Research graph
References from YAP1 inhibition delays the progression of posterior capsular opacification through attenuation of lens epithelial-mesenchymal transition. Local targets link to admitted publications; unresolved targets remain external evidence.
Posterior capsular opacification: a problem reduced but not yet eradicated
10.1001/archophthalmol.2009.3 · 2009 · External reference
EMT, cancer stem cells and autophagy; The three main axes of metastasis
10.1016/j.biopha.2020.110909 · 2021 · External reference
Comparison of HIF-1α and survivin levels in patients with diabetes and retinopathy of varying severity
10.5935/0004-2749.2023-0112 · 2024 · External reference
Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway
10.7150/ijms.23460 · 2018 · External reference
Role of YAP/TAZ in mechanotransduction
10.1038/nature10137 · 2011 · External reference
The Hippo signalling pathway and its implications in human health and diseases
10.1038/s41392-022-01191-9 · 2022 · External reference
Non-Photoinduced Biological Properties of Verteporfin
10.2174/0929867323666160316125048 · 2016 · External reference
The Hippo pathway: Organ size control and beyond
10.1016/j.pharmr.2024.100031 · 2025 · External reference
TGF-β2 induces epithelial-mesenchymal transition in cultured human lens epithelial cells through activation of the PI3K/Akt/mTOR signaling pathway
10.3892/mmr.2015.4645 · 2016 · External reference
Deficiency of yes-associated protein induces cataract in mice
10.14336/ad.2018.0910 · 2019 · External reference
The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1
10.1158/0008-5472.can-17-3139 · 2018 · External reference
Survivin expression is associated with lens epithelial cell proliferation and fiber cell differentiation
2012 · External reference
Visudyne In Occult CNV (VIO) study group. Verteporfin PDT for subfoveal occult CNV in AMD: two-year results of a randomized trial
10.1185/03007990903038616 · 2009 · External reference
The basics of epithelial-mesenchymal transition
10.1172/jci39104 · 2009 · External reference
Posterior capsule opacification: a review of experimental studies
10.3390/jcm10132847 · 2021 · External reference
Lens stretching modulates lens epithelial cell proliferation via YAP regulation
10.1167/iovs.19-26893 · 2019 · External reference
Hippo-yap signaling in ocular development and disease
10.1002/dvdy.24628 · 2018 · External reference
Implication of Smad2 and Smad3 in transforming growth factor-β-induced posterior capsular opacification of human lens epithelial cells
10.3109/02713683.2014.925932 · 2015 · External reference
Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1-YAP-PROX1 axis
10.1096/fj.202201187rr · 2023 · External reference
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
10.1101/gad.192856.112 · 2012 · External reference
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring
10.1126/science.aba2374 · 2021 · External reference
Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition
10.1152/ajprenal.00183.2002 · 2003 · External reference
Aspirin inhibits TGFβ2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3
10.1042/bcj20190540 · 2020 · External reference
Recent advances in developing bioorthogonally activatable photosensitizers for photodynamic therapy
10.1016/j.ejmech.2025.117672 · 2025 · External reference
Hippo signaling in organ size control
10.1101/gad.1536007 · 2007 · External reference
Relationship between posterior capsule opacification and intraocular lens biocompatibility
10.1016/j.preteyeres.2004.02.004 · 2004 · External reference
Accumulation of thrombospondin-1 in post-operative capsular fibrosis and its down-regulation in lens cells during lens fiber formation
10.1016/j.exer.2004.03.003 · 2004 · External reference
Role of decorin in posterior capsule opacification and eye lens development
10.3390/cells10040863 · 2021 · External reference
Photosensitizers incorporation in SOPC films at different hydration levels
10.1016/j.bbamem.2022.184077 · 2023 · External reference
Evaluation of Verteporfin as a Novel Antifibrotic Agent in a Rabbit Model of Glaucoma Filtration Surgery: A Pilot Study
10.1016/j.xops.2023.100448 · 2024 · External reference
Understanding the role of yes-associated protein (YAP) signaling in the transformation of lens epithelial cells (EMT) and fibrosis
10.3390/biom13121767 · 2023 · External reference
Epithelial cell plasticity in development and tumor progression
10.1023/a:1006256219004 · 1999 · External reference
GBD 2019 Blindness and Vision Impairment Collaborators. Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020
10.1038/s41433-024-02961-1 · 2024 · External reference
Verteporfin suppresses cell survival, angiogenesis and vasculogenic mimicry of pancreatic ductal adenocarcinoma via disrupting the YAP-TEAD complex
10.1111/cas.13138 · 2017 · External reference
Posterior capsule opacification: what’s in the bag?
10.1016/j.preteyeres.2020.100905 · 2021 · External reference
Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex
10.1073/pnas.2115217119 · 2022 · External reference
Hippo signaling in embryogenesis and development
10.1016/j.tibs.2020.08.008 · 2021 · External reference
Long noncoding RNA expression profile in HLE B-3 cells during TGF-β2-induced epithelial-mesenchymal transition
10.1186/s12886-017-0461-z · 2017 · External reference
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
10.1074/jbc.m900843200 · 2009 · External reference
Yes-associated protein is essential for proliferative vitreoretinopathy development via the epithelial-mesenchymal transition in retinal pigment epithelial fibrosis
10.1111/jcmm.16958 · 2021 · External reference
Celastrol-Based Nanomedicine Hydrogels Eliminate Posterior Capsule Opacification
10.2217/nnm-2022-0191 · 2022 · External reference
Inhibitory effect of siRNA-YAP1 on TGF-β2-induced epithelial-mesenchymal transition in human lens epithelial cells
2021 · External reference
Objective quantification of posterior capsule opacification after cataract surgery with swept-source optical coherence tomography
10.1186/s12886-023-03064-3 · 2023 · External reference
Posterior capsular opacification: a problem reduced but not yet eradicated
10.1001/archophthalmol.2009.3 · ExternalCitation · doi-reference
Hippo-yap signaling in ocular development and disease
10.1002/dvdy.24628 · ExternalCitation · doi-reference
Photosensitizers incorporation in SOPC films at different hydration levels
10.1016/j.bbamem.2022.184077 · ExternalCitation · doi-reference
EMT, cancer stem cells and autophagy; The three main axes of metastasis
10.1016/j.biopha.2020.110909 · ExternalCitation · doi-reference
Recent advances in developing bioorthogonally activatable photosensitizers for photodynamic therapy
10.1016/j.ejmech.2025.117672 · ExternalCitation · doi-reference
Accumulation of thrombospondin-1 in post-operative capsular fibrosis and its down-regulation in lens cells during lens fiber formation
10.1016/j.exer.2004.03.003 · ExternalCitation · doi-reference
The Hippo pathway: Organ size control and beyond
10.1016/j.pharmr.2024.100031 · ExternalCitation · doi-reference
Relationship between posterior capsule opacification and intraocular lens biocompatibility
10.1016/j.preteyeres.2004.02.004 · ExternalCitation · doi-reference
Posterior capsule opacification: what’s in the bag?
10.1016/j.preteyeres.2020.100905 · ExternalCitation · doi-reference
Hippo signaling in embryogenesis and development
10.1016/j.tibs.2020.08.008 · ExternalCitation · doi-reference
Evaluation of Verteporfin as a Novel Antifibrotic Agent in a Rabbit Model of Glaucoma Filtration Surgery: A Pilot Study
10.1016/j.xops.2023.100448 · ExternalCitation · doi-reference
Epithelial cell plasticity in development and tumor progression
10.1023/a:1006256219004 · ExternalCitation · doi-reference
Role of YAP/TAZ in mechanotransduction
10.1038/nature10137 · ExternalCitation · doi-reference
The Hippo signalling pathway and its implications in human health and diseases
10.1038/s41392-022-01191-9 · ExternalCitation · doi-reference
GBD 2019 Blindness and Vision Impairment Collaborators. Global estimates on the number of people blind or visually impaired by cataract: a meta-analysis from 2000 to 2020
10.1038/s41433-024-02961-1 · ExternalCitation · doi-reference
Aspirin inhibits TGFβ2-induced epithelial to mesenchymal transition of lens epithelial cells: selective acetylation of K56 and K122 in histone H3
10.1042/bcj20190540 · ExternalCitation · doi-reference
Vimentin intermediate filaments and filamentous actin form unexpected interpenetrating networks that redefine the cell cortex
10.1073/pnas.2115217119 · ExternalCitation · doi-reference
TEAD transcription factors mediate the function of TAZ in cell growth and epithelial-mesenchymal transition
10.1074/jbc.m900843200 · ExternalCitation · doi-reference
Extracellular HSP90 promotes differentiation of lens epithelial cells to fiber cells by activating LRP1-YAP-PROX1 axis
10.1096/fj.202201187rr · ExternalCitation · doi-reference
Hippo signaling in organ size control
10.1101/gad.1536007 · ExternalCitation · doi-reference
Genetic and pharmacological disruption of the TEAD-YAP complex suppresses the oncogenic activity of YAP
10.1101/gad.192856.112 · ExternalCitation · doi-reference
Verteporfin suppresses cell survival, angiogenesis and vasculogenic mimicry of pancreatic ductal adenocarcinoma via disrupting the YAP-TEAD complex
10.1111/cas.13138 · ExternalCitation · doi-reference
Yes-associated protein is essential for proliferative vitreoretinopathy development via the epithelial-mesenchymal transition in retinal pigment epithelial fibrosis
10.1111/jcmm.16958 · ExternalCitation · doi-reference
Preventing Engrailed-1 activation in fibroblasts yields wound regeneration without scarring
10.1126/science.aba2374 · ExternalCitation · doi-reference
Central role for Rho in TGF-beta1-induced alpha-smooth muscle actin expression during epithelial-mesenchymal transition
10.1152/ajprenal.00183.2002 · ExternalCitation · doi-reference
The Hippo Pathway Component TAZ Promotes Immune Evasion in Human Cancer through PD-L1
10.1158/0008-5472.can-17-3139 · ExternalCitation · doi-reference
Lens stretching modulates lens epithelial cell proliferation via YAP regulation
10.1167/iovs.19-26893 · ExternalCitation · doi-reference
The basics of epithelial-mesenchymal transition
10.1172/jci39104 · ExternalCitation · doi-reference
Visudyne In Occult CNV (VIO) study group. Verteporfin PDT for subfoveal occult CNV in AMD: two-year results of a randomized trial
10.1185/03007990903038616 · ExternalCitation · doi-reference
Long noncoding RNA expression profile in HLE B-3 cells during TGF-β2-induced epithelial-mesenchymal transition
10.1186/s12886-017-0461-z · ExternalCitation · doi-reference
Objective quantification of posterior capsule opacification after cataract surgery with swept-source optical coherence tomography
10.1186/s12886-023-03064-3 · ExternalCitation · doi-reference
Deficiency of yes-associated protein induces cataract in mice
10.14336/ad.2018.0910 · ExternalCitation · doi-reference
Non-Photoinduced Biological Properties of Verteporfin
10.2174/0929867323666160316125048 · ExternalCitation · doi-reference
Celastrol-Based Nanomedicine Hydrogels Eliminate Posterior Capsule Opacification
10.2217/nnm-2022-0191 · ExternalCitation · doi-reference
Implication of Smad2 and Smad3 in transforming growth factor-β-induced posterior capsular opacification of human lens epithelial cells
10.3109/02713683.2014.925932 · ExternalCitation · doi-reference
Understanding the role of yes-associated protein (YAP) signaling in the transformation of lens epithelial cells (EMT) and fibrosis
10.3390/biom13121767 · ExternalCitation · doi-reference
Role of decorin in posterior capsule opacification and eye lens development
10.3390/cells10040863 · ExternalCitation · doi-reference
Posterior capsule opacification: a review of experimental studies
10.3390/jcm10132847 · ExternalCitation · doi-reference
TGF-β2 induces epithelial-mesenchymal transition in cultured human lens epithelial cells through activation of the PI3K/Akt/mTOR signaling pathway
10.3892/mmr.2015.4645 · ExternalCitation · doi-reference
Comparison of HIF-1α and survivin levels in patients with diabetes and retinopathy of varying severity
10.5935/0004-2749.2023-0112 · ExternalCitation · doi-reference
Verteporfin inhibits YAP-induced bladder cancer cell growth and invasion via Hippo signaling pathway
10.7150/ijms.23460 · ExternalCitation · doi-reference
