Research graph
References from The levels of Twist1 homodimerization over heterodimerization with E proteins control osteogenic differentiation and calcification in the adult porcine aortic cusps. Local targets link to admitted publications; unresolved targets remain external evidence.
Id4 functions downstream of Bmp signaling to restrict TCF function in endocardial cells during atrioventricular valve development
10.1016/j.ydbio.2016.02.003 · 2016 · External reference
Heart valve development: endothelial cell signaling and differentiation
10.1161/01.res.0000141146.95728.da · 2004 · External reference
Interstitial cells in calcified aortic valves have reduced differentiation potential and stem cell-like properties
10.1038/s41598-019-49016-0 · 2019 · External reference
Models and techniques to study aortic valve calcification in Vitro, ex Vivo and in Vivo. An overview
10.3389/fphar.2022.835825 · 2022 · External reference
Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease
10.1016/j.yjmcc.2013.04.001 · 2013 · External reference
Dimerization partners determine the activity of the Twist bHLH protein during Drosophila mesoderm development
10.1242/dev.128.16.3145 · 2001 · External reference
Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves
10.1016/j.ydbio.2010.08.021 · 2010 · External reference
An evolutionarily conserved DNA architecture determines target specificity of the TWIST family bHLH transcription factors
10.1101/gad.242842.114 · 2015 · External reference
Global, regional, and national burden of valvular heart disease, 1990–2021
10.1161/jaha.124.037991 · 2024 · External reference
Organ culture model of aortic valve calcification
10.3389/fcvm.2021.734692 · 2021 · External reference
Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closure
10.1016/j.ydbio.2008.03.037 · 2008 · External reference
Twist1 dimer selection regulates cranial suture patterning and fusion
2006 · External reference
Cannabidiol treatment results in a common gene expression response across aggressive cancer cells from various origins
10.1089/can.2019.0081 · 2021 · External reference
Functional analysis of TWIST1 domains regulating smooth muscle cell phenotype
10.3389/fcvm.2025.1659847 · 2025 · External reference
TWIST1 homodimers and heterodimers orchestrate lineage-specific differentiation
10.1128/mcb.00663-19 · 2020 · External reference
Altered twist1 and hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities
10.1038/ng1525 · 2005 · External reference
NFκB (Nuclear Factor κ-Light-Chain Enhancer of Activated B Cells) activity regulates cell-type-specific and context-specific susceptibility to calcification in the aortic valve
10.1161/atvbaha.119.313248 · 2020 · External reference
Bone morphogenetic protein signaling is required for aortic valve calcification
10.1161/atvbaha.116.307526 · 2016 · External reference
Aortic valve stenosis: from basic mechanisms to novel therapeutic targets
10.1161/atvbaha.119.313067 · 2020 · External reference
Role of Wnt/β-catenin signaling pathway in the mechanism of calcification of aortic valve
10.1007/s11596-014-1228-x · 2014 · External reference
Aortic stenosis prevention: is a new cardiovascular disease paradigm coming of age?
10.3390/jcm14030903 · 2025 · External reference
Comparative roles of Twist-1 and Id1 in transcriptional regulation by BMP signaling
10.1242/jcs.000067 · 2007 · External reference
Inhibitor of DNA binding in heart development and cardiovascular diseases
10.1186/s12964-019-0365-z · 2019 · External reference
Harmine attenuates renal fibrosis via Twist1 suppression: a novel anti-fibrotic strategy for chronic kidney disease with efficacy/safety profiling
2026 · External reference
The heterodimeric TWIST1-E12 complex drives the oncogenic potential of TWIST1 in human mammary epithelial cells
10.1016/j.neo.2016.03.007 · 2016 · External reference
Differential BMP signaling mediates the interplay between genetics and leaflet numbers in aortic valve calcification
10.1016/j.jacbts.2021.12.006 · 2022 · External reference
Cannabidiol induces autophagy to protects neural cells from mitochondrial dysfunction by upregulating SIRT1 to inhibits NF-κB and NOTCH pathways
10.3389/fncel.2021.654340 · 2021 · External reference
TWIST1 activates cancer stem cell marker genes to promote epithelial-mesenchymal transition and tumorigenesis in esophageal squamous cell carcinoma
10.1186/s12885-022-10252-9 · 2022 · External reference
Twist1 activity thresholds define multiple functions in limb development
10.1016/j.ydbio.2010.08.015 · 2010 · External reference
The F-box protein Ppa is a common regulator of core EMT factors Twist, Snail, Slug, and Sip1
10.1083/jcb.201012085 · 2011 · External reference
Twist1 directly regulates genes that promote cell proliferation and migration in developing heart valves
10.1371/journal.pone.0029758 · 2011 · External reference
Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling
10.1126/sciadv.abe3706 · 2021 · External reference
Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
10.1158/1535-7163.mct-07-0371 · 2007 · External reference
Deep-learning survival analysis for patients with calcific aortic valve disease undergoing valve replacement
10.1038/s41598-024-61685-0 · 2024 · External reference
Harmine inhibits breast cancer cell migration and invasion by inducing the degradation of Twist1
10.1371/journal.pone.0247652 · 2021 · External reference
Human and porcine aortic valve endothelial and interstitial cell isolation and characterization
10.3389/fcvm.2023.1151028 · 2023 · External reference
Harmine Hydrochloride Mediates the Induction of G2/M Cell Cycle Arrest in Breast Cancer Cells by Regulating the MAPKs and AKT/FOXO3a Signaling Pathways
10.3390/molecules26216714 · 2021 · External reference
Calcific Aortic Stenosis: A Review
10.1001/jama.2024.16477 · 2024 · External reference
Normal and disease-related biological functions of Twist1 and underlying molecular mechanisms
10.1038/cr.2011.144 · 2012 · External reference
The role of stress concentration in calcified bicuspid aortic valve
10.1098/rsif.2019.0893 · 2020 · External reference
Twist1 function in endocardial cushion cell proliferation, migration, and differentiation during heart valve development
10.1016/j.ydbio.2008.02.037 · 2008 · External reference
Oxidative stress and valvular endothelial cells in aortic valve calcification
10.1016/j.biopha.2023.114775 · 2023 · External reference
Animal models of calcific aortic valve disease
2011 · External reference
BMP-2 and TGF-β1 mediate biglycan-induced pro-osteogenic reprogramming in aortic valve interstitial cells
10.1007/s00109-014-1229-z · 2015 · External reference
Id-1 is a key transcriptional regulator of glioblastoma aggressiveness and a novel therapeutic target
10.1158/0008-5472.can-12-1943 · 2013 · External reference
Integrative genomic analyses identify candidate causal genes for calcific aortic valve stenosis involving tissue-specific regulation
10.1038/s41467-024-46639-4 · 2024 · External reference
The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral pattern
10.1093/nar/15.8.3439 · 1987 · External reference
Large animal models of cardiovascular disease
10.1002/cbf.3173 · 2016 · External reference
Emerging biological functions of Twist1 in cell differentiation
2025 · External reference
Potency assessment of CBD oils by their effects on cell signaling pathways
10.3390/nu12020357 · 2020 · External reference
The small molecule harmine is an antidiabetic cell-type-specific regulator of PPARgamma expression
10.1016/j.cmet.2007.03.010 · 2007 · External reference
Ligation of ICAM-1 on human aortic valve interstitial cells induces the osteogenic response: a critical role of the Notch1-NF-κB pathway in BMP-2 expression
10.1016/j.bbamcr.2014.07.017 · 2014 · External reference
Trends in the global burden of aortic valve calcification disease in the working-age population from 1992 to 2021
10.3389/fcvm.2025.1544273 · 2025 · External reference
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
10.1016/j.cell.2004.06.006 · 2004 · External reference
Changing epidemiology of calcific aortic valve disease: 30-year trends of incidence, prevalence, and deaths across 204 countries and territories
10.18632/aging.202942 · 2021 · External reference
A first-in-class TWIST1 inhibitor with activity in oncogene-driven lung cancer
10.1158/1541-7786.mcr-17-0298 · 2017 · External reference
Global burden of calcific aortic valve disease and attributable risk factors from 1990 to 2019
10.3389/fcvm.2022.1003233 · 2022 · External reference
A novel Ex Vivo model of aortic valve calcification. A preliminary report
10.3389/fphar.2020.568764 · 2020 · External reference
Twist-related protein 1 negatively regulated osteoblastic transdifferentiation of human aortic valve interstitial cells by directly inhibiting runt-related transcription factor 2
10.1016/j.jtcvs.2014.02.084 · 2014 · External reference
Evaluation of aortic arch calcification to predict prognosis after transcatheter aortic valve replacement
10.1038/s41598-024-83536-8 · 2025 · External reference
