413 · 2025 · External reference
Dual role of pregnane x receptor in nonalcoholic fatty liver disease
2024 · External reference
m6 a transferase METTL3-induced lncRNA ABHD11-AS1 promotes the Warburg effect of non-small-cell lung cancer
10.1002/jcp.30023 · 2021 · External reference
A global view of hepatocellular carcinoma: trends, risk, prevention and management
10.1038/s41575-019-0186-y · 2019 · External reference
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m6A-demethylation of NANOG mRNA
2016 · External reference
Dynamic landscape and evolution of m6A methylation in human
10.1093/nar/gkaa347 · 2020 · External reference
METTL3 inhibition promotes radiosensitivity in hepatocellular carcinoma through regulation of SLC7A11 expression
10.1038/s41419-024-07317-x · 2025 · External reference
Long non-coding RNA PTTG3P functions as an oncogene by sponging miR-383 and up-regulating CCND1 and PARP2 in hepatocellular carcinoma
10.1186/s12885-019-5936-2 · 2019 · External reference
METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition
10.1038/s41419-022-04817-6 · 2022 · External reference
