Research graph
References from Halohydrin dehalogenases in organic synthesis. Local targets link to admitted publications; unresolved targets remain external evidence.
Unresolved reference
2012 · External reference
Power of biocatalysis for organic synthesis
10.1021/acscentsci.0c01496 · 2021 · External reference
Engineering the third wave of biocatalysis
10.1038/nature11117 · 2012 · External reference
Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods
10.1021/acs.chemrev.1c00574 · 2022 · External reference
Industrial methods for the production of optically active intermediates
10.1002/anie.200300599 · 2004 · External reference
Extending the application of biocatalysis to meet the challenges of drug development
10.1038/s41570-018-0055-1 · 2018 · External reference
Biocatalysis: a smart and green tool for the preparation of chiral drugs
10.1002/chir.23498 · 2022 · External reference
7.8 hydrolysis and reverse hydrolysis: halohydrin dehalogenases
2012 · External reference
Biodehalogenation. Epoxidation of halohydrins, epoxide opening, and transhalogenation by a flavobacterium species
10.1021/bi00849a025 · 1968 · External reference
Halohydrin dehalogenases are structurally and mechanistically related to short-chain dehydrogenases/reductases
10.1128/jb.183.17.5058-5066.2001 · 2001 · External reference
Unresolved reference
2003 · External reference
Recent advances on halohydrin dehalogenases—from enzyme identification to novel biocatalytic applications
10.1007/s00253-016-7750-y · 2016 · External reference
Structural basis for the enantioselectivity of an epoxide ring opening reaction catalyzed by halo alcohol dehalogenase HheC
10.1021/ja0531733 · 2005 · External reference
Expanding the halohydrin dehalogenase enzyme family: identification of novel enzymes by database mining
10.1128/aem.01985-14 · 2014 · External reference
Biochemical and biocatalytic characterization of 17 novel halohydrin dehalogenases
10.1007/s00253-016-7493-9 · 2016 · External reference
Catalytic promiscuity of halohydrin dehalogenase and its application in enantioselective epoxide ring opening
10.1002/cbic.200700734 · 2008 · External reference
Stereoselective synthesis of oxetanes catalyzed by an engineered halohydrin dehalogenase
10.1002/anie.202411326 · 2024 · External reference
Enantiocomplementary synthesis of tetrahydrofurans by engineered halohydrin dehalogenases
10.1002/adsc.202400777 · 2024 · External reference
Engineered halohydrin dehalogenase mediates remote enantiocontrolled dehalogenative hydroxylation via an unconventional mechanism
10.1038/s41467-026-74796-1 · 2026 · External reference
Halohydrin dehalogenases and their potential in industrial application – a viewpoint of enzyme reaction engineering
10.1002/adsc.202000984 · 2021 · External reference
Halohydrin dehalogenase-catalysed synthesis of enantiopure fluorinated building blocks: bottlenecks found and explained by applying a reaction engineering approach
10.1039/d2re00461e · 2022 · External reference
HHDH-catalyzed synthesis of enantioenriched fluorinated β-Hydroxy nitrile─process advances through a reaction engineering approach
10.1021/acs.iecr.4c00477 · 2024 · External reference
Inhibitory effect of DMSO on halohydrin dehalogenase: experimental and computational insights into the influence of an organic Co-solvent on the structural and catalytic properties of a biocatalyst
2022 · External reference
Reactions catalyzed by halohydrin dehalogenases
2014 · External reference
Biocatalytically active and stable cross-linked enzyme crystals of halohydrin dehalogenase HheG by protein engineering
10.1002/cctc.202200145 · 2022 · External reference
Exploring the enantioselective mechanism of halohydrin dehalogenase from Agrobacterium radiobacter AD1 by iterative saturation mutagenesis
10.1128/aem.04153-14 · 2015 · External reference
A single point mutation enhances hydroxynitrile synthesis by halohydrin dehalogenase
10.1016/j.enzmictec.2014.12.009 · 2015 · External reference
A robust cosolvent-compatible halohydrin dehalogenase by computational library design
2017 · External reference
Exploring the thermostable properties of halohydrin dehalogenase from Agrobacterium radiobacter AD1 by a combinatorial directed evolution strategy
10.1007/s00253-017-8090-2 · 2017 · External reference
Position 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity
10.1038/s41598-019-41498-2 · 2019 · External reference
Insights into the molecular determinants of thermal stability in halohydrin dehalogenase HheD2
10.1111/febs.15777 · 2021 · External reference
A dynamic loop in halohydrin dehalogenase HheG regulates activity and enantioselectivity in epoxide ring opening
10.1021/acscatal.4c04815 · 2024 · External reference
Engineering of conserved sequence motif 1 residues in halohydrin dehalogenase HheC simultaneously enhances activity, stability, and enantioselectivity
10.1021/acscatal.5c00819 · 2025 · External reference
Performance of cross-linked enzyme crystals of engineered halohydrin dehalogenase HheG in different chemical reactor systems
10.1002/bit.28528 · 2023 · External reference
Catalytic enantioselective synthesis of quaternary carbon stereocentres
10.1038/nature14007 · 2014 · External reference
Characterization of a novel enantioselective halohydrin hydrogen-halide-lyase
10.1128/aem.60.4.1297-1301.1994 · 1994 · External reference
A new enzymatic synthesis of (R)-γ-chloro-β-hydroxybutyronitrile
10.1016/s0040-4020(01)89297-8 · 1994 · External reference
Enantioselective ring opening of epoxides with cyanide catalysed by halohydrin dehalogenases: a new approach to non-racemic β-hydroxy nitriles
10.1002/adsc.200505333 · 2006 · External reference
Enzyme-catalyzed nucleophilic ring opening of epoxides for the preparation of enantiopure tertiary alcohols
10.1002/adsc.200700146 · 2007 · External reference
Halohydrin dehalogenase-catalysed synthesis of fluorinated aromatic chiral building blocks
10.1016/j.catcom.2021.106285 · 2021 · External reference
Biocatalytic enantioselective synthesis of chiral β-Hydroxy nitriles using cyanohydrins as cyano sources
10.1021/acscatal.3c03173 · 2023 · External reference
Highly enantioselective and regioselective biocatalytic azidolysis of aromatic epoxides
10.1021/ol0067540 · 2001 · External reference
Resolution of 2,2-disubstituted epoxides via biocatalytic azidolysis
10.1021/ol101406k · 2010 · External reference
Catalytic activity of halohydrin dehalogenases towards spiroepoxides
10.1039/c2ob25470k · 2012 · External reference
Selective ring-opening of Di-Substituted epoxides catalysed by halohydrin dehalogenases
10.1002/cctc.201900103 · 2019 · External reference
Highly α-position regioselective ring-opening of epoxides catalyzed by halohydrin dehalogenase from: Ilumatobacter coccineus: a biocatalytic approach to 2-azido-2-aryl-1-ols
10.1039/c9ra03774h · 2019 · External reference
Enzymatic kinetic resolution of bulky spiro-epoxyoxindoles via halohydrin dehalogenase-catalyzed Enantio- and regioselective azidolysis
10.1021/acscatal.1c02345 · 2021 · External reference
Synthesis and HHDH-catalyzed kinetic resolution of propargylic epoxides
10.1002/adsc.202400734 · 2024 · External reference
Biocatalytic approach to chiral fluoroaromatic scaffolds
10.1039/d2ob01955h · 2022 · External reference
Biocatalytic synthesis of fluorine-containing chiral azido compounds in a two-phase system
10.1016/j.tetlet.2026.155982 · 2026 · External reference
Formation of enantiopure 5-substituted oxazolidinones through enzyme-catalysed kinetic resolution of epoxides
10.1021/ol800698t · 2008 · External reference
Biocatalytic synthesis of metaxalone and its analogues
10.1021/acs.orglett.3c01752 · 2023 · External reference
Flipping the substrate creates a highly selective halohydrin dehalogenase for the synthesis of chiral 4-Aryl-2-oxazolidinones from readily available epoxides
10.1021/acscatal.2c06417 · 2023 · External reference
A self-regulated process from bench to pilot production of non-natural heterocycles using halohydrin dehalogenases
10.1002/cctc.202400095 · 2024 · External reference
Biocatalytic construction of spiro-oxazolidinones via halohydrin dehalogenase-catalyzed ring expansion of spiro-epoxides
10.1021/acscatal.4c02122 · 2024 · External reference
Regioselective ring-opening of styrene oxide derivatives using halohydrin dehalogenase for synthesis of 4-Aryloxazolidinones
10.1002/adsc.201900786 · 2019 · External reference
HheG, a halohydrin dehalogenase with activity on cyclic epoxides
10.1021/acscatal.7b01854 · 2017 · External reference
Biocatalytic Regio- and enantiocomplementary synthesis of chiral aryloxazolidinones
10.1002/adsc.202400169 · 2024 · External reference
Biocatalytic thionation of epoxides for enantioselective synthesis of thiiranes
10.1002/anie.202212589 · 2022 · External reference
G-type halohydrin dehalogenases catalyze ring opening reactions of cyclic epoxides with diverse anionic nucleophiles
10.1002/chem.202202343 · 2022 · External reference
Expanding the scope of enantioselective halohydrin dehalogenases – Group B
10.1002/adsc.202200342 · 2022 · External reference
Biocatalytically generated library of chiral building blocks containing a Quaternary stereocenter
10.1021/acs.orglett.4c03399 · 2024 · External reference
Identification and structure analysis of an unusual halohydrin dehalogenase for highly Chemo-, Regio- and enantioselective bio-nitration of epoxides
2022 · External reference
Nitrite-mediated hydrolysis of epoxides catalyzed by halohydrin dehalogenase from Agrobacterium radiobacter AD1: a new tool for the kinetic resolution of epoxides
10.1016/j.tetasy.2005.03.021 · 2005 · External reference
Enantiocomplementary chemoenzymatic asymmetric synthesis of (R)- and (S)-chromanemethanol
10.1002/ejoc.200800950 · 2009 · External reference
Enantiocomplementary synthesis of β-adrenergic blocker precursors via biocatalytic nitration of phenyl glycidyl ethers
10.1016/j.bioorg.2023.106640 · 2023 · External reference
Biocatalytic noncanonical enantioconvergent synthesis of vicinal diols
10.1021/acscatal.5c05849 · 2025 · External reference
Enantioconvergent catalysis
10.3762/bjoc.12.192 · 2016 · External reference
Synthesis of enantiopure chloroalcohols by enzymatic kinetic resolution
10.1039/b613937j · 2007 · External reference
Sequential kinetic resolution catalyzed by halohydrin dehalogenase
10.1021/ol061369h · 2006 · External reference
A one-step biocatalytic process for (S)-4-Chloro-3-hydroxybutyronitrile using halohydrin dehalogenase: a chiral building block for atorvastatin
10.1002/cctc.201500453 · 2015 · External reference
Stereodivergent synthesis of epoxides and oxazolidinones via the halohydrin dehalogenase-catalyzed desymmetrization strategy
10.1021/acscatal.2c00718 · 2022 · External reference
A green-by-design biocatalytic process for atorvastatin intermediate
10.1039/b919115c · 2010 · External reference
Stereo-complementary two-step cascades using a two-enzyme system leading to enantiopure epoxides
10.1002/adsc.200700027 · 2007 · External reference
Biocatalytic cascade for the synthesis of enantiopure β-azidoalcohols and β-hydroxynitriles
10.1002/ejoc.200900091 · 2009 · External reference
Multi-enzymatic biosynthesis of chiral β-hydroxy nitriles through co-expression of oxidoreductase and halohydrin dehalogenase
10.1002/adsc.201300549 · 2013 · External reference
Production of (R)-epichlorohydrin from 1,3-dichloro-2-propanol by two-step biocatalysis using haloalcohol dehalogenase and epoxide hydrolase in two-phase system
10.1016/j.bej.2013.02.005 · 2013 · External reference
Efficient synthesis of (S)-epichlorohydrin in high yield by cascade biocatalysis with halohydrin dehalogenase and epoxide hydrolase mutants
10.1016/j.catcom.2015.09.025 · 2015 · External reference
Efficient biosynthesis of ethyl (R)-3-hydroxyglutarate through a one-pot bienzymatic cascade of halohydrin dehalogenase and nitrilase
10.1002/cctc.201500061 · 2015 · External reference
Biodegradation of 1,2,3-trichloropropane to valuable (S)-2,3-DCP using a one-pot reaction system
2020 · External reference
Identification and characterization of a highly S-enantioselective halohydrin dehalogenase from Tsukamurella sp. 1534 for kinetic resolution of halohydrins
10.1016/j.bioorg.2018.09.012 · 2018 · External reference
Cascade bio-hydroxylation and dehalogenation for one-pot enantioselective synthesis of optically active β-halohydrins from halohydrocarbons
10.1039/c9gc01802f · 2019 · External reference
Stereoselective synthesis of enantiopure oxazolidinones via biocatalytic asymmetric aminohydroxylation of alkenes
10.1002/adsc.202100468 · 2021 · External reference
Regiodivergent and stereoselective hydroxyazidation of alkenes by biocatalytic cascades
10.1016/j.isci.2021.102883 · 2021 · External reference
Biocatalytic efficient and enantiocomplementary synthesis of 3-Hydroxy-3-hydroxymethyloxindoles by combining halohydrin dehalogenase and epoxide hydrolase
10.1021/acscatal.4c07482 · 2025 · External reference
Artificial biocatalytic cascades for the enantiocomplementary synthesis of 3-hydroxy-γ-butyrolactones
10.1039/d5gc02480c · 2025 · External reference
Opportunities and challenges for combining chemo- and biocatalysis
10.1038/s41929-017-0010-4 · 2018 · External reference
One pot “click” reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition
10.1039/b919434g · 2010 · External reference
Combining designer cells and click chemistry for a one-pot four-step preparation of enantiopure β-hydroxytriazoles
10.1002/adsc.201000502 · 2010 · External reference
Two (Chemo)-enzymatic cascades for the production of opposite enantiomers of chiral azidoalcohols
10.3390/catal11080982 · 2021 · External reference
Asymmetric azidohydroxylation of styrene derivatives mediated by a biomimetic styrene monooxygenase enzymatic cascade
10.1039/d1cy00855b · 2021 · External reference
Directed evolution of stereoselective enzymes meets click reactions: asymmetric synthesis of chiral triazoles using a Cu(I)-compatible halohydrin dehalogenase
2024 · External reference
Chirality from dynamic kinetic resolution
2011 · External reference
Dynamic kinetic resolution of racemic β-haloalcohols: direct access to enantioenriched epoxides
10.1021/ja805128x · 2008 · External reference
Oxazolidinone synthesis through halohydrin Dehalogenase- catalyzed dynamic kinetic resolution
10.1002/adsc.201500111 · 2015 · External reference
Biocatalytic enantioselective formation and ring-opening of oxetanes
10.1038/s41467-025-56463-z · 2025 · External reference
Biocatalytic stereo-perfect desymmetrization of oxetanes
10.1021/acscatal.5c08014 · 2026 · External reference
Biocatalytic kinetic resolution for efficient and enantioselective synthesis of δ-haloalcohols and tetrahydrofurans
10.1038/s42004-025-01713-w · 2025 · External reference
Key residues for controlling enantioselectivity of halohydrin dehalogenase from Arthrobacter sp. strain AD2, revealed by structure-guided directed evolution
10.1128/aem.06586-11 · 2012 · External reference
Improvement of enantioselectivity of the B-type halohydrin hydrogen-halide-lyase from corynebacterium sp. N-1074
10.1016/j.jbiosc.2016.02.003 · 2016 · External reference
