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References from Synonymous sequence design controls the folding, processing, and activity of the therapeutic protein ADAMTS13. Local targets link to admitted publications; unresolved targets remain external evidence.
The effects of codon usage on protein structure and folding
10.1146/annurev-biophys-030722-020555 · 2024 · External reference
Synonymous codon usage regulates translation initiation
10.1016/j.celrep.2023.113413 · 2023 · External reference
Synonymous but not silent: the codon usage code for gene expression and protein folding
10.1146/annurev-biochem-071320-112701 · 2021 · External reference
Codon usage and protein length-dependent feedback from translation elongation regulates translation initiation and elongation speed
10.1093/nar/gkab729 · 2021 · External reference
An evolutionarily conserved mechanism for controlling the efficiency of protein translation
10.1016/j.cell.2010.03.031 · 2010 · External reference
Translation efficiency is determined by both codon bias and folding energy
10.1073/pnas.0909910107 · 2010 · External reference
Innovative design and comprehensive characterization of a valine-enhanced lipid nanoparticle-coated mRNA vaccine targeting the SARS-CoV-2 S-RBD antigen
10.1038/s41598-025-08142-8 · 2025 · External reference
Folding at the birth of the nascent chain: coordinating translation with co-translational folding
10.1016/j.sbi.2010.10.008 · 2011 · External reference
Roles for synonymous codon usage in protein biogenesis
10.1146/annurev-biophys-060414-034333 · 2015 · External reference
Codon optimality, bias and usage in translation and mRNA decay
10.1038/nrm.2017.91 · 2018 · External reference
Translation rates and protein folding
10.1016/j.jmb.2023.168384 · 2024 · External reference
Synonymous mutations in representative yeast genes are mostly strongly non-neutral
10.1038/s41586-022-04823-w · 2022 · External reference
When silence disrupts
10.1056/nejmcibr2207405 · 2022 · External reference
Codon optimality is a major determinant of mRNA stability
10.1016/j.cell.2015.02.029 · 2015 · External reference
Codon usage biases co-evolve with transcription termination machinery to suppress premature cleavage and polyadenylation
10.7554/elife.33569 · 2018 · External reference
The Yin and Yang of codon usage
10.1093/hmg/ddw207 · 2016 · External reference
Synonymous codons direct cotranslational folding toward different protein conformations
10.1016/j.molcel.2016.01.008 · 2016 · External reference
Characterization of coding synonymous and non-synonymous variants in ADAMTS13 using ex vivo and in silico approaches
10.1371/journal.pone.0038864 · 2012 · External reference
A single synonymous variant (c.354G>A [p.P118P]) in ADAMTS13 confers enhanced specific activity
10.3390/ijms20225734 · 2019 · External reference
Therapeutic implications of synonymous gene recoding: insights into mechanisms controlling protein biogenesis and activity
10.1093/procel/pwaf028 · 2025 · External reference
Thrombotic thrombocytopenic purpura: pathogenesis, diagnosis and potential novel therapeutics
10.1111/jth.13764 · 2017 · External reference
Structure–function and regulation of ADAMTS-13 protease
10.1111/jth.12221 · 2013 · External reference
Recombinant ADAMTS-13: first-in-human pharmacokinetics and safety in congenital thrombotic thrombocytopenic purpura
10.1182/blood-2017-06-788026 · 2017 · External reference
Improvement of recombinant ADAMTS13 production through a more optimal signal peptide or an N-terminal fusion protein
10.1111/jth.15819 · 2022 · External reference
Anti-ADAMTS13 antibodies and a novel heterozygous p.R1177Q mutation in a case of pregnancy-onset immune-mediated thrombotic thrombocytopenic purpura
10.1055/s-0037-1615252 · 2018 · External reference
Pathogenicity of anti-ADAMTS13 autoantibodies in acquired thrombotic thrombocytopenic purpura
10.1016/j.ebiom.2015.06.007 · 2015 · External reference
Multiple domains of ADAMTS13 are targeted by autoantibodies against ADAMTS13 in patients with acquired idiopathic thrombotic thrombocytopenic purpura
10.3324/haematol.2009.019299 · 2010 · External reference
Hypochlorous acid generated by neutrophils inactivates ADAMTS13: an oxidative mechanism for regulating ADAMTS13 proteolytic activity during inflammation
10.1074/jbc.m114.599084 · 2015 · External reference
Conformational activation of ADAMTS13
10.1073/pnas.1411979112 · 2014 · External reference
Systematic determination of the packaging limit of lentiviral vectors
10.1089/104303401753153947 · 2001 · External reference
Effect of genome size on AAV vector packaging
10.1038/mt.2009.255 · 2010 · External reference
Synonymous ADAMTS13 variants impact molecular characteristics and contribute to variability in active protein abundance
2022 · External reference
Decoding mechanisms by which silent codon changes influence protein biogenesis and function
10.1016/j.biocel.2015.03.011 · 2015 · External reference
Effects of codon optimization on coagulation factor IX translation and structure: implications for protein and gene therapies
10.1038/s41598-019-51984-2 · 2019 · External reference
Codon and codon-pair usage tables (CoCoPUTs): facilitating genetic variation analyses and recombinant gene design
10.1016/j.jmb.2019.04.021 · 2019 · External reference
Uncovering position-specific patterns in codon and codon-pair usage in candidate genes associated with blood coagulation diseases
2025 · External reference
A machine learning approach uncovers principles and determinants of eukaryotic ribosome pausing
10.1126/sciadv.ado0738 · 2024 · External reference
A synonymous single nucleotide polymorphism in ∆F508 CFTR alters the secondary structure of the mRNA and the expression of the mutant protein
10.1074/jbc.m110.154575 · 2010 · External reference
Synonymous variants that disrupt messenger RNA structure are significantly constrained in the human population
10.1093/gigascience/giab023 · 2021 · External reference
Kinetic modeling of the plasma pharmacokinetic profiles of ADAMTS13 fragment and its Fc-fusion counterpart in mice
10.3389/fphar.2024.1352842 · 2024 · External reference
Cleavage of von Willebrand factor requires the spacer domain of the metalloprotease ADAMTS13
10.1074/jbc.m305331200 · 2003 · External reference
The cooperative activity between the carboxyl-terminal TSP1 repeats and the CUB domains of ADAMTS13 is crucial for recognition of von Willebrand factor under flow
10.1182/blood-2007-04-083329 · 2007 · External reference
An autoantibody epitope comprising residues R660, Y661, and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF
10.1182/blood-2009-06-229203 · 2010 · External reference
Multi-step binding of ADAMTS-13 to von Willebrand factor
10.1111/j.1538-7836.2009.03620.x · 2009 · External reference
Proteolytic inactivation of ADAMTS13 by thrombin and plasmin
10.1182/blood-2004-03-1101 · 2005 · External reference
Predicting the translation efficiency of messenger RNA in mammalian cells
10.1038/s41587-025-02712-x · 2026 · External reference
Functional activity and binding specificity of small Ankyrin repeat proteins called Ankyrons against SARS-CoV-2 variants
10.1208/s12248-025-01043-8 · 2025 · External reference
Implementing computational methods in tandem with synonymous gene recoding for therapeutic development
10.1016/j.tips.2022.09.008 · 2023 · External reference
Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction
10.1038/nbt.4172 · 2018 · External reference
Rare codons cluster
10.1371/journal.pone.0003412 · 2008 · External reference
Cell lines CoCoPUTs: a database of codon and codon-pair usage frequencies in cell lines
10.1016/j.jmb.2026.169718 · 2026 · External reference
Translational control by 5′-untranslated regions of eukaryotic mRNAs
10.1126/science.aad9868 · 2016 · External reference
High-throughput 5′ UTR engineering for enhanced protein production in non-viral gene therapies
10.1038/s41467-021-24436-7 · 2021 · External reference
What are 3′ UTRs doing?
10.1101/cshperspect.a034728 · 2019 · External reference
The interplay between translational efficiency, poly(A) tails, microRNAs, and neuronal activation
10.1261/rna.079046.121 · 2022 · External reference
Human 5′ UTR design and variant effect prediction from a massively parallel translation assay
10.1038/s41587-019-0164-5 · 2019 · External reference
Effects of combinations of untranslated-region sequences on translation of mRNA
10.3390/biom13111677 · 2023 · External reference
Combinatorial tuning of 5′UTR and N-terminal coding sequences for enhanced recombinant protein expression in Corynebacterium glutamicum
10.1021/acssynbio.5c00250 · 2025 · External reference
Removal of the C-terminal domains of ADAMTS13 by activated coagulation factor XI induces platelet adhesion on endothelial cells under flow conditions
10.3389/fmed.2017.00232 · 2017 · External reference
Analysis of protein landscapes around N-glycosylation sites from the PDB repository for understanding the structural basis of N-glycoprotein processing and maturation
10.1093/glycob/cwy059 · 2018 · External reference
N-Glycans of ADAMTS13 modulate its secretion and von Willebrand factor cleaving activity
10.1182/blood-2008-07-167775 · 2009 · External reference
O-fucosylation is required for ADAMTS13 secretion
10.1074/jbc.m700317200 · 2007 · External reference
ADAMTS-13 glycans and conformation-dependent activity
10.1111/jth.13688 · 2017 · External reference
Gene variants of coagulation related proteins that interact with SARS-CoV-2
10.1371/journal.pcbi.1008805 · 2021 · External reference
AAV9-mediated gene therapy for infantile-onset Pompe’s disease
10.1056/nejmoa2407766 · 2025 · External reference
Gene therapy for hemophilia
10.1182/hematology.2022000388 · 2022 · External reference
Codon optimization in the production of recombinant biotherapeutics: potential risks and considerations
10.1007/s40259-018-0261-x · 2018 · External reference
A critical analysis of codon optimization in human therapeutics
10.1016/j.molmed.2014.09.003 · 2014 · External reference
Understanding the contribution of synonymous mutations to human disease
10.1038/nrg3051 · 2011 · External reference
CodonTransformer: a multispecies codon optimizer using context-aware neural networks
10.1038/s41467-025-58588-7 · 2025 · External reference
Recombinant therapeutic proteins degradation and overcoming strategies in CHO cells
10.1007/s00253-024-13008-6 · 2024 · External reference
Severe secondary deficiency of von Willebrand factor-cleaving protease (ADAMTS13) in patients with sepsis-induced disseminated intravascular coagulation: its correlation with development of renal failure
10.1182/blood-2005-03-1087 · 2006 · External reference
Assessment of the role of afucosylated glycoforms on the in vitro antibody-dependent phagocytosis activity of an antibody to Aβ aggregates
10.1080/19420862.2020.1803645 · 2020 · External reference
Unraveling the scissile bond: how ADAMTS13 recognizes and cleaves von Willebrand factor
10.1182/blood-2011-02-306597 · 2011 · External reference
ADAMTS13 and von Willebrand factor interactions
10.1097/moh.0000000000000169 · 2015 · External reference
Crystal structure and substrate-induced activation of ADAMTS13
10.1038/s41467-019-11474-5 · 2019 · External reference
Codon-optimization in gene therapy: promises, prospects and challenges
10.3389/fbioe.2024.1371596 · 2024 · External reference
Comparative analysis of codon optimization tools: advancing toward a multi-criteria framework for synthetic gene design
10.4014/jmb.2411.11066 · 2025 · External reference
CHARMING: harmonizing synonymous codon usage to replicate a desired codon usage pattern
10.1002/pro.4223 · 2022 · External reference
Adjustment of codon usage frequencies by codon harmonization improves protein expression and folding
10.1007/978-1-61737-967-3_1 · 2011 · External reference
mRNA vaccine sequence and structure design and optimization: advances and challenges
10.1016/j.jbc.2024.108015 · 2025 · External reference
Exploring and retrieving sequence and metadata for species across the tree of life with NCBI Datasets
10.1038/s41597-024-03571-y · 2024 · External reference
MACSE v2: toolkit for the alignment of coding sequences accounting for frameshifts and stop codons
10.1093/molbev/msy159 · 2018 · External reference
MACSE: multiple alignment of coding sequences accounting for frameshifts and stop codons
10.1371/journal.pone.0022594 · 2011 · External reference
Trimmomatic: a flexible trimmer for Illumina sequence data
10.1093/bioinformatics/btu170 · 2014 · External reference
STAR: ultrafast universal RNA-seq aligner
10.1093/bioinformatics/bts635 · 2013 · External reference
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
10.1093/bioinformatics/btt656 · 2013 · External reference
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
10.1186/s13059-014-0550-8 · 2014 · External reference
edgeR: a bioconductor package for differential expression analysis of digital gene expression data
10.1093/bioinformatics/btp616 · 2009 · External reference
clusterProfiler: an R package for comparing biological themes among gene clusters
10.1089/omi.2011.0118 · 2012 · External reference
Kinetic and structural comparison of a protein’s cotranslational folding and refolding pathways
10.1126/sciadv.aas9098 · 2018 · External reference
A translation system reconstituted with human factors proves that processing of encephalomyocarditis virus proteins 2A and 2B occurs in the elongation phase of translation without eukaryotic release factors
10.1074/jbc.m114.593343 · 2014 · External reference
A human cell-derived in vitro coupled transcription/translation system optimized for production of recombinant proteins
10.1016/j.pep.2008.09.002 · 2008 · External reference
An optimized purification design for extracting active adamts13 from conditioned media
10.3390/pr10020322 · 2022 · External reference
Biochemical and functional characterization of a recombinant monomeric factor VIII-Fc fusion protein
10.1111/jth.12076 · 2013 · External reference
