Research graph
References from Claudin-2 overexpression protects against methamphetamine-induced apoptosis in renal tubular cells. Local targets link to admitted publications; unresolved targets remain external evidence.
Toxicological and histopathological analysis of a patient who died nine days after a single intravenous dose of methamphetamine: a case report
10.1016/j.legalmed.2006.03.002 · 2006 · External reference
Autophagy prevents ER stress-induced Tight Junction barrier disruption via claudin-2 homeostasis
2026 · External reference
Methamphetamine (N-methylamphetamine)-induced renal disease: underevaluated cause of end-stage renal disease (ESRD)
10.1136/bcr-2019-230288 · 2019 · External reference
Occludin is required for apoptosis when claudin-claudin interactions are disrupted
10.1038/cddis.2012.14 · 2012 · External reference
Contribution of guanine exchange factor H1 in phorbol ester-induced apoptosis
10.1038/sj.cdd.4401901 · 2006 · External reference
Molecular mechanisms of neuronal death in brain injury after subarachnoid hemorrhage
10.3389/fncel.2022.1025708 · 2022 · External reference
Neuronal caspase-3 signaling: not only cell death
10.1038/cdd.2009.180 · 2010 · External reference
Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells
10.1074/jbc.ra118.006484 · 2019 · External reference
Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids
10.1038/s41380-020-0676-x · 2021 · External reference
Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment
10.1016/s0165-0173(01)00054-6 · 2001 · External reference
Cellular proliferation, apoptosis and angiogenesis: molecular targets for nutritional preemption of cancer
10.1053/j.seminoncol.2010.05.001 · 2010 · External reference
Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats
10.1016/j.ijpharm.2018.06.008 · 2018 · External reference
Extent of illicit drug use and dependence, and their contribution to the global burden of disease
10.1016/s0140-6736(11)61138-0 · 2012 · External reference
Meth/amphetamine use and associated HIV: Implications for global policy and public health
10.1016/j.drugpo.2009.11.007 · 2010 · External reference
Regulation and bioinformatic analysis of circ_0015891/miR-129-1-3p axis in methamphetamine-induced dopaminergic apoptosis
10.3389/fendo.2022.999211 · 2022 · External reference
Luteolin Ameliorates Methamphetamine-Induced Podocyte Pathology by Inhibiting Tau Phosphorylation in Mice
10.1155/2022/5909926 · 2022 · External reference
Nrf2 protects against methamphetamine-induced nephrotoxicity by mitigating oxidative stress and autophagy in mice
10.1016/j.toxlet.2023.08.002 · 2023 · External reference
Spi-B-mediated silencing of claudin-2 promotes early dissemination of lung cancer cells from primary tumors
10.1158/0008-5472.can-17-0020 · 2017 · External reference
Apoptosis: a review of programmed cell death
10.1080/01926230701320337 · 2007 · External reference
Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis
10.1083/jcb.202201159 · 2022 · External reference
Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates
10.1016/j.biopsych.2009.02.021 · 2009 · External reference
Review article: amphetamines and related drugs of abuse
10.1111/j.1742-6723.2008.01114.x · 2008 · External reference
Acute cardiovascular complications of sympathomimetic recreational drug use
10.1080/15563650.2026.2701369 · 2026 · External reference
Molecular mechanisms of programmed cell death in methamphetamine-induced neuronal damage
2022 · External reference
Multisystem toxicity after methamphetamine use
10.1002/ccr3.487 · 2016 · External reference
LncRNA NKILA knockdown promotes cell viability and represses cell apoptosis, autophagy and inflammation in lipopolysaccharide-induced sepsis model by regulating miR-140-5p/CLDN2 axis
10.1016/j.bbrc.2021.04.074 · 2021 · External reference
The effect of dual bioactive compounds artemisinin and metformin co-loaded in PLGA-PEG nano-particles on breast cancer cell lines: potential apoptotic and anti-proliferative action
10.1007/s12010-022-04000-9 · 2022 · External reference
Down-regulation of Claudin-2 expression and proliferation by epigenetic inhibitors in human lung adenocarcinoma A549 cells
10.1074/jbc.m116.762807 · 2017 · External reference
Global epidemiology and outcomes of acute kidney injury
10.1038/s41581-018-0052-0 · 2018 · External reference
Autophagy and tight junction proteins in the intestine and intestinal diseases
10.1016/j.aninu.2015.08.014 · 2015 · External reference
Methamphetamine intoxication and acute kidney injury: a prospective observational case series
10.1111/nep.13762 · 2020 · External reference
Potentiation of Folate-Functionalized PLGA-PEG nanoparticles loaded with metformin for the treatment of breast Cancer: possible clinical application
10.1007/s11033-022-08171-w · 2023 · External reference
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
10.1038/bjc.1972.33 · 1972 · External reference
Elevation of pro-inflammatory and anti-inflammatory cytokines in rat serum after acute methamphetamine treatment and traumatic brain injury
10.1007/s12031-021-01886-8 · 2022 · External reference
Proteomics: an in-depth review on recent technical advances and their applications in biomedicine
10.1002/med.22098 · 2025 · External reference
The role of HSP90alpha in methamphetamine/hyperthermia-induced necroptosis in rat striatal neurons
10.3389/fphar.2021.716394 · 2021 · External reference
siRNA mediated downregulation of RhoA expression reduces oxidative induced apoptosis in retinal ganglion cells
2023 · External reference
Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model
10.1016/j.cbi.2023.110512 · 2023 · External reference
iTRAQ-based proteomic analysis of the rat striatum in response to methamphetamine preconditioning
10.1093/abbs/gmab024 · 2021 · External reference
CLDN-2 expression aligns with invasion-associated epithelial remodeling in colorectal cancer
10.3390/cancers18111772 · 2026 · External reference
The effects of methamphetamine intoxication on acute kidney injury in Iraqi male addicts
2025 · External reference
Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in vitro
10.1016/j.yexcr.2005.07.017 · 2005 · External reference
Omics integration analysis unravel the landscape of driving mechanisms of colorectal cancer
10.31557/apjcp.2020.21.12.3539 · 2020 · External reference
The role of claudin-2 in kidney function and dysfunction
10.1042/bst20220639 · 2023 · External reference
Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension
10.1152/ajplung.00453.2016 · 2017 · External reference
Methamphetamine and its immune-modulating effects
10.1016/j.maturitas.2018.12.003 · 2019 · External reference
New insights into cell apoptosis and proliferation: the potential role of vaspin
2021 · External reference
The clinical toxicology of metamfetamine
10.3109/15563650.2010.516752 · 2010 · External reference
Neurocognitive effects of methamphetamine: a critical review and meta-analysis
10.1007/s11065-007-9031-0 · 2007 · External reference
Bardoxolone ameliorates TGF-beta1-associated renal fibrosis through Nrf2/Smad7 elevation
10.1016/j.freeradbiomed.2019.04.033 · 2019 · External reference
Kaempherol and Luteolin decrease Claudin-2 expression mediated by inhibition of STAT3 in lung adenocarcinoma A549 cells
10.3390/nu9060597 · 2017 · External reference
Emotion regulation in substance use disorders: a systematic review and meta-analysis
10.1111/add.16001 · 2023 · External reference
Role of MARK4 in methamphetamine-induced acute kidney injury
2024 · External reference
Renal tight junction proteins are decreased in cisplatin-induced nephrotoxicity in rats
10.3109/15376516.2014.948248 · 2014 · External reference
Unresolved reference
External reference
The interplay between autophagy and apoptosis mediates toxicity triggered by synthetic cathinones in human kidney cells
10.1016/j.toxlet.2020.05.025 · 2020 · External reference
Inhibition of mitochondrial VDAC1 oligomerization alleviates apoptosis and necroptosis of retinal neurons following OGD/R injury
10.1016/j.aanat.2023.152049 · 2023 · External reference
MALAT1/miR-185-5p mediated high glucose-induced oxidative stress, mitochondrial injury and cardiomyocyte apoptosis via the RhoA/ROCK pathway
10.1111/jcmm.17835 · 2023 · External reference
Acute renal failure due to accelerated hypertension following ingestion of 3,4-methylenedioxymethamphetamine ('ecstasy')
10.1093/ndt/10.3.399 · 1995 · External reference
Role of microglia in methamphetamine-induced neurotoxicity
2017 · External reference
Role of the Peli1-RIPK1 signaling axis in methamphetamine-induced neuroinflammation
10.1021/acschemneuro.2c00623 · 2023 · External reference
Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies
10.4103/1673-5374.331539 · 2022 · External reference
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons
10.4103/1673-5374.346545 · 2023 · External reference
The main molecular mechanisms underlying methamphetamine- induced neurotoxicity and implications for pharmacological treatment
10.3389/fnmol.2018.00186 · 2018 · External reference
Insight into crosstalk between mitophagy and apoptosis/necroptosis: mechanisms and clinical applications in ischemic stroke
10.1007/s11596-022-2579-3 · 2022 · External reference
Regulation of the KEAP1/NRF2 pathway by claudin-2-targeted lymphoid enhancer-binding factor 1 binding in gastric cancer progression
2026 · External reference
Changes in the expression and distribution of claudins, increased epithelial apoptosis, and a mannan-binding lectin-associated immune response lead to barrier dysfunction in dextran sodium sulfate-induced rat colitis
10.5009/gnl14155 · 2015 · External reference
New insight into methamphetamine-associated heart failure revealed by transcriptomic analyses: circadian rhythm disorder
10.1016/j.taap.2022.116172 · 2022 · External reference
Simultaneous determination of metabolic and elemental markers in methamphetamine-induced hepatic injury to rats using LC-MS/MS and ICP-MS
10.1007/s00216-019-01810-5 · 2019 · External reference
Mechanism of claudin-2 in RTECs apoptosis after renal obstruction
10.1007/s00240-026-01949-8 · 2026 · External reference
Methamphetamine induces intestinal inflammatory injury via nod-like receptor 3 protein (NLRP3) inflammasome overexpression in vitro and in vivo
10.12659/msm.920190 · 2019 · External reference
Regulated cell death of retinal ganglion cells in glaucoma: molecular insights and therapeutic potentials
10.1007/s10571-023-01373-1 · 2023 · External reference
Methamphetamine induces cardiomyopathy through GATA4/NF-kappaB/SASP axis-mediated cellular senescence
10.1016/j.taap.2023.116457 · 2023 · External reference
Multisystem toxicity after methamphetamine use
10.1002/ccr3.487 · ExternalCitation · doi-reference
Proteomics: an in-depth review on recent technical advances and their applications in biomedicine
10.1002/med.22098 · ExternalCitation · doi-reference
Simultaneous determination of metabolic and elemental markers in methamphetamine-induced hepatic injury to rats using LC-MS/MS and ICP-MS
10.1007/s00216-019-01810-5 · ExternalCitation · doi-reference
Mechanism of claudin-2 in RTECs apoptosis after renal obstruction
10.1007/s00240-026-01949-8 · ExternalCitation · doi-reference
Regulated cell death of retinal ganglion cells in glaucoma: molecular insights and therapeutic potentials
10.1007/s10571-023-01373-1 · ExternalCitation · doi-reference
Potentiation of Folate-Functionalized PLGA-PEG nanoparticles loaded with metformin for the treatment of breast Cancer: possible clinical application
10.1007/s11033-022-08171-w · ExternalCitation · doi-reference
Neurocognitive effects of methamphetamine: a critical review and meta-analysis
10.1007/s11065-007-9031-0 · ExternalCitation · doi-reference
Insight into crosstalk between mitophagy and apoptosis/necroptosis: mechanisms and clinical applications in ischemic stroke
10.1007/s11596-022-2579-3 · ExternalCitation · doi-reference
The effect of dual bioactive compounds artemisinin and metformin co-loaded in PLGA-PEG nano-particles on breast cancer cell lines: potential apoptotic and anti-proliferative action
10.1007/s12010-022-04000-9 · ExternalCitation · doi-reference
Elevation of pro-inflammatory and anti-inflammatory cytokines in rat serum after acute methamphetamine treatment and traumatic brain injury
10.1007/s12031-021-01886-8 · ExternalCitation · doi-reference
Inhibition of mitochondrial VDAC1 oligomerization alleviates apoptosis and necroptosis of retinal neurons following OGD/R injury
10.1016/j.aanat.2023.152049 · ExternalCitation · doi-reference
Autophagy and tight junction proteins in the intestine and intestinal diseases
10.1016/j.aninu.2015.08.014 · ExternalCitation · doi-reference
LncRNA NKILA knockdown promotes cell viability and represses cell apoptosis, autophagy and inflammation in lipopolysaccharide-induced sepsis model by regulating miR-140-5p/CLDN2 axis
10.1016/j.bbrc.2021.04.074 · ExternalCitation · doi-reference
Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates
10.1016/j.biopsych.2009.02.021 · ExternalCitation · doi-reference
Gut microbiota contribute to Methamphetamine-induced cardiotoxicity in mouse model
10.1016/j.cbi.2023.110512 · ExternalCitation · doi-reference
Meth/amphetamine use and associated HIV: Implications for global policy and public health
10.1016/j.drugpo.2009.11.007 · ExternalCitation · doi-reference
Bardoxolone ameliorates TGF-beta1-associated renal fibrosis through Nrf2/Smad7 elevation
10.1016/j.freeradbiomed.2019.04.033 · ExternalCitation · doi-reference
Spherical neutral gold nanoparticles improve anti-inflammatory response, oxidative stress and fibrosis in alcohol-methamphetamine-induced liver injury in rats
10.1016/j.ijpharm.2018.06.008 · ExternalCitation · doi-reference
Toxicological and histopathological analysis of a patient who died nine days after a single intravenous dose of methamphetamine: a case report
10.1016/j.legalmed.2006.03.002 · ExternalCitation · doi-reference
Methamphetamine and its immune-modulating effects
10.1016/j.maturitas.2018.12.003 · ExternalCitation · doi-reference
New insight into methamphetamine-associated heart failure revealed by transcriptomic analyses: circadian rhythm disorder
10.1016/j.taap.2022.116172 · ExternalCitation · doi-reference
Methamphetamine induces cardiomyopathy through GATA4/NF-kappaB/SASP axis-mediated cellular senescence
10.1016/j.taap.2023.116457 · ExternalCitation · doi-reference
The interplay between autophagy and apoptosis mediates toxicity triggered by synthetic cathinones in human kidney cells
10.1016/j.toxlet.2020.05.025 · ExternalCitation · doi-reference
Nrf2 protects against methamphetamine-induced nephrotoxicity by mitigating oxidative stress and autophagy in mice
10.1016/j.toxlet.2023.08.002 · ExternalCitation · doi-reference
Down-regulation of survival signaling through MAPK and Akt in occludin-deficient mouse hepatocytes in vitro
10.1016/j.yexcr.2005.07.017 · ExternalCitation · doi-reference
Extent of illicit drug use and dependence, and their contribution to the global burden of disease
10.1016/s0140-6736(11)61138-0 · ExternalCitation · doi-reference
Methamphetamine neurotoxicity: necrotic and apoptotic mechanisms and relevance to human abuse and treatment
10.1016/s0165-0173(01)00054-6 · ExternalCitation · doi-reference
Role of the Peli1-RIPK1 signaling axis in methamphetamine-induced neuroinflammation
10.1021/acschemneuro.2c00623 · ExternalCitation · doi-reference
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics
10.1038/bjc.1972.33 · ExternalCitation · doi-reference
Neuronal caspase-3 signaling: not only cell death
10.1038/cdd.2009.180 · ExternalCitation · doi-reference
Occludin is required for apoptosis when claudin-claudin interactions are disrupted
10.1038/cddis.2012.14 · ExternalCitation · doi-reference
Glial cell diversity and methamphetamine-induced neuroinflammation in human cerebral organoids
10.1038/s41380-020-0676-x · ExternalCitation · doi-reference
Global epidemiology and outcomes of acute kidney injury
10.1038/s41581-018-0052-0 · ExternalCitation · doi-reference
Contribution of guanine exchange factor H1 in phorbol ester-induced apoptosis
10.1038/sj.cdd.4401901 · ExternalCitation · doi-reference
The role of claudin-2 in kidney function and dysfunction
10.1042/bst20220639 · ExternalCitation · doi-reference
Cellular proliferation, apoptosis and angiogenesis: molecular targets for nutritional preemption of cancer
10.1053/j.seminoncol.2010.05.001 · ExternalCitation · doi-reference
Down-regulation of Claudin-2 expression and proliferation by epigenetic inhibitors in human lung adenocarcinoma A549 cells
10.1074/jbc.m116.762807 · ExternalCitation · doi-reference
Claudin-2 suppresses GEF-H1, RHOA, and MRTF, thereby impacting proliferation and profibrotic phenotype of tubular cells
10.1074/jbc.ra118.006484 · ExternalCitation · doi-reference
Apoptosis: a review of programmed cell death
10.1080/01926230701320337 · ExternalCitation · doi-reference
Acute cardiovascular complications of sympathomimetic recreational drug use
10.1080/15563650.2026.2701369 · ExternalCitation · doi-reference
Paradoxical roles of caspase-3 in regulating cell survival, proliferation, and tumorigenesis
10.1083/jcb.202201159 · ExternalCitation · doi-reference
iTRAQ-based proteomic analysis of the rat striatum in response to methamphetamine preconditioning
10.1093/abbs/gmab024 · ExternalCitation · doi-reference
Acute renal failure due to accelerated hypertension following ingestion of 3,4-methylenedioxymethamphetamine ('ecstasy')
10.1093/ndt/10.3.399 · ExternalCitation · doi-reference
Emotion regulation in substance use disorders: a systematic review and meta-analysis
10.1111/add.16001 · ExternalCitation · doi-reference
Review article: amphetamines and related drugs of abuse
10.1111/j.1742-6723.2008.01114.x · ExternalCitation · doi-reference
MALAT1/miR-185-5p mediated high glucose-induced oxidative stress, mitochondrial injury and cardiomyocyte apoptosis via the RhoA/ROCK pathway
10.1111/jcmm.17835 · ExternalCitation · doi-reference
Methamphetamine intoxication and acute kidney injury: a prospective observational case series
10.1111/nep.13762 · ExternalCitation · doi-reference
Methamphetamine (N-methylamphetamine)-induced renal disease: underevaluated cause of end-stage renal disease (ESRD)
10.1136/bcr-2019-230288 · ExternalCitation · doi-reference
Reduced carboxylesterase 1 is associated with endothelial injury in methamphetamine-induced pulmonary arterial hypertension
10.1152/ajplung.00453.2016 · ExternalCitation · doi-reference
Luteolin Ameliorates Methamphetamine-Induced Podocyte Pathology by Inhibiting Tau Phosphorylation in Mice
10.1155/2022/5909926 · ExternalCitation · doi-reference
Spi-B-mediated silencing of claudin-2 promotes early dissemination of lung cancer cells from primary tumors
10.1158/0008-5472.can-17-0020 · ExternalCitation · doi-reference
Methamphetamine induces intestinal inflammatory injury via nod-like receptor 3 protein (NLRP3) inflammasome overexpression in vitro and in vivo
10.12659/msm.920190 · ExternalCitation · doi-reference
Renal tight junction proteins are decreased in cisplatin-induced nephrotoxicity in rats
10.3109/15376516.2014.948248 · ExternalCitation · doi-reference
The clinical toxicology of metamfetamine
10.3109/15563650.2010.516752 · ExternalCitation · doi-reference
Omics integration analysis unravel the landscape of driving mechanisms of colorectal cancer
10.31557/apjcp.2020.21.12.3539 · ExternalCitation · doi-reference
Regulation and bioinformatic analysis of circ_0015891/miR-129-1-3p axis in methamphetamine-induced dopaminergic apoptosis
10.3389/fendo.2022.999211 · ExternalCitation · doi-reference
Molecular mechanisms of neuronal death in brain injury after subarachnoid hemorrhage
10.3389/fncel.2022.1025708 · ExternalCitation · doi-reference
The main molecular mechanisms underlying methamphetamine- induced neurotoxicity and implications for pharmacological treatment
10.3389/fnmol.2018.00186 · ExternalCitation · doi-reference
The role of HSP90alpha in methamphetamine/hyperthermia-induced necroptosis in rat striatal neurons
10.3389/fphar.2021.716394 · ExternalCitation · doi-reference
CLDN-2 expression aligns with invasion-associated epithelial remodeling in colorectal cancer
10.3390/cancers18111772 · ExternalCitation · doi-reference
Kaempherol and Luteolin decrease Claudin-2 expression mediated by inhibition of STAT3 in lung adenocarcinoma A549 cells
10.3390/nu9060597 · ExternalCitation · doi-reference
Do pyroptosis, apoptosis, and necroptosis (PANoptosis) exist in cerebral ischemia? Evidence from cell and rodent studies
10.4103/1673-5374.331539 · ExternalCitation · doi-reference
PANoptosis-like cell death in ischemia/reperfusion injury of retinal neurons
10.4103/1673-5374.346545 · ExternalCitation · doi-reference
Changes in the expression and distribution of claudins, increased epithelial apoptosis, and a mannan-binding lectin-associated immune response lead to barrier dysfunction in dextran sodium sulfate-induced rat colitis
10.5009/gnl14155 · ExternalCitation · doi-reference
