Research graph
References from Isoform usage dynamics in metabolic adaptation. Local targets link to admitted publications; unresolved targets remain external evidence.
Nutrient sensors and their crosstalk
10.1038/s12276-023-01006-z · 2023 · External reference
Post-ingestive systemic nutrient sensing for whole-body homeostasis
2025 · External reference
Alternative splicing as a source of phenotypic diversity
10.1038/s41576-022-00514-4 · 2022 · External reference
Isoform usage as a distinct regulatory layer driving nutrient-responsive metabolic adaptation
10.1016/j.cmet.2025.01.009 · 2025 · External reference
Metabolic regulation of mRNA splicing
10.1016/j.tcb.2024.02.002 · 2024 · External reference
Unveiling tissue-specific RNA landscapes in mouse organs during fasting and feeding using nanopore direct RNA sequencing
2025 · External reference
Nutrient control of growth and metabolism through mTORC1 regulation of mRNA splicing
10.1016/j.molcel.2024.10.037 · 2024 · External reference
Isoform age splice isoform profiling using long-read technologies
2021 · External reference
Systematic assessment of long-read RNA-seq methods for transcript identification and quantification
10.1038/s41592-024-02298-3 · 2024 · External reference
The organization, promoter analysis, and expression of the human PPARγ gene
10.1074/jbc.272.30.18779 · 1997 · External reference
Peroxisome proliferator-activated receptor gene expression in human tissues: effects of obesity, weight loss, and regulation by insulin and glucocorticoids
10.1172/jci119424 · 1997 · External reference
PPARγ2 prevents lipotoxicity by controlling adipose tissue expandability and peripheral lipid metabolism
10.1371/journal.pgen.0030064 · 2007 · External reference
Peroxisome proliferator-activated receptor γ2 controls the rate of adipose tissue lipid storage and determines metabolic flexibility
10.1016/j.celrep.2018.07.063 · 2018 · External reference
Isoform-specific functions of PPARγ in gene regulation and metabolism
10.1101/gad.349232.121 · 2022 · External reference
A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
10.1038/3099 · 1998 · External reference
The association between the peroxisome proliferator-activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-analysis
10.1093/aje/kwp450 · 2010 · External reference
The role of SCAP/SREBP as central regulators of lipid metabolism in hepatic steatosis
10.3390/ijms25021109 · 2024 · External reference
Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells
10.1172/jci119247 · 1997 · External reference
Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells
10.1172/jci119248 · 1997 · External reference
Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
10.1172/jci118951 · 1996 · External reference
Sterol regulatory element binding protein 1a regulates hepatic fatty acid partitioning by activating acetyl coenzyme A carboxylase 2
10.1128/mcb.00553-09 · 2009 · External reference
Linking lipid metabolism to the innate immune response in macrophages through sterol regulatory element binding protein-1a
10.1016/j.cmet.2011.04.001 · 2011 · External reference
Hepatocyte- or macrophage-specific SREBP-1a deficiency in mice exacerbates methionine- and choline-deficient diet-induced nonalcoholic fatty liver disease
10.1152/ajpgi.00090.2022 · 2022 · External reference
Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes
10.1073/pnas.96.22.12737 · 1999 · External reference
ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose
10.1128/mcb.19.5.3760 · 1999 · External reference
Diminished hepatic response to fasting/refeeding and liver X receptor agonists in mice with selective deficiency of sterol regulatory element-binding protein-1c
10.1074/jbc.m111421200 · 2002 · External reference
Differential signaling activation by insulin and insulin-like growth factors I and II upon binding to insulin receptor isoform A
10.1210/en.2009-0377 · 2009 · External reference
Insulin receptor isoforms in physiology and disease: an updated view
10.1210/er.2017-00073 · 2017 · External reference
Insulin receptor isoform A, a newly recognized, high-affinity insulin-like growth factor II receptor in fetal and cancer cells
10.1128/mcb.19.5.3278 · 1999 · External reference
Tissue-specific expression of two alternatively spliced insulin receptor mRNAs in man
10.1210/mend-3-8-1263 · 1989 · External reference
Insulin receptor alternative splicing is regulated by insulin signalling and modulates beta cell survival
10.1038/srep31222 · 2016 · External reference
Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat adipose tissue
10.1677/jme.1.01635 · 2005 · External reference
Insulin analogues differently activate insulin receptor isoforms and post-receptor signalling
10.1007/s00125-010-1760-6 · 2010 · External reference
Signalling differences from the A and B isoforms of the insulin receptor (IR) in 32D cells in the presence or absence of IR substrate-1
10.1210/en.2002-0136 · 2003 · External reference
Insulin receptor isoform B is required for efficient proinsulin processing in pancreatic β cells
10.1016/j.isci.2024.110017 · 2024 · External reference
Phosphorylation of RXRα mediates the effect of JNK to suppress hepatic FGF21 expression and promote metabolic syndrome
10.1073/pnas.2210434119 · 2022 · External reference
Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK
10.1073/pnas.2527162123 · 2026 · External reference
Three mammalian lipins act as phosphatidate phosphatases with distinct tissue expression patterns
10.1074/jbc.m610745200 · 2007 · External reference
Alternatively spliced lipin isoforms exhibit distinct expression pattern, subcellular localization, and role in adipogenesis
10.1074/jbc.m503885200 · 2005 · External reference
Natural structural variants of the nuclear receptor farnesoid X receptor affect transcriptional activation
10.1074/jbc.m209505200 · 2003 · External reference
FXR isoforms control different metabolic functions in liver cells via binding to specific DNA motifs
10.1053/j.gastro.2020.07.036 · 2020 · External reference
Hepatic farnesoid X-receptor isoforms α2 and α4 differentially modulate bile salt and lipoprotein metabolism in mice
10.1371/journal.pone.0115028 · 2014 · External reference
SR-BII, an isoform of the scavenger receptor BI containing an alternate cytoplasmic tail, mediates lipid transfer between high-density lipoprotein and cells
10.1074/jbc.273.24.15241 · 1998 · External reference
Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice
10.1038/s42255-022-00681-y · 2022 · External reference
High-density lipoprotein endocytosis by scavenger receptor SR-BII is clathrin-dependent and requires a carboxyl-terminal dileucine motif
10.1074/jbc.m513154200 · 2006 · External reference
Post-transcriptional regulation of de novo lipogenesis by mTORC1-S6K1-SRPK2 signaling
10.1016/j.cell.2017.10.037 · 2017 · External reference
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase
10.1053/j.gastro.2006.04.019 · 2006 · External reference
AMP-activated kinase regulates cytoplasmic HuR
10.1128/mcb.22.10.3425-3436.2002 · 2002 · External reference
AMP-activated protein kinase-regulated phosphorylation and acetylation of importin α1: involvement in the nuclear import of RNA-binding protein HuR
10.1074/jbc.m409014200 · 2004 · External reference
The RNA-binding protein HuR is a negative regulator in adipogenesis
10.1038/s41467-019-14001-8 · 2020 · External reference
Adipose HuR protects against diet-induced obesity and insulin resistance
10.1038/s41467-019-10348-0 · 2019 · External reference
The RNA-binding protein NONO coordinates hepatic adaptation to feeding
10.1016/j.cmet.2017.12.010 · 2018 · External reference
SRSF10 regulates alternative splicing and is required for adipocyte differentiation
10.1128/mcb.01674-13 · 2014 · External reference
SRSF10 plays a role in myoblast differentiation and glucose production via regulation of alternative splicing
10.1016/j.celrep.2015.10.038 · 2015 · External reference
Targeting hepatic serine-arginine protein kinase 2 ameliorates alcohol-associated liver disease by alternative splicing control of lipogenesis
10.1097/hep.0000000000000433 · 2023 · External reference
Dysregulated RNA polyadenylation contributes to metabolic impairment in non-alcoholic fatty liver disease
10.1093/nar/gkac165 · 2022 · External reference
Glucose dissociates DDX21 dimers to regulate mRNA splicing and tissue differentiation
10.1016/j.cell.2022.12.004 · 2023 · External reference
Expression of the splicing factor gene SFRS10 is reduced in human obesity and contributes to enhanced lipogenesis
10.1016/j.cmet.2011.06.007 · 2011 · External reference
HNF1A and A1CF coordinate a beta cell transcription-splicing axis that is disrupted in type 2 diabetes
10.1016/j.cmet.2025.07.007 · 2025 · External reference
Pancreatic microexons regulate islet function and glucose homeostasis
2023 · External reference
Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
10.2337/db07-0156 · 2007 · External reference
De novo lipogenesis in human fat and liver is linked to ChREBP-β and metabolic health
10.1038/ncomms2537 · 2013 · External reference
Dysregulation of RNA splicing in early non-alcoholic fatty liver disease through hepatocellular carcinoma
10.1038/s41598-024-52237-7 · 2024 · External reference
Global prevalence, incidence, and outcomes of non-obese or lean non-alcoholic fatty liver disease: a systematic review and meta-analysis
10.1016/s2468-1253(20)30077-7 · 2020 · External reference
Regulation of endocrine cell alternative splicing revealed by single-cell RNA sequencing in type 2 diabetes pathogenesis
10.1038/s42003-024-06475-0 · 2024 · External reference
Genetic regulation of RNA splicing in human pancreatic islets
10.1186/s13059-022-02757-0 · 2022 · External reference
Subcutaneous adipose tissue splice quantitative trait loci reveal differences in isoform usage associated with cardiometabolic traits
10.1016/j.ajhg.2021.11.019 · 2022 · External reference
A splice-switching oligonucleotide treatment ameliorates glycogen storage disease type 1a in mice with G6PC c.648G>T
10.1172/jci163464 · 2023 · External reference
TM7SF3 controls TEAD1 splicing to prevent MASH-induced liver fibrosis
10.1016/j.cmet.2024.04.003 · 2024 · External reference
DRAK2 aggravates nonalcoholic fatty liver disease progression through SRSF6-associated RNA alternative splicing
10.1016/j.cmet.2021.09.008 · 2021 · External reference
Functional 5′ UTR mRNA structures in eukaryotic translation regulation and how to find them
10.1038/nrm.2017.103 · 2018 · External reference
Long-read Ribo-STAMP simultaneously measures transcription and translation with isoform resolution
10.1101/gr.279176.124 · 2024 · External reference
Evolution and biological roles of alternative 3′UTRs
10.1016/j.tcb.2015.10.012 · 2016 · External reference
Single-cell long-read targeted sequencing reveals transcriptional variation in ovarian cancer
10.1038/s41467-024-51252-6 · 2024 · External reference
Regulation of alternative splicing by histone modifications
10.1126/science.1184208 · 2010 · External reference
Nuclear m6A reader YTHDC1 regulates mRNA splicing
10.1016/j.molcel.2016.01.012 · 2016 · External reference
mTORC1 promotes cell growth via m6A-dependent mRNA degradation
10.1016/j.molcel.2021.03.010 · 2021 · External reference
mTORC1 stimulates cell growth through SAM synthesis and m6A mRNA-dependent control of protein synthesis
10.1016/j.molcel.2021.03.009 · 2021 · External reference
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
10.1038/cr.2014.151 · 2014 · External reference
