Research graph
References from Recent advances in catalytic α-deuteration of carbonyl compounds. Local targets link to admitted publications; unresolved targets remain external evidence.
Using deuterium in drug discovery: leaving the label in the drug
10.1021/jm4007998 · 2014 · External reference
Applications of deuterium in medicinal chemistry
10.1021/acs.jmedchem.8b01808 · 2019 · External reference
Deuterium in drug discovery: progress, opportunities and challenges
10.1038/s41573-023-00703-8 · 2023 · External reference
Ruthenium catalyzed deuterium labelling of α-carbon in primary alcohol and primary/secondary amine in D2O
10.1246/cl.2005.192 · 2005 · External reference
Ruthenium-catalyzed selective α,β-deuteration of bioactive amines
10.1021/ja3041338 · 2012 · External reference
Photoredox-catalyzed deuteration and tritiation of pharmaceutical compounds
10.1126/science.aap9674 · 2017 · External reference
Highly selective directed iridium-catalyzed hydrogen isotope exchange reactions of aliphatic amides
10.1002/anie.201804010 · 2018 · External reference
Catalytic deuterium incorporation within metabolically stable β-amino C-H bonds of drug molecules
10.1021/jacs.9b08662 · 2019 · External reference
Late-stage β-C(sp3)-H deuteration of carboxylic acids
10.1021/jacs.1c06474 · 2021 · External reference
Iridium-catalyzed α-selective deuteration of alcohols
10.1039/d2sc01805e · 2022 · External reference
Organophotocatalytic α-deuteration of unprotected primary amines via H/D exchange with D2O
10.1039/d3cc04634f · 2023 · External reference
Deuteration and tritiation of pharmaceuticals by non-directed palladium-catalyzed C−H activation in heavy and super-heavy water
10.1002/anie.202410162 · 2024 · External reference
Unlocking the potential of hydrogen deuterium exchange via an iterative continuous-flow deuteration process
10.1038/s41467-025-56600-8 · 2025 · External reference
The renaissance of H/D exchange
10.1002/anie.200700039 · 2007 · External reference
C−H functionalisation for hydrogen isotope exchange
10.1002/anie.201708903 · 2018 · External reference
C-H deuteration of organic compounds and potential drug candidates
10.1039/d0cs01496f · 2022 · External reference
Recent developments for the deuterium and tritium labeling of organic molecules
10.1021/acs.chemrev.1c00795 · 2022 · External reference
Late-stage C-H deuteration of organic compounds via ligand-enabled palladium-catalyzed hydrogen isotope exchange
2023 · External reference
Recent advances in deuteration reactions
10.1002/cjoc.202300570 · 2024 · External reference
Structure and reactivity of lithium enolates. From pinacolone to selective C-alkylations of peptides. Difficulties and opportunities afforded by complex structures
10.1002/anie.198816241 · 1988 · External reference
Catalytic enantioselective alkylation of prochiral enolates
10.1021/acs.chemrev.0c00564 · 2021 · External reference
Asymmetric aldol reactions using boron enolates
1997 · External reference
New cross-aldol reactions. Reactions of silyl enol ethers with carbonyl compounds activated by titanium tetrachloride
10.1021/ja00831a019 · 1974 · External reference
Direct catalytic asymmetric aldol reactions of aldehydes with unmodified ketones
10.1002/anie.199718711 · 1997 · External reference
Direct catalytic asymmetric aldol reaction
10.1021/ja990031y · 1999 · External reference
Lanthanide complexes in multifunctional asymmetric catalysis
10.1021/cr010297z · 2002 · External reference
Recent progress in asymmetric bifunctional catalysis using multimetallic systems
10.1021/ar9000108 · 2009 · External reference
Base-catalyzed deuterium and tritium labelling of 1-biphenyl-4-ylpropane-1,2-dione and deuteration of aryl methyl ketones
10.1002/jlcr.879 · 2004 · External reference
Triazabicyclodecene: an effective isotope exchange catalyst in CDCl3
10.1021/jo070307h · 2007 · External reference
A simple method for α-position deuterated carbonyl compounds with pyrrolidine as catalyst
10.1002/jlcr.3210 · 2014 · External reference
B(C6F5)3-Catalyzed α-deuteration of bioactive carbonyl compounds with D2O
10.1002/adsc.201901419 · 2020 · External reference
Organocatalyzed α-deuteration of ketones and bioactive carbonyl compounds using D2O as deuterium source
10.1002/slct.202405725 · 2025 · External reference
Organocatalyst-controlled highly α’-selective deuteration and α,α′-deuteration of enones
10.1021/acs.joc.6c00382 · 2026 · External reference
Superacid-catalysed α-deuteration of ketones with D2O
10.1039/d5ob00683j · 2025 · External reference
Organocatalytic α-deuteration of carbonyl compounds: a pTSA/D2O strategy for bioactive and natural products
2025 · External reference
Deuteration of amino acids in acidic deuterium oxide solution at supercritical temperatures
10.1016/s0896-8446(96)90027-3 · 1996 · External reference
Enantioselective synthesis of α-carbon deuterium-labelled L-α-amino acids
10.1016/s0040-4039(02)01251-0 · 2002 · External reference
Catalytic asymmetric synthesis of enantioenriched α-deuterated pyrrolidine derivatives
10.1039/d2sc00826b · 2022 · External reference
Simple and efficient preparation of (R)- and (S)-enantiomers of α-carbon deuterium-labelled α-amino acids
10.1002/(sici)1099-1344(200004)43:5<449::aid-jlcr331>3.0.co;2-0 · 2000 · External reference
Catalytic stereoinversion of L-alanine to deuterated D-alanine
10.1002/anie.201503616 · 2015 · External reference
Biocatalytic, stereoselective deuteration of α-amino acids and methyl esters
10.1021/acscatal.0c01885 · 2020 · External reference
Site-selective deuteration of amino acids through dual-protein catalysis
10.1021/jacs.2c00608 · 2022 · External reference
Site-selective deuteration of α-amino esters with 2-hydroxynicotinaldehyde as a catalyst
10.1021/acsomega.3c09974 · 2024 · External reference
Binary catalytic hydrogen/deuterium exchange of free α-amino acids and derivatives
10.1002/chem.202402045 · 2024 · External reference
Cooperative catalysis of a cationic ruthenium complex, amine base, and Na salt: catalytic activation of acetonitrile as a nucleophile
10.1021/ja0450509 · 2004 · External reference
Catalytic silicon-mediated carbon-carbon bond-forming reactions of unactivated amides
10.1021/ja108764d · 2011 · External reference
Efficient C-H/C-D exchange reaction on the alkyl side chain of aromatic compounds using heterogeneous Pd/C in D2O
10.1021/ol0496374 · 2004 · External reference
Efficient H/D exchange reactions of alkyl-substituted benzene derivatives by means of the Pd/C-H2-D2O system
10.1002/chem.200601615 · 2007 · External reference
Mild and direct multiple deuterium-labeling of saturated fatty acids
10.1002/adsc.201600363 · 2016 · External reference
Organocatalytic deuteration induced by the dynamic covalent interaction of imidazolium cations with ketones
10.1002/adsc.202001507 · 2021 · External reference
Manganese-pincer-catalyzed nitrile hydration, α-deuteration, and α-deuterated amide formation via metal ligand cooperation
10.1021/acscatal.1c01748 · 2021 · External reference
Nitrile hydration and α-deuteration of amides catalyzed by a PCNHCP Mn(I) pincer complex
10.1039/d5cc02804c · 2025 · External reference
Ternary catalytic α-deuteration of carboxylic acids
10.1038/s44160-022-00139-9 · 2022 · External reference
Sulfonium salt reagents for the introduction of deuterated alkyl groups in drug discovery
2023 · External reference
Metallaphotoredox deuteroalkylation utilizing thianthrenium salts
10.1038/s41467-024-48590-w · 2024 · External reference
Hydrodeuteroalkylation of unactivated olefins using thianthrenium salts
2024 · External reference
Thianthrenium-enabled chromium-catalyzed deuterated alkyl addition to aldehydes via a photoactive electron donor-acceptor complex
2025 · External reference
Pentafluorophenyl group as activating group: synthesis of α-deuterio carboxylic acid derivatives via Et3N catalyzed H/D exchange
10.1002/adsc.202200258 · 2022 · External reference
Electrochemical α-deuteration of amides
10.1039/d3gc02345a · 2023 · External reference
Boron clusters as efficient shuttles for electrocatalytic deuterium labelling via radical H/D exchange
10.1038/s41929-025-01379-6 · 2025 · External reference
Silicon frustrated lewis pairs catalyse α-deuteration of amides and esters
10.1038/s41929-025-01420-8 · 2025 · External reference
Selective hydrogen isotope exchange catalysed by simple alkali-metal bases in DMSO
10.1002/anie.202421736 · 2025 · External reference
Simple and efficient enantioselective α-deuteration method of α-amino acids without external chiral sources
10.1021/jacsau.4c00185 · 2024 · External reference
