Research graph
References from SIRT2-dependent SQSTM1 decrotonylation at K100 rescues impaired mitophagy in aged bovine oocytes. Local targets link to admitted publications; unresolved targets remain external evidence.
Mitochondria-targeted therapy rescues development and quality of embryos derived from oocytes matured under oxidative stress conditions: a bovine in vitro model
10.1093/humrep/dez161 · 2019 · External reference
Sirtuins' control of autophagy and mitophagy in cancer
2021 · External reference
Mitochondrial dysfunction in ovarian aging
10.1097/cm9.0000000000003801 · 2025 · External reference
Control of mitochondrial integrity influences oocyte quality during reproductive aging
10.1093/molehr/gaad028 · 2023 · External reference
Effect of mitophagy in oocytes and granulosa cells on oocyte quality
10.1093/biolre/ioaa194 · 2021 · External reference
SIRT2: controversy and multiple roles in disease and physiology
10.1016/j.arr.2019.100961 · 2019 · External reference
SIRT2 inhibition results in meiotic arrest, mitochondrial dysfunction, and disturbance of redox homeostasis during bovine oocyte maturation
10.3390/ijms20061365 · 2019 · External reference
SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction
10.1111/j.1474-9726.2007.00304.x · 2007 · External reference
NMN/NAD(+) enhances SIRT2-modulated microtubule dynamics to improve mitochondrial and mitophagy functions in senescent cells
2026 · External reference
Long-term atorvastatin improves cognitive function by modulating SIRT2-mediated dynamic transition of NFL lysine 272 crotonylation to ubiquitination in naturally aging rats
10.1038/s41420-025-02764-7 · 2025 · External reference
Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule
10.1016/j.devcel.2024.04.020 · 2024 · External reference
Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy
10.1182/blood-2018-02-833475 · 2019 · External reference
Molecular characterization of p62, a mitotic apparatus protein required for mitotic progression
10.1074/jbc.272.6.3606 · 1997 · External reference
S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in Mammalian autophagy
10.1016/j.molcel.2023.09.004 · 2023 · External reference
Lysine catabolism reprograms tumour immunity through histone crotonylation
10.1038/s41586-023-06061-0 · 2023 · External reference
Inhibition of ACSS2-mediated histone crotonylation alleviates kidney fibrosis via IL-1β-dependent macrophage activation and tubular cell senescence
10.1038/s41467-024-47315-3 · 2024 · External reference
The SIRT5-SUCLG2 desuccinylation axis delays ovarian aging via a mitochondrial-epigenetic regulatory mechanism
10.1038/s41467-026-75502-x · 2026 · External reference
Succinyl-CoA ligase deficiency in pro-inflammatory and tissue-invasive T cells
10.1016/j.cmet.2020.10.025 · 2020 · External reference
Mitochondrial dysfunction in oocytes: implications for fertility and ageing
10.1186/s13048-025-01764-6 · 2025 · External reference
Aging-related mitochondrial alterations in bovine oocytes
10.1016/j.theriogenology.2020.07.036 · 2020 · External reference
SIRT2 regulates apoptosis by inducing mitophagy in sheep cumulus cells
10.1016/j.theriogenology.2024.02.004 · 2024 · External reference
Loss of NAD-dependent protein deacetylase sirtuin-2 alters mitochondrial protein acetylation and dysregulates mitophagy
10.1089/ars.2016.6662 · 2017 · External reference
SirT2 is a histone deacetylase with preference for histone H4 lys 16 during mitosis
10.1101/gad.1412706 · 2006 · External reference
Primary oocytes with cellular senescence features are involved in ovarian aging in mice
2024 · External reference
Ovarian aging: energy metabolism of oocytes
10.1186/s13048-024-01427-y · 2024 · External reference
Polyamine metabolite spermidine rejuvenates oocyte quality by enhancing mitophagy during female reproductive aging
10.1038/s43587-023-00498-8 · 2023 · External reference
Putrescine promotes maturation of oocytes from reproductively old mice via mitochondrial autophagy
10.1016/j.rbmo.2024.104495 · 2025 · External reference
Ferulic acid enhances oocyte maturation and the subsequent development of bovine oocytes
10.3390/ijms241914804 · 2023 · External reference
Long-term atorvastatin improves cognitive function by modulating SIRT2-mediated dynamic transition of NFL lysine 272 crotonylation to ubiquitination in naturally aging rats
10.1038/s41420-025-02764-7 · 2025 · External reference
A metabolite-bridged complex between SerRS and SIRT2 couples NAD+ metabolism to translation control
10.1038/s41467-026-75266-4 · 2026 · External reference
The role of mitochondria in oocyte maturation
10.3390/cells10092484 · 2021 · External reference
Mitochondrial SIRT2-mediated CPT2 deacetylation prevents diabetic cardiomyopathy by impeding cardiac fatty acid oxidation
10.7150/ijbs.102834 · 2025 · External reference
Mitophagy is involved in the mitochondrial dysfunction of vitrified porcine oocytes
10.1002/mrd.23472 · 2021 · External reference
Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2
10.1091/mbc.e19-05-0291 · 2019 · External reference
Targeted deletion of mitofusin 1 and mitofusin 2 causes female infertility and loss of follicular reserve
10.1007/s43032-022-01014-w · 2023 · External reference
Dysregulated mitophagy and mitochondrial organization in optic atrophy due to OPA1 mutations
10.1212/wnl.0000000000003491 · 2017 · External reference
Mitochondrial SIRT3 as a protective factor against cyclosporine a-induced nephrotoxicity
2024 · External reference
Tumor-suppressive function of SIRT4 in neuroblastoma through mitochondrial damage
10.2147/cmar.s172509 · 2018 · External reference
SIRT5 modulates mitochondria function via mitophagy and antioxidant mechanisms to facilitate oocyte maturation in mice
10.1016/j.ijbiomac.2025.141488 · 2025 · External reference
The role of LC3B in autophagy as an RNA-binding protein
10.1080/15548627.2022.2111083 · 2023 · External reference
TRIM38 suppresses breast cancer progression via modulating SQSTM1 ubiquitination and autophagic flux
10.1002/advs.202512725 · 2026 · External reference
Extracellular SQSTM1 exacerbates acute pancreatitis by activating autophagy-dependent ferroptosis
10.1080/15548627.2022.2152209 · 2023 · External reference
SIRT2-knockdown rescues GARS-induced charcot-marie-tooth neuropathy
10.1111/acel.13391 · 2021 · External reference
Histone lysine methacrylation is a dynamic post-translational modification regulated by HAT1 and SIRT2
10.1038/s41421-021-00344-4 · 2021 · External reference
Requirement for p62 acetylation in the aggregation of ubiquitylated proteins under nutrient stress
10.1038/s41467-019-13718-w · 2019 · External reference
Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis
10.1038/s41419-021-03666-z · 2021 · External reference
VEGFR3 mitigates hypertensive nephropathy by enhancing mitophagy via regulating crotonylation of HSPA1L
10.1186/s12964-025-02045-x · 2025 · External reference
Flightless-I blocks p62-mediated recognition of LC3 to impede selective autophagy and promote breast cancer progression
10.1158/0008-5472.can-17-3835 · 2018 · External reference
LC3B/p62-mediated mitophagy protects A549 cells from resveratrol-induced apoptosis
10.1016/j.lfs.2021.119139 · 2021 · External reference
Astragalus polysaccharide promotes autophagy and alleviates diabetic nephropathy by targeting the lncRNA Gm41268/PRLR pathway
10.1080/0886022x.2023.2284211 · 2023 · External reference
Fate of the sperm mitochondria, and the incorporation, conversion, and disassembly of the sperm tail structures during bovine fertilization
10.1095/biolreprod55.6.1195 · 1996 · External reference
Elimination of paternal mitochondria in mouse embryos occurs through autophagic degradation dependent on PARKIN and MUL1
10.7554/elife.17896 · 2016 · External reference
