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References from Olea europaea leaf extract mitigates doxorubicin-induced hepatotoxicity associated with modulation of oxidative stress, inflammation, and apoptosis: Integrated biochemical, molecular, and histopathological evidence. Local targets link to admitted publications; unresolved targets remain external evidence.
[13] Catalase in Vitro
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Unresolved reference
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Hepatoprotective effects of olive leaf extract against carbon tetrachloride-induced oxidative stress: in vivo and in-silico insights into the Nrf2-NFκB Pathway
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Esculetin attenuates doxorubicin-induced cardiotoxicity via modulation of apoptotic and mitochondrial gene expression networks
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Esculetin attenuates doxorubicin-induced cardiac toxicity: evidence from gene expression, enzyme activity, and molecular docking analyses
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Hesperidin reduces hepatic injury induced by doxorubicin in rat model through its antioxidative and anti-inflammatory effects, focusing on SIRT-1/NRF-2 Pathways
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Therapeutic efficacy of melatonin pretreated bone marrow mesenchymal stem cells versus mesenchymal stem cells in experimental diabetic cardiomyopathy in rat
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Determination of the main phenolic compounds of olive (Olea europaea L.) leaves by near infrared spectroscopy (NIR)
10.1038/s41598-025-14292-6 · 2025 · External reference
In vitro and in vivo assessment of the anti-inflammatory activity of olive leaf extract in rats
10.1007/s10787-023-01208-x · 2023 · External reference
Comparative study on beneficial effects of hydroxytyrosol- and oleuropein-rich olive leaf extracts on high-fat diet-induced lipid metabolism disturbance and liver injury in rats
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Protective effect of zhuyeqing liquor, a chinese traditional health liquor, on acute alcohol-induced liver injury in mice
10.1186/1476-9255-10-30 · 2013 · External reference
Taurine protects doxorubicin-induced hepatotoxicity via its membrane-stabilizing effect in rats
10.3390/life13102031 · 2023 · External reference
Endogenous FGF1 deficiency aggravates doxorubicin-induced hepatotoxicity
10.3390/toxics11110925 · 2023 · External reference
Regulation of the NRF2 transcription factor activity by SIRT1-induced deacetylation: a possible SIRT1–NRF2 Feedback Loop
10.1134/s1022795424701485 · 2025 · External reference
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10.1186/1758-2946-4-17 · 2012 · External reference
S2674 a subtle case of doxorubicin-induced hepatotoxicity
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Small molecule activators of sirtuins extend saccharomyces cerevisiae lifespan
10.1038/nature01960 · 2003 · External reference
Evidence for a common mechanism of SIRT1 regulation by allosteric activators
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Integrated Bioinformatics and Molecular Docking Identify CCNB1, CDK1, and CYP1A2 as therapeutic targets of phytochemicals in hepatocellular carcinoma
10.1007/s00210-025-04729-0 · 2026 · External reference
Hepatoprotective effect of oleuropein-rich extract from olive leaves against cadmium-induced toxicity in mice
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Highly accurate protein structure prediction with AlphaFold
10.1038/s41586-021-03819-2 · 2021 · External reference
Esculetin Improves inflammation of the kidney via gene expression against doxorubicin-induced nephrotoxicity in rats: In Vivo and in Silico Studies
10.1016/j.fbio.2024.105159 · 2024 · External reference
Doxorubicin—an agent with multiple mechanisms of anticancer activity
10.3390/cells12040659 · 2023 · External reference
Serum lipid peroxide in cerebrovascular disorders determined by a new colorimetric method
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Unresolved reference
External reference
Effect of tannic acid on doxorubicin-induced cellular stress: expression levels of heat shock genes in rat spleen
10.1002/bab.2633 · 2024 · External reference
The protective effects of esculetin against doxorubicin-induced hepatotoxicity in rats: insights into the modulation of caspase, FOXOs, and heat shock protein pathways
10.1002/jbt.23861 · 2024 · External reference
Protective effects of esculetin against doxorubicin-induced toxicity correlated with oxidative stress in rat liver: in vivo and in silico studies
10.1002/jbt.23702 · 2024 · External reference
Effect of olive leaf extract treatment on doxorubicin-induced cardiac, hepatic and renal toxicity in rats
10.1016/j.pathophys.2015.04.002 · 2015 · External reference
Metformin alleviates doxorubicin-induced hepatic damage by modulating oxidative stress: a molecular, biochemical, and histopathological approach in a rat model
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10.3390/ijms161125942 · 2015 · External reference
Antioxidant actions of olive leaf extract (Olea europaea L.) on Reactive Species Scavengers
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Molecular modelling and optimization of a high-affinity nanobody targeting the nipah virus fusion protein through in silico site-directed mutagenesis
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The hepatoprotective potential of tannic acid against doxorubicin-induced hepatotoxicity: insights into its antioxidative, anti-inflammatory, and antiapoptotic mechanisms
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Measurement of total bilirubin by use of bilirubin oxidase
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Comparative in vitro study of the cytotoxic effects of Doxorubicin’s main metabolites on cardiac AC16 Cells Versus the Parent Drug
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Hepatoprotective effect of Olea europaea L. seeds extracts against methotrexate induced liver injury in mice
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Doxorubicin and doxorubicin-loaded nanoliposome induce senescence by enhancing oxidative stress, hepatotoxicity, and in vivo genotoxicity in male wistar rats
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Anti-inflammatory effects of olive leaf extract and its bioactive compounds oleacin and oleuropein-aglycone on senescent endothelial and small airway epithelial cells
10.3390/antiox12081509 · 2023 · External reference
Mechanisms of drug induced liver injury
10.1007/s00018-025-05744-3 · 2025 · External reference
Protective effects of alamandine against doxorubicin-induced liver injury in rats
10.1186/s40360-025-00932-0 · 2025 · External reference
Protective effects of dioscin against doxorubicin-induced hepatotoxicity via regulation of Sirt1/FOXO1/NF-Κb Signal
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Possible protective effect of olive leaves extract on paracetamol induced hepatotoxicity in male albino rats
10.14393/bj-v36n1a2020-49960 · 2020 · External reference
Olive (Olea europaea L.) leaf extract boosts antioxidant status and attenuates hepatic and pancreatic changes in diabetic rats
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10.1021/acs.accounts.5c00155 · 2025 · External reference
Posttreatment Effects of Olea europaea L. leaf extract on carbon tetrachloride-induced liver injury and oxidative stress in rats
10.1089/jmf.2017.0143 · 2018 · External reference
Naringenin regulates doxorubicin-induced liver dysfunction: impact on oxidative stress and inflammation
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Luteolin Attenuates Doxorubicin-Induced Cardiotoxicity by Modulating the PHLPP1/AKT/Bcl-2 Signalling Pathway
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Mitigating doxorubicin-induced hepatotoxicity in male rats: the role of aerobic interval training and curcumin supplementation in reducing oxidative stress, endoplasmic reticulum stress and apoptosis
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