Research graph
References from Nebulized inhalation of exosomes from human umbilical cord mesenchymal stem cells alleviates bleomycin-induced pulmonary fibrosis through tsRNA cargos. Local targets link to admitted publications; unresolved targets remain external evidence.
First-in-human high-cumulative-dose stem cell therapy in idiopathic pulmonary fibrosis with rapid lung function decline
10.1002/sctm.19-0037 · 2020 · External reference
HSPB1 inhibits the endothelial-to-mesenchymal transition to suppress pulmonary fibrosis and lung tumorigenesis
10.1158/0008-5472.can-15-0952 · 2016 · External reference
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis
10.1038/s41467-020-14344-7 · 2020 · External reference
Statins: cause of fibrosis or the opposite? Effect of cardiovascular drugs in idiopathic pulmonary fibrosis
2021 · External reference
R213G polymorphism in SOD3 protects against bleomycin-induced inflammation and attenuates induction of proinflammatory pathways
10.1152/physiolgenomics.00053.2018 · 2018 · External reference
Slicing tRNAs to boost functional ncRNA diversity
10.4161/rna.27177 · 2013 · External reference
Targeting early pulmonary fibrosis with bone marrow mesenchymal stem cells and their derived exosomes: a comparative study of inhalation versus injection delivery in bleomycin-induced rat lung injury
10.1007/s00210-026-05750-7 · 2026 · External reference
Engineering of stimulus-responsive pirfenidone liposomes for pulmonary delivery during treatment of idiopathic pulmonary fibrosis
2022 · External reference
Bioinformatics analysis identifies potential ferroptosis key genes in the pathogenesis of pulmonary fibrosis
2021 · External reference
An official american thoracic society workshop report: use of animal models for the preclinical assessment of potential therapies for pulmonary fibrosis
10.1165/rcmb.2017-0096st · 2017 · External reference
Advances in mesenchymal stem cell and exosome-based therapies for aging and age-related diseases
10.1186/s13287-025-04318-1 · 2025 · External reference
Clinical investigation on nebulized human umbilical cord MSC-derived extracellular vesicles for pulmonary fibrosis treatment
10.1038/s41392-025-02262-3 · 2025 · External reference
tRNA and tsRNA: from heterogeneity to multifaceted regulators
10.3390/biom14101340 · 2024 · External reference
tsRNA modifications: an emerging layer of biological regulation in disease
10.1016/j.jare.2024.09.010 · 2025 · External reference
Donor MSCs release apoptotic bodies to improve myocardial infarction via autophagy regulation in recipient cells
10.1080/15548627.2020.1717128 · 2020 · External reference
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: promises, problems and prospects
10.1002/med.22002 · 2024 · External reference
Targeting growth factor and cytokine pathways to treat idiopathic pulmonary fibrosis
2022 · External reference
Hydrogen peroxide preconditioning promotes protective effects of umbilical cord vein mesenchymal stem cells in experimental pulmonary fibrosis
10.15171/apb.2020.009 · 2020 · External reference
Idiopathic pulmonary fibrosis: an update on pathogenesis
2021 · External reference
Pulmonary fibrosis and exosomes: pathways to treatment
10.1007/s11033-025-10855-y · 2025 · External reference
Anti-fibrotic effects of different sources of MSC in bleomycin-induced lung fibrosis in C57BL6 male mice
10.1111/resp.13928 · 2021 · External reference
Sigmar1 ablation leads to lung pathological changes associated with pulmonary fibrosis, inflammation, and altered surfactant proteins levels
10.3389/fphys.2023.1118770 · 2023 · External reference
ACSL4 Drives C5a/C5aR1-calcium-induced fibroblast-to-myofibroblast transition in a bleomycin-induced mouse model of pulmonary fibrosis
10.3390/biom15081106 · 2025 · External reference
A candidate gene study reveals association between a variant of the SRp55 splicing factor gene and systemic sclerosis
2022 · External reference
Immune dysregulation as a driver of idiopathic pulmonary fibrosis
10.1172/jci143226 · 2021 · External reference
Functions and mechanisms of UC-MSC-derived exosomal miR-486-5p in pulmonary fibrosis
2025 · External reference
Mechanisms of mesenchymal stem/stromal cell function
10.1186/s13287-016-0363-7 · 2016 · External reference
The long non-coding RNA PFI protects against pulmonary fibrosis by interacting with splicing regulator SRSF1
10.1038/s41418-021-00792-1 · 2021 · External reference
LncRNA DACH1 protects against pulmonary fibrosis by binding to SRSF1 to suppress CTNNB1 accumulation
10.1016/j.apsb.2022.04.006 · 2022 · External reference
Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
10.1080/20013078.2018.1535750 · 2018 · External reference
Minimal information for studies of extracellular vesicles (MISEV2023): From basic to advanced approaches
10.1002/jev2.12404 · 2024 · External reference
Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer
10.1186/s13045-021-01141-y · 2021 · External reference
Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis
10.1080/10717544.2022.2057617 · 2022 · External reference
Arctiin-encapsulated DSPE-PEG bubble-like nanoparticles inhibit alveolar epithelial type 2 cell senescence to alleviate pulmonary fibrosis via the p38/p53/p21 pathway
10.3389/fphar.2023.1141800 · 2023 · External reference
Human umbilical cord mesenchymal stem cells derived-exosomes in diseases treatment
10.1016/j.lfs.2019.116733 · 2019 · External reference
Every road leads to Rome: therapeutic effect and mechanism of the extracellular vesicles of human embryonic stem cell-derived immune and matrix regulatory cells administered to mouse models of pulmonary fibrosis through different routes
10.1186/s13287-022-02839-7 · 2022 · External reference
Roles of exosomes and exosome-derived miRNAs in pulmonary fibrosis
2022 · External reference
Role of SOD3 in silica-related lung fibrosis and pulmonary vascular remodeling
10.1186/s12931-018-0933-6 · 2018 · External reference
Investigation of the pharmacological effect and mechanism of jinbei oral liquid in the treatment of idiopathic pulmonary fibrosis using network pharmacology and experimental validation
2022 · External reference
Classification, function, and advances in tsRNA in non-neoplastic diseases
10.1038/s41419-023-06250-9 · 2023 · External reference
S-RBD-modified and miR-486-5p-engineered exosomes derived from mesenchymal stem cells suppress ferroptosis and alleviate radiation-induced lung injury and long-term pulmonary fibrosis
10.1186/s12951-024-02830-9 · 2024 · External reference
Human umbilical cord mesenchymal stem cell-derived exosomes prevent and alleviate experimental pulmonary fibrosis by modulating the cytoskeleton of macrophages
10.1186/s13287-025-04646-2 · 2025 · External reference
Inhalation of MSC-EVs is a noninvasive strategy for ameliorating acute lung injury
10.1016/j.jconrel.2022.03.025 · 2022 · External reference
Role of tRNA-derived fragments in cancer: novel diagnostic and therapeutic targets tRFs in cancer
2020 · External reference
