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References from Cell-free RNA fragmentomics: rethinking the biology of RNA liquid biopsies. Local targets link to admitted publications; unresolved targets remain external evidence.
The Liquid Biopsy Consortium: challenges and opportunities for early cancer detection and monitoring
2023 · External reference
Circulating tumour cells in cancer patients: challenges and perspectives
10.1016/j.molmed.2010.07.001 · 2010 · External reference
Detection of circulating tumor DNA in early- and late-stage human malignancies
10.1126/scitranslmed.3007094 · 2014 · External reference
Liquid biopsy based on cell-free DNA and RNA
10.1146/annurev-bioeng-110222-111259 · 2024 · External reference
Noninvasive detection of cancer-associated genome-wide hypomethylation and copy number aberrations by plasma DNA bisulfite sequencing
10.1073/pnas.1313995110 · 2013 · External reference
Cell-free DNA comprises an in vivo nucleosome footprint that informs its tissues-of-origin
10.1016/j.cell.2015.11.050 · 2016 · External reference
Cell-free DNA fragmentomics in cancer
10.1016/j.ccell.2025.09.006 · 2025 · External reference
Size distributions of maternal and fetal DNA in maternal plasma
10.1373/clinchem.2003.024893 · 2004 · External reference
Maternal plasma DNA sequencing reveals the genome-wide genetic and mutational profile of the fetus
10.1126/scitranslmed.3001720 · 2010 · External reference
Lengthening and shortening of plasma DNA in hepatocellular carcinoma patients
10.1073/pnas.1500076112 · 2015 · External reference
Genome-wide cell-free DNA fragmentation in patients with cancer
10.1038/s41586-019-1272-6 · 2019 · External reference
Circulating DNA fragmentomics and cancer screening
2023 · External reference
Comprehensive human cell-type methylation atlas reveals origins of circulating cell-free DNA in health and disease
10.1038/s41467-018-07466-6 · 2018 · External reference
Epigenetics, fragmentomics, and topology of cell-free DNA in liquid biopsies
10.1126/science.aaw3616 · 2021 · External reference
Clonal hematopoiesis of indeterminate potential in patients with solid tumor malignancies
10.1158/0008-5472.can-22-0985 · 2022 · External reference
High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants
10.1038/s41591-019-0652-7 · 2019 · External reference
Cell type inference in cell-free nucleic acid liquid biopsy
10.1038/s41587-025-02904-5 · 2025 · External reference
Cell types of origin of the cell-free transcriptome
10.1038/s41587-021-01188-9 · 2022 · External reference
Early prediction of preeclampsia in pregnancy with cell-free RNA
10.1038/s41586-022-04410-z · 2022 · External reference
An ultrasensitive method for detection of cell-free RNA
10.1038/s41586-025-08834-1 · 2025 · External reference
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
10.1038/ncb1596 · 2007 · External reference
Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
10.1073/pnas.1019055108 · 2011 · External reference
Characterization of extracellular circulating microRNA
10.1093/nar/gkr254 · 2011 · External reference
Systematic cross-study assessment of RNA-Seq experimental workflows for plasma cell-free transcriptome profiling
2025 · External reference
Circulating microRNA biomarker studies: pitfalls and potential solutions
10.1373/clinchem.2014.221341 · 2015 · External reference
Blood collection tube and RNA purification method recommendations for extracellular RNA transcriptome profiling
10.1038/s41467-025-58607-7 · 2025 · External reference
Secretory autophagy
10.1016/j.ceb.2015.04.016 · 2015 · External reference
Regulated cell death in neutrophils: from apoptosis to NETosis and pyroptosis
10.1016/j.smim.2023.101849 · 2023 · External reference
Fragmentation of extracellular ribosomes and tRNAs shapes the extracellular RNAome
10.1093/nar/gkaa674 · 2020 · External reference
Processing by RNase 1 forms tRNA halves and distinct Y RNA fragments in the extracellular environment
10.1093/nar/gkaa526 · 2020 · External reference
Revisiting extracellular RNA release, processing, and function
10.1016/j.tibs.2020.12.008 · 2021 · External reference
Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA
10.1093/narcan/zcac037 · 2022 · External reference
Comparative functional analysis of ribonuclease 1 homologs: molecular insights into evolving vertebrate physiology
10.1042/bcj20170173 · 2017 · External reference
MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins
10.1038/ncb2210 · 2011 · External reference
Extracellular microRNAs in human circulation are associated with miRISC complexes that are accessible to anti-AGO2 antibody and can bind target mimic oligonucleotides
10.1073/pnas.2008323117 · 2020 · External reference
Coding and noncoding landscape of extracellular RNA released by human glioma stem cells
10.1038/s41467-017-01196-x · 2017 · External reference
Assessment of small RNA sorting into different extracellular fractions revealed by high-throughput sequencing of breast cell lines
10.1093/nar/gkv432 · 2015 · External reference
5' tRNA halves are present as abundant complexes in serum, concentrated in blood cells, and modulated by aging and calorie restriction
10.1186/1471-2164-14-298 · 2013 · External reference
5'-YRNA fragments derived by processing of transcripts from specific YRNA genes and pseudogenes are abundant in human serum and plasma
10.1152/physiolgenomics.00129.2013 · 2013 · External reference
mGem: guides or triggers? Extracellular RNAs beyond vesicular miRNAs
10.1128/mbio.03129-24 · 2025 · External reference
Identification of distinct nanoparticles and subsets of extracellular vesicles by asymmetric flow field-flow fractionation
10.1038/s41556-018-0040-4 · 2018 · External reference
Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
10.1038/s41556-021-00805-8 · 2021 · External reference
Ribonuclease activity undermines immune sensing of naked extracellular RNA
2025 · External reference
Broad role for YBX1 in defining the small noncoding RNA composition of exosomes
10.1073/pnas.1712108114 · 2017 · External reference
The eight human “canonical” ribonucleases: molecular diversity, catalytic properties, and special biological actions of the enzyme proteins
10.1016/j.febslet.2010.04.018 · 2010 · External reference
Nicked tRNAs are stable reservoirs of tRNA halves in cells and biofluids
10.1073/pnas.2216330120 · 2023 · External reference
Transfer RNA halves are found as nicked tRNAs in cells: evidence that nicked tRNAs regulate expression of an RNA repair operon
10.1261/rna.079575.122 · 2023 · External reference
Processivity of translation in the eukaryote cell: role of aminoacyl-tRNA synthetases
10.1016/j.febslet.2009.11.027 · 2010 · External reference
Extracellular aaRSs drive autoimmune and inflammatory responses in rheumatoid arthritis via the release of cytokines and PAD4
10.1136/ard-2023-224055 · 2023 · External reference
Exomeres and supermeres: monolithic or diverse?
10.1002/jex2.45 · 2022 · External reference
Detection of circulating extracellular mRNAs by modified small-RNA-sequencing analysis
2019 · External reference
Polyadenylation ligation-mediated sequencing (PALM-Seq) characterizes cell-free coding and non-coding RNAs in human biofluids
10.1002/ctm2.987 · 2022 · External reference
Small RNA structural biochemistry in a post-sequencing era
10.1038/s41596-023-00936-2 · 2024 · External reference
PANDORA-seq expands the repertoire of regulatory small RNAs by overcoming RNA modifications
10.1038/s41556-021-00652-7 · 2021 · External reference
Peak analysis of cell-free RNA finds recurrently protected narrow regions with clinical potential
10.1186/s13059-025-03590-x · 2025 · External reference
exRNA-eCLIP intersection analysis reveals a map of extracellular RNA binding proteins and associated RNAs across major human biofluids and carriers
2023 · External reference
Identification of protein-protected mRNA fragments and structured excised intron RNAs in human plasma by TGIRT-seq peak calling
10.7554/elife.60743 · 2020 · External reference
Mechanistic insights into RNA chaperoning by Ro60 and La autoantigens
10.1016/j.cell.2025.12.030 · 2026 · External reference
Charting extracellular transcriptomes in the human biofluid RNA atlas
10.1016/j.celrep.2020.108552 · 2020 · External reference
Circulating microRNAs as novel biomarkers for platelet activation
10.1161/circresaha.111.300539 · 2013 · External reference
Human plasma and serum extracellular small RNA reference profiles and their clinical utility
10.1073/pnas.1714397115 · 2018 · External reference
Haemolysis during sample preparation alters microRNA content of plasma
10.1371/journal.pone.0024145 · 2011 · External reference
Large differences in small RNA composition between human biofluids
10.1016/j.celrep.2018.10.014 · 2018 · External reference
Mg2+ induces a sharp and reversible transition in U1 and U2 small nuclear ribonucleoprotein configurations
1984 · External reference
Platelets sequester extracellular DNA, capturing tumor-derived and free fetal DNA
10.1126/science.adp3971 · 2025 · External reference
Escaping the nuclear confines: signal-dependent pre-mRNA splicing in anucleate platelets
10.1016/j.cell.2005.06.015 · 2005 · External reference
RNA-seq of tumor-educated platelets enables blood-based pan-cancer, multiclass, and molecular pathway cancer diagnostics
10.1016/j.ccell.2015.09.018 · 2015 · External reference
Tumour-educated platelets for breast cancer detection: biological and technical insights
10.1038/s41416-023-02174-5 · 2023 · External reference
Cancer cells exploit an orphan RNA to drive metastatic progression
10.1038/s41591-018-0230-4 · 2018 · External reference
Systematic annotation of orphan RNAs reveals blood-accessible molecular barcodes of cancer identity and cancer-emergent oncogenic drivers
2026 · External reference
Clinical utility of circulating tumor RNA (ctRNA) in a combined circulating tumor DNA (ctDNA) and ctRNA next-generation sequencing (NGS) pan-cancer liquid biopsy assay
10.1200/jco.2025.43.16_suppl.3016 · 2025 · External reference
A comprehensive characterization of the cell-free transcriptome reveals tissue- and subtype-specific biomarkers for cancer detection
10.1038/s41467-021-22444-1 · 2021 · External reference
Patient-specific alterations in blood plasma cfRNA profiles enable accurate classification of cancer patients and controls
10.1038/s43856-026-01507-8 · 2026 · External reference
Expression and localisation of vascular ribonucleases in endothelial cells
10.1160/th10-06-0345 · 2011 · External reference
Defining the reference proteomes for small extracellular vesicles and non-vesicular components
10.1038/s41556-026-01878-z · 2026 · External reference
Ri-sec-seq: comprehensive profiling of nonvesicular extracellular rnas with different stabilities
10.21769/bioprotoc.3918 · 2021 · External reference
