Research graph
References from Quercetin-mediated selenium nanoparticles protect against hyperthyroidism-induced hepatic injury: Involvement of Nrf2/NF-κB signaling, mitochondrial apoptosis, and iron/heme imbalance. Local targets link to admitted publications; unresolved targets remain external evidence.
Amelioration of 5-Fluorouracil–Induced Hepatorenal Toxicity by Epigallocatechin Gallate–Functionalized Selenium Nanoparticles: A Multi-Targeted Protective Approach
10.3390/ijms27093887 · 2026 · External reference
The synergistic effects of citicoline and silymarin on liver injury and thyroid hormone disturbances in γ-irradiated rats
10.1007/s11033-025-10255-2 · 2025 · External reference
Hepatic and immune modulatory effectiveness of lactoferrin loaded Selenium nanoparticles on bleomycin induced hepatic injury
10.1038/s41598-024-70894-6 · 2024 · External reference
Nano-chitosan/bovine lactoperoxidase and lactoferrin formulation modulates the hepatic deterioration induced by 7,12-dimethylbenz[a]anthracene
10.1007/s00580-023-03510-0 · 2023 · External reference
EGCG-mediated selenium nanoparticles protect against 5-fluorouracil–induced cardiotoxicity via Nrf2/Keap1 signaling
10.1007/s00210-026-05413-7 · 2026 · External reference
Primary Hypothyroidism and Alzheimer’s Disease: A Tale of Two
10.1007/s10571-023-01392-y · 2023 · External reference
Anti-nephrotoxic, antioxidant and anti-inflammatory efficiency of Nigella sativa ethanolic extract against CCl4-induced nephrotoxicity in rats
10.5455/ovj.2025.v15.i1.36 · 2025 · External reference
Cardioprotective, anti-inflammatory, and antioxidative outcome of costus against bleomycin-induced cardiotoxicity in rat model
10.1016/j.jgeb.2025.100466 · 2025 · External reference
Biosynthesized Selenium Nanoparticles Using Epigallocatechin Gallate Protect against Pentylenetetrazole-Induced Acute Epileptic Seizures in Mice via Antioxidative, Anti-Inflammatory, and Anti-Apoptotic Activities
10.3390/biomedicines11071955 · 2023 · External reference
Targeting JAK2/STAT3, NLRP3/Caspase-1, and PK2/PKR2 Pathways with Arbutin Ameliorates Lead Acetate-Induced Testicular Injury in Rats
10.3390/ph17070909 · 2024 · External reference
Nephroprotective Effects of Quercetin–Selenium Nanoparticles Against Glycerol-Induced AKI
10.3390/ijms262412187 · 2025 · External reference
Latest Updates on Pharmaceutical Properties of Quercetin and its Deriva-tives as Bioactive Flavonoids in Health Protection and Disease Treatment
10.2174/0115748855406912251202101011 · 2026 · External reference
Interleukin-6 protects liver against warm ischemia/reperfusion injury and promotes hepatocyte proliferation in the rodent
10.1002/hep.510260619 · 1997 · External reference
Thyroid-Liver Axis: The Role of Thyroid Dysfunction in the Pathogenesis and Progression of MASLD: A Comprehensive Review
10.1111/liv.70431 · 2026 · External reference
Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism
10.3389/fimmu.2022.943321 · 2022 · External reference
The Relationship Between Non-Transferrin-Bound Iron (NTBI), Labile Plasma Iron (LPI), and Iron Toxicity
10.3390/ijms26136433 · 2025 · External reference
Natural product-based interventions for thyroid disorders: mechanisms and applications
10.1007/s00210-025-04604-y · 2026 · External reference
Decoding the effect of Diceratella elliptica on the oxidative stress–Inflammation axis in hyperthyroid-induced hepatotoxicity
10.1016/j.jgeb.2025.100625 · 2025 · External reference
Hesperidin Reduces Hepatic Injury Induced by Doxorubicin in Rat Model Through Its Antioxidative and Anti-Inflammatory Effects, Focusing on SIRT-1/NRF-2 Pathways
10.1002/jbt.70465 · 2025 · External reference
Withania somnifera-Functionalized Selenium Nanoparticles Attenuate Glycerol-Induced Rhabdomyolysis-Associated Acute Renal Failure
10.3390/ijms27156746 · 2026 · External reference
Rutin-biosynthesized selenium nanoparticles mitigate 5-fluorouracil induced neurotoxicity via modulation of the ROS/Nrf2/NF-κB mitochondrial apoptosis axis
10.1016/j.nanoso.2026.101697 · 2026 · External reference
Chronic Microplastic Exposure Dose-Dependently Induces Liver Failure via Oxidative Stress, Inflammation, and Apoptosis in Rats
10.1002/jat.70002 · 2026 · External reference
Hepatoprotection by Methylene Blue Against Doxorubicin Toxicity Through Coordinated Modulation of Oxidative Stress, ER Stress, and Apoptotic Pathways
10.3390/ph18111625 · 2025 · External reference
pH-Responsive Carboxymethyl Cellulose-Encapsulating Hesperidin–Selenium Nanoparticles Attenuate Paracetamol-Induced Acute Kidney Injury via Keap-1/Nrf2, NF-κB, and Mitochondrial Apoptosis Modulation
10.3390/ijms27157049 · 2026 · External reference
pH-Responsive Carboxymethyl Cellulose-Encapsulating Hesperidin–Selenium Nanoparticles Attenuate Paracetamol-Induced Acute Kidney Injury via Keap-1/Nrf2, NF-κB, and Mitochondrial Apoptosis Modulation
10.3390/ijms27157049 · 2026 · External reference
Antioxidant Defense Capacity Is Reduced in Thyroid Stem/Precursor Cells Compared to Differentiated Thyrocytes
10.3390/ijms241411509 · 2023 · External reference
The flavonoid quercetin inhibits thyroid-restricted genes expression and thyroid function
10.1016/j.fct.2014.01.016 · 2014 · External reference
Fe3+ Reducing Power as the Most Common Assay for Understanding the Biological Functions of Antioxidants
10.3390/pr13051296 · 2025 · External reference
Biologically-Guided Isolation of Natural Lead Antithyroid Drug from Medicago sativa L. Sprouts and Its Toxic Profile in Comparison with Propylthiouracil
2020 · External reference
Biologically-Guided Isolation of Natural Lead Antithyroid Drug from Medicago sativa L. Sprouts and Its Toxic Profile in Comparison with Propylthiouracil
2020 · External reference
Biomedical Potential of Plant-Based Selenium Nanoparticles: A Comprehensive Review on Therapeutic and Mechanistic Aspects
10.2147/ijn.s295053 · 2021 · External reference
Evaluation of thyroxine resistance in patients with hypothyroidism: a laboratory study
2025 · External reference
Intrathyroidal feedforward and feedback network regulating thyroid hormone synthesis and secretion
10.3389/fendo.2022.992883 · 2022 · External reference
Thyroid-specific mitochondrial dysfunction results in abnormal thyrotropin responses
10.1530/endoabs.56.gp251 · 2018 · External reference
Thyroid Hormones and Cancer: A Comprehensive Review of Preclinical and Clinical Studies
10.3389/fendo.2019.00059 · 2019 · External reference
Antioxidant Activity, Total Polyphenol Content, and Cytotoxicity of Various Types of Starch with the Addition of Different Polyphenols
10.3390/molecules30112458 · 2025 · External reference
Hepcidin mediates the disorder of iron homeostasis and mitochondrial function in mice under hypobaric hypoxia exposure
10.1007/s10495-025-02079-z · 2025 · External reference
Targeting Oxidative Stress and Neuroinflammation: Epigallocatechin-3-gallate-Selenium Nanoparticles Mitigate Sleep Deprivation-Induced Cortical Impairment
10.3390/ijms262211173 · 2025 · External reference
Therapeutic effect of Diceratella elliptica on hyperthyroid-induced renal and pancreatic damage
10.1016/j.tice.2026.103697 · 2026 · External reference
Therapeutic effect of Diceratella elliptica on hyperthyroid-induced renal and pancreatic damage
10.1016/j.tice.2026.103697 · 2026 · External reference
Multifaceted Roles of Bcl-2 Family Proteins: Regulatory Roles in Apoptosis, Physiological Functions, and Therapeutic Potential
10.1007/s11596-025-00124-1 · 2025 · External reference
The effects of L-thyroxine and its association with physical exercise decrease the inflammation in an acute lung injury model
10.1139/facets-2023-0239 · 2025 · External reference
Advancing Cancer Treatment: A Review of Immune Checkpoint Inhibitors and Combination Strategies
10.3390/cancers17091408 · 2025 · External reference
Studying the Role of L-Thyroxine in Long-Term Management of Hypothyroidism: A Comparative Analysis with Healthy Control
10.62472/kjps.v15.i24.35-56 · 2024 · External reference
Thyroid Hormone Regulation of Metabolism
10.1152/physrev.00030.2013 · 2014 · External reference
Quercetin and Its Lecithin-Based Formulation: Potential Applications for Allergic Diseases Based on a Narrative Review
10.3390/nu17091476 · 2025 · External reference
Nrf2 and Oxidative Stress: A General Overview of Mechanisms and Implications in Human Disease
10.3390/antiox11122345 · 2022 · External reference
Molecular Mechanisms and Biomarker-Based Early-Warning Indicators of Heavy Metal Toxicity in Marine Fish
10.3390/fishes10070339 · 2025 · External reference
Quercetin-loaded selenium nanoparticles inhibit amyloid-β aggregation and exhibit antioxidant activity
10.1016/j.colsurfa.2020.125058 · 2020 · External reference
An “increase-decrease-increase” pattern: TSH levels and anxiety symptoms in treatment-naïve first-episode patients with major depressive disorder
10.1016/j.jad.2026.121778 · 2026 · External reference
The key roles of thyroid hormone in mitochondrial regulation, at interface of human health and disease
10.1515/jbcpp-2024-0108 · 2024 · External reference
An Overview of Nrf2 signaling pathway and its role in inflammation
10.3390/molecules25225474 · 2020 · External reference
Role of Endoplasmic Reticulum Stress-Associated Genes in Septic Neonatal Foals
10.3390/antiox14081024 · 2025 · External reference
Heat-Related Illness in Emergency and Critical Care: Recommendations for Recognition and Management with Medico-Legal Considerations
10.3390/biomedicines10102542 · 2022 · External reference
EGCG-Functionalized Selenium Nanoparticles Mitigate High-Fat Diet-Induced Hepatic Lipotoxicity Through Keap1/Nrf2 Redox Modulation and Transcriptional Regulation of AMPK/SIRT1/PGC-1α/MFN2-Associated Mitochondrial Homeostasis
10.3390/ijms27135768 · 2026 · External reference
Repurposing the antimalarial chloroquine: a potential therapy for hepatic injury in a rat model of hindlimb ischemia–reperfusion by modulating apoptosis, autophagy, inflammation, and oxidative stress
10.1186/s43094-025-00781-y · 2025 · External reference
Hepatic oxidative stress, up-regulation of pro-inflammatory cytokines, apoptotic and oncogenic markers following 2-methoxyethanol administrations in rats
2020 · External reference
The mechanism and application of Scrophulariae Radix in the treatment of endocrine disorders: focusing on thyroid diseases and diabetes mellitus
10.3389/fendo.2025.1684744 · 2025 · External reference
Measurement of oxidative stress and total antioxidant capacity in hyperthyroid patients following treatment with carbimazole and antioxidant
2021 · External reference
Severe hyperthyroidism induces mitochondria-mediated apoptosis in rat liver
10.1002/hep.20085 · 2004 · External reference
The BCL2 family: from apoptosis mechanisms to new advances in targeted therapy
10.1038/s41392-025-02176-0 · 2025 · External reference
Thiamazole-loaded nanohybrid hydrogel microneedles for treating hyperthyroidism
10.1016/j.matdes.2026.116284 · 2026 · External reference
Hyperthyroidism: aetiology, pathogenesis, diagnosis, management, complications, and prognosis
10.1016/s2213-8587(23)00005-0 · 2023 · External reference
Mitochondria in oxidative stress, inflammation and aging: from mechanisms to therapeutic advances
10.1038/s41392-025-02253-4 · 2025 · External reference
Evaluation of selenoproteins and proinflammatory cytokines in L-thyroxine-induced hyperthyroid rats: effects of selenium supplementation
10.20945/2359-4292-2024-0444 · 2025 · External reference
Hyperthyroidism and Liver Dysfunction: A Review of a Common Comorbidity
10.1177/11795514221074672 · 2022 · External reference
Biogenic Selenium Nanoparticles in Biomedical Sciences: Properties, Current Trends, Novel Opportunities and Emerging Challenges in Theranostic Nanomedicine
10.3390/nano13030424 · 2023 · External reference
Quercetin alleviates hyperthyroidism-induced liver damage via Nrf2 Signaling pathway
10.1002/biof.1626 · 2020 · External reference
Quercetin alleviates hyperthyroidism-induced liver damage via Nrf2 Signaling pathway
10.1002/biof.1626 · 2020 · External reference
