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References from Transition metal-free synthesis of 4-trifluoromethyl-1,2,3-triazoles via regioselective (3+2) cycloaddition reactions. Local targets link to admitted publications; unresolved targets remain external evidence.
Fluorine in pharmaceuticals: looking beyond intuition
10.1126/science.1131943 · 2007 · External reference
Fluorine in pharmaceutical industry: fluorine-containing drugs introduced to the market in the last decade (2001–2011)
10.1021/cr4002879 · 2014 · External reference
Applications of fluorine in medicinal chemistry
10.1021/acs.jmedchem.5b00258 · 2015 · External reference
Modern carbon–fluorine bond forming reactions for aryl fluoride synthesis
10.1021/cr500366b · 2015 · External reference
FDA approved fluorine-containing drugs in 2023
10.1016/j.cclet.2024.109780 · 2024 · External reference
Aromatic trifluoromethylation with metal complexes
10.1021/cr1004293 · 2011 · External reference
Asymmetric construction of stereogenic carbon centers featuring a trifluoromethyl group from prochiral trifluoromethylated substrates
10.1021/cr100166a · 2011 · External reference
Carbon trifluoromethylation reactions of hydrocarbon derivatives and heteroarenes
10.1021/cr500368h · 2015 · External reference
Where does the fluorine come from? A review on the challenges associated with the synthesis of organofluorine compounds
10.1021/acs.oprd.0c00030 · 2020 · External reference
Electrophilic trifluoromethylation by use of hypervalent iodine reagents
10.1021/cr500223h · 2015 · External reference
Recent advances in transition-metal-free trifluoromethylation with Togni's reagents
10.1039/d1qo01504d · 2022 · External reference
Trifluoromethyltrimethylsilane: nucleophilic trifluoromethylation and beyond
10.1021/cr400473a · 2015 · External reference
α-Trifluoromethylated carbanion synthons
10.1021/ar7002573 · 2008 · External reference
Pd-catalyzed defluorination/arylation of α-trifluoromethyl ketones via consecutive β-F elimination and C–F bond activation
10.1039/c8cc01568f · 2018 · External reference
Palladium-catalyzed selective defluorinative arylation for the efficient stereospecific synthesis of (E)-β-fluoroacrylamides
10.1039/d1qo00721a · 2021 · External reference
Copper-catalyzed selective defluorinative sulfuration of trifluoropropanamides leading to α-Fluorothioacrylamides
10.1021/acs.joc.0c02436 · 2021 · External reference
Palladium-catalyzed selective C-F bond cleavage of trifluoropropanamides leading to (Z)-N-α-Fluorovinylindoles
10.1002/adsc.202200352 · 2022 · External reference
Cascade C–H activation and defluorinative annulation of 2-Arylbenzimidazoles with α-Trifluoromethyl-α-diazoketones: modular assembly of 6-Fluorobenzimidazo[2,1-a]isoquinolines
10.1021/acs.orglett.3c01296 · 2023 · External reference
Transition-metal-free conversion of trifluoropropanamides into cyanoformamides through C–CF3 bond cleavage and nitrogenation
10.1021/acs.joc.7b00626 · 2017 · External reference
Cs2CO3-promoted defluorination and functionalization of α-CF3 carbonyl compounds in the presence of N-, O-, and/or S-nucleophiles
10.1039/c8ra02353k · 2018 · External reference
Nickel-catalysed chelation-assisted reductive defluorinative sulfenylation of trifluoropropionic acid derivatives
10.1039/d3cc06041a · 2024 · External reference
β-Acyloxyl alkenyl amide synthesis via multiple defluorination: α-trifluoromethyl ketone–amine as synergistic peptide coupling reagent
10.1126/sciadv.aea4120 · 2025 · External reference
Direct generation of Ti-Enolate of α-CF3 ketone: theoretical study and high-yielding and diastereoselective aldol reaction
10.1021/ja046518a · 2004 · External reference
Ligand-dependent regiodivergent enantioselective allylic alkylations of α-Trifluoromethylated ketones
10.1021/acs.orglett.1c00329 · 2021 · External reference
Metal enolates of α-CF3 ketones: theoretical guideline, direct generation, and synthetic use
10.1002/tcr.20066 · 2006 · External reference
Advances in the synthesis of α-Trifluoromethyl ketones and their application via defluorinative reactions
10.6023/cjoc202411018 · 2025 · External reference
Copper(I)-Catalyzed interrupted click reaction with TMSCF3: synthesis of 5-Trifluoromethyl 1,2,3-Triazoles
10.1021/acs.orglett.7b01116 · 2017 · External reference
Multi-component syntheses of diverse 5-fluoroalkyl-1,2,3-triazoles facilitated by air oxidation and copper catalysis
10.1039/c9gc00647h · 2019 · External reference
Defluorinative [4 + 1] annulation of perfluoroalkyl N-mesylhydrazones with primary amines provides 5-fluoroalkyl 1,2,3-triazoles
10.1039/d1gc02749b · 2021 · External reference
Synthesis of 5-trifluoromethyl-1,2,3-triazoles via base-mediated cascade annulation of diazo compounds with trifluoroacetimidoyl chlorides
10.1039/d1qo00445j · 2021 · External reference
Interrupted click reaction with CuCF2CF3 reagent: synthesis of 5-Pentafluoroethyl 1,2,3-Triazoles
10.1021/acs.orglett.3c01855 · 2023 · External reference
Furan dearomatization: a route to diverse fluoroalkyl/aryl triazoles
10.1021/acs.joc.3c02402 · 2024 · External reference
Recent advances in the synthesis of CF3-Substituted triazoles and tetrazoles
10.6023/cjoc201808007 · 2019 · External reference
Chemistry of fluoroalkyl-substituted 1,2,3-triazoles
10.1016/j.jfluchem.2018.02.012 · 2018 · External reference
Copper(I)-catalyzed interrupted click/radical relay: a four-component modular synthesis of triazole sulfones
2024 · External reference
Synthesis and applications of fluorinated, polyfluoroalkyl- and polyfluoroaryl-substituted 1,2,3-triazoles
10.1039/d4qo01334d · 2024 · External reference
A stepwise huisgen cycloaddition process: copper(i)-catalyzed regioselective “ligation” of azides and terminal alkynes
10.1002/1521-3773(20020715)41:14<2596::aid-anie2596>3.0.co;2-4 · 2002 · External reference
Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific Copper(I)-Catalyzed 1,3-Dipolar cycloadditions of terminal alkynes to azides
10.1021/jo011148j · 2002 · External reference
Direct evidence of a dinuclear copper intermediate in Cu(I)-Catalyzed azide-alkyne cycloadditions
10.1126/science.1229506 · 2013 · External reference
Copper-catalyzed synthesis of 5-Carboxyl-4-perfluoroalkyl triazoles
10.1021/acs.orglett.1c02037 · 2021 · External reference
Silver-catalyzed [3 + 2] cycloaddition of isocyanides with diazo compounds: new regioselective access to 1,4-disubstituted-1,2,3-triazoles
10.1039/c5qo00219b · 2015 · External reference
Silver-catalyzed three-component route to trifluoromethylated 1,2,3-Triazolines using aldehydes, amines, and trifluorodiazoethane
10.1021/acs.orglett.9b01159 · 2019 · External reference
Two approaches to a trifluoromethyl triazole: a fit-for-purpose trifluoromethylation in flow-mode and a long-term decarboxylative click approach
10.1021/acs.oprd.9b00492 · 2020 · External reference
Metal- and azide-free iodine-promoted aerobic oxidative cyclization to trifluoromethylated triazoles
10.1021/acs.joc.4c02312 · 2025 · External reference
An organocatalytic azide–aldehyde [3+2] cycloaddition: high-yielding regioselective synthesis of 1,4-Disubstituted 1,2,3-Triazoles
10.1002/anie.201406721 · 2014 · External reference
Reaction engineering and photophysical studies of fully enriched C-vinyl-1,2,3-triazoles
10.1039/c9qo00864k · 2019 · External reference
Organocatalytic synthesis of 1,2,3-Triazoles from unactivated ketones and arylazides
10.1002/chem.201102046 · 2011 · External reference
Lewis base catalyzed aerobic oxidative intermolecular azide–zwitterion cycloaddition
10.1002/anie.201408265 · 2014 · External reference
Organocatalytic enamide–azide cycloaddition reactions: regiospecific synthesis of 1,4,5-Trisubstituted-1,2,3-Triazoles
10.1002/chem.201002775 · 2011 · External reference
Three-component reactions of α-CF3 carbonyls, NaN3, and amines for the synthesis of NH-1,2,3-Triazoles
10.1021/acs.joc.1c02288 · 2021 · External reference
Three-component coupling of α-Trifluoromethyl carbonyls, azides and amines for the regioselective synthesis of 1,4,5-Trisubstituted 1,2,3-Triazoles
10.1002/adsc.202200094 · 2022 · External reference
Amine-induced selective C–C bond cleavage of 2,2,2-Trifluoroethyl carbonyls for the synthesis of ureas and amides
10.1021/acs.joc.3c00979 · 2023 · External reference
Synthesis of multisubstituted 1,2,3-Triazoles: regioselective formation and reaction mechanism
10.1021/acs.joc.3c02836 · 2024 · External reference
Organocatalytic 1,3-dipolar cycloaddition reactions of ketones and azides with water as a solvent
10.1039/c3gc41126e · 2013 · External reference
Unresolved reference
2020 · External reference
Design and preclinical characterization program toward Asundexian (BAY 2433334), an oral factor XIa inhibitor for the prevention and treatment of thromboembolic disorders
10.1021/acs.jmedchem.3c00795 · 2023 · External reference
