Research graph
References from Raloxifene suppresses chemically-induced oxidative hepatocyte injury in vitro and in vivo by targeting protein disulfide isomerase. Local targets link to admitted publications; unresolved targets remain external evidence.
Raloxifene: cardiovascular considerations
10.2174/138955707781387911 · 2007 · External reference
Protein disulfide isomerase a multifunctional protein with multiple physiological roles
10.3389/fchem.2014.00070 · 2014 · External reference
The potential renoprotective effect of Raloxifene in renal ischemia-reperfusion injury in a male rat model
10.25122/jml-2023-0100 · 2023 · External reference
The Protein Data Bank
10.1093/nar/28.1.235 · 2000 · External reference
The crystal structure of human microsomal triglyceride transfer protein
10.1073/pnas.1903029116 · 2019 · External reference
Genetic variants in COMT and ESR1 genes shape treatment response to raloxifene in schizophrenia-spectrum disorders
10.1016/j.psyneuen.2024.107274 · 2025 · External reference
Coupling of receptor conformation and ligand orientation determine graded activity
10.1038/nchembio.451 · 2010 · External reference
Mechanisms of ferroptosis
10.1007/s00018-016-2194-1 · 2016 · External reference
Raloxifene: a review of its use in postmenopausal osteoporosis
10.2165/00003495-200060020-00013 · 2000 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Broadening horizons: the multifaceted functions of ferroptosis in kidney diseases
10.7150/ijbs.85674 · 2023 · External reference
Selective estrogen receptor modulators (SERMs) affect cholesterol homeostasis through the master regulators SREBP and LXR
10.1016/j.biopha.2021.111871 · 2021 · External reference
Protein disulphide isomerase: building bridges in protein folding
10.1016/0968-0004(94)90072-8 · 1994 · External reference
Extra precision glide: docking and scoring incorporating a model of hydrophobic enclosure for protein-ligand complexes
10.1021/jm051256o · 2006 · External reference
Characterization of the estradiol-binding site structure of human protein disulfide isomerase (PDI)
10.1371/journal.pone.0027185 · 2011 · External reference
Hydrogen peroxide and redox modulation sensitize primary mouse hepatocytes to TNF-induced apoptosis
10.1016/j.freeradbiomed.2006.05.002 · 2006 · External reference
Raloxifene prevents chemically-induced Ferroptotic neuronal death in vitro and in vivo
10.1007/s12035-024-04497-7 · 2025 · External reference
Strong protection by bazedoxifene against chemically-induced ferroptotic neuronal death in vitro and in vivo
10.1186/s12964-025-02209-9 · 2025 · External reference
Identification and enzymatic activities of four protein disulfide isomerase (PDI) isoforms of Leishmania amazonensis
10.1007/s00436-007-0784-4 · 2008 · External reference
Biochemical mechanism of erastin-induced ferroptotic cell death in neuronal cells
2023 · External reference
Mechanism of RSL3-induced ferroptotic cell death in HT22 cells: crucial role of protein disulfide isomerase
10.3724/abbs.2024165 · 2024 · External reference
Acetaminophen hepatotoxicity: paradigm for understanding mechanisms of drug-induced liver injury
10.1146/annurev-pathmechdis-051122-094016 · 2024 · External reference
The cellular thermal shift assay for evaluating drug target interactions in cells
10.1038/nprot.2014.138 · 2014 · External reference
Mechanism of FINO2-induced oxidative ferroptosis: inhibition of TrxR1-mediated PDI reduction
2025 · External reference
Ferroptosis: mechanisms, biology and role in disease
10.1038/s41580-020-00324-8 · 2021 · External reference
Red/ox states of human protein disulfide isomerase regulate binding affinity of 17 beta-estradiol
10.1016/j.abb.2017.02.010 · 2017 · External reference
Treating ER-positive breast cancer: a review of the current FDA-approved SERMs and SERDs and their mechanisms of action
10.3389/or.2025.1564642 · 2025 · External reference
Discovery and mechanistic elucidation of a class of protein disulfide isomerase inhibitors for the treatment of glioblastoma
10.1002/cmdc.201700629 · 2018 · External reference
OPLS4: improving force field accuracy on challenging regimes of chemical space
10.1021/acs.jctc.1c00302 · 2021 · External reference
Catalysis of the oxidative folding of ribonuclease a by protein disulfide isomerase: dependence of the rate on the composition of the redox buffer
10.1021/bi00217a004 · 1991 · External reference
The cellular thermal shift assay: a novel biophysical assay for in situ drug target engagement and mechanistic biomarker studies
10.1146/annurev-pharmtox-010715-103715 · 2016 · External reference
Neuroprotective potential of Raloxifene via G-protein-coupled estrogen receptors in aβ-oligomer-induced neuronal injury
10.3390/biomedicines11082135 · 2023 · External reference
Protein disulfide isomerase mediates glutathione depletion-induced cytotoxicity
10.1016/j.bbrc.2016.06.066 · 2016 · External reference
Therapeutic inhibition of ferroptosis in neurodegenerative disease
10.1016/j.tips.2023.07.007 · 2023 · External reference
Global survey of cell death mechanisms reveals metabolic regulation of ferroptosis
10.1038/nchembio.2079 · 2016 · External reference
Protective effect of 2-hydroxyestrone and 2-hydroxyestradiol against chemically induced hepatotoxicity in vitro and in vivo
10.1016/j.jpet.2024.100050 · 2025 · External reference
I. Arginine
10.1016/s0753-3322(02)00284-6 · 2002 · External reference
Large-scale prediction of binding affinity in protein-small ligand complexes: the PRODIGY-LIG web server
10.1093/bioinformatics/bty816 · 2019 · External reference
Raloxifene as treatment for various types of brain injuries and neurodegenerative diseases: a good start
10.3390/ijms21207586 · 2020 · External reference
Raloxifene attenuates oxidative stress and preserves mitochondrial function in astrocytic cells upon glucose deprivation
10.1002/jcp.27481 · 2019 · External reference
Improving scoring-docking-screening powers of protein-ligand scoring functions using random forest
10.1002/jcc.24667 · 2017 · External reference
Structural insights into the redox-regulated dynamic conformations of human protein disulfide isomerase
10.1089/ars.2012.4630 · 2013 · External reference
Protein disulfide-isomerase, a folding catalyst and a redox-regulated chaperone
10.1016/j.freeradbiomed.2015.02.007 · 2015 · External reference
Protein disulfide isomerase is regulated in multiple ways: consequences for conformation, activities, and pathophysiological functions
10.1002/bies.202000147 · 2021 · External reference
Further development and validation of empirical scoring functions for structure-based binding affinity prediction
10.1023/a:1016357811882 · 2002 · External reference
Molecular basis of rutin inhibition of protein disulfide isomerase (PDI) by combined in silico and experimental methods
10.1039/c8ra02683a · 2018 · External reference
Mechanism of L-buthionine-(S,R)-sulfoximine-induced ferroptotic cell death in mouse hippocampal neuronal cells
10.1186/s12964-026-02861-9 · 2026 · External reference
SWISS-MODEL: homology modelling of protein structures and complexes
10.1093/nar/gky427 · 2018 · External reference
Ferroptosis as a novel therapeutic target for cardiovascular disease
10.7150/thno.54113 · 2021 · External reference
Role of protein disulfide isomerase in mediating sulfasalazine-induced ferroptosis in HT22 cells: the PDI-NOS-NO-ROS/lipid-ROS cascade
10.1016/j.abb.2025.110366 · 2025 · External reference
Design, synthesis, and biological evaluation of novel allosteric protein disulfide isomerase inhibitors
10.1021/acs.jmedchem.8b01951 · 2019 · External reference
Binding of selected ligands to human protein disulfide isomerase and microsomal triglyceride transfer protein complex and the associated conformational changes: a computational molecular modelling study
10.1002/open.202400034 · 2025 · External reference
4-Hydroxyestrogen metabolites strongly prevent chemically-induced ferroptotic hepatocyte injury in vitro and in vivo
10.1016/j.ejphar.2025.177313 · 2025 · External reference
Protein disulfide isomerase plays a crucial role in mediating chemically-induced, glutathione depletion-associated hepatocyte injury in vitro and in vivo
10.1186/s12964-024-01798-1 · 2024 · External reference
