Research graph
References from Icariin synergistically inhibits glycolysis and mitochondrial energy metabolism in lung cancer in association with the HIF-1α/LONP1 axis. Local targets link to admitted publications; unresolved targets remain external evidence.
LONP1 targets HMGCS2 to protect mitochondrial function and attenuate chronic kidney disease
10.15252/emmm.202216581 · 2023 · External reference
Hypoxia-Inducible Factor 1-Alpha (HIF-1α): An Essential Regulator in Cellular Metabolic Control
2024 · External reference
Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries
2024 · External reference
Mitochondrial ROS, ER Stress, and Nrf2 Crosstalk in the Regulation of Mitochondrial Apoptosis Induced by Arsenite
10.3390/antiox11051034 · 2022 · External reference
Mitochondria: It is all about energy
10.3389/fphys.2023.1114231 · 2023 · External reference
The effect of unhealthy lifestyle on the pathogenesis of sick sinus syndrome: A life-guiding review
2024 · External reference
Targeting mitochondria by lipid-selenium conjugate drug results in malate/fumarate exhaustion and induces mitophagy-mediated necroptosis suppression
10.7150/ijbs.102424 · 2024 · External reference
Potential Candidates of Natural Antioxidants From Herbs for Treating Lung Disorders: Focus on Redox Balance and Natural Products
10.1002/ptr.70008 · 2025 · External reference
Integration of machine learning and experimental validation reveals new lipid-lowering drug candidates
10.1038/s41401-025-01539-1 · 2025 · External reference
Citrullination modulation stabilizes HIF-1α to promote tumour progression
10.1038/s41467-024-51882-w · 2024 · External reference
Circ_0000376 regulates miR-577/HK2/LDHA signaling pathway to promote the growth, invasion and glycolysis of osteosarcoma
10.1186/s13018-023-04520-y · 2024 · External reference
Icariin against osteoporosis: a review of advances in molecular mechanisms to biomedical applications
10.3389/fphar.2025.1688847 · 2025 · External reference
Icariin mediates autophagy and apoptosis of hepatocellular carcinoma cells induced by the β-catenin signaling pathway through lncRNA LOXL1-AS1
10.1007/s00210-024-03692-6 · 2025 · External reference
Cancer cachexia: biomarkers and the influence of age
2024 · External reference
Icariin promoted ferroptosis by activating mitochondrial dysfunction to inhibit colorectal cancer and synergistically enhanced the efficacy of PD-1 inhibitors
10.1016/j.phymed.2024.156224 · 2025 · External reference
Acquired resistance to anti-PD1 therapy in patients with NSCLC associates with immunosuppressive T cell phenotype
10.1038/s41467-023-40745-5 · 2023 · External reference
Metabolic reprogramming in lung cancer and its clinical implication
10.3389/fphar.2024.1516650 · 2024 · External reference
GDF15: from biomarker to target in cancer cachexia
10.1016/j.trecan.2025.06.007 · 2025 · External reference
Modern therapies of nonsmall cell lung cancer
10.1007/s13353-023-00786-4 · 2023 · External reference
Inhibition of TFAM-Mediated Mitophagy by Oroxylin A Restored Sorafenib Sensitivity Under Hypoxia Conditions in HepG2 Cells
10.3390/ph17121727 · 2024 · External reference
Icariin Inhibits Lung Adenocarcinoma Progression Through TP53-Mediated Ferroptosis
10.2147/ott.s539483 · 2025 · External reference
A review of the basics of mitochondrial bioenergetics, metabolism, and related signaling pathways in cancer cells: Therapeutic targeting of tumor mitochondria with lipophilic cationic compounds
10.1016/j.redox.2017.09.020 · 2018 · External reference
Skeletal muscle endothelial dysfunction through the activin A–PGC1α axis drives progression of cancer cachexia
10.1038/s43018-025-00975-6 · 2025 · External reference
Current status and trend of mitochondrial research in lung cancer: A bibliometric and visualization analysis
10.1016/j.heliyon.2024.e34442 · 2024 · External reference
Mitochondrial DNA stress triggers autophagy-dependent ferroptotic death
10.1080/15548627.2020.1739447 · 2021 · External reference
Autophagy and Glycometabolic Reprograming in the Malignant Progression of Lung Cancer: A Review
10.1177/15330338231190545 · 2023 · External reference
Icariin as a potential anticancer agent: a review of its biological effects on various cancers
2023 · External reference
TFAM is an autophagy receptor that limits inflammation by binding to cytoplasmic mitochondrial DNA
10.1038/s41556-024-01419-6 · 2024 · External reference
Icariin as an emerging candidate drug for anticancer treatment: Current status and perspective
10.1016/j.biopha.2022.113991 · 2023 · External reference
Epithelial–Mesenchymal Transition in Osteosarcoma as a Key Driver of Pulmonary Metastasis
10.3390/cancers17172922 · 2025 · External reference
Rewiring cancer metabolism: oncogenic signaling pathways and targeted therapeutics
10.1007/s11427-025-2979-3 · 2025 · External reference
Roles of LonP1 in Oral-Maxillofacial Developmental Defects and Tumors: A Novel Insight
10.3390/ijms232113370 · 2022 · External reference
Energy stress-induced circZFR enhances oxidative phosphorylation in lung adenocarcinoma via regulating alternative splicing
10.1186/s13046-023-02723-z · 2023 · External reference
Advances in pathogenesis and treatment of vascular endothelial injury-related diseases mediated by mitochondrial abnormality
10.3389/fphar.2024.1422686 · 2024 · External reference
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
10.1007/s10456-024-09938-4 · 2024 · External reference
Metabolic adaptation in hypoxia and cancer
10.1016/j.canlet.2020.12.020 · 2021 · External reference
Natural Product-Based Glycolysis Inhibitors as a Therapeutic Strategy for Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor-Resistant Non-Small Cell Lung Cancer
10.3390/ijms25020807 · 2024 · External reference
Ginsenoside Rb1 attenuates coronary microvascular inflammatory injury via NDUFS4-SIRT5-DUSP1-mediated mitochondrial quality control in a murine ischemia-reperfusion model
10.1016/j.jgr.2025.04.006 · 2025 · External reference
Tanshinone IIA modulates Sirt5 and Metll3 interaction to govern mitochondria-endoplasmic reticulum unfolded protein response in coronary microvascular injury
10.1016/j.phymed.2025.156982 · 2025 · External reference
The regulatory roles and clinical significance of glycolysis in tumor
10.1002/cac2.12549 · 2024 · External reference
Blocking ActRIIB and restoring appetite reverses cachexia and improves survival in mice with lung cancer
10.1038/s41467-022-32135-0 · 2022 · External reference
Role of LDH in tumor glycolysis: Regulation of LDHA by small molecules for cancer therapeutics
10.1016/j.semcancer.2022.11.007 · 2022 · External reference
Powering down the mitochondrial LonP1 protease: a novel strategy for anticancer therapeutics
10.1080/14728222.2023.2298358 · 2024 · External reference
A novel ligustrazine-based nanodelivery system protects against doxorubicin-induced cardiotoxicity by targeting the SIRT5-DUSP1 axis for mitochondrial repair
10.1186/s12951-025-03667-6 · 2025 · External reference
Advances of HIF-1α/glycolysis axis in non-small cell lung cancer (Review)
10.3892/or.2024.8714 · 2024 · External reference
Mitochondrial DNA mutations in ageing and cancer
10.1002/1878-0261.13291 · 2022 · External reference
HIF-1 mediated metabolic reprogramming in cancer: Mechanisms and therapeutic implications
10.1016/j.lfs.2024.122890 · 2024 · External reference
Epidemiology of lung cancer
2021 · External reference
Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity
10.3390/ijms241512012 · 2023 · External reference
DNA-PKcs-Driven YAP1 Phosphorylation and Nuclear Translocation: a Key Regulator of Ferroptosis in Hyperglycemia-Induced Cardiac Dysfunction in Type 1 Diabetes
2025 · External reference
Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy
10.7150/ijbs.95853 · 2024 · External reference
Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondrial quality surveillance
10.1186/s12951-025-03420-z · 2025 · External reference
Unresolved reference
External reference
Microtubules and cardiovascular diseases: insights into pathology and therapeutic strategies
10.1016/j.biocel.2024.106650 · 2024 · External reference
Traditional Chinese medicine in lung cancer treatment
10.1186/s12943-025-02245-6 · 2025 · External reference
Targeting glycolysis in non-small cell lung cancer: Promises and challenges
10.3389/fphar.2022.1037341 · 2022 · External reference
Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury
10.1016/j.jpha.2024.101034 · 2024 · External reference
Mitochondrial-cytochrome c oxidase II promotes glutaminolysis to sustain tumor cell survival upon glucose deprivation
10.1038/s41467-024-55768-9 · 2025 · External reference
The Regulatory Mechanism of Hypoxia-inducible Factor 1 and its Clinical Significance
10.2174/0118761429266116231123160809 · 2024 · External reference
Long Non-Coding RNA DUXAP8 Facilitates Cell Viability, Migration, and Glycolysis in Non-Small-Cell Lung Cancer via Regulating HK2 and LDHA by Inhibition of miR-409-3p
10.2147/ott.s243542 · 2020 · External reference
Correlation between TCM Constitutional Types and Lung Carcinoma in Various Geographical Areas: A Systematic Review and Meta-Analysis
10.1155/2022/5660231 · 2022 · External reference
Lung cancer palindromia due to the deficiency of vital energy and blood syndrome treated by TCM herbs: A case report
2025 · External reference
Current Research on the Application of Xuefu Zhuyu Decoction and Its Modifications in the Treatment of Lung Cancer
10.53469/jcmp.2024.06(12).40 · 2024 · External reference
Differential Expression of Lonp1 Isoforms in Cancer Cells
10.3390/cells11233940 · 2022 · External reference
Silencing ZIC5 suppresses glycolysis and promotes disulfidptosis in lung adenocarcinoma cells
10.1080/15384047.2025.2501780 · 2025 · External reference
CAF-derived exosomal LncRNA ANRIL promotes glycolytic metabolism and proliferation in non-small cell lung cancer via the miR-186-5p/HIF-1α axis
10.1007/s12672-025-03109-7 · 2025 · External reference
LONP1 alleviates ageing-related renal fibrosis by maintaining mitochondrial homeostasis
10.1111/jcmm.70090 · 2024 · External reference
Mitochondrial quality control proteases and their modulation for cancer therapy
10.1002/med.21929 · 2023 · External reference
Traditional Chinese medicine and lung cancer——From theory to practice
2021 · External reference
Understanding Immunomodulation and Managing Cancer Cachexia: A Narrative Review
10.2174/012212697x400236250630115449 · 2025 · External reference
Ginsenoside compound K-based multifunctional liposomes for the treatment of rheumatoid arthritis
10.1080/10717544.2025.2464190 · 2025 · External reference
Astragaloside VI attenuates mechanical stress-induced cardiac remodeling through piezo1-VDAC1 dependent endoplasmic reticulum unfolded protein response
10.1016/j.phymed.2025.157288 · 2025 · External reference
A TCM Formula YYWY Inhibits Tumor Growth in Non-Small Cell Lung Cancer and Enhances Immune-Response Through Facilitating the Maturation of Dendritic Cells
10.3389/fphar.2020.00798 · 2020 · External reference
Clinical Research Progress of Cancer Cachexia Treated by Chinese and Western Medicine
2025 · External reference
TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis
10.1007/s10565-024-09918-w · 2024 · External reference
Icariin inhibits the malignant progression of lung cancer by affecting the PI3K/Akt pathway through the miR‑205‑5p/PTEN axis
10.3892/or.2022.8326 · 2022 · External reference
Mitochondrial dysfunction: mechanisms and advances in therapy
10.1038/s41392-024-01839-8 · 2024 · External reference
