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References from Artemether induces JNK1/FOXO1/GPX4-mediated ferroptosis to suppress colorectal cancer. Local targets link to admitted publications; unresolved targets remain external evidence.
vitro evaluation of the cytotoxic and genotoxic effects of artemether, an antimalarial drug, in a gastric cancer cell line (PG100)
10.1002/jat.1734 · 2013 · External reference
Pteris wallichiana bioactives induce ferroptosis via the SLC7A11-GSH-GPX4 axis to directly suppress colorectal cancer
10.1016/j.phymed.2025.157463 · 2025 · External reference
β-tubulin contributes to Tongyang Huoxue decoction-induced protection against hypoxia/reoxygenation-induced injury of sinoatrial node cells through SIRT1-mediated regulation of mitochondrial quality surveillance
10.1016/j.phymed.2022.154502 · 2023 · External reference
Molecular mechanisms of Mitochondrial Quality Control in Ischemic Cardiomyopathy
10.7150/ijbs.76223 · 2023 · External reference
Quercetin inhibits necroptosis in cardiomyocytes after ischemia-reperfusion via DNA-PKcs-SIRT5-orchestrated mitochondrial quality control
10.1002/ptr.8177 · 2024 · External reference
Zishenhuoxue decoction-induced myocardial protection against ischemic injury through TMBIM6-VDAC1-mediated regulation of calcium homeostasis and mitochondrial quality surveillance
10.1016/j.phymed.2023.155331 · 2024 · External reference
Zishen Tongyang Huoxue decoction (TYHX) alleviates sinoatrial node cell ischemia/reperfusion injury by directing mitochondrial quality control via the VDAC1-β-tubulin signaling axis
10.1016/j.jep.2023.117371 · 2024 · External reference
Artemether attenuates the progression of non-small cell lung cancer by inducing apoptosis, cell cycle arrest and promoting cellular senescence
10.1248/bpb.b19-00391 · 2019 · External reference
Oxidative stress induces mitochondrial iron overload and ferroptotic cell death
2023 · External reference
Assessment of the relationship between gut microbiota, inflammatory markers, and colorectal cancer
10.3389/fcimb.2025.1604651 · 2025 · External reference
Artemether exhibits amoebicidal activity against Acanthamoeba castellanii through Inhibition of the serine biosynthesis pathway
10.1128/aac.04758-14 · 2015 · External reference
Vitexicarpin suppresses malignant progression of colorectal cancer through affecting c-Myc ubiquitination by targeting IMPDH2
2024 · External reference
Ferroptosis: an iron-dependent form of nonapoptotic cell death
10.1016/j.cell.2012.03.042 · 2012 · External reference
Inhibition of ferroptosis rescues M2 macrophages and alleviates arthritis by suppressing the HMGB1/TLR4/STAT3 axis in M1 macrophages
10.1016/j.redox.2024.103255 · 2024 · External reference
Repurposing of rebamipide as a neuroprotective agent to alleviate letrozole-induced depressive-like behaviors in female rats: Targeting SIRT1/FoxO1/wnt/ β-catenin, and related ferroptosis pathways
10.1016/j.lfs.2025.123941 · 2025 · External reference
Puerarin suppresses macrophage M1 polarization to alleviate renal inflammatory injury through antagonizing TLR4/MyD88-mediated NF-κB p65 and JNK/FoxO1 activation
2024 · External reference
Ferroptosis: mechanisms, biology and role in disease
10.1038/s41580-020-00324-8 · 2021 · External reference
Current and emerging therapeutic approaches for colorectal cancer: a comprehensive review
10.4240/wjgs.v15.i4.495 · 2023 · External reference
Sanqi Qushi formula alleviates podocyte damage in passive Heymann Nephritis rats by inhibiting GPX4 deficiency-mediated ferroptosis via the JNK/FoxO1 signaling pathway
10.1016/j.phymed.2025.157507 · 2026 · External reference
New insights into the role of mitochondrial metabolic dysregulation and immune infiltration in septic cardiomyopathy by integrated bioinformatics analysis and experimental validation
10.1186/s11658-024-00536-2 · 2024 · External reference
Mechanism of Bazhen decoction in the treatment of colorectal cancer based on network pharmacology, molecular docking, and experimental validation
10.3389/fimmu.2023.1235575 · 2023 · External reference
Therapeutic efficacy of artemether-lumefantrine, artesunate-amodiaquine and dihydroartemisinin-piperaquine in the treatment of uncomplicated Plasmodium falciparum malaria in Sub-Saharan Africa: a systematic review and meta-analysis
10.1371/journal.pone.0264339 · 2022 · External reference
Sensitization of FOLFOX-resistant colorectal cancer cells via the modulation of a novel pathway involving protein phosphatase 2A
10.1016/j.isci.2022.104518 · 2022 · External reference
Inflammation and tumor microenvironment
2023 · External reference
Emerging insights into the pathogenesis and therapeutic strategies for vascular endothelial injury-associated diseases: focus on mitochondrial dysfunction
10.1007/s10456-024-09938-4 · 2024 · External reference
Kaempferol sensitizes cell proliferation inhibition in oxaliplatin-resistant colon cancer cells
10.1007/s12272-021-01358-y · 2021 · External reference
Ginsenoside Rb1 ameliorates heart failure through DUSP-1-TMBIM-6-mediated mitochondrial quality control and gut flora interactions
10.1016/j.phymed.2024.155880 · 2024 · External reference
Artemether exerts neuroprotective effect in Parkinson’s disease through the PI3K/Akt/GSK-3β signaling pathway
10.1016/j.ejphar.2025.177566 · 2025 · External reference
Myoferlin targeting triggers mitophagy and primes ferroptosis in pancreatic cancer cells
10.1016/j.redox.2022.102324 · 2022 · External reference
Inhibition of MK2 suppresses IL-1β, IL-6, and TNF-α-dependent colorectal cancer growth
10.1002/ijc.31191 · 2018 · External reference
Quantitative determination of the antimalarials artemether and lumefantrine in biological samples: A review
10.1016/j.jpba.2018.12.021 · 2019 · External reference
Perioperative chemotherapy for liver metastasis of colorectal cancer: Lessons learned and future Perspectives
10.1007/s11864-022-01008-5 · 2022 · External reference
Dichloroacetate enhances the anti-tumor effect of sorafenib via modulating the ROS-JNK-Mcl-1 pathway in liver cancer cells
10.1016/j.yexcr.2021.112755 · 2021 · External reference
Berberine is a suppressor of Hedgehog signaling cascade in colorectal cancer
10.1016/j.phymed.2023.154792 · 2023 · External reference
Influence of Citrobacter freundii on NINJ2 expression and oxaliplatin resistance in colorectal cancer
10.1002/cam4.70940 · 2025 · External reference
Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy
10.7150/ijbs.95853 · 2024 · External reference
Exploring the mechanism of ferroptosis induction by sappanone A in cancer: insights into the mitochondrial dysfunction mediated by NRF2/xCT/GPX4 axis
10.7150/ijbs.96748 · 2024 · External reference
Senescent cells promote breast cancer cells motility by secreting GM-CSF and bFGF that activate the JNK signaling pathway
10.1186/s12964-024-01861-x · 2024 · External reference
Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells
10.7150/ijbs.59404 · 2021 · External reference
Revising the hemodynamic criteria for pulmonary hypertension: a perspective from China
10.2478/jtim-2022-0023 · 2023 · External reference
Multi-target regulation by artemether in MAFLD through EGFR/HSP90 pathways
2025 · External reference
Apigenin ameliorates non-eosinophilic inflammation, dysregulated immune homeostasis and mitochondria-mediated airway epithelial cell apoptosis in chronic obese asthma via the ROS-ASK1-MAPK pathway
10.1016/j.phymed.2023.154646 · 2023 · External reference
Inhibition of CDK1 overcomes oxaliplatin resistance by regulating ACSL4-mediated ferroptosis in colorectal cancer
10.1002/advs.202301088 · 2023 · External reference
Artemether attenuates high glucose-induced inflammation and fibrogenesis in renal tubular epithelial cells by modulating the TGF-β/Smad pathway via PPARγ activation
10.1155/jdr/5052561 · 2025 · External reference
Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury
10.1007/s00204-023-03599-w · 2023 · External reference
Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies
10.1038/s41392-024-01769-5 · 2024 · External reference